AU2019260608A1 - Tricyclic Heterocycle Compounds useful as HIV integrase inhibitors - Google Patents
Tricyclic Heterocycle Compounds useful as HIV integrase inhibitors Download PDFInfo
- Publication number
- AU2019260608A1 AU2019260608A1 AU2019260608A AU2019260608A AU2019260608A1 AU 2019260608 A1 AU2019260608 A1 AU 2019260608A1 AU 2019260608 A AU2019260608 A AU 2019260608A AU 2019260608 A AU2019260608 A AU 2019260608A AU 2019260608 A1 AU2019260608 A1 AU 2019260608A1
- Authority
- AU
- Australia
- Prior art keywords
- compound
- mmol
- isomer
- compound int
- int
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Quinoline Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862663377P | 2018-04-27 | 2018-04-27 | |
| US62/663,377 | 2018-04-27 | ||
| US201862664527P | 2018-04-30 | 2018-04-30 | |
| US62/664,527 | 2018-04-30 | ||
| PCT/US2019/028432 WO2019209667A1 (en) | 2018-04-27 | 2019-04-22 | Tricyclic heterocycle compounds useful as hiv integrase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2019260608A1 true AU2019260608A1 (en) | 2020-10-29 |
Family
ID=68294232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2019260608A Abandoned AU2019260608A1 (en) | 2018-04-27 | 2019-04-22 | Tricyclic Heterocycle Compounds useful as HIV integrase inhibitors |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP3784241A4 (ko) |
| JP (1) | JP2021522254A (ko) |
| KR (1) | KR20210005139A (ko) |
| CN (1) | CN112088005A (ko) |
| AU (1) | AU2019260608A1 (ko) |
| BR (1) | BR112020021768A2 (ko) |
| CA (1) | CA3101180A1 (ko) |
| MA (1) | MA52367A (ko) |
| MX (1) | MX2020011317A (ko) |
| WO (1) | WO2019209667A1 (ko) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11453669B2 (en) | 2018-05-31 | 2022-09-27 | Shionogi & Co., Ltd. | Polycyclic pyridone derivative |
| PT3805220T (pt) | 2018-05-31 | 2024-08-16 | Shionogi & Co | Derivados policíclicos de carbamoilpiridona para o tratamento do hiv |
| EP3801543B1 (en) | 2018-06-05 | 2024-09-11 | Merck Sharp & Dohme LLC | Tricyclic heterocycle compounds useful as hiv integrase inhibitors |
| UA127822C2 (uk) | 2019-03-22 | 2024-01-10 | Гіліад Сайєнсіз, Інк. | Місткові трициклічні карбамоїлпіридонові сполуки та їх фармацевтичне застосування |
| EP4065567B1 (en) * | 2019-11-26 | 2024-09-11 | Gilead Sciences, Inc. | Processes and intermediates for preparing mcl1 inhibitors |
| BR112022015771A2 (pt) * | 2020-02-24 | 2022-10-11 | Gilead Sciences Inc | Compostos tetracíclicos para tratar a infecção por hiv |
| JP2024503116A (ja) | 2021-01-19 | 2024-01-24 | ギリアード サイエンシーズ， インコーポレイテッド | 置換ピリドトリアジン化合物及びその使用 |
| TWI843506B (zh) | 2022-04-06 | 2024-05-21 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1441734T1 (sl) * | 2001-10-26 | 2007-08-31 | Angeletti P Ist Richerche Bio | Dihidropirimidin karboksamidni inhibitorji HIV-integraze |
| TW200510425A (en) * | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
| US7902182B2 (en) * | 2005-11-16 | 2011-03-08 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| PL2997033T3 (pl) * | 2013-05-17 | 2018-04-30 | Merck Sharp & Dohme Corp. | Skondensowane tricykliczne związki heterocykliczne jako inhibitory integrazy hiv |
| WO2017113288A1 (en) * | 2015-12-31 | 2017-07-06 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
-
2019
- 2019-04-22 KR KR1020207033726A patent/KR20210005139A/ko unknown
- 2019-04-22 BR BR112020021768-9A patent/BR112020021768A2/pt not_active Application Discontinuation
- 2019-04-22 EP EP19793407.8A patent/EP3784241A4/en not_active Withdrawn
- 2019-04-22 WO PCT/US2019/028432 patent/WO2019209667A1/en active Application Filing
- 2019-04-22 MA MA052367A patent/MA52367A/fr unknown
- 2019-04-22 AU AU2019260608A patent/AU2019260608A1/en not_active Abandoned
- 2019-04-22 CN CN201980028504.5A patent/CN112088005A/zh active Pending
- 2019-04-22 CA CA3101180A patent/CA3101180A1/en active Pending
- 2019-04-22 JP JP2020559525A patent/JP2021522254A/ja active Pending
- 2019-04-22 MX MX2020011317A patent/MX2020011317A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112020021768A2 (pt) | 2021-01-26 |
| KR20210005139A (ko) | 2021-01-13 |
| MX2020011317A (es) | 2020-11-18 |
| JP2021522254A (ja) | 2021-08-30 |
| CA3101180A1 (en) | 2019-10-31 |
| MA52367A (fr) | 2021-03-03 |
| CN112088005A (zh) | 2020-12-15 |
| EP3784241A1 (en) | 2021-03-03 |
| EP3784241A4 (en) | 2022-01-19 |
| WO2019209667A1 (en) | 2019-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1 | Application lapsed section 142(2)(a) - no request for examination in relevant period |