AU4198400A - Neurotrophic thio substituted pyrimidines - Google Patents

Neurotrophic thio substituted pyrimidines

Info

Publication number: AU4198400A
Authority: AU; Australia
Prior art keywords: neurotrophic; substituted pyrimidines; thio substituted; thio; pyrimidines
Prior art date: 1999-04-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU41984/00A

Inventor

Lilia M. Beauchamp

James L. Kelley

Thomas A. Krenitsky

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Krenitsky Pharmaceuticals Inc

Original Assignee

Krenitsky Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-06

Filing date

2000-04-05

Publication date

2000-10-23

2000-04-05 Application filed by Krenitsky Pharmaceuticals Inc filed Critical Krenitsky Pharmaceuticals Inc

2000-10-23 Publication of AU4198400A publication Critical patent/AU4198400A/en

Status Abandoned legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AU41984/00A 1999-04-06 2000-04-05 Neurotrophic thio substituted pyrimidines Abandoned AU4198400A (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US12792399P	1999-04-06	1999-04-06
US60127923		1999-04-06
US12884299P	1999-04-12	1999-04-12
US60128842		1999-04-12
PCT/US2000/009004 WO2000059893A1 (en)	1999-04-06	2000-04-05	Neurotrophic thio substituted pyrimidines

Publications (1)

Publication Number	Publication Date
AU4198400A true AU4198400A (en)	2000-10-23

Family

ID=26826090

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU41984/00A Abandoned AU4198400A (en)	1999-04-06	2000-04-05	Neurotrophic thio substituted pyrimidines

Country Status (4)

Country	Link
EP (1)	EP1165522A1 (en)
AU (1)	AU4198400A (en)
CA (1)	CA2369945A1 (en)
WO (1)	WO2000059893A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1217000A1 (en) *	2000-12-23	2002-06-26	Aventis Pharma Deutschland GmbH	Inhibitors of factor Xa and factor VIIa
TWI329105B (en)	2002-02-01	2010-08-21	Rigel Pharmaceuticals Inc	2,4-pyrimidinediamine compounds and their uses
ES2445208T3 (en)	2002-07-29	2014-02-28	Rigel Pharmaceuticals, Inc.	2,4-Pyrimidinediamine compounds for use in methods to treat or prevent autoimmune diseases
US6800652B2 (en)	2002-08-16	2004-10-05	Pfizer Inc.	Diaryl compounds
RS53109B (en)	2003-07-30	2014-06-30	Rigel Pharmaceuticals Inc.	2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases
CA2584295C (en)	2004-11-24	2014-08-26	Rigel Pharmaceuticals, Inc.	Spiro-2, 4-pyrimidinediamine compounds and their uses
FR2932481B1 (en)	2008-06-13	2010-10-08	Sanofi Aventis	4- {2-4-PHENYL-3,6-DIHYDRO-2H-PYRIDIN-1-YL] -2-OXO-ALKYL} -1-PIPERAZIN-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE.
FR2932482B1 (en)	2008-06-13	2010-10-08	Sanofi Aventis	NOVEL (PHENYL-3,6-DIHYDRO-2H-PYRIDINYL) - (PIPERAZINYL PONTE) -1-ALKANONE DERIVATIVES AND THEIR USE AS P75 INHIBITORS
EP2467142B1 (en)	2009-08-17	2016-09-21	Memorial Sloan-Kettering Cancer Center	2-(Pyrimidin-5-yl)-thiopyrimidine derivatives as Hsp70 and Hsc70 modulators for the treatment of proliferative disorders
FR2953836B1 (en)	2009-12-14	2012-03-16	Sanofi Aventis	NOVEL DERIVATIVES (HETEROCYCLE-TETRAHYDRO-PYRIDINE) - (PIPERAZINYL) -1-ALKANONE AND (HETEROCYCLE-DIHYDRO-PYRROLIDINE) - (PIPERAZINYL) -1-ALKANONE AND THEIR USE AS INHIBITORS OF P75
FR2953839A1 (en)	2009-12-14	2011-06-17	Sanofi Aventis	NOVEL (HETEROCYCLE-PIPERIDINE CONDENSEE) - (PIPERAZINYL) -1ALCANONE OR (HETEROCYCLE-PYRROLIDINE CONDENSED) - (PIPERAZINYL) -1ALCANONE DERIVATIVES AND THEIR USE AS INHIBITORS OF P75
EP2606894A1 (en)	2011-12-20	2013-06-26	Sanofi	Novel therapeutic use of p75 receptor antagonists
JO3517B1 (en)	2014-01-17	2020-07-05	Novartis Ag	N-azaspirocycloalkane substituted n-heteroaryl compounds and compositions for inhibiting the activity of shp2
ES2699354T3 (en)	2014-01-17	2019-02-08	Novartis Ag	Derivatives of 1- (triazin-3-yl / pyridazin-3-yl) -piper (-azin) idine and compositions thereof to inhibit the activity of SHP2
WO2015107493A1 (en)	2014-01-17	2015-07-23	Novartis Ag	1 -pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and and compositions thereof for inhibiting the activity of shp2
EP3310779B1 (en)	2015-06-19	2019-05-08	Novartis AG	Compounds and compositions for inhibiting the activity of shp2
CN112625028B (en)	2015-06-19	2024-10-29	诺华股份有限公司	Compounds and compositions for inhibiting SHP2 activity
ES2824576T3 (en)	2015-06-19	2021-05-12	Novartis Ag	Compounds and compositions to inhibit SHP2 activity
MA43821A (en)	2016-03-14	2018-11-28	Afferent Pharmaceuticals Inc	PYRIMIDINS AND VARIANTS THEREOF, AND THEIR USES
JP6902045B2 (en) *	2016-03-25	2021-07-14	アファレントファーマシューティカルズインコーポレイテッド	Pyrimidines and their variants, and their use
EA036446B1 (en)	2016-06-14	2020-11-11	Новартис Аг	Compounds and compositions for inhibiting the activity of shp2
KR102571130B1 (en)	2017-01-10	2023-08-28	노파르티스 아게	A pharmaceutical combination comprising an ALK inhibitor and a SHP2 inhibitor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB951431A (en) *	1959-03-17	1964-03-04	Wellcome Found	Pyrimidine derivatives and the manufacture thereof
CA2217034A1 (en) *	1995-04-03	1996-10-10	Sumitomo Pharmaceuticals Company, Limited	Novel pyrimidine derivatives effective as psychotropic drug and process for the production thereof

