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AU2016202488A1 - Common light chain mouse - Google Patents

Common light chain mouse

Info

Publication number
AU2016202488A1
AU2016202488A1 AU2016202488A AU2016202488A AU2016202488A1 AU 2016202488 A1 AU2016202488 A1 AU 2016202488A1 AU 2016202488 A AU2016202488 A AU 2016202488A AU 2016202488 A AU2016202488 A AU 2016202488A AU 2016202488 A1 AU2016202488 A1 AU 2016202488A1
Authority
AU
Australia
Prior art keywords
light chain
common light
chain mouse
mouse
common
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU2016202488A
Other versions
AU2016202488C1 (en
AU2016202488B2 (en
Inventor
Robert Babb
David R. Buckler
Samuel Davis
Lynn Macdonald
John Mcwhirter
Karolina A. Meagher
Andrew J. Murphy
Sean Stevens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Regeneron Pharmaceuticals Inc
Original Assignee
Regeneron Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/412,936 external-priority patent/US20120192300A1/en
Priority claimed from AU2013204140A external-priority patent/AU2013204140B2/en
Application filed by Regeneron Pharmaceuticals Inc filed Critical Regeneron Pharmaceuticals Inc
Priority to AU2016202488A priority Critical patent/AU2016202488C1/en
Publication of AU2016202488A1 publication Critical patent/AU2016202488A1/en
Application granted granted Critical
Publication of AU2016202488B2 publication Critical patent/AU2016202488B2/en
Publication of AU2016202488C1 publication Critical patent/AU2016202488C1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

AU2016202488A 2012-03-06 2016-04-20 Common light chain mouse Active AU2016202488C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2016202488A AU2016202488C1 (en) 2012-03-06 2016-04-20 Common light chain mouse

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13/412,936 2012-03-06
US13/412,936 US20120192300A1 (en) 2010-02-08 2012-03-06 Common Light Chain Mouse
AU2013204140A AU2013204140B2 (en) 2012-03-06 2013-03-05 Common light chain mouse
PCT/US2013/029125 WO2013134263A1 (en) 2012-03-06 2013-03-05 Common light chain mouse
AU2016202488A AU2016202488C1 (en) 2012-03-06 2016-04-20 Common light chain mouse

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
AU2013204140A Division AU2013204140B2 (en) 2012-03-06 2013-03-05 Common light chain mouse

Publications (3)

Publication Number Publication Date
AU2016202488A1 true AU2016202488A1 (en) 2016-05-12
AU2016202488B2 AU2016202488B2 (en) 2018-04-05
AU2016202488C1 AU2016202488C1 (en) 2018-10-18

Family

ID=47998513

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2013204140A Active AU2013204140B2 (en) 2012-03-06 2013-03-05 Common light chain mouse
AU2016202488A Active AU2016202488C1 (en) 2012-03-06 2016-04-20 Common light chain mouse

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU2013204140A Active AU2013204140B2 (en) 2012-03-06 2013-03-05 Common light chain mouse

Country Status (14)

Country Link
EP (2) EP3165086A1 (en)
JP (1) JP2015509380A (en)
KR (1) KR20140136462A (en)
CN (2) CN104244709B (en)
AU (2) AU2013204140B2 (en)
CA (1) CA2865029A1 (en)
HK (1) HK1205873A1 (en)
IL (1) IL234207A0 (en)
IN (1) IN2014DN08163A (en)
MX (1) MX353278B (en)
NZ (1) NZ630637A (en)
RU (1) RU2683514C2 (en)
SG (1) SG11201405088QA (en)
WO (1) WO2013134263A1 (en)

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US9445581B2 (en) 2012-03-28 2016-09-20 Kymab Limited Animal models and therapeutic molecules
PL3241435T3 (en) 2009-07-08 2021-12-13 Kymab Limited Animal models and therapeutic molecules
US9796788B2 (en) 2010-02-08 2017-10-24 Regeneron Pharmaceuticals, Inc. Mice expressing a limited immunoglobulin light chain repertoire
BR112012019887B1 (en) 2010-02-08 2021-06-08 Regeneron Pharmaceuticals, Inc method for making antibody and method for selecting a human heavy chain variable region nucleic acid sequence to produce an antibody
US20130045492A1 (en) 2010-02-08 2013-02-21 Regeneron Pharmaceuticals, Inc. Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
EP3128009B1 (en) 2011-09-19 2020-07-29 Kymab Limited Antibodies, variable domains & chains tailored for human use
WO2013045916A1 (en) 2011-09-26 2013-04-04 Kymab Limited Chimaeric surrogate light chains (slc) comprising human vpreb
US9253965B2 (en) 2012-03-28 2016-02-09 Kymab Limited Animal models and therapeutic molecules
RU2017135754A (en) 2012-03-16 2019-02-08 Регенерон Фармасьютикалз, Инк. ANTIBODIES WITH HISTIDINE INTEGRATED IN LIGHT CHAINS AND GENETICALLY MODIFIED ANIMALS DIFFERENT FROM HUMAN FOR THEIR OBTAINING
RU2664473C2 (en) 2012-03-16 2018-08-17 Регенерон Фармасьютикалз, Инк. Non-human animals expressing ph-sensitive immunoglobulin sequences
JP2015512245A (en) 2012-03-16 2015-04-27 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Mice producing antigen-binding proteins with pH-dependent binding characteristics
US20140013456A1 (en) 2012-03-16 2014-01-09 Regeneron Pharmaceuticals, Inc. Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same
US10251377B2 (en) 2012-03-28 2019-04-09 Kymab Limited Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
GB2502127A (en) 2012-05-17 2013-11-20 Kymab Ltd Multivalent antibodies and in vivo methods for their production
NZ799532A (en) 2012-04-20 2023-07-28 Merus Nv Methods and means for the production of ig-like molecules
AU2014244079A1 (en) * 2013-03-13 2015-09-24 Regeneron Pharmaceuticals, Inc. Common light chain mouse
US9788534B2 (en) 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
US9783593B2 (en) 2013-05-02 2017-10-10 Kymab Limited Antibodies, variable domains and chains tailored for human use
US11707056B2 (en) 2013-05-02 2023-07-25 Kymab Limited Animals, repertoires and methods
FR3011249A1 (en) * 2013-10-01 2015-04-03 Kymab Ltd
TW201546284A (en) * 2013-10-01 2015-12-16 Kymab Ltd Animal models and therapeutic molecules
AU2015230938C1 (en) 2014-03-21 2021-10-14 Regeneron Pharmaceuticals, Inc. Non-human animals that make single domain binding proteins
EP3271403A1 (en) 2015-03-19 2018-01-24 Regeneron Pharmaceuticals, Inc. Non-human animals that select for light chain variable regions that bind antigen
JP2018525014A (en) * 2015-08-27 2018-09-06 クリスタル バイオサイエンス インコーポレイテッドＣｒｙｓｔａｌ Ｂｉｏｓｃｉｅｎｃｅ Ｉｎｃ． Transgenic animals for producing antibodies having a common light chain
JP6979955B2 (en) 2016-01-13 2021-12-15 リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. Rodents with manipulated heavy chain variable regions
WO2019236670A1 (en) * 2018-06-08 2019-12-12 Crystal Bioscience Inc. Transgenic animal for producing diversified antibodies that have the same light chain i
MX2020013652A (en) 2018-06-14 2022-04-21 Regeneron Pharma Non-human animals capable of dh-dh rearrangement in the immunoglobulin heavy chain coding sequences.
JP2022521358A (en) 2019-02-18 2022-04-06 バイオサイトジェン ファーマシューティカルズ （ベイジン） カンパニー リミテッド Genetically modified non-human animal with humanized immunoglobulin locus
CN113473850A (en) 2019-02-22 2021-10-01 瑞泽恩制药公司 Rodents having genetically modified sodium channels and methods of use thereof
KR20210095781A (en) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 A multi-specific antibody comprising a fusion construct consisting of a Fab and a bioactive effector moiety
IL298632A (en) * 2020-06-02 2023-01-01 Biocytogen Pharmaceuticals Beijing Co Ltd Genetically modified non-human animals with common light chain immunoglobulin locus
KR20230066386A (en) 2020-09-11 2023-05-15 리제너론 파마슈티칼스 인코포레이티드 Identification and production of antigen-specific antibodies
CN116848254A (en) 2020-12-16 2023-10-03 瑞泽恩制药公司 Mice expressing humanized Fc alpha receptors
CN116635413A (en) 2020-12-23 2023-08-22 再生元制药公司 Method for obtaining antibodies that bind transmembrane proteins and cells for producing said antibodies
EP4051700A1 (en) 2020-12-23 2022-09-07 Regeneron Pharmaceuticals, Inc. Nucleic acids encoding anchor modified antibodies and uses thereof
GB202217978D0 (en) 2022-11-30 2023-01-11 Petmedix Ltd Rodents expressing a common light chain
TW202430641A (en) 2023-01-18 2024-08-01 美商基利科學股份有限公司 Human immunoglobulin binary light chain transgene constructs and uses thereof

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US7084260B1 (en) * 1996-10-10 2006-08-01 Genpharm International, Inc. High affinity human antibodies and human antibodies against human antigens
US20020062010A1 (en) * 1997-05-02 2002-05-23 Genentech, Inc. Method for making multispecific antibodies having heteromultimeric and common components
US6774279B2 (en) 1997-05-30 2004-08-10 Carnegie Institution Of Washington Use of FLP recombinase in mice
WO2004009618A2 (en) * 2002-07-18 2004-01-29 Crucell Holland B.V. Recombinant production of mixtures of antibodies
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US7105348B2 (en) 2000-10-31 2006-09-12 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US20100069614A1 (en) * 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
SI1802193T1 (en) 2004-10-19 2014-08-29 Regeneron Pharmaceuticals, Inc. Method for generating a mouse homozygous for a genetic modification
EP2041177B1 (en) 2006-06-02 2011-12-14 Regeneron Pharmaceuticals, Inc. High affinity antibodies to human il-6 receptor
DK2147594T3 (en) * 2008-06-27 2014-02-10 Merus B V Antibody-producing non-human mammals
KR20120027055A (en) 2009-06-26 2012-03-20 리제네론 파라마큐티칼스 인코포레이티드 Readily isolated bispecific antibodies with native immunoglobulin format
PL3241435T3 (en) * 2009-07-08 2021-12-13 Kymab Limited Animal models and therapeutic molecules
RU2425880C2 (en) * 2009-07-30 2011-08-10 Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН Method of producing transgene mice
BR112012019887B1 (en) * 2010-02-08 2021-06-08 Regeneron Pharmaceuticals, Inc method for making antibody and method for selecting a human heavy chain variable region nucleic acid sequence to produce an antibody

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