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AU4331700A - Anti-tumor activity of vitamin e, cholesterol, taxol and betulinic acid derivatives - Google Patents

Anti-tumor activity of vitamin e, cholesterol, taxol and betulinic acid derivatives

Info

Publication number
AU4331700A
AU4331700A AU43317/00A AU4331700A AU4331700A AU 4331700 A AU4331700 A AU 4331700A AU 43317/00 A AU43317/00 A AU 43317/00A AU 4331700 A AU4331700 A AU 4331700A AU 4331700 A AU4331700 A AU 4331700A
Authority
AU
Australia
Prior art keywords
taxol
cholesterol
vitamin
acid derivatives
tumor activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU43317/00A
Inventor
Marc Fariss
J. Doyle Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Virginia Commonwealth University
Washington State University Research Foundation
Original Assignee
University of Washington
Virginia Commonwealth University
Washington State University Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, Virginia Commonwealth University, Washington State University Research Foundation filed Critical University of Washington
Publication of AU4331700A publication Critical patent/AU4331700A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU43317/00A 1999-04-07 2000-04-07 Anti-tumor activity of vitamin e, cholesterol, taxol and betulinic acid derivatives Abandoned AU4331700A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12804799P 1999-04-07 1999-04-07
US60128047 1999-04-07
PCT/US2000/009141 WO2000059492A2 (en) 1999-04-07 2000-04-07 Anti-tumor activity of vitamin e, cholesterol, taxol and betulinic acid derivatives

Publications (1)

Publication Number Publication Date
AU4331700A true AU4331700A (en) 2000-10-23

Family

ID=22433345

Family Applications (1)

Application Number Title Priority Date Filing Date
AU43317/00A Abandoned AU4331700A (en) 1999-04-07 2000-04-07 Anti-tumor activity of vitamin e, cholesterol, taxol and betulinic acid derivatives

Country Status (4)

Country Link
EP (1) EP1189607A2 (en)
AU (1) AU4331700A (en)
CA (1) CA2366807A1 (en)
WO (1) WO2000059492A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001284946B2 (en) * 2000-08-18 2007-02-01 Advanced Life Sciences Inc. Prodrugs of betulinic acid derivatives for the treatment of cancer and HIV

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869535A (en) 1995-03-21 1999-02-09 The Board Of Trustees Of The University Of Illinois Method and composition for selectively inhibiting melanoma
WO2003011280A1 (en) * 2001-07-27 2003-02-13 University Of Rochester Use of vitamin e succinate and antiandrogen combination
US7365221B2 (en) 2002-09-26 2008-04-29 Panacos Pharmaceuticals, Inc. Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof
US20040102421A1 (en) * 2002-11-21 2004-05-27 Children's Hospital Research Center At Oakland Tocopherol and tocotrienol anti-inflammatory medicaments
AU2006235486A1 (en) 2005-04-12 2006-10-19 Panacos Pharmaceuticals, Inc. Polymorphs of 3-o-(3',3'-dimethylsuccinyl) betulinic acid di-N-methyl-D-glucamine
US20110195910A1 (en) * 2008-10-23 2011-08-11 Davos Life Science Pte. Ltd. Use of tocotrienol composition for the prevention of cancer
EP2531028B1 (en) * 2010-02-05 2014-12-31 First Tech International Limited Tocotrienol esters

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610180A (en) * 1988-01-29 1997-03-11 Virginia Commonwealth University Ionizable congeners of aromatic and aliphatic alcohols as anti-leukemia agents
WO1994005282A1 (en) * 1992-09-04 1994-03-17 The Scripps Research Institute Water soluble taxol derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001284946B2 (en) * 2000-08-18 2007-02-01 Advanced Life Sciences Inc. Prodrugs of betulinic acid derivatives for the treatment of cancer and HIV

Also Published As

Publication number Publication date
EP1189607A2 (en) 2002-03-27
CA2366807A1 (en) 2000-10-12
WO2000059492A3 (en) 2002-01-24
WO2000059492A2 (en) 2000-10-12

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase