AU705386B2 - Method of manufacturing a sensitive single-layer system for measuring the concentration of analytes and a system produced by this method - Google Patents
Method of manufacturing a sensitive single-layer system for measuring the concentration of analytes and a system produced by this method Download PDFInfo
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- AU705386B2 AU705386B2 AU58909/96A AU5890996A AU705386B2 AU 705386 B2 AU705386 B2 AU 705386B2 AU 58909/96 A AU58909/96 A AU 58909/96A AU 5890996 A AU5890996 A AU 5890996A AU 705386 B2 AU705386 B2 AU 705386B2
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
- G01N21/783—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour for analysing gases
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Abstract
PCT No. PCT/DE96/00915 Sec. 371 Date Jan. 6, 1998 Sec. 102(e) Date Jan. 6, 1998 PCT Filed May 24, 1996 PCT Pub. No. WO96/37768 PCT Pub. Date Nov. 28, 1996Method of manufacturing a sensitive single-layer system for optically detecting a concentration of an analyte, such as, for example, oxygen, the analyte being capable of investigation in liquid or gaseous aggregate condition or in a dissolved condition, by adsorption, luminescence or luminescence quenching of an indicator sensitive to the analyte, which is preferably permanently immobilized in the optical beam path. The sensitive single-layer system achieves a reproducible and extremely short response behavior. Indicators are adsorbed on a filler material and thereafter a mixture is produced with a matrix material permeable to the analyte to be detected. Then, under the action of pressure, the mixture is extruded onto a substrate, the layer thickness being formed in dependence on the applied pressure used. The applied sensitive layer is polymerized, polycondensed or hardened and the layer is also homogenized by swelling in a fluorescence indicator solution.
Description
ccmrinaTion wih chloride or cercliorate as a ruthenium complex whose phosphorescence is quenchable by oxygen.
These indicator pigments are immobilised in polysiloxane matrix materials permeable to oxygen and therein are applied to glass fibres. Polysiloxanes with differing substituents and additives as well as specific layer sequences or protective membranes are proposed. Further, an arrangement of the indicator matrix system on the glass fibres is named, which can be ground at a specific angle.
In EP 190 829 a plurality of plasticisers are proposed as addatives to the matrix material, which in this case is disposed on a fibre ground at an angle of 20' to 30°. As described in EP 190 830, the indicator matrix system can partly represent also the optical periphery of the fibre.
In EP 0 313 655 WO 88/00339, without fastening on a specific material, an optically transparent matrix material is proposed, upon which the indicator is adsorbed or in which it is immobilised.
In EP 0 344 313 there is proposed a layer sequence of transparent substrate, indicator and gas-permeable membrane. According to DE 33 46 810, in addition to a plurality of indicators, among which are also found ruthenium compounds, and matrix polymers, among which are also polysiloxanes, special forms of the matrix, such as 7 A* 0, lamellae, spheres and fims, bur also scid addiives such as silica gel, are proposed. :n addition, various methods of introducing the indicator into the matrix are described, such as inward diffusion, mechanical mixing or covalent binding; additional protective layers are also named. The document DE-PS 37 02 210 describes the use of a two-component silicon polymer.
Finally, DE 41 08 808 proposes an indicator-containing silicon membrane convexly spread on a transparent substrate.
There is further described in DE 31 48 830 a device for determining the cxygen concentration in gases, liquids and tissues, in which a single-size layer is present on a transparent carrier with a luminescent surface formed with an adhesive or glue layer, an evaluable signal being intended to be obtained by irradiation with light at a specific wave length. The single-sized layer in this case is formed from a luminescent pigment itself or an inert carrier adsorbing this pigment, such as silica gel, or another water-rejecting plastic.
In GB 1 190 583 a gas sensor is named, in which a luminescent material is taken up into a permeable or porous carrier matrix material, the matrix material
ZPL\\
r 0 preferably being a natural or synthetic polymer or porous glass.
There may be seen from EP 0 417 535 an optical oxygen sensor, in which oxygen indicator molecules are incorporated in a polymer. As an example of such a polymer, polydimethylsiloxane is named there, which is intended to be used as a carrier for the oxygen indicators. The polymers used are then dissolved in a solvent which contains the oxygen indicators. The solution is then applied in a thin layer to the substrate and hardened; only an indirect influence can be exerted on the layer thickness formed, and thus reproducible results are not always achievable.
In the sensor member described in EP 0 244 394 for determining material concentrations in gaseous and liquid samples, a carrier layer and an indicator layer with at least one indicator substance are named. In this case at least one photosensitive member -is applied to the carrier layer.
A fibre-optic system for determining parameters in fluids is described in WO 94/10553. Here a fluorescent pigment is adsorbed from a solution on to a solid carrier, and, mixed with a liquid silicon, applied to a carrier; in this case for example polydimethylphenylsiloxane or 7t O unhardened pclydimeohylsilcxane may ce usec as a silicon in addition to others. The indicator matrix further contains indicator molecules on a carrier. A permeable membrane protects the indicator matrix, and the carrier in addition contains porous glass particles or a porous material based on silica gel or other porous glass particles and a carrier polymer of a non-ionic gel.
Ru(1,10-phenanthroline) chloride is proposed as a possible indicator.
In the sensor member described in AT 390 678 for determining material concentrations, che use of an indicator layer consisting of polymer with a fluorescence indicator is proposed. The indicator layer is intended to consist of a porous glass layer, in which the indicator substance is immobilised. The indicator layer in this case can be a porous glass layer or a spun-on or rolled-on silicon layer, in which the indicator substance is present.
A similar device is also described in EP 0 578 630, in which case the sensor membrane of an optical sensor for determining a physical or chemical parameter of a sample is likewise intended to have a polymer matrix with an immobilised indicator substance.
In the optical sensor described in 7E 0 334 204, carrier particles of silica gel spheres are proposed, which are irreversibly bound to a fluorescence indicator.
The possible use of an adsorbent such as silica gel upon which a heterocyclic organic fluorescent dye stuff is adsorbed, can be seen in DE 28 23 318.
In: Lippitsch, Max E. Et al.: fibre-Optic Oxygen Sensor with the Fluorescence Decay Time as the Information Carrier, in: Analytica Chimica Acta, 205, 1988, pp. 1 to 6, M. Lippitsch describes a fibre-optic oxygen sensor.
Exploitation of the alteration in luminescence for an oxygen sensor is likewise to be seen in an article by Wenying; Xu, et. al.: Oxygen Sensors Based on Luminescence Quenching: Interactions of Metal Complexes with the Polymer Supports. In: Anal. Chem. 1934, 66, pp.
4133-4141. Here it is proposed to use the oxygen influence on [Ru(Ph2phen) 3 ]Cl 2 (Ph 2 phen=4,7-diphenyl-l,10phenanthroline) in combination with a polymer, such for example as polydimethylsiloxane. In addition silica gel is to be added, in order to be able to influence the sensor properties.
Ruthenium compounds are generally advantageous and appropriate for the named case of application due to -ner 'arge Stokes Shift (large distance between energisaricn and emission) and the relatively long-wave energisation and emission; in this connection these are already widely described in the literature (see among others J.R. Bacon, K.N. Demas: Determination of Oxygen Concentrations by Luminescence Quenching of a Polymer- Immcbilised Transition-Metal Complex; Anal. Chem. 59, 2780 85, 1987).
Polysiloxanes are the polymers which have the greatest permeability for oxygen (see among others S. Egli, A.
Ruf, A. Buck; Gastrennung mittels Membranen; Swiss.
Chem. 6, 89 126, 1984).
Initially, a sufficient strength of the indicator-matrix systems is of great importance for practical use of such sensors. This is not sufficiently provided in the bonding of the indicator merely to the surface of a carrier. Furthermore, short response times, reproducible in the case of various examples of applicators, are to be achievable. The response times increase significantly, even in the case of polymers with good oxygen permeability, as the layer thickness increases or additional protective layers are applied.
It is therefore the object of the invention to propose a method of manufacturing, and a sensitive single-layer system or mneasuring the concen-cration or he carial pressure of analytes, by means of which a reproducible and extremely short response behaviour becomes obtainable.
According to the invention, this object is achieved by the features named in claim 1 for the method and the features of claim 4 for the single-layer system.
Advantageous embodiments and further developments of the invention will become apparent upon using the features named in the subordinate claims.
According to the invention, the sensitive single-layer system is produced in such a way that the fluorescence indicators are adsorbed on to a filling material, and in connection therewith a mixture is produced with a matrix material permeable to the analyte to be investigated.
The mixture produced is then compressed under the action of pressure, advantageously at an applied pressure of 12 to 20 x 104 Pa, preferably 15 x 104 Pa on a substrate, the layer thickness being formed in dependence on the applied pressure used. The sensitive layer thus applied is polymerised, polycondensed or hardened, this preferably being carried out in an extrusion mould to be used. The layer is additionally homogenised by swelling in a fluorescence indicator solution.
On rcer to swell he permeable matrix material which preferably polydimethylsiloxane, a methylene chloride solution containing a fluorescence indicator with a concentration of 10-' to 10- 6 preferably 10- 3 to 10- 4 molar concentration is used. The sensitive single layer system thus produced has in the sensitive layer an overall concentration of the fluorescence indicators in the permeable matrix of 10-_ to 10- mol/l, preferably 10-2 to 3 mol/. Furthermore, there is also contained in the matrix a filler with a weight proportion of 5 to 65% by weight, preferably 20 to 30% by weight. In this respect in an advantageous way silica gel or porous glass should be used as a filler, upon which the fluorescence indicators are adsorbed.
Ruthenium-diamine complexes are advantageously used as fluorescence indicators, these more preferably being Ru(4,7ph 2 phen)3 Cl 2 x 5H 2 0 and being particularly suitable for detecting oxygen concentration.
An oxygen-permeable matrix material is for example polysiloxane and preferably polydimethylsiloxane.
The substrate material can be an optically transparent or reflective material and be used in various forms, the sensitive layer being applied to the substrate in accordance with the measuring purpose envisaged.
The sensitive single-layer system manufactured and designed according to the invention can be used for process monitoring in the most varied areas of technology and medicine, in order to monitor the concentration of the analyte, particularly of the oxygen, in almost any fluids, materials, mixtures of materials, and if necessary to utilise the measurement signals for influencing specific processes. Thus in particular the response time in millisecond range of the system according to the invention, in comparison to solutions previously known, is a positive factor. This is achieved by the capacity to produce extremely thin layers under pressure action with good adhesion and resistance.
However, the most varied analyses may be carried out and supported, one example being the investigation of soil samples.
The sensitive single-layer system according to the invention can operate without additional adhesion promoters and protective layers. This is advantageously achieved by true-to-form polymerisation, polycondensation or hardening and subsequent homogenisation of the indicator matrix system on the substrate. An optical fibre or an optically transparent or reflective substrate can in this case preferably serve as a substrate.
according to the invention for a sensor system for optical detection of the concentration or of the partial pressure of an analyte, by adsorption, luminescence or luminescence quenching of an indicator immobilised in a permeable matrix material, is advantageously characterised in that good chronological durability and resistance in the utility medium even in flowing liquids, and further a signal level sufficient for good resolution, low response times, very low copy scatter of the values measured with various applications, and not least simplicity of manufacture, have been achieved.
The invention will be explained in more detail in the following with reference to an embodiment given by way of example.
In the associated drawing: Figure 1: a graphical view of the sensor characteristic curve of the single-layer system after manufacture and after 4 months' storage.
In order to produce the applicator, an appropriate filler material such as silica gel is treated with a solution of the indicator in a suitable solvent. After adsorption of the indicator on the filler material, excess solvent is removed. The desired quantity of filler material is mixed into a prepolymer or plasticised polymer, which is preferably permeable to the material to be detected after hardening, and the mass is pressed on to the substrate in a mould with a pressure which in conjunction with the geometry and size of the mould determines the layer thickness and the layer shape. The pressure action can however also be effected by other appropriate methods, e.g. by the use of profiled rollers or presses. Thus an indicator matrix may be produced with a defined thickness and shape on the substrate.
In this example, after the polymer is hardened, the indicator distribution is homogenised by swelling the layer located on the substrate in a solution of the same indicator, with final rinsing with solvent and drying.
The preferred embodiment described in the following relates to an applicator for an optical sensor system for detecting the oxygen concentration or the oxygen partial pressure by luminescence quenching of a ruthenium-adiamine compound immobilised in polysiloxane.
A silica gel of suitable consistency is treated in a 10 4 molar solution Ru(4,7ph 2 phen) 3 C1 2 5 H20 in methylene chloride until it is discoloured.
After the silica gel is dried, corresponding proportions by weight of silica gel and corresponding proportions by weight of polydimethylsiloxane prepolymer are well mixed and painted in extrusion dyes. Thereafter the substrate is pressed into the dyes at a pressure of 15 10 4 Pa.
The film thickness can be correspondingly adjusted via the pressure. The dye used should be so designed that the substrate may also be taken up and held in a defined way, so that the sensitive layer is formed in the desired shape, position and thickness.
After hardening the polydimethylsiloxane, the coverings are subjected in a subsequent swelling in an indicatorcontaining methylene chloride solution, and then are thoroughly rinsed and dried.
The resulting substrate is covered with a securelyadhering indicator matrix film which is also extremely stable in solutions, and which forms the actual sensitive layer.
Advantageously, the substrate should be optically transparent or reflective, in order to avoid losses.
An optical fibre or a fibre bundle may advantageously be used as a substrate. It may also however be in the form of an optically transparent plate or an optically transparent member or reflective member of the type of a lens, GRIN lens or of a prism. It may likewise be an integrated optical system, comprising a plurality of appropriate optical members.
As Figure 1 shows, the sensor characteristic curve (Stern Volmer equation) of such a layer, deposited on a glass fibre with a core diameter of 400 pm, is shown on the one hand immediately after manufacture and on the other hand after a period of 4 months.
15 THE CLAIMS DEFINING THE INVENTION ARE AS FOLLOWS: 1. Method of manufacturing a single-layer system for measuring the concentration of analytes, in which a fluorescence indicator is immobilised in a polymer matrix permeable to the analyte to be measured, in the presence of a filler material of silica gel or porous glass, characterised in that the fluorescence indicator is adsorbed on to a filler material and mixed with permeable matrix material, the mixture is applied under the action of pressure predetermining the layer thickness and layer shape on to a substrate; the matrix material is polymerised, polycondensed or hardened and the layer is homogenised by swelling with a solvent dissolving the fluorescence indicator.
2. Method according to claim 1, characterised in that the mixture is compressed on to the substrate with an applied pressure of 12 to 20 x 10 4 Pa.
3. Method according to claim 1 or 2, characterised in that the mixture of fluorescence indicator, filler material and permeable matrix material is extruded into a 25 mould, in such a way that the sensitive layer is formed on the substrate in the desired shape, position and thickness.
4. Method according to one of claims 1 to 3, characterised in that a solution containing fluorescence indicator at a molar concentration of 10 1 to 10 6 is used for swelling the permeable matrix material.
Sensitive-single layer system produced by a method according to one of claims 1 to 4, characterised in that the sensitive layer has an overall concentration of the fluorescence indicators in the permeable matrix of 10 1 to 10 6 mol/l, and H:\Sim1eona\Keep\58909 96.doc 15/07/98
Claims (4)
- 6. Single-layer system according to claim characterised in that, in order to determine the oxygen concentration, the fluorescence indicator is a ruthenium- diamine complex.
- 7. Single-layer system according to claim 5 or 6, characterised in that the permeable matrix is formed from polysiloxane, preferably polydimethylsiloxane.
- 8. Single-layer system according to one of claims 15 to 7, characterised in that the sensitive layer is formed on an optically transparent or reflective substrate.
- 9. Single-layer system according to one of claims to 8, characterised in that the substrate is an optical 20 fibre, a bundle of optical fibres, a plate, a member, a lens, a GRIN lens, a prism or an integrated optical structure. Dated this 14th day of July 1998 UWE KIRSCHNER, MATTHIAS LAU, BIRGIT HANNEMANN and ADRIANA TAMACHKIAROWA By their Patent Attorneys GRIFFITH HACK Fellows Institute of Patent Attorneys of Australia H:\Simeona\Keep\58909 96.doc 14/07/98 fibre, a bundle of optical fibres, a plate, a member, a lens, a GRIN lens, a prism or an integrated optical structure. Abstract The invention relates to a method of manufacturing a sensitive single-layer system for optically detecting a concentration of an analyte, such for example as oxygen, the analyte being capable of investigation in liquid or gaseous aggregate condition or in a dissolved condition, by adsorption, luminescence or luminescence quenching of an indicator sensitive to the analyte, which is preferably permanently immobilised in the optical beam path. The sensitive single-layer system should achieve a reproducible and extremely short response behaviour. For this purpose indicators are adsorbed on a filler material and thereafter a mixture is produced with a matrix material permeable to the analyte to be detected. Then, under the action of pressure, the mixture is extruded on to a substrate, the layer thickness being formed in dependence on the applied pressure used. The applied sensitive layer is polymerised, polycondensed or hardened and the layer is also homogenised by swelling in a fluorescence indicator solution.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19519496 | 1995-05-27 | ||
| DE19519496A DE19519496A1 (en) | 1995-05-27 | 1995-05-27 | Oxygen-sensitive single-layer system and method for arranging the system |
| PCT/DE1996/000915 WO1996037768A1 (en) | 1995-05-27 | 1996-05-24 | Process for producing a sensitive single-layer system for measuring the concentration of analytes and a system produced by said process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU5890996A AU5890996A (en) | 1996-12-11 |
| AU705386B2 true AU705386B2 (en) | 1999-05-20 |
Family
ID=7763028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU58909/96A Ceased AU705386B2 (en) | 1995-05-27 | 1996-05-24 | Method of manufacturing a sensitive single-layer system for measuring the concentration of analytes and a system produced by this method |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6015715A (en) |
| EP (1) | EP0829006B1 (en) |
| JP (1) | JP3830968B2 (en) |
| CN (1) | CN1122177C (en) |
| AT (1) | ATE247826T1 (en) |
| AU (1) | AU705386B2 (en) |
| CA (1) | CA2222298A1 (en) |
| DE (2) | DE19519496A1 (en) |
| WO (1) | WO1996037768A1 (en) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6325978B1 (en) | 1998-08-04 | 2001-12-04 | Ntc Technology Inc. | Oxygen monitoring and apparatus |
| US20070225612A1 (en) * | 1996-07-15 | 2007-09-27 | Mace Leslie E | Metabolic measurements system including a multiple function airway adapter |
| US6815211B1 (en) * | 1998-08-04 | 2004-11-09 | Ntc Technology | Oxygen monitoring methods and apparatus (I) |
| DE19747187A1 (en) * | 1997-10-24 | 1999-05-12 | Lavision 2D Messtechnik Gmbh | Oxygen sensor for optically measuring non-stationary oxygen partial pressure |
| DE19831770C2 (en) * | 1998-07-15 | 2001-12-13 | Inst Chemo Biosensorik | Process for the production of a sensor membrane |
| US6512580B1 (en) * | 1999-10-27 | 2003-01-28 | Verification Technologies, Inc. | Method and apparatus for portable product authentication |
| NL1013871C2 (en) * | 1999-12-16 | 2001-06-21 | Applikon B V | Production of a sensor used to measure oxygen concentration, involves a mixture of a polymer and a curing agent and impregnating with an organometal compound |
| CA2406167A1 (en) * | 2000-05-19 | 2001-11-29 | Verification Technologies, Inc. | Method and apparatus for portable product authentication |
| US6689438B2 (en) * | 2001-06-06 | 2004-02-10 | Cryovac, Inc. | Oxygen detection system for a solid article |
| US20040062683A1 (en) * | 2002-09-30 | 2004-04-01 | The University Of Hong Kong | Sensitive single-layer sensing device of covalently attached luminescent indicator on glass surface for measuring the concentration of analytes |
| US7368153B2 (en) * | 2002-12-06 | 2008-05-06 | Cryovac, Inc. | Oxygen detection system for a rigid container |
| US20040121474A1 (en) * | 2002-12-19 | 2004-06-24 | Genoptix, Inc | Detection and evaluation of chemically-mediated and ligand-mediated t-cell activation using optophoretic analysis |
