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AU2007325315A1 - Heterocyclic modulators of TGR5 - Google Patents

Heterocyclic modulators of TGR5

Info

Publication number
AU2007325315A1
AU2007325315A1 AU2007325315A AU2007325315A AU2007325315A1 AU 2007325315 A1 AU2007325315 A1 AU 2007325315A1 AU 2007325315 A AU2007325315 A AU 2007325315A AU 2007325315 A AU2007325315 A AU 2007325315A AU 2007325315 A1 AU2007325315 A1 AU 2007325315A1
Authority
AU
Australia
Prior art keywords
tgr5
heterocyclic modulators
modulators
heterocyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2007325315A
Other versions
AU2007325315A8 (en
Inventor
Anthony B Pinkerton
Ayman Kabakibi
Timothy C Gahman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kalypsys Inc
Original Assignee
Kalypsys Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kalypsys Inc filed Critical Kalypsys Inc
Publication of AU2007325315A1 publication Critical patent/AU2007325315A1/en
Publication of AU2007325315A8 publication Critical patent/AU2007325315A8/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2007325315A 2006-11-28 2007-11-20 Heterocyclic modulators of TGR5 Pending AU2007325315A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86758306P 2006-11-28 2006-11-28
PCT/US2007/085267 WO2008067222A1 (en) 2006-11-28 2007-11-20 Heterocyclic modulators of tgr5

Publications (2)

Publication Number Publication Date
AU2007325315A1 true AU2007325315A1 (en) 2008-06-05
AU2007325315A8 AU2007325315A8 (en) 2009-07-09

Family

ID=39126169

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007325315A Pending AU2007325315A1 (en) 2006-11-28 2007-11-20 Heterocyclic modulators of TGR5

Country Status (2)

Country Link
AU (1) AU2007325315A1 (en)
WO (1) WO2008067222A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009032754A2 (en) * 2007-08-31 2009-03-12 Kalypsys, Inc. Heterocyclodiazepine cannabinoid receptor modulators for treatment of disease
FR2921658A1 (en) * 2007-09-27 2009-04-03 Sod Conseils Rech Applic New pyrazolo-pyrazine derivatives are G protein inhibitors useful for preparing a medicament to treat or prevent disease or disorder e.g. cancer, non-tumor proliferative diseases, neurodegenerative diseases and parasitic diseases
BR112012028445A2 (en) 2010-05-06 2016-07-19 Bristol Myers Squibb Co bicyclic heteroaryl compounds as gpr119 modulators
US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
EP2702042A1 (en) 2011-04-28 2014-03-05 Bristol-Myers Squibb Company Novel bicyclic nitrogen containing heteroaryl tgr5 receptor modulators
SG11201401359SA (en) 2011-10-21 2014-05-29 Torrent Pharmaceuticals Ltd Novel substituted imidazopyrimidines as gpbar1 receptor modulators
WO2013102929A1 (en) 2011-12-26 2013-07-11 Cadila Healthcare Limited Novel compounds for treatment of diabetes, obesity or related disorders
EP2828263B1 (en) * 2012-03-07 2019-12-11 Rigel Pharmaceuticals, Inc. Synthesis of polycyclic alkaloids and their use as tgr5 agonists
WO2014100021A1 (en) 2012-12-17 2014-06-26 Exelixis, Inc. Tgr5 agonists: imidazole and triazole compounds containing a quaternary nitrogen
WO2015023675A2 (en) 2013-08-12 2015-02-19 Pharmaceutical Manufacturing Research Services, Inc. Extruded immediate release abuse deterrent pill
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US10172797B2 (en) 2013-12-17 2019-01-08 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
DK3169315T3 (en) 2014-07-17 2020-08-10 Pharmaceutical Manufacturing Res Services In Liquid-filled dosage form to prevent immediate release abuse
WO2016064873A1 (en) 2014-10-20 2016-04-28 Pharmaceutical Manufacturing Research Services, Inc. Extended release abuse deterrent liquid fill dosage form
EP3572411A1 (en) 2018-05-21 2019-11-27 Antabio SAS Thiazole derivatives as metallo-beta-lactamase inhibitors
SG11202012625PA (en) 2018-06-19 2021-01-28 Novartis Ag N-substituted tetrahydrothienopyridine derivatives and uses thereof
WO2021071837A1 (en) 2019-10-07 2021-04-15 Kallyope, Inc. Gpr119 agonists
UY39222A (en) 2020-05-19 2021-11-30 Kallyope Inc AMPK ACTIVATORS
JP2023531726A (en) 2020-06-26 2023-07-25 キャリーオペ，インク． AMPK Activator

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3934018A (en) * 1970-09-03 1976-01-20 Abbott Laboratories 4,6-Dihydro-1,3-dimethyl-8-phenylpyrazolo[4,3-e] [1,4]diazepin-5-(1H)-one and derivatives as anti-inflammatory agents
WO1988009333A1 (en) * 1987-05-28 1988-12-01 Yoshitomi Pharmaceutical Industries, Ltd. Thieno(triazolo)diazepine compound and medicinal application of the same
WO1994006802A1 (en) * 1992-09-18 1994-03-31 Yoshitomi Pharmaceutical Industries, Ltd. Thienodiazepine compound and medicinal use thereof
JPH11209356A (en) * 1997-04-21 1999-08-03 Takeda Chem Ind Ltd Condensed cyclic compound, its production and agent
FR2791980B1 (en) * 1999-04-09 2001-07-06 Sod Conseils Rech Applic PYRIDO-THIENO-DIAZEPINES, THEIR PREPARATION PROCESS, AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CA2451163A1 (en) * 2001-06-28 2003-01-09 Takeda Chemical Industries, Ltd. Agent for preventing or treating organ functional disorders and order dysfunction
CA2514547A1 (en) * 2003-01-28 2004-08-12 Takeda Pharmaceutical Company Limited Receptor agonists
WO2004113300A1 (en) * 2003-06-23 2004-12-29 Ono Pharmaceutical Co., Ltd. Novel tricyclic heterocycle compound
CA2553329A1 (en) * 2004-01-14 2005-07-28 Ajinomoto Co., Inc. New fused polycyclic compounds
JP2006056881A (en) * 2004-07-21 2006-03-02 Takeda Chem Ind Ltd Fused ring compound
JP2006063064A (en) * 2004-07-27 2006-03-09 Takeda Chem Ind Ltd Receptor agonist

Also Published As

Publication number Publication date
WO2008067222A1 (en) 2008-06-05
AU2007325315A8 (en) 2009-07-09

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Legal Events

Date Code Title Description
TH Corrigenda

Free format text: IN VOL 23, NO 23, PAGE(S) 8658 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE -NAME INDEX UNDER THE NAME KALYPSYS, INC., DELETE ALL REFERENCE TO APPLICATION NO. 2007325315.