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AU2925392A - Synthesis and purification of truncated and mutein forms of human ciliary neuronotrophic factor - Google Patents

Synthesis and purification of truncated and mutein forms of human ciliary neuronotrophic factor

Info

Publication number
AU2925392A
AU2925392A AU29253/92A AU2925392A AU2925392A AU 2925392 A AU2925392 A AU 2925392A AU 29253/92 A AU29253/92 A AU 29253/92A AU 2925392 A AU2925392 A AU 2925392A AU 2925392 A AU2925392 A AU 2925392A
Authority
AU
Australia
Prior art keywords
truncated
purification
synthesis
human ciliary
mutein forms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU29253/92A
Inventor
Lanfranco Callegaro
Alessandro Negro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fidia SpA
Original Assignee
Fidia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITPD910207A external-priority patent/IT1254703B/en
Priority claimed from ITPD920087A external-priority patent/IT1260150B/en
Application filed by Fidia SpA filed Critical Fidia SpA
Publication of AU2925392A publication Critical patent/AU2925392A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AU29253/92A 1991-11-11 1992-11-11 Synthesis and purification of truncated and mutein forms of human ciliary neuronotrophic factor Abandoned AU2925392A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ITPD91A0207 1991-11-11
ITPD910207A IT1254703B (en) 1991-11-11 1991-11-11 Process for the synthesis and purification of truncated forms of human ciliar neurotrophic factor
ITPD92A0087 1992-05-20
ITPD920087A IT1260150B (en) 1992-05-20 1992-05-20 Process for the purification of mutated monomer forms of human ciliary neurotrophic factor

Publications (1)

Publication Number Publication Date
AU2925392A true AU2925392A (en) 1993-06-15

Family

ID=26331779

Family Applications (1)

Application Number Title Priority Date Filing Date
AU29253/92A Abandoned AU2925392A (en) 1991-11-11 1992-11-11 Synthesis and purification of truncated and mutein forms of human ciliary neuronotrophic factor

Country Status (5)

Country Link
EP (1) EP0668911A1 (en)
JP (1) JPH07503128A (en)
AU (1) AU2925392A (en)
CA (1) CA2123234A1 (en)
WO (1) WO1993010233A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166317A (en) * 1988-10-31 1992-11-24 Houston Biotechnology Incorporated Neurotrophic factor
JPH07500725A (en) * 1991-07-23 1995-01-26 シンテックス−シナージェン　ニューロサイエンス　ジョイント　ベンチャー Purification of recombinant ciliary neurotrophic factor and C-terminally truncated ciliary neurotrophic factor and method for treating peripheral neuropathy
US5593857A (en) * 1991-08-23 1997-01-14 Scios Inc. Production of homogeneous truncated CNTF
US6472178B1 (en) * 1998-02-27 2002-10-29 Regeneron Pharmaceuticals, Inc. Nucleic acids encoding a modified ciliary neurotrophic factor and method of making thereof
EP1011730A2 (en) * 1996-10-07 2000-06-28 Edge Biosystems, Inc. Targeted addition of soluble polymers to recombinant proteins
IT1288388B1 (en) 1996-11-19 1998-09-22 Angeletti P Ist Richerche Bio USE OF SUBSTANCES THAT ACTIVATE THE CNTF RECEPTOR (NEUROTROPHIC CHILI FACTOR) FOR THE PREPARATION OF DRUGS FOR THERAPY
IT1291114B1 (en) * 1997-03-20 1998-12-29 Angeletti P Ist Richerche Bio VARIATIONS OF THE CHILIARY NEUROTROPHIC FACTOR (CNTF) WITH IMPROVED RECEPTOR SELECTIVITY, AND METHOD FOR THEIR SELECTION
US20040087503A1 (en) * 2001-03-02 2004-05-06 Carr Francis J. Modified ciliary neurotrophic factor (cntf ) with reduced immunogenicity
WO2005033137A1 (en) * 2003-09-30 2005-04-14 Regeneron Pharmaceuticals, Inc. Modified ciliary neurotrophic factor polypeptides with reduced antigenicity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5141856A (en) * 1989-01-05 1992-08-25 Synergen, Inc. Expression of purified ciliary neurotrophic factor
IE903130A1 (en) * 1989-09-15 1991-03-27 Regeneron Pharma Ciliary neurotrophic factor
HUT62033A (en) * 1990-03-14 1993-03-29 Fidia Spa Process for producing human ciliary body neuronotropic factor

Also Published As

Publication number Publication date
WO1993010233A1 (en) 1993-05-27
EP0668911A1 (en) 1995-08-30
JPH07503128A (en) 1995-04-06
CA2123234A1 (en) 1993-05-27

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