| WO2006022823A1 (en) | 2004-07-29 | 2006-03-02 | Centrus International, Inc. | Detection of microorganisms with a fluorescence-based device |
| US7534615B2 (en) * | 2004-12-03 | 2009-05-19 | Cryovac, Inc. | Process for detecting leaks in sealed packages |
| US7749768B2 (en) * | 2006-03-13 | 2010-07-06 | Cryovac, Inc. | Non-invasive method of determining oxygen concentration in a sealed package |
| US7569395B2 (en) * | 2006-03-13 | 2009-08-04 | Cryovac, Inc. | Method and apparatus for measuring oxygen concentration |
| US7704751B2 (en) * | 2006-09-18 | 2010-04-27 | 3M Innovative Properties Company | Polymeric fluorescent chemical sensor |
| US7638541B2 (en) | 2006-12-28 | 2009-12-29 | Metabolex Inc. | 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
| US8293178B2 (en) * | 2007-11-06 | 2012-10-23 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Chemochromic detector for sensing gas leakage and process for producing the same |
| WO2010001298A1 (en) * | 2008-06-30 | 2010-01-07 | Braskem S.A. | Chemical sensors modified by the sol-gel method and its application to polymeric matrixes |
| WO2011041154A1 (en) | 2009-10-01 | 2011-04-07 | Metabolex, Inc. | Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts |
| GB0918212D0 (en) * | 2009-10-16 | 2009-12-02 | Univ Strathclyde | Intelligent pigments and plastics |
| US8815603B2 (en) | 2011-07-11 | 2014-08-26 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Incorporation of chemochromic pigment into a variety of articles as an indicator for the presence of hypergolic fuels |
| US10292983B2 (en) | 2016-08-03 | 2019-05-21 | Cymabay Therapeutics, Inc. | Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions |
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| EP0417535A2 (en) * | 1989-09-11 | 1991-03-20 | F. Hoffmann-La Roche Ag | Optical oxygen sensor |
| US5039490A (en) * | 1986-04-23 | 1991-08-13 | Avl Ag | Sensor element for determination of concentration of substances |
| US5408999A (en) * | 1992-10-23 | 1995-04-25 | Optex Biomedical, Inc. | Fiber-optic probe for the measurement of fluid parameters |
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| DE3148830A1 (en) * | 1981-12-10 | 1983-06-23 | Wolfgang Prof. Dr.Dr. 6500 Mainz Barnikol | "DEVICE FOR DETERMINING THE OXYGEN CONCENTRATION IN GASES, LIQUIDS AND TISSUES" |
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| US4752115A (en) * | 1985-02-07 | 1988-06-21 | Spectramed, Inc. | Optical sensor for monitoring the partial pressure of oxygen |
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| AT399402B (en) * | 1992-07-09 | 1995-05-26 | Avl Verbrennungskraft Messtech | SENSOR MEMBRANE OF AN OPTICAL SENSOR FOR DETERMINING A PHYSICAL OR CHEMICAL PARAMETER OF A SAMPLE |
-
1995
- 1995-05-27 DE DE19519496A patent/DE19519496A1/en not_active Withdrawn
-
1996
- 1996-05-24 US US08/952,506 patent/US6015715A/en not_active Expired - Fee Related
- 1996-05-24 JP JP53526996A patent/JP3830968B2/en not_active Expired - Fee Related
- 1996-05-24 AU AU58909/96A patent/AU705386B2/en not_active Ceased
- 1996-05-24 AT AT96915950T patent/ATE247826T1/en not_active IP Right Cessation
- 1996-05-24 CN CN96194141A patent/CN1122177C/en not_active Expired - Fee Related
- 1996-05-24 WO PCT/DE1996/000915 patent/WO1996037768A1/en active IP Right Grant
- 1996-05-24 EP EP96915950A patent/EP0829006B1/en not_active Expired - Lifetime
- 1996-05-24 DE DE59610674T patent/DE59610674D1/en not_active Expired - Fee Related
- 1996-05-24 CA CA002222298A patent/CA2222298A1/en not_active Abandoned
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| US5039490A (en) * | 1986-04-23 | 1991-08-13 | Avl Ag | Sensor element for determination of concentration of substances |
| EP0417535A2 (en) * | 1989-09-11 | 1991-03-20 | F. Hoffmann-La Roche Ag | Optical oxygen sensor |
| US5408999A (en) * | 1992-10-23 | 1995-04-25 | Optex Biomedical, Inc. | Fiber-optic probe for the measurement of fluid parameters |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH11505923A (en) | 1999-05-25 |
| ATE247826T1 (en) | 2003-09-15 |
| AU5890996A (en) | 1996-12-11 |
| CN1185208A (en) | 1998-06-17 |
| DE59610674D1 (en) | 2003-09-25 |
| US6015715A (en) | 2000-01-18 |
| DE19519496A1 (en) | 1996-11-28 |
| JP3830968B2 (en) | 2006-10-11 |
| CA2222298A1 (en) | 1996-11-28 |
| CN1122177C (en) | 2003-09-24 |
| WO1996037768A1 (en) | 1996-11-28 |
| EP0829006A1 (en) | 1998-03-18 |
| EP0829006B1 (en) | 2003-08-20 |
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