2000
- 2000-04-05 EP EP00921705A patent/EP1165522A1/en not_active Withdrawn
- 2000-04-05 CA CA002369945A patent/CA2369945A1/en not_active Abandoned
- 2000-04-05 WO PCT/US2000/009004 patent/WO2000059893A1/en not_active Application Discontinuation
- 2000-04-05 AU AU41984/00A patent/AU4198400A/en not_active Abandoned

Also Published As

Publication number	Publication date
CA2369945A1 (en)	2000-10-12
WO2000059893A1 (en)	2000-10-12
EP1165522A1 (en)	2002-01-02

Publication	Publication Date	Title
AU4198400A (en)	2000-10-23	Neurotrophic thio substituted pyrimidines
AU5759999A (en)	2000-04-17	Pyrimidone derivatives
AU3420599A (en)	1999-11-08	Novel 2-heterocyclically substituted dihydropyrimidines
AU3813399A (en)	1999-11-08	Dihydropyrimidines
AU2634600A (en)	2000-08-18	Pipetter
AU5325400A (en)	2001-01-02	Multi-connection via
AU1173201A (en)	2001-05-14	Skin-gripper
PL351690A1 (en)	2003-06-02	Pyrimidinone compounds
AU4556700A (en)	2000-11-17	Pyrimidine compounds
AU5391099A (en)	2000-02-21	Substituted quinazoline derivatives
AU1104301A (en)	2001-05-08	Primary n-hydroxylamines
AU2187301A (en)	2001-06-25	Protein kinase regulation
AU2002362806A1 (en)	2003-07-03	Pyrimidine derivatives
AU3819200A (en)	2000-11-02	2,4-diamino-pyrimidine derivatives
AU5858000A (en)	2001-01-02	Switched capacitors
AU7419300A (en)	2001-04-30	Quinazolinones
AU5039699A (en)	2001-01-22	Lamp structure
AU7654800A (en)	2001-04-30	Quinazolinones
AU3467197A (en)	1998-10-22	Tetracyclical derivatives from pyrimidine
AU1800700A (en)	2000-07-31	Ikk3 kinase
AU1042701A (en)	2001-05-08	Antiviral combinations
AU1675800A (en)	2000-07-24	Lighting system
AU6827300A (en)	2001-03-05	Substituted arylalkylamino-1,3,5-triazines
AU6567400A (en)	2001-03-05	Substituted 2-imino-thiazolines
AU1785599A (en)	1999-08-02	Novel pyrimidine derivatives

Legal Events

Date	Code	Title	Description
2002-03-07	MK6	Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase