AU2004303445B2 - Polycyclic agents for the treatment of respiratory syncytial virus infections - Google Patents

Description

WO 2005/061513 PCT/AU2004/001830 POLYCYCLIC AGENTS FOR THE TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS INFECTIONS 5 Field of the invention The present invention relates to antiviral compounds, methods for their preparation and compositions containing them, and use at the compounds and composition in the treatment of viral infections. In particular, the invention relates to the use of compounds of formula I for the treatment of respiratory syncytial virus infection. 10 Background Art Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection in adults and in young children. In the western world approximately all children have been infected by the age of two. In most cases the RSV infections will only cause minor 15 upper respiratory illness with symptoms resembling that of the common cold. However, severe infection With the virus may result in bronchiolitis or pneumonia which may result in hospitalization or death. Infants who have been born prematurely or have a pre-existing lung disease are a, high risk of severe infection and complications. 20 Respiratory syncytial virus (RSV) is a member of the order Mononegalirales, which consists of the non-segmented negative strand RNA viruses in the Families Paranyxoviridae, Rhabdoviridae and Filoviridae. RSV of humans (often termed RSV or HRSV) is a member of the Pneumovirus genus of the sub-family Pneumovirinae within the Family Paramyxoviridae. Other members of the Pneumovirus genus include viruses 25 such as bovine RSV (BRSV), ovine RSV (ORSV) and murine pneumonia virus (MPV) amongst others. The sub-family Pneumovirinae also includes the genus Metapneumovirus which contains the recently identified and important human pathogen human metapneumovirus. 30 In addition to the genome features described above, Family characteristics include a lipid envelope containing one or more glycoprotein species considered to be associated with attachment and entry of the host cell. Entry is considered to require a process by which the viral envelope fuses with the membrane of the host cell. Fusion of infected cells with, for example, their neighbours, can also result in the formation of fused multinucleate cells 35 known as syncytia in some cases. The fusion process is believed to be glycoprotein mediated and is a feature shared with diverse enveloped viruses in other taxonomic groups. In the case of the Paramyxoviridae viruses of all genera characteristically express a fusion glycoprotein (F) which mediates membrane fusion WO 2005/061513 PCT/AU2004/001830 -2 The only drug currently approved for the treatment of severe RSV is the antiviral medication, Virazole, also known as Ribavirin. This agent has a broad spectrum antiviral with virustatic effects, and acts by inhibiting RSV replication. It also improves arterial blood oxygenation. Unfortunately, the agent is toxic so that administration of the agent is 5 confined to a hospital setting. Its administration is further complicated by the need to follow a strict procedural process when administering the agent in order to minimise the likelihood of certain adverse affects. The agent has a number of adverse effects including sudden deterioration of respiratory function (bronchiospasm). The efficacy of the agent has remained controversial and thus there is a real need to find an alternative agent for the 10 treatment of RSV infection. A number of agents are known to inhibit RSV. Published patent applications WO 01/95910 and WO 02/26228 (Bristol Myers Squib Company), the contents of which are incorporated by cross reference, describe a number of different types of compounds 15 which exhibit anti-RSV activity in their description of the background art. Moreover, these applications describe compounds having antiviral activity against RSV of the formula R2 RR R4 N / N R9

R

11

R

1 2 >R7 Re N\R1 i 1 7 R RR3 R2 /R2 R4N N N 20 Re R1 B There are also a number of patent specifications that disclose imidazo-[2,1-a]-isoindole derivatives for uses other than treating RSV. US Patent 3,507,863 describes a number of polycyclic compounds that have anti-inflammatory and anti-convulsive activity. These compounds have the following general structure 25 WO 2005/061513 PCT/AU2004/001830 -3 A -- (CH2)n iN / I. 0 where A is -NH-, -0- or -S-, and n is 1-3. US Patent 3,770,766 describes polycyclic compounds that have antidepressant activity, 5 and have the following general structure N ND R3 HO where R 3 is selected from various aromatic substituents. 10 US Patent 4,058,529 discloses anti-inflammatory and anti-convulsive activity polycyclic compounds of the general formula A, and includes compounds of the formula B where R 2 is hydrogen or lower alkyl group (including amino substituted groups) and n is 1-3.

R

1

R

2 12 N A- N N ,(CH2)n 0C-N- 15 0 Formula A Formula B CH 482,697 (Graf) discloses a number of compounds of the general formula B above, where R 2 is -CO-CHR-N 3 and R is hydrogen or alkyl, and intermediates where R 2 is -CO 20 CHR-NH 2 , -CO-CHR-OH or hydrogen. Likewise US Patent No. 3,590,043 (Graf) relates to compounds of the formula B where R 2 is -CO-CHR-NR'R". In this document n is 1 to WO 2005/061513 PCT/AU2004/001830 -4 3, R is H or lower alkyl, R' and R" may be lower alkyl or benzyl or together form a piperidinyl or morpholinyl ring. The Graf compounds may have anti-inflammatory uses. WO 02/066479 (Banyu Pharmaceutical) lists some compounds of the general formula B, 5 where R 2 is lower alkyl, -CO-C 2

H

5 and selected other moieties. It also appears to suggest a compound of formula B where the fused phenyl ring has been replaced with pyridyl and

R

2 is methyl. It is not clear whether all of these compounds have been made. The compounds are for use in the treatment of high blood pressure and diabetes. 10 GB 1,038,735 discloses anti-inflammatory compounds of the general formula B, where n is 1 to 3, R 2 is lower alkyl or, for example, an dimethylaminoethyl group. Canadian patent application no. 2,108,899 (also see family member WO 92/16207) discloses various oxazolo-[2,3-a]-isoindole and imidazo-[2,1-a]-isoindole derivatives for 15 use in antiviral medicaments, particularly for use in the treatment of AIDS and HIV. There are marked differences between HIV and RSV viruses, the diseases they are associated with, and the respective modes of action of the disclosed compounds. The specification generally describes compounds of the structure below where R is C1-C 6 alkyl group or Ci-C 6 acyl group, and specifically discloses compounds where R is -COCH 3 or 20 CH 3 . A number of documents disclose compounds of the above formula or substituted forms thereof, where R is hydrogen. See for example the herbicidal compounds disclosed in US 25 Patent No's 4,726,838 and 4,846,876. Summary of the Invention The invention relates to the discovery that certain compounds exhibit favourable anti-RSV activity by inhibition of the RSV virus's essential fusion processes. 30 This invention provides for the use of a compound of formula I -5 R2

R

1 N B A I x Formula I and pharmaceutically acceptable derivatives salts thereof, in the treatment of respiratory syncytial virus S (RSV) infections, wherein R is selected from C1.

1 2 alkyl, C 2 -1 2 alkenyl, C 2

-

1 2 alkynyl, -(CH 2 )nC 3

.

7 cycloalkyl, -(CH 2 )nC 4

.

7 cycloalkenyl, -(CH 2 ). aryl, -(CH 2 )n arylCi., 2 alkyl, -(CH 2 )n arylC 2

.

12 alkenyl, -(CH 2 )n arylC 2 -1 2 alkynyl, and -(CH 2 ), heterocyclyl; n is 0-6 and said alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl and 10 heterocyclyl groups are optionally substituted;

R

2 is selected from -C-1 2

R

3 , -C(Y)R 3 , -C(Y)OR 3 , -C(Y)N(R4)R 3 , -C(Y)CH 2 N(R4)R 3 , -C(Y)C-1,SR 3 and S(O).RS, where R3 is selected from hydrogen, CI.

2 alkyl. C 2

.

2 alkenyl, C 2

.

1 2 alkynyl, -(CH-l 2 )mC3.7 cycloalkyl, -(CH 2 )mC 4

.

7 cycloalkenyl, -(CH 2 )m aryl, -(CH-l 2 )m arylCI., 2 alkyl, -(CH 2 )m arylC 2 ., alkenyl. 15 (CH- 2 )m arylC 2

.,

2 alkynyl and -(CH 2 )m heterocyclyl; and when R 2 is -CH 2

R

3 , or -C(Y)R 3

R

3 is further selected from -S-Rs and -O-Rs; m is 0-6; R4 is hydrogen or C 1 ., alkyl; R 5 is CI.- alkyl, C 2 .6 alkenyl. C 2 ., alkynyl, C 3

.

7 cycloalkyl, C 4

.

7 cycloalkenyl, benzyl, aryl or heterocyclyl; w is 0, 1 or 2; and the alkyl, alkenyl. alkynyl. cycloalkyl, cycloalkenyl, aryl and heterocyclyl groups are optionally substituted; 20 X and Y are independently selected from 0, S and NR 6 , where R is independently selected from hydrogen, lower alkyl, hydroxy and lower alkoxy; A together with the atoms to which it is attached, forms an optionally substituted aryl or heteroarylring; 25 B-C together with the atoms to which it is attached, forms an optionally substituted heterocyclic ring having from 5 to 8 ring atoms. The invention also provides for the use of compounds of formula 1, and pharmaceutically acceptable salts and derivatives thereof, in the treatment of RSV infections by the inhibition of the virus's fusion 30 processes. 2334232_2 (GHMatters) 9107110 WO 2005/061513 PCT/AU2004/001830 -6 The invention also provides novel compounds of formula I, their salts, and pharmaceutically acceptable derivatives thereof. Description of Preferred Embodiments 5 As used herein the term "aromatic" refers to aryl rings or ring systems and aromatic heterocyclic rings or ring systems, as known as heteroaryl or heteroaromatic rings. As used herein the term "aryl" refers to carbocyclic (non-heterocyclic) aromatic rings or ring systems. The aromatic rings may be mono- or bi-cyclic ring systems. The aromatic 10 rings or ring systems are generally composed of 5 to 10 carbon atoms. Examples of suitable aryl groups include but are not limited to phenyl, biphenyl, naphthyl, tetrahydronaphthyl, and the like. Preferred aryl groups include phenyl, naphthyl, indenyl, azulenyl, fluorenyl or 15 anthracenyl. The term "heterocyclic" or "heterocyclyl" as used herein refers to mono or bicyclic rings or ring systems that include one or more heteroatoms selected from N, S and 0. -The rings or ring systems generally include 1 to 9 carbon atoms in addition to the heteroatom(s) and 20 may be saturated, unsaturated or aromatic (including pseudoaromatic). The term "pseudoaromatic" refers to a ring system which is not strictly aromatic, but which is stabilized by means of delocalization of electrons and behaves in a similar manner to aromatic rings. Aromatic includes pseudoaromatic ring systems, such as furyl, thienyl and pyrrolyl rings. 25 Examples of 5-membered monocyclic heterocycles include furyl, thienyl, pyrrolyl, H pyrrolyl, pyrrolinyl, pyrrolidinyl, oxazolyl, oxadiazolyl, (including 1,2,3 and 1,2,4 oxadiazolyls) thiazolyl, isoxazolyl, furazanyl, isothiazolyl, pyrazolyl, pyrazolinyl, pyrazolidinyl, imidazolyl, imidazolinyl, triazolyl (including 1,2,3 and 1,3, 4 triazolyls), 30 tetrazolyl, thiadiazolyl (including 1,2,3 and 1,3,4 thiadiazolyls). Examples of 6-membered monocyclic heterocycles include pyridyl, pyrimidinyl, pyridazinyl, pyranyl, pyrazinyl, piperidinyl, 1,4-dioxanyl, morpholinyl, 1,4-dithianyl, thiomorpholinyl, piperazinyl, 1,3,5 trithianyl and triazinyl. The heterocycles may be optionally substituted with a broad range of substituents, and preferably with CI- 6 alkyl, C 1

-

6 alkoxy, C 2

.

6 alkenyl, C 2

-

6 alkynyl, halo, 35 hydroxy, mercapto, trifluoromethyl, amino, cyano or mono or di(CI- 6 alkyl) amino. The heterocycle may be fused to a carbocyclic ring such as phenyl, naphthyl, indenyl, azulenyl, fluorenyl, and anthracenyl.

WO 2005/061513 PCT/AU2004/001830 -7 Examples of 8, 9 and 10-membered bicyclic heterocycles include 1H thieno[2,3 c]pyrazolyl, thieno[2,3-b]furyl, indolyl, isoindolyl, benzofuranyl, benzothienyl, benzoxazolyl, benzothiazolyl, benzisoxazolyl, benzisothiazolyl, benzimidazolyl, indazolyl, isoquinolinyl, quinolinyl, quinoxalinyl, uridinyl, purinyl, cinnolinyl, 5 phthalazinyl, quinazolinyl, quinoxalinyl, benzotriazinyl, naphthyridinyl, pteridinyl and the like. These heterocycles may be optionally substituted, for example with CI- 6 alkyl, C 1 . 6 alkoxy, C 2

-

6 alkenyl, C 2

-

6 alkynyl, halo, hydroxy, mercapto, trifluoromethyl, amino, cyano or mono or di(C 1

.

6 alkyl) amino. 10 Examples of preferred heterocyclic radicals include (optionally substituted) isoxazoles, isothiazoles, 1,3,4-oxadiazoles, 1,3,4-thiadiazoles, 1,2,4-oxadiazoles, 1,2,4-thiadiazoles, oxazoles, thiazoles, pyridines, pyridazines, pyrimidines, pyrazines, 1,2,4-triazines, 1,3,5 triazines, benzoxazoles, benzothiazoles, benzisoxazoles, benzisothiazoles, quinolines and quinoxalines. These heterocycles can be optionally substituted with, by example, with C 1 . 15 6 alkyl, C 1

-

6 alkoxy, C 2

-

6 alkenyl, C 2

-

6 alkynyl, halo, hydroxy, mercapto, trifluoromethyl, amino, cyano or mono or di(C1- 6 alkyl) amino. Examples of particularly preferred heterocyclic radicals include furyl, thienyl, pyridyl, oxazolyl, thiazolyl, pyrazolyl, furazanyl, isoxazolyl, isothiazolyl, 1,2,3-triazolyl, 1,3,4 20 triazolyl, 1,2,3-thiadiazolyl, 1,3,4-thiadiazolyl, pyridazinyl, pyrimidinyl, benzo[b]furanyl, benzo[b]thiophenyl and benzoisoxazolyl. Examples of unsaturated 5-membered heterocyclic rings include oxazole, thiazole, imidazole, 1,2,3-triazole, isoxazole, isothiazole, pyrazole, furan, thiophene and pyrrole. 25 Examples of unsaturated 6-membered heterocyclic rings include pyridine, pyrimidine, pyrazine, pyridazine and 1,2,4-triazine. In a preferred embodiment, the heterocyclic ring is an aromatic ring. Heteroaryl and heteroaromatic are used herein to refer to this subset of heterocyclic rings. Heteroaryl 30 rings include furyl, thienyl, pyridyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,4-oxadiazol-5-one, 1,2,3-triazolyl, 1,3,4-thiadiazolyl, pyridazinyl, pyrimidinyl, pyrazinyl, 1,3,5-triazinyl, 1H thieno[2,3-c]pyrazolyl, thieno[2,3-b]furyl, indolizinyl, indolyl, isoindolyl, 3H-indolyl, indolinyl, benzo[b]furanyl, benzo[b]thiophenyl, 1H-indazolyl, benzimidazolyl, tetrazolyl, 35 uridinyl, and cytosinyl. More preferably heteroaryl or heteroaromatic is selected from isoxazolyl, oxazolyl, imidazolyl, thiazolyl, thiadiazolyl, isothiazolyl, furazanyl, triazolyl, pyridyl, pyrimidinyl, furyl, pyrazolyl, pyridazinyl, thienyl and aryl fused heteroaromatic rings such as 40 benzfuranyl, benzothiophenyl and benzoisoxazolyl.

WO 2005/061513 PCT/AU2004/001830 -8 In another preferred embodiment, the heterocyclic ring is a non-aromatic ring selected from the group consisting of pyrrolidine, imidazoline, 2-imidazolidone, 2-pyrrolidone, pyrrolin-2-one, tetrahydrofuran, 1,3-dioxolane, piperidine, tetrahydropyran, oxazoline, 5 1,3-dioxane, 1,4-piperazine, morpholine and thiomorpholine. The heterocyclic ring containing the linker group B-C may be selected from the above described heterocyclic rings provided the ring meets the requirement of containing at least two nitrogen atoms and excludes aromatic ring systems. 10 Unless otherwise defined, the term "optionally substituted" as used herein means that a group may include one or more substituents that do not interfere with the binding activity of the compound of formula I. In some instances the substituent may be selected to improve binding. The group may be substituted with one or more substituents selected 15 from halogens, C 1

.

6 alkyl, C 2

.

6 alkenyl, C 2

-

6 alkynyl, -(CH 2 )pC 3

-

7 cycloalkyl, -(CH 2 )pC 4

.

7 cycloalkenyl, -(CH 2 )p aryl, -(CH 2 )p heterocyclyl, -C 6

H

4 S(O)tC 1

.

6 alkyl, -C(Ph) 3 , -(CH 2 )pZ, -COZ, -CN, -OR, -O-(CH 2

)

1

-

6 -R, -O-(CH 2

)

1

.

6 -OR, -OCOR, -COR, -COOR, -OCONR'R", -- NR'R", -NRCOR', -NRCONR'R", -NRC(S)NR'R", -NRSO 2 R', -NRCOOR', -C(NR)NR'R", -CRNOR', -C(=NOH)NR'R", -CONR'R", -C(=NCN)-NR'R", 20 C(=NR)NR'R", -C(=NR')SR", -NR'C(=NCN)SR", -CONRS0 2 R', -C(S)NR'R", -S(O)tR,

-SO

2 NR'R", -SO 2 NRCOR', -OS(O) 2 R, -PO(OR) 2 and -NO 2 ; where p is 0-6, t is 0-2, Z is an N-linked amino acid selected from the group consisting of alanine, asparagine, aspartic acid, glutamic acid, glutamine, glycine, pipecolic acid, a-amino-butyric acid, a-amino propanoic acid, and iminodiacetic acid, Z being linked through a nitrogen atom of said N 25 linked amino acid to the carbon atom, and each R, R' and R" is independently selected from H, C 1

.

6 alkyl, C 2

-

6 alkenyl, C 2

-

6 alkynyl, C 3 .7 cycloalkyl, C 4

.

7 cycloalkenyl, aryl, heterocyclyl, C 1

.

6 alkylaryl abd C 1

-

6 alkylheterocyclyl, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heterocyclyl, C 1

.

6 alkylaryl or C 1

-

6 alkylheterocyclyl, may be optionally substituted with one to six of same or different selected from halogen, 30 hydroxy, lower alkyl, lower alkoxy, -CO 2 H, CF 3 , CN, phenyl, NH 2 and -NO 2 ; or when R' and R" are attached to the same nitrogen atom, they may, together with the atom to which they are attached, form a 5 to 7 membered nitrogen containing heterocyclic ring. When the optional substituent is or contains an alkyl, alkenyl, alkynyl, cycloalkyl, 35 cycloalkenyl, aryl or heterocyclyl group, the group may itself be optionally substituted with one to six of the same or different halogen atoms, hydroxy, lower alkyl, lower alkoxy, halo-C 1

.

6 alkyl (including -CF 3 ), phenyl, benzyl, -CN, -C(O)-C 1 - alkyl, mercapto,

-NH

2 , mono or di (lower alkyl) amino or -NO 2

.

WO 2005/061513 PCT/AU2004/001830 -9 In relation to nitrogen containing heterocyclic rings, unless otherwise defined optionally substituted includes pyridinium salts and the N-oxide form of suitable ring nitrogens. In relation to non-aromatic carbocyclic or heterocyclic compounds, unless otherwise 5 defined such compounds may also be optionally substituted with one or two =0 groups, instead of or in addition to the above described optional substituents. Examples of optional substituents include halogens, C 1

..

4 alkyl, C 2 4 alkenyl, C 2

.

4 alkynyl,

C

1

.

4 alkoxy, C1.

4 haloalkyl, -CF 3 , -OH, phenyl, -NH 2 , -NHC 1

..

4 alkyl, -N(C 1

.

4

)

2 , -CN, 10 mercapto, C 1

.

4 alkylcarbonyl and C 1

.

4 alkoxycarbonyl. As used herein the term "C1-12 alkyl" refers to straight chain or branched saturated hydrocarbon group having from 1 to 12 carbon atoms. Examples of such alkyl groups include methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl or tert-butyl. 15 Similarly "C 1

.

6 alkyl" or "lower alkyl" refers to such groups having from 1 to 6 carbon atoms. As used herein the term "C 3

.

7 cycloalkyl" refers to non-aromatic, saturated cyclic groups having from 3 to 7 carbon atoms. Examples include cyclopentyl and cyclohexyl. 20 As used herein the term "alkoxy" refers to a straight or branched alkyl group covalently bound via an 0 linkage and the terms "C 1

-

6 alkoxy" and "lower alkoxy" refer to such groups containing from one to six carbon atoms, such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, t-butoxy and the like. 25 As used herein the term "C 2

-

12 alkenyl" refers to groups formed from C 2

..

1 2 straight chain or branched non-cyclic hydrocarbon containing one or more double bonds. Examples of C 2 12 alkenyl include allyl, 1-methylvinyl, butenyl, iso-butenyl, 1, 3-butadienyl, 3-methyl-2 butenyl, 1,3-butadienyl, 1,4-pentadienyl, 1-pentenyl, 1-hexenyl, 3-hexenyl, 1,3 30 hexadienyl, 1,4-hexadienyl and 1, 3, 5-hexatrienyl. As used herein the term "C 4

.

7 cycloalkenyl" refers to non aromatic carbocycles having 4 to 7 carbon atoms and having one or more double carbon bonds. Examples include cyclopentenyl, 1 -methyl-cyclopentenyl, cyclohexenyl, 1,3-cyclopentadienyl, 1,3 35 cyclohexadienyl and 1,4-cyclohexadienyl. As used herein the term "C 2

-

12 alkynyl" refers to C 2

..

12 straight or branched non-cyclic hydrocarbon containing one or more triple bonds, preferably one or two triple bonds. Examples include 2-propynyl and 2- or 3-butynyl. 40 WO 2005/061513 PCT/AU2004/001830 -10 The term "aryl C1-12 alkyl" refers to carbocyclic aromatic rings or ring systems as previously described and substituted by a C 1

-

12 alkyl group, also as previously described. Likewise the terms "aryl C 2

..

12 alkenyl" and "aryl C 2

-

12 alkynyl" refer to carbocyclic aromatic rings or ring systems as previously described and substituted by a C 2

-

12 alkenyl 5 or C 2

-

12 alkynyl group, as previously described. The aryl group and the alkyl, alkenyl or alkynyl group may be optionally substituted. Preferably the aryl group is not optionally substituted. 10 Preferably the alkyl, alkenyl or alkynyl group is optionally substituted, and more preferably with a substituent selected from halogens, -CN, -NR'R", -COR, -COOR, or CONR'R". Preferably R, R' and R" are independently selected from hydrogen or lower alkyl. 15 As used herein the term "halo" or "halogen" refers to fluoro, chloro, bromo and iodo groups. As used herein a "halo alkyl" group has one or more of the hydrogen atoms on an alkyl group replaced with halogens. An example includes -CF 3 . 20 Particularly preferred compounds of the invention include those compounds where A is a bivalent link of 3 or 4 atoms selected from C, N, 0 and S. In that arrangement A and the atoms to which they are attached together form an aromatic ring having five or six ring atoms. When the linking atoms are all carbon, the ring formed is a carbocyclic aromatic 25 ring or ring system. When the linking atoms include one or more of N, 0 or S then the ring formed is an aromatic heterocyclic ring. Examples include where the substructure A 30 is:- P.\OPERe)C\SpecictionsN2558020 Au.ian speci AMENDED doc-26022007 - 11 NN N N ro N N. N 5 peeayapnyjl orprdlng. TeotnalsutietsincueNoidso h * N N H 0 H N ~ 0~-s -- N or N\ Preferably ring A is an optionally substituted aryl or optionally substituted heteroaryl ring, more preferably a phenyl, pyridyl, pyridazinyl, pyrimidinyl or pyrazinyl ring, and most 5 preferably a phenyl or pyridyl ring. The optionally substituents include N-oxides of the ring nitrogen atoms. The aromatic rings may be optionally substituted, preferably by no more than 3 substituents. Of the optional substituents, it is particular preferred to use I to 3 10 substituents selected from halo, lower alkyl, halogenated forms of lower alkyl, hydroxy, lower alkoxy, nitro, amino, loweralkylamino, carboxy, carboxamido, phenyl and benzyl. N-oxide forms of the nitrogen atoms of nitrogen containing rings are also preferred. When A is a pyridyl ring, the ring nitrogen may be in a N-oxide form, or the ring may be in the form of a pyridinium salt. 15 In respect of the heterocyclic ring formed by B-C, it will be understood that this ring can not be selected from all of the heterocyclic rings discussed earlier in relation to the meaning of the term due to the atoms to which B-C are attached. This ring is limited to WO 2005/061513 PCT/AU2004/001830 - 12 monocyclic, non-aromatic heterocyclic rings that include at least two nitrogen atoms. The ring may include additional hetero atoms and may be partially unsaturated. Particularly preferred are compounds in which B-C represents a bivalent link of 1 to 3 5 atoms. The link B-C together with the atoms to which it is attached forms a non-aromatic heterocyclic ring. Examples include where the substructure: NB is: N N N N N N N H S NN N ND 'N N/ N: N 1 / or | In a preferred form of the invention, B-C represents -CH2-(CH2)z-, where z is 1-4, more preferably 1,2 or 3, more preferably 1 or 2 and most preferably z is 1. The atoms forming the link B-C may be optionally substituted, preferably by no more than 15 3 substituents. A broad range of substituents are possible and include halo, lower alkyl, hydroxy, lower alkoxy, phenyl and benzyl. A preferred form of the invention includes those compounds where B-C represents -CH2CH2-.

PIOPER\MJC\SpecifcanonsNj2558O20 Austraanh spcci AMENDED doc-26/02/2007 - 13 Preferably X is oxygen or sulphur, more preferably X is oxygen. In an embodiment of the invention fused ring A and the ring containing the bivalent link 5 B-C are optionally substituted with one or two substituents independently selected from halogen and C 1

-

6 alkyl. Preferably fused ring A and the ring containing the bivalent link B-C are not substituted. R, may be an optionally substituted aryl, optionally substituted alkyl or optionally 10 substituted heterocyclyl. Preferably R, is an optionally substituted aryl or heterocyclyl group, more preferably a phenyl, thienyl, pyrrolyl or pyridyl ring. R 1 may also be a -CI.6 alkylphenyl group. The rings of R, may b optional substituted with halo, hydroxy, nitro, NR'R" (where R' and R" are independently selected from hydrogen, lower alkyl and C(O)R, where R is C 1

-

6 alkyl, phenyl or heterocyclyl), CI.

2 alkyl, phenyl and -O-Ra, where 15 Ra is -CI.

12 alkyl, -C 3

.

7 cycloalkyl, -C 1 i 2 alkylC 3

.

7 cycloalkyl, phenyl or -C.

12 alkylphenyl; and the C 1 12 alkyl, phenyl or Ra group may be optionally substituted with halo, -CN, NR 0 R", -CO 2 R 12 or -CONR'OR", where R' 0 , R" and R are independently selected from hydrogen or lower alkyl. Preferably, the ring is phenyl and is optionally substituted in the para or 4-position. 20 R, may be -phenyl substituted with C 1

.

1 o alkyl chain, where the alkyl chain is substituted with halo, -CN, -NR'R", -CO 2 R or -CONR'R", where R, R' and R" are independently selected from hydrogen or lower alkyl. More preferably the alkyl chain is in the 4 position of the phenyl ring, and substituents are attached to the carbon at the free end of 25 the alkyl group. R, may be phenyl optionally substituted with a substituent selected from halo, -Ci- 6 alkyl, Ci.

6 alkylhalo, -CI 6 alkylCN, -OC 1

.

6 alkyl, -OCI 6 alkylhalo, -OC1.

6 alkylCO 2

NH

2 , -OCI. 6 alkylCN, -OC 1

.

6 alkylC 3

.

7 cycloalkyl, -OC 1

-

6 alkylC 6

H

5 , -OC 1

.

6 alkylOCH 3 , -OC 6

H

5 , 30 OC 6

H

4 halo, -CF 3 , -OCF 3 , -NR'R" (where R' and R" are independently selected from hydrogen, -C(O)CI- 6 alkyl, -C(O)C 6

H

5 , -C(O)CH=CHCO 2 H, -C(O)Ci- 6 alkylCO 2 H, C(O)C i.

6 alkylCO 2

CH

3 , -C(O)Ci.

6 alkylC 6 HS, -C(O)C 1

.

6 alkylC 6

H

4

CH

3 , -C(O)Ci. 6 alkylC 6

H

4 0CH 3 and -C(O)C 1

.

6 alkylC 6

H

4 halo), -CO 2 H, -CO 2 Ci- 6 alkyl, -NO 2 , -OH, -C 6

H

5 ,

-C

6

H

4 C I.

6 alkyl, -C 6

H

4 halo and -OC(O)C 1

.

6 alkyl. 35 Preferably R, is halophenyl, most preferably 4-chlorophenyl. Compounds where R 2 is hydrogen do not form part of the present invention. These compounds are useful as intermediates for the production of compounds of the invention 40 in which R 2 is not hydrogen.

- 14 R 2 is not an unsubstituted -C 1

.

6 alkyl or unsubstituted -C(O)-C,.

6 alkyl. When R, is -Cl]-R 3 , it is preferred that R 3 is -(Cl- 2 )m aryl or -(Cl-l 2 ), heterocyclyl, where m is 0 to 3. 5 R 3 may be benzyl (m=l). The ring atoms may by optionally substituted with a broad range of substituents. Preferred substituents are selected from halo, lower alkyl, hydroxy, lower alkoxy and phenyl. When R 2 is -C(Y)-R 3 , it is preferred that Y is 0. It is also preferred that R 3 is -(CH 2 )m aryl or -(ClH 2 )m 10 heteroaryl, where m is 0 to 3. It is particularly preferred for R3 to be aryl or heteroaryl (m=0), and more preferably a 5 or 6 membered monocyclic heterocycle or 9 or 10 membered bicyclic heterocycle or an aryl group. When R 2 is -C(Y)C1 2

N(R

4

)R

3 or -C(Y)CH 2

SR

3 , R 3 is preferably -(CH 2 )m aryl or -(CH 2 )m heterocyclyl 15 where m is 0 to 3. The heterocycyl may itself be substituted with an oxo group, hydroxy or lower alkyl. More preferably R 3 is phenyl, naphthyl, furyl, thienyl, pyrrolyl, H-pyrrolyl, pyrrolinyl, pyrrolidinyl, oxazolyl, oxadiazolyl, (including 1,2,3 and 1,2,4 oxadiazolyls) thiazolyl, isoxazolyl, furazanyl, isothiazolyl, pyrazolyl, pyrazolinyl, pyrazolidinyl, imidazolyl, imidazolinyl, triazolyl (including 1,2,3 and 20 1,3,4 triazolyls), tetrazolyl, thiadiazolyl (including 1,2,3 and 1,3,4 thiadiazolyls), pyridyl, pyrimidinyl, pyridazinyl, pyranyl, pyrazinyl, piperidinyl, 1,4-dioxanyl, morpholinyl, 1,4-dithianyl, thiomorpholinyl, piperazinyl, 1,3,5-trithianyl, triazinyl, IlH thieno[2,3-c]pyrazolyl, thieno[2,3-bjfuryl, indolyl, isoindolyl, benzofuranyl, bcnzothienyl, benzoxazolyl, benzothiazolyl. benzisoxazolyl, benzisothiazolyl. benzimidazolyl, indazolyl. isoquinolinyl, quinolinyl, quinoxalinyl, uridinyl, purinyl, cinnolinyl., 25 phthalazinyl, quinazolinyl, quinoxalinyl, benzotriazinyl, naphthyridinyl or pteridinyl. The heterocyclic ring may be fused to a carbocyclic ring such as phenyl, naphthyl, indenyl, azulenyl, fluorenyl, and anthracenyl. 30 The aryl or heterocyclic may be optionally substituted with a broad range of substituents, and preferably with C 1

.

6 alkyl, C 1

.

6 alkoxy, C 2

.

6 alkenyl, C 2

-

6 alkynyl, halo, hydroxy, mercapto, trifluoromethyl, amino, nitro, cyano and mono or di(C 1

.

6 alkyl) amino. The substituents also include phenyl, benzyl and heterocyclyl. 35 Most preferably R 3 is selected from phenyl, furyl, thienyl, pyridyl, oxazolyl, thiazolyl, pyrazolyl, furazanyl, isoxazolyl, isothiazolyl, I,2,3-triazolyl, 1,3,4-triazolyl, 1,2,3-thiadiazolyl, 1,3,4-thiadiazolyl, pyridazinyl, pyrimidinyl, benzo[blfuranyl, benzo[b]thiophenyl and benzoisoxazolyl. 23342322 (GHMatters) 9/07/10 WO 2005/061513 PCT/AU2004/001830 - 15 When R 2 is -COR 3 , it is also preferred for R 3 to be -phenylC1.-o alkyl, where the alkyl is substituted with halo, -CN, -NR'R", -CO 2 R or -CONR'R", where R, R' and R" are independently selected from hydrogen or lower alkyl. More preferably the alkyl chain is 5 in the 4-position of the phenyl ring, and substituents are attached to the carbon at the free end of the alkyl group. When R 2 is -CON(R 4

)R

3 it is preferred for R 4 to be hydrogen and R 3 to be -(CH 2 )m aryl or

-(CH

2 )m heteroaryl. Preferably m is 0 to 2, more preferably 0 to 1. The aryl and 10 heteroaryl ring atoms may be optionally substituted with a broad range of substituents. Preferred substituents include halo, lower alkyl, hydroxy, lower alkoxy and phenyl. Another preferred embodiment of the invention are those compounds where R 2 is -COR 3 and fused ring A contains at least one ring nitrogen atom. 15 When the invention relates to compounds of formula I per se, it is preferred that when R 1 is unsubstituted phenyl, X is 0, A together with the atoms to which it is attached forms an unsubstituted phenyl ring and B-C is -CH 2

CH

2 -, R2 is not unsubstituted C 1

.

6 alkyl or C(O)C 1

.

6 alkyl. 20 It will be appreciated that compound of formula I and some derivatives thereof may have at least one asymmetric centre, and therefore are capable of existing in more than one stereoisomeric form. The invention extends to each of these forms individually and to mixtures thereof, including racemates. The isomers may be separated conventionally by 25 chromatographic methods or using a resolving agent. Alternatively the individual isomers may be prepared by asymmetric synthesis using chiral intermediates. Where the compound has at least one carbon-carbon double bond, it may occur in Z- and E- forms and all isomeric forms of the compounds being included in the present invention. 30 The salts of the compound of formula I are preferably pharmaceutically acceptable, but it will be appreciated that non-pharmaceutically acceptable salts also fall within the scope of the present invention, since these are useful as intermediates in the preparation of pharmaceutically acceptable salts. 35 The term "pharmaceutically acceptable derivatives" includes pharmaceutically acceptable esters, prodrugs, solvates and hydrates, and pharmaceutically acceptable addition salts of the compounds or the derivatives. Pharmaceutically acceptable derivatives may include any pharmaceutically acceptable salt, solvate, hydrate or any other compound or prodrug which, upon administration to a subject, is capable of providing (directly or indirectly) a 40 compound of formula I or an antivirally active metabolite or residue thereof.

P.%OPER\MJCSpecficons' 2558020 Auala spw AMENDED doc-26Z/2007 -16 The pharmaceutically acceptable salts include acid addition salts, base addition salts, salts of pharmaceutically acceptable esters and the salts of quaternary amines and pyridiniums. The acid addition salts are formed from a compound of the invention and a pharmaceutically acceptable inorganic or organic acid including but not limited to 5 hydrochloric, hydrobromic, sulfuric, phosphoric, methanesulfonic, toluenesulphonic, benzenesulphonic, acetic, propionic, ascorbic, citric, malonic, fumaric, maleic, lactic, salicyclic, sulfamic, or tartartic acids. The counter ion of quarternary amines and pyridiniums include chloride, bromide, iodide, sulfate, phosphate, methanesulfonate, citrate, acetate, malonate, fumarate, sulfamate, and tartate. The base addition salts include 10 but are not limited to salts such as sodium, potassium, calcium, lithium, magnesium, ammonium and alkylammonium. Also, basic nitrogen-containing groups may be quaternised with such agents as lower alkyl halides, such as methyl, ethyl, propyl, and butyl chlorides, bromides and iodides; dialkyl sulfates like dimethyl and diethyl sulfate; and others. The salts may be made in a known manner, for example by treating the 15 compound with an appropriate acid or base in the presence of a suitable solvent. The compounds of the invention may be in crystalline form or as solvates (e.g. hydrates) and it is intended that both forms be within the scope of the present invention. The term "solvate" is a complex of variable stoichiometry formed by a solute (in this invention, a 20 compound of the invention) and a solvent. Such solvents should not interfere with the biological activity of the solute. Solvents may be, by way of example, water, ethanol or acetic acid. Methods of solvation are generally known within the art. The term "pro-drug" is used in its broadest sense and encompasses those derivatives that 25 are converted in vivo to the compounds of the invention. Such derivatives would readily occur to those skilled in the art, and include, for example, compounds where a free hydroxy group is converted into an ester derivative or a ring nitrogen atom is converted to an N-oxide. Examples of ester derivatives include alkyl esters, phosphate esters and those formed from amino acids, preferably valine. Any compound that is a prodrug of a 30 compound of the invention is within the scope and spirit of the invention. Conventional procedures for the preparation of suitable prodrugs according to the invention are described in text books, such as "Design of Prodrugs" Ed. H. Bundgaard, Elsevier, 1985. The term "pharmaceutically acceptable ester" includes biologically acceptable esters of 35 compound of the invention such as sulphonic, phosphonic and carboxylic acid derivatives. Thus, in another aspect of the invention, there is provided a prodrug or pharmaceutically acceptable ester of a compound of formula 1.

P \OPER\MJC\Specfications\ 2558020 Ausrahian spc AMENDED doc-26/2/2X)7 - 17 In another aspect of the invention, there is provided a pharmaceutical composition that comprises a therapeutically effective amount of one or more of the aforementioned anti RSV compounds of formula I, including pharmaceutically acceptable salts and derivatives thereof, and optionally a pharmaceutically acceptable carrier or diluent. 5 Unless otherwise specified the terms "treatment" or "treating", in the context of a method or use of the invention, includes both therapeutic and prophylactic treatments. In further aspect of the present invention, there is provided the use of a compound of 10 formula I, or a pharmaceutically acceptable salt or derivative thereof in the preparation of a medicament for the treatment (therapeutic or prophylactic) of RSV infections. In another aspect of the invention, there is provided a method of treating RSV by the administration of a compound of formula I, including the administration of 15 pharmaceutically acceptable salts, or derivatives such as prodrugs of formula I, or a composition containing at least one compound of formula I, to a patient in need to treatment. In another aspect of the invention, there is provided a method for treating mammals 20 infected with RSV, and in need thereof, which comprises administering to said mammal a therapeutically effective amount of one or more of the aforementioned compounds of formula I or pharmaceutically acceptable salts or derivatives thereof. In another aspect of the invention, there is provided a method for preventing the infection 25 of mammals with RSV, which comprises administering to said mammal a therapeutically effective amount of one or more of the aforementioned compounds of formula I, or pharmaceutically acceptable salts or derivatives thereof. Although the invention has been described with reference to treating RSV, and in 30 particularly human RSV, it will be appreciated that the invention may also be useful in the treatment of other viruses of the sub-family Pneumovirinae, more particularly, the genera Pneumovirus and Metapneumovirus, more particularly animal and human strains of RSV and metapneumovirus. 35 In a further form of the invention there is provided a process for the production of compounds of formula I. These compounds may be prepared using the procedure outlined in the following methods. Scheme I depicts a general process for manufacture of compounds of formula III. 40 Compounds of formula III are intermediates, similar to formula I but where R 2 is H.

WO 2005/061513 PCT/AU2004/001830 - 18 Compounds of formula III may be prepared via appropriate starting materials of formula II. General methods for the preparation of 2-(aroyl)benzoic acids and 3-(aroyl)pyridine-2 carboxylic acids of formula II are described by Yamaguchi, M. et. al, J. Med. Chem. 1993, 36, 4052-4060 and Natsugari, H. et.al, J. Med. Chem. 1995, 38, 3106-3120. 5 Scheme 1 R I R 1 B 0 TsOHI + H 2

N-B-C-NH

2 T A OH toluene x x Formula II Formula III In general, one equivalent of an appropriate keto-acid of formula II is reacted with 10 approximately 3 equivalents of an appropriate diamine of the general formula H 2

N-B-C

NH

2 . The mixture is heated under reflux in an inert solvent, such as toluene or xylene, with a Dean-Stark apparatus for 3-10 h. A catalyst, such as an acid tosylate, can be used. After this time the reaction is allowed to cool and the product filtered and recrystallised from an appropriate solvent. If no precipitate forms the solvent is evaporated in-vacuo 15 and the residue recrystallised or purified using flash chromatography or preparative HPLC. Compounds of formula III can also be produced by the methods described in US 4,058,529, Sulkowski, T.S., et. al, J. Org. Chem. 1967, 32, 2180-2184 and Houlihan, W.J., 20 et. al, J. Med. Chem. 1975, 18, 182-185. Other (novel) compounds of formula I may be obtained by acylating compounds of formula III as described in Scheme 2. Scheme 2 Y R3 R1 Y R 1

N.-

N C C I R m AC + x x 25 Formula III Formula I WO 2005/061513 PCT/AU2004/001830 -19 In one method, two equivalents of diisopropylethylamine or triethylamine are added to one equivalent of a compound of formula III in THF at 0 0 C. An acid chloride, or other acylating agent, is added to the mixture and the reaction monitored by HPLC. When the reaction is complete the reaction is quenched with water and the product extracted into a 5 suitable organic solvent and worked up according to standard methods. Similar acylation may also be carried out by reacting one equivalent of the compound of formula III with one equivalent of the appropriate acid chloride in xylene at 120'C for 1-24h. The reaction is then allowed to cool and the product isolated. Alternatively, compounds of formula III may be treated with approximately 2.2 equivalents of an appropriate acid chloride or 10 anhydride in pyridine at approximately -5'C. The mixture is allowed to arm to room temperature and after stirring for 2-24h the product is isolated by standard methods. Acylation may also be achieved by treating the appropriate compound of formula III with the appropriate carboxylic acid (3 equivalents), TFFH (3.3 equivalents) and DIEA (3.3 equivalents) in DMF and heating to 45'C for approximately 14 days. After this time the 15 product is isolated by standard methods. N-alkylated and N-sulfonylated compounds of Formula I are best obtained using suitable N-substituted diamines. These may be prepared by known methods for example that described by Kruse L.I., et. al, J. Med. Chem. 1990, 33, 781-789. 20 R12

R

1 N B A + R 2

HN-B-C-NH

2 A N.-C OH 1 x x In which R 2 is -CHR 3 or -S(O) 2

R

5 , as earlier defined in the summary of the invention. Hence, the appropriate keto-acid (2 equivalents) and N-substituted diamine (1 equivalent) 25 in chlorobenzene, toluene or xylene are placed in a flask equipped with a stirrer and Dean Stark water separator and heated at reflux until no further water is seen to separate (1 -8h). The solvent is then removed by distillation and the residue cooled. The residue can be purified using standard methods. 30 Compounds of Formula I where R 2 is a urea or thiourea are prepared using the following method. One equivalent of the appropriate compound of formula III is reacted with one equivalent of the appropriate isocyanate or isothiocyanate in THF or xylene at a temperature ranging WO 2005/061513 PCT/AU2004/001830 - 20 from 20-120*C for 1-24h. The reaction is then allowed to cool and the product filtered, washed and generally recrystallised from an appropriate solvent. If no precipitate is formed the product can be purified using standard chromatographic methods. 5 Other compounds of formula I can be prepared by the addition, removal or modification of existing substituents. This could be achieved by using standard techniques for functional group inter-conversion, well known in the industry such as those described in Comprehensive organic transformations: a guide to functional group preparations by Larock R C, New York, VCH Publishers, Inc. 1989. 10 Examples of functional group inter-conversions are: -C(O)NR'R" from -CO 2

CH

3 by heating with or without catalytic metal cyanide, e.g. NaCN, and HNRR" in CH 3 0H; OC(O)R from -OH with e.g., ClC(O)R in pyridine; -NC(S)NR'R" from -NHR with an alkylisothiocyanate or thiocyanic acid; -NRC(O)OR' from -NHR with alkyl 15 chloroformate; -NRC(O)NR'R" from -NHR by treatment with an isocyanate, e.g. HN=C=O or RN=C=0; -NRC(O)R' from -NHR by treatment with ClC(O)R' in pyridine; C(=NR)NR'R" from -C(NR'R")SR with H 3 NR*OAc- by heating in alcohol; -C(NR'R")SR from -C(S)NR'R" with R-I in an inert solvent, e.g. acetone; -C(S)NR'R" (where R' or R" is not hydrogen) from -C(S)NH 2 with HNR'R"; -C(=NCN)-NR'R" from -C(=NR'R")-SR 20 with NH 2 CN by heating in anhydrous alcohol, alternatively from -C(=NH)-NR'R" by treatment with BrCN and NaOEt in EtOH; -NR-C(=NCN)SR from -NHR' by treatment with (RS) 2 C=NCN; -NR"S0 2 R from -NHR' by treatment with CISO 2 R by heating in pyridine; -NR'C(S)R from -NR'C(O)R by treatment with Lawesson's reagent [2,4-bis(4 methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide];

-NRSO

2

CF

3 from -NHR with 25 triflic anhydride and base, -CH(NH 2 )CHO from -CH(NH 2 )C(O)OR' with Na(Hg) and HC1/EtOH; -CH 2 C(O)OH from -C(O)OH by treatment with SOCl 2 then CH 2

N

2 then

H

2 0/Ag 2 O; -C(O)OH from -CH 2

C(O)OCH

3 by treatment with PhMgX/HX then acetic anhydride then Cr0 3 ; R-OC(O)R' from RC(O)R' by R"CO 3 H; -CCH 2 OH from -C(O)OR' with Na / R'OH; -CHCH 2 from -CH 2

CH

2 OH by the Chugaev reaction; -NH 2 from 30 C(O)OH by the Curtius reaction; -NH 2 from -C(O)NHOH with TsCl/base then H 2 0; CHC(O)CHR from -CHCHOHCHR by using the Dess-Martin Periodinane regent or Cr0 3 / aqH2SO4 / acetone; -C 6

H

5 CHO from -C 6

H

5

CH

3 with CrO 2 Cl 2 ; -CHO from -CN with SnCl 2 / HCl; -CN from -C(O)NHR with PCl 5 ; -CH 2 R from -C(O)R with N 2

H

4 / KOH. 35 During the reactions a number of the moieties may need to be protected. ~ Suitable protecting groups are well known in industry and have been described in many references such as Protecting Groups in Organic Synthesis, Greene T W, Wiley-Interscience, New York, 1981.

WO 2005/061513 PCT/AU2004/001830 -21 The abbreviations that may be used herein, including in Schemes I-II, and experimental section are as follows unless indicated otherwise: DCM: dichloromethane 5 DIEA: diisopropylethylamine DMF: dimethylformamide Et: ethyl EtOAc: ethyl acetate Me: methyl 10 MeOH: methyl alcohol MS: mass spectrometry NMR: nuclear magnetic resonance Ph: phenyl HPLC: high performance liquid chromatography 15 TEA: triethylamine TFA: Trifluoroacetic acid TFFH: Fluoro-N,N,N",N"-tetramethylformamidinium hexafluorophosphate THF: tetrahydrofuran TsCl: Tosyl chloride 20 TsOH: Toluenesulphonic acid The invention also pertains to therapeutic compositions containing at least one compound of formula I including pharmaceutical acceptable salts or prodrugs. 25 The compositions may further contain one or more other compounds having anti-viral activity in respect of RSV, such as Virazole, or other agents such as RespiGam or Synagis. The compositions may further contain or be administered in combination with other drugs to treat symptoms of the disease, such as for example anti-inflammatory medicaments. 30 The term "composition" is intended to include the formulation of an active ingredient with conventional carriers and excipients, and also with encapsulating materials as the carrier, to give a capsule in which the active ingredient (with or without other carriers) is surrounded by the encapsulation carrier. 35 As will be readily appreciated by those skilled in the art, the route of administration and the nature of the pharmaceutically acceptable carrier will depend on the nature of the condition and the animal to be treated. It is believed that the choice of a particular carrier or delivery system, and route of administration could be readily determined by a person 40 skilled in the art. In the preparation of any formulation containing the compounds care WO 2005/061513 PCT/AU2004/001830 -22 should be taken to ensure that the activity of the compound is not destroyed in the process and that the compound is able to reach its site of action without being destroyed. In some circumstances it may be necessary to protect the compound by means known in the art, such as, for example, micro encapsulation. Similarly the route of administration chosen 5 should be such that the compound reaches its site of action. The pharmaceutical compositions or formulations include those suitable for oral, rectal, nasal, topical (including buccal and sub-lingual), vaginal or parenteral (including intramuscular, sub-cutaneous and intravenous) administration or in a form suitable for 10 administration by inhalation or insufflation. It is envisaged that the compositions should be provided in a form suitable for oral or nasal administration or by inhalation or insufflation. The compounds of the invention, together with a conventional adjuvant, carrier, or diluent, 15 may thus be placed into the form of pharmaceutical compositions and unit dosages thereof, and in such form may be employed as solids, such as tablets or filled capsules, or liquids such as solutions, suspensions, emulsions, elixirs, or capsules filled with the same, all for oral use, in the form of suppositories for rectal administration; or in the form of sterile injectable solutions for parenteral (including subcutaneous) use. 20 Such pharmaceutical compositions and unit dosage forms thereof may comprise conventional ingredients in conventional proportions, with or without additional active compounds or principles, and such unit dosage forms may contain any suitable effective amount of the active ingredient commensurate with the intended daily dosage range to be 25 employed. Formulations containing ten (10) milligrams of active ingredient or, more broadly, 0.1 to one hundred (100) milligrams, per tablet, are accordingly suitable representative unit dosage forms. The compounds of the present invention can be administrated in a wide variety of oral and 30 parenteral dosage forms. It will be obvious to those skilled in the art that the following dosage forms may comprise, as the active component, either a compound of the invention or a pharmaceutically acceptable salt of a compound of the invention. For preparing pharmaceutical compositions from the compounds of the present invention, 35 pharmaceutically acceptable carriers can be either solid or liquid. Solid form preparations include powders, tablets, pills, capsules, cachets, suppositories, and dispensable granules. A solid carrier can be one or more substances which may also act as diluents, flavouring agents, solubilisers, lubricants, suspending agents, binders, preservatives, tablet disintegrating agents, or an encapsulating material. 40 WO 2005/061513 PCT/AU2004/001830 - 23 In powders, the carrier is a finely divided solid that is in a mixture with the finely divided active component. In tablets, the active component is mixed with the carrier having the necessary binding 5 capacity in suitable proportions and compacted in the shape and size desired. The powders and tablets preferably contain from five or ten to about seventy percent of the active compound. Suitable carriers are magnesium carbonate, magnesium stearate, talc, sugar, lactose, pectin, dextrin, starch, gelatin, tragacanth, methylcellulose, sodium 10 carboxymethylcellulose, a low melting wax, cocoa butter, and the like. The term "preparation" is intended to include the formulation of the active compound with encapsulating material as carrier providing a capsule in which the active component, with or without carriers, is surrounded by a carrier, which is thus in association with it. Similarly, cachets and lozenges are included. Tablets, powders, capsules, pills, cachets, 15 and lozenges can be used as solid forms suitable for oral administration. For preparing suppositories, a low melting wax, such as admixture of fatty acid glycerides or cocoa butter, is first melted and the active component is dispersed homogeneously therein, as by stirring. The molten homogenous mixture is then poured into convenient 20 sized moulds, allowed to cool, and thereby to solidify. Formulations suitable for vaginal administration may be presented as pessaries, tampons, creams, gels, pastes, foams or sprays containing in addition to the active ingredient such carriers as are known in the art to be appropriate. 25 Liquid form preparations include solutions, suspensions, and emulsions, for example, water or water-propylene glycol solutions. For example, parenteral injection liquid preparations can be formulated as solutions in aqueous polyethylene glycol solution. 30 Sterile liquid form compositions include sterile solutions, suspensions, emulsions, syrups and elixirs. The active ingredient can be dissolved or suspended in a pharmaceutically acceptable carrier, such as sterile water, sterile organic solvent or a mixture of both. The compositions according to the present invention may thus be formulated for parenteral 35 administration (e.g. by injection, for example bolus injection or continuous infusion) and may be presented in unit dose form in ampoules, pre-filled syringes, small volume infusion or in multi-dose containers with an added preservative. The compositions may take such forms as suspensions, solutions, or emulsions in oily or aqueous vehicles, and may contain formulation agents such as suspending, stabilising and/or dispersing agents. 40 Alternatively, the active ingredient may be in powder form, obtained by aseptic isolation WO 2005/061513 PCT/AU2004/001830 - 24 of sterile solid or by lyophilisation from solution, for constitution with a suitable vehicle, eg. sterile, pyrogen-free water, before use. Pharmaceutical forms suitable for injectable use include sterile injectable solutions or 5 dispersions, and sterile powders for the extemporaneous preparation of sterile injectable solutions. They should be stable under the conditions of manufacture and storage and may be preserved against oxidation and the contaminating action of microorganisms such as bacteria or fungi. 10 Those skilled in the art may readily determine appropriate formulations for the compounds of the present invention using conventional approaches. Identification of preferred pH ranges and suitable excipients, for example antioxidants, is routine in the art (see for example Cleland et al, 1993). Buffer systems are routinely used to provide pH values of a desired range and include carboxylic acid buffers for example acetate, citrate, lactate and 15 succinate. A variety of antioxidants are available for such formulations including phenolic compounds such as BHT or vitamin E, reducing agents such as methionine or sulphite, and metal chelators such as EDTA. The solvent or dispersion medium for the injectable solution or dispersion may contain 20 any of the conventional solvent or carrier systems for the compounds, and may contain, for example, water, ethanol, polyol (for example, glycerol, propylene glycol and liquid polyethylene glycol, and the like), suitable mixtures thereof, and vegetable oils. The proper fluidity can be maintained, for example, by the use of a coating such as lecithin, by the maintenance of the required particle size in the case of dispersion and by the use of 25 surfactants. The prevention of the action of microorganisms can be brought about where necessary by the inclusion of various antibacterial and antifungal agents, for example, parabens, chlorobutanol, phenol, sorbic acid, thimerosal and the like. In many cases, it will be preferable to include agents to adjust osmolality, for example, sugars or sodium chloride. Preferably, the formulation for injection will be isotonic with blood. Prolonged 30 absorption of the injectable compositions can be brought about by the use in the compositions of agents delaying absorption, for example, aluminium monostearate and gelatin. Pharmaceutical forms suitable for injectable use may be delivered by any appropriate route including intravenous, intramuscular, intracerebral, intrathecal, epidural injection or infusion. 35 Sterile injectable solutions are prepared by incorporating the active compounds in the required amount in the appropriate solvent with various other ingredients such as these enumerated above, as required, followed by filtered sterilization. Generally, dispersions are prepared by incorporating the various sterilised active ingredient into a sterile vehicle 40 which contains the basic dispersion medium and the required other ingredients from those WO 2005/061513 PCT/AU2004/001830 -25 enumerated above. In the case of sterile powders for the preparation of sterile injectable solutions, preferred methods of preparation are vacuum drying or freeze-drying of a previously sterile-filtered solution of the active ingredient plus any additional desired ingredients. 5 When the active ingredients are suitably protected they may be orally administered, for example, with an inert diluent or with an assimilable edible carrier, or it may be enclosed in hard or soft shell gelatin capsule, or it may be compressed into tablets, or it may be incorporated directly with the food of the diet. For oral therapeutic administration, the 10 active compound may be incorporated with excipients and used in the form of ingestible tablets, buccal tablets, troches, capsules, elixirs, suspensions, syrups, wafers, and the like. Such compositions and preparations preferably contain at least 1% by weight of active compound. The percentage of the compositions and preparations may, of course, be varied and may conveniently be between about 5 to about 80% of the weight of the unit. 15 The amount of active compound in therapeutically useful compositions should be sufficient that a suitable dosage will be obtained. The tablets, troches, pills, capsules and the like may also contain the components as listed hereafter: a binder such as gum, acacia, corn starch or gelatin; excipients such as 20 dicalcium phosphate; a disintegrating agent such as corn starch, potato starch, alginic acid and the like; a lubricant such as magnesium stearate; and a sweetening agent such a sucrose, lactose or saccharin may be added or a flavouring agent such as peppermint, oil of wintergreen, or cherry flavouring. When the dosage unit form is a capsule, it may contain, in addition to materials of the above type, a liquid carrier. 25 Various other materials may be present as coatings or to otherwise modify the physical form of the dosage unit. For instance, tablets, pills, or capsules may be coated with shellac, sugar or both. A syrup or elixir may contain the active compound, sucrose as a sweetening agent, methyl and propylparabens as preservatives, a dye and flavouring such 30 as cherry or orange flavour. Of course, any material used in preparing any dosage unit form should be pharmaceutically pure and substantially non-toxic in the amounts employed. In addition, the active compound(s) may be incorporated into sustained-release preparations and formulations, including those that allow specific delivery of the active peptide to specific regions of the gut. 35 Aqueous solutions suitable for oral use can be prepared by dissolving the active component in water and adding suitable colorants, flavours, stabilising and thickening agents, as desired.

WO 2005/061513 PCT/AU2004/001830 -26 Aqueous suspensions suitable for oral use can be made by dispersing the finely divided active component in water with viscous material, such as natural or synthetic gums, resins, methylcellulose, sodium carboxymethylcellulose, or other well known suspending agents. 5 Pharmaceutically acceptable carriers and/or diluents include any and all solvents, dispersion media, coatings, antibacterial and antifungal agents, isotonic and absorption delaying agents and the like. The use of such media and agents for pharmaceutical active substances is well known in the art. Except in so far as any conventional media or agent is incompatible with the active ingredient, use thereof in the therapeutic compositions is 10 contemplated. Supplementary active ingredients can also be incorporated into the compositions. Also included are solid form preparations that are intended to be converted, shortly before use, to liquid form preparations for oral administration. Such liquid forms include 15 solutions, suspensions, and emulsions. These preparations may contain, in addition to the active component, colorants, flavours, stabilisers, buffers, artificial and natural sweeteners, dispersants, thickeners, solubilising agents, and the like. For topical administration to the epidermis the compounds according to the invention may 20 be formulated as ointments, creams or lotions, or as a transdermal patch. Ointments and creams may, for example, be formulated with an aqueous or oily base with the addition of suitable thickening and/or gelling agents. Lotions may be formulated with an aqueous or oily base and will in general also contain one or more emulsifying agents, stabilising agents, dispersing agents, suspending agents, thickening agents, or colouring agents. 25 Formulations suitable for topical administration in the mouth include lozenges comprising active agent in a flavoured base, usually sucrose and acacia or tragacanth; pastilles comprising the active ingredient in an inert base such as gelatin and glycerin or sucrose and acacia; and mouthwashes comprising the active ingredient in a suitable liquid carrier. 30 Solutions or suspensions are applied directly to the nasal cavity by conventional means, for example with a dropper, pipette or spray. The formulations may be provided in single or multidose form. In the latter case of a dropper or pipette, this may be achieved by the patient administering an appropriate, predetermined volume of the solution or suspension. 35 In the case of a spray, this may be achieved for example by means of a metering atomising spray pump. To improve nasal delivery and retention the compounds according to the invention may be encapsulated with cyclodextrins, or formulated with other agents expected to enhance delivery and retention in the nasal mucosa.

WO 2005/061513 PCT/AU2004/001830 - 27 Administration to the respiratory tract may also be achieved by means of an aerosol formulation in which the active ingredient is provided in a pressurised pack with a suitable propellant such as a chlorofluorocarbon (CFC) for example dichlorodifluoromethane, trichlorofluoromethane, or dichlorotetrafluoroethane, carbon dioxide, or other suitable gas. 5 The aerosol may conveniently also contain a surfactant such as lecithin. The dose of drug may be controlled by provision of a metered valve. Alternatively the active ingredients may be provided in the form of a dry powder, for example a powder mix of the compound in a suitable powder base such as lactose, starch, 10 starch derivatives such as hydroxypropylmethyl cellulose and polyvinylpyrrolidone (PVP). Conveniently the powder carrier will form a gel in the nasal cavity. The powder composition may be presented in unit dose form for example in capsules or cartridges of, e.g., gelatin, or blister packs from which the powder may be administered by means of an inhaler. 15 In formulations intended for administration to the respiratory tract, including intranasal formulations, the compound will generally have a small particle size for example of the order of 5 to 10 microns or less. Such a particle size may be obtained by means known in the art, for example by micronisation. 20 When desired, formulations adapted to give sustained release of the active ingredient may be employed. The pharmaceutical preparations are preferably in unit dosage forms. In such form, the 25 preparation is subdivided into unit doses containing appropriate quantities of the active component. The unit dosage form can be a packaged preparation, the package containing discrete quantities of preparation, such as packeted tablets, capsules, and powders in vials or ampoules. Also, the unit dosage form can be a capsule, tablet, cachet, or lozenge itself, or it can be the appropriate number of any of these in packaged form. 30 It is especially advantageous to formulate parenteral compositions in dosage unit form for ease of administration and uniformity of dosage. Dosage unit form as used herein refers to physically discrete units suited as unitary dosages for the subjects to be treated; each unit containing a predetermined quantity of active material calculated to produce the desired 35 therapeutic effect in association with the required pharmaceutical carrier. The specification for the novel dosage unit forms of the invention are dictated by and directly dependent on (a) the unique characteristics of the active material and the particular therapeutic effect to be achieved, and (b) the limitations inherent in the art of compounding such an active material for the treatment of disease in living subjects having 40 a diseased condition in which bodily health is impaired as herein disclosed in detail.

WO 2005/061513 PCT/AU2004/001830 -28 The invention also includes the compounds in the absence of carrier where the compounds are in unit dosage form. 5 The amount of compound of formula I administered may be in the range from about 10 mg to 2000 mg per day, depending on the activity of the compound and the disease to be treated. Liquids or powders for intranasal administration, tablets or capsules for oral 10 administration and liquids for intravenous administration are the preferred compositions. Experimental Data 'H NMR spectra were recorded on either a Bruker Avance DRX 400, AC 200 or AM 300 spectrometer. Spectra were recorded in CDCl 3 , d 6 -acetone, CD 3 0D or d 6 -DMSO using 15 the residual solvent peak as a reference. Chemical shifts are reported on the 8 scale in parts per million (ppm) using the following conventions to assign the multiplicity: s (singlet), d (doublet), t (triplet), q (quartet) m (multiplet) and prefixed b (broad). Mass spectra (ESI) were recorded on either a Micromass Platform QMS or Finnigan LCQ Advantage spectrometer. Flash chromatography was performed on 40-63 [m silica gel 60 20 (Merck No. 9385). Analytical HPLC was carried out using a Waters 600 Pump, Waters 717 Autosampler and a Waters 490E UV detector. Preparative HPLC was carried out using a Gilson 322 pump with a Gilson 215 liquid handler and a HP 1100 PDA detector. Both HPLC systems employed Phenomonex C8(2) columns using either acetonitrile or acetonitrile containing 0.06% TFA in water or water containing 0.1% TFA. 25 Method A One equivalent of an appropriate keto-acid of formula II, is reacted with approximately 3 equivalents of an appropriate diamine of the general formula H 2

N-B-C-NH

2 . The mixture 30 is heated under reflux in an inert solvent, such as toluene or xylene, with a Dean-Stark apparatus for 3-10 h. A catalyst, such as an acid tosylate, can be used. After this time the reaction is allowed to cool and the product filtered and recrystallised from an appropriate solvent. If no precipitate forms the solvent is evaporated in-vacuo and the residue recrystallised or purified using flash chromatography or preparative HPLC. 35 Compound 1 Compound 1 was prepared using Method A employing 2-(4-chlorobenzoyl)benzoic acid CI H

N

WO 2005/061513 PCT/AU2004/001830 - 29 and ethylene diamine. 'H NMR (300MHz, CDCl 3 ) 8 2.05 (bs, 1H), 3.11-3.26 (m, 2H), 3.61-3.68 (m, 1H), 3.76 3.84 (m, 1H), 7.22-7.26 (m, 1H), 7.30 (d, J 8.9 Hz, 2H), 7.42-7.48 (m, 2H), 7.62 (d, J 8.8 5 Hz, 2H), 7.74-7.80 (m, 1H). MS m/z 285 ([M+H+] Compound 2 C1 H ~-N N 0 10 Compound 2 was prepared using Method A from 2-(4-chlorobenzoyl)benzoic acid and 1,3-diaminopropane. 'H NMR (300MHz, CDCL 3 ) 5 1.48-1.62 (m, 2H), 2.83-2.96 (m, 1H), 2.97-3.13 (m, 2H), 4.47-4.60 (m, 1H), 7.22-7.29 (m, 1H), 7.31-7.37 (m, 2H), 7.38-7.47 (m, 2H), 7.48-7.56 15 (m, 2H), 7.82-7.89 (m, 1H). MS m/z ([M+H*] 299 Compound 7 C1 -N N 0 20 Compound 7 was prepared using Method A from 2-(4-chlorobenzoyl)benzoic acid and 1,4-diaminobutane. 'H NMR (300MHz, CDC1 3 ) 6 1.13-1.32 (m, 2H), 1.33-1.57 (m, 2H), 2.15-2.44 (m, 2H), 2.73-2.90 (m, 1H), 3.32-3.49 (m, 1H), 7.10-7.20 (m, 1H), 7.21-7.34 (m, 4H), 7.35-7.49 25 (m, 2H), 7.60-7.71 (m, 1H). MS m/z ([M+H*] 313 WO 2005/061513 PCT/AU2004/001830 -30 The methods for forming compounds of formula III are based on those described in US 4,058,529, Sulkowski, T.S., et. al, J. Org. Chem. 1967, 32, 2180-2184 and Houlihan, W.J., et. al, J. Med. Chem. 1975, 18, 182-185. 5 Method B Two equivalents of diisopropylethylamine or triethylamine are added to one equivalent of compound of formula III in THF at 0 0 C. An acid chloride, or other acylating agent, is added to the mixture and the reaction monitored by HPLC. When the reaction is complete 10 the reaction is quenched with water and the product extracted into EtOAc. The EtOAc is subsequently washed with a 1:1 solution of sat. NH 4 Cl (aq):water, 1:1 sat. Na2CO3(aq):water and sat. Na 2

CO

3 (aq). The EtOAc was dried (Na 2

SO

4 ), the solvent evaporated in vacuo and the residue either crystallised or purified by flash chromatography using EtOAc/hexanes or by preparative HPLC. 15 Method C One equivalent of the appropriate compound of formula III is reacted with one equivalent of the appropriate acid chloride in xylene at 120'C for 1-24h. The reaction is then allowed 20 to cool and the product filtered and recrystallised from an appropriate solvent. If no precipitate is formed the reaction is purified using flash chromatography or preparative HPLC. Method D 25 N-alkylated diamines may be prepared according to the procedure outlined in Kruse L.I., et. al, J. Med. Chem. 1990, 33, 781-789. Appropriate keto-acid (2 equivalents) and N-substituted diamine(1 equivalent) in 30 chlorobenzene, toluene or xylene are placed in a flask equipped with a stirrer and Dean Stark water separator. The mixture is refluxed until no further water is seen to separate (1 8h) after which time the solvent is then distilled off and the residue cooled. The residue is purified using flash chromatography or preparative HPLC. 35 Method E One equivalent of the appropriate compound of formula III is reacted with one equivalent of the appropriate isocyanate or isothiocyanate in THF or xylene at a temperature ranging from 20-120*C for 1-24h. The reaction is then allowed to cool and the product filtered, WO 2005/061513 PCT/AU2004/001830 -31 washed and recrystallised from an appropriate solvent. If no precipitate was formed the reaction was purified using flash chromatography or preparative HPLC. Compound 12 ci F N IN 5 0 Compound 12 was prepared using Method C using Compound 1 and 4-fluorobenzoyl chloride. 10 'H NMR (300MHz, CDC1 3 ) 8 3.22-3.34 (in, 1H), 3.73-3.82 (in, 1H), 3.91-4.03 (in, 1H), 4.28-4.36 (in, 1H), 7.05-7.13 (in, 2H), 7.17 (d, J 7.8 Hz, 2H), 7.33 (d, J 7.8 Hz, 2H), 7.43 7.52 (in, 2H), 7.54-7.65 (in, 2H), 7.84-7.90 (in, 1H), 8.00-8.06 (in, 1H). MS m/z 407 ([M+H*] 15 Compound 13 ci |N 0 Compound 13 was prepared using Method C using Compound 1 and benzoyl chloride. 'H NMR (300MHz, CDCl 3 ) 8 3.21-3.31 (in, 1H), 3.72-3.79 (in, 1H), 3.91-4.00 (in, 1H), 20 4.26-4.33 (in, 1H), 7.20 (d, J 8.8 Hz, 2H), 7.34 (d, J 8.8 Hz, 2H), 7.38-7.48 (in, 5H), 7.56 7.61 (in, 2H), 7.85-7.88 (in, 1H), 8.04-8.07 (in, 1H). MS m/z 389 ([M+H*] Compound 23 Ci N N 250 WO 2005/061513 PCT/AU2004/001830 -32 Compound 23 was prepared using Method D from 2-(4-chlorobenzoyl)benzoic acid and N-benzyl ethylenediamine. 5 'H NMR (300MHz, CDC1 3 ) 5 2.97 (d, JA 13Hz, 1H), 3.07-3.32 (m, 3H), 3.42 (d, JA 13Hz, 1H), 3.83-3.96 (m, 1H), 7.04-7.09 (m, 1H), 7.17-7.38 (m, 8H), 7.39-7.46 (m, 1H), 7.66-7.73 (m, 2H), 7.81-7.86 (m, 1H). MS m/z ([M+H*] 375 10 Compound 24 N ND 0 Compound 24 was prepared using Method D from 2-benzoylbenzoic acid and N-benzyl ethylenediamine. 15 'H NMR (300MHz, CDC1 3 ) 8 2.99 (d, JA 13Hz, 1H), 3.10-3.29 (m, 3H), 3.44 (d, JA 13Hz, 1H), 3.84-3.99 (m,1H), 7.07-7.13 (m, 1H), 7.18-7.44 (m, 10H), 7.73-7.81 (m, 2H), 7.82-7.87 (m, 1H). MS m/z ([M+H+] 341 20 Compound 25 N ND 0 Compound 25 was prepared using Method D from 2-(4-toluoyl)benzoic acid and N-benzyl 25 ethylenediamine. 'H NMR (300MHz, CDC1 3 ) 8 2.36 (s, 3H), 3.00 (d, Ja 13Hz, 1H), 3.11-3.29 (m, 3H), 3.45 (d, JA 13Hz, 1H), 3.86-3.98 (m, 1H), 7.08-7.14 (m, 1H), 7.15-7.21 (m, 2H), 7.22 7.44 (m, 7H), 7.63-7.69 (m, 2H), 7.81-7.86 (m, 1H). 30 MS m/z ([M+H*] 355 WO 2005/061513 PCT/AU2004/001830 - 33 Compound 106 Compound 106 was prepared using Method A employing 3-bromo-(4 5 chlorobenzoyl)benzoic acid and ethylene diamine. 1H NMR (300 MHz, CDCl3): 8 3.12-3.25 (in, 2H), 3.64-3.71 (in, 1H), 3.76-3.83 (in, 1H), 7.13, (dd, J 8.1, 0.6 Hz, 1H), 7.33 (d, J 8.7 Hz, 2H), 7.57-7.61 (in, 3H), 7.91 (dd, J 1.8, 0.6 Hz, 1H). 10 MS m/z ([M+H]+) 365 Compound 107 Compound 107 was prepared using Method A employing 4-bromo-(4 15 chlorobenzoyl)benzoic acid and ethylene diamine. 1H NMR (300 MHz, CDCl3): 5 3.11-3.24 (in, 2H), 3.69-3.63 (in, 1H), 3.76-3.82 (in, 1H), 7.34, (d, J 8.7 Hz, 1H), 7.39 (dd, J 1.5, 0.6 Hz, 1H), 7.59-7.66 (in, 4H). MS m/z ([M+H]+) 365 20 Method F Two equivalents of boronic acid or ester, five equivalents of Na 2

CO

3 and palladium on charcoal (catalytic) or 0.1 equivalents of [PdCl 2 (dppf)] (dichloro [ ,1'-bis 25 (diphenylphosphino) ferrocene]palladium (II) dichloromethane adduct) are added to the appropriate bromo-substituted compound of formula III in DME/H20 (93:7). The reaction is heated to 50'C for 1-4h. The reaction is then cooled, filtered and evaporated in vacuo to give a solid or oily residue. The residue is then either recrystallised or purified by flash chromatography using EtOAc/hexanes or by preparative HPLC. 30 Method G Three equivalents of boronic acid or ester, six equivalents of K 2 C0 3 and 0.3 equivalents of tetrakis(tripheynylphosphine)palladium are added to the appropriate bromo-substituted 35 compound of formula III in toluene. The reaction is heated to 100 C for 1-24h. The reaction is then quenched with CH 2 C1 2 and washed with water. The CH 2 C1 2 layer was dried (Na 2

SO

4 ) and evaporated in vacuo to give a solid or oily residue. The residue is then either recrystallised or purified by flash chromatography using EtOAc/hexanes or by preparative HPLC. 40 WO 2005/061513 PCT/AU2004/001830 - 34 Method H The acid chloride or anhydride or isocyanate or isothiocyanate (2.2eq) is added directly for liquids or as a solution in pyridine (-M) for solids to a solution of the appropriate 5 compound of formula III (0.1mmol) in pyridine (500pL) at -5*C. The reaction is stirred and allowed to warm to room temperature for between 2-24h after which time the starting material has been consumed. The reaction is subsequently diluted with water and extracted with CH 2 C1 2 (3x). The combined CH 2 Cl 2 extracts are washed with 1N NaOH (3x) and 10% HCI (3x). In the case of basic products the acid wash is omitted and in the 10 case of acidic products the basic wash is omitted. For neutral or basic products the crude purity is improved markedly by stirring the combined CH 2 Cl 2 extract in the presence of a carbonate resin (MP-Carbonate -3eq) for 0.5-12h. The CH 2 Cl 2 extracts are dried (MgSO 4 ) and the solvent evaporated in-vacuo. The crude products are subsequently purified by flash chromatography using a EtOAc/Hexane solvent system. 15 Compound 120 Compound 120 was prepared using Method F employing compound 107 and 4-tolylboronic acid. 20 1H NMR (300 MHz, CDCl3): 5 3.19-3.26 (m, 2H), 3.65-3.72 (m, 1H), 3.86-3.89 (in, 1H), 7.23, (d, J 8.1 Hz, 2H), 7.34 (d, J 8.7 Hz, 2H), 7.39-7.45 (in, 3H), 7.65-7.71 (in, 3H), 7.82 (dd, J 8.1, 0.6 Hz, 4H). MS m/z ([M+H]+) 375 25 Compound 132 Compound 132 was prepared using Method G employing compound 107 and n butylboronic acid. 30 1H NMR (300 MHz, CDCl3): 5 0.89 (t, J 7.5 Hz, 3H), 1.23-1.37 (in, 3H), 1.48-1.56 (m, 2H), 2.59 (t, J 7.8 Hz, 2H), 3.12-3.26 (in, 2H), 3.62-3.69 (in, 1H), 3.83-3.78 (m, 1H), 7.26 7.35 (m, 3H), 7.62-7.69 (in, 3H). MS m/z ([M+H]+) 341 35 Method I A mixture of an appropriate carboxylic acid (3eq) and TFFH (3.3eq) was suspended in anhydrous DMF (0.25M) and DIEA (3.3eq) under nitrogen. The mixture was heated at 40 45*C for 30min. This solution was added to the appropriate compound of Formula III WO 2005/061513 PCT/AU2004/001830 -35 (leq) under nitrogen and heated at 45*C for 14 days. The reaction mixture was transferred to a 1OmL tube and diluted with CH 2 C1 2 (2mL). The organic phase was washed with 10% citric acid (2mL), sat. NaHC0 3 (aq) (2mL) and evaporated to dryness. The residue was purified by flash chromatography over silica, using 0.4% methanol/CH 2 Cl 2 as eluent, to 5 isolate the desired product. Method J This method is an adaptation of the method described by Copdret, C. et al., J.Org. Chem., 10 1998, 63, 1740-1741. 30% Hydrogen peroxide (1Oeq) was added to a solution of either an appropriate compound of Formula I or Formula III (leq) and trioxorhenium 2.5mol% in

CH

2 Cl 2 (4x volume of hydrogen peroxide solution) at rt. The mixture was stirred overnight after which time the mixture was diluted with water and stirred for a further 30mins. After this time the CH 2 Cl 2 was separated and the aqueous layer extracted further 15 with CH 2 Cl 2 (2x). The combined extracts were dried and the solvent evaporated in-vacuo to yield the desired product which was purified by crystallisation or chromatography as required. 20 Method K An appropriate substrate of Formula I, wherein R 2 = 6-fluoronicotinoyl or 6 chloronicotinoyl, was produced using Method H. To this substrate was added an excess of an appropriate amine. In a suitable solvent, such as THF or ethanol, the mixture was 25 heated in a sealed vessel to approximately 150*C for 1-5 h (or 60'C for 72h in the case where the nucleophile was hydrazine). After this time the solvent was evaporated and the residue purified using flash chromatography or preparative HPLC. Method L 30 A suitable phenolic compound of formula III was acylated according to Method H. Ester hydrolysis was then effected by dissolving the product in a minimal volume of methanol and treating with an excess of 1M NaOH (aq) at ambient temperature. The reaction mixture was then acidified, extracted with dichloromethane and purified by flash 35 chromatography to yield a phenolic compound of formula I. If desired, conversion of this phenol to a phenyl ether was then performed using standard techniques known in the industry such as those described in Vogel's Textbook of Practical Organic Chemistry by B. S. Furniss et al., Harlow, Longman Scientific & Technical, 1989 WO 2005/061513 PCT/AU2004/001830 -36 or Mitsunobu, 0. Synthesis 1981, 1. The crude products were subsequently purified using flash chromatography or preparative HPLC. Compound 239 0 N F 5 0 Compound 239 was prepared from 9b-(4-hydroxyphenyl)-1,2,3,9b-tetrahydroimidazo[2,1 a]isoindol-5-one using Method L. The tetrahydroimidazoisoindolone was bis-acylated with 4-fluorobenzoyl chloride according to Method H and the resulting phenolic ester 10 function was converted to a phenol by basic hydrolysis. The product was then treated with chloroacetonitrile and K 2 C0 3 in acetone and heated to reflux for 30h to yield phenyl ether compound 239. 1 H NMR (300 MHz, d6-acetone) 8 3.28-3.38 (in, 1H), 3.91-3.97 (in, 1H), 4.09-4.27 (in, 15 2H), 5.12 (s, 2H), 7.08 (d, J 9.0 Hz, 2H), 7.17-7.26 (in, 2H), 7.30 (d, J 9.0 Hz, 2H), 7.61 7.71 (in, 4H), 7.79-7.82 (in, 1H), 8.05-8.08 (in, 1H). Method M 20 This method involves nucleophilic displacement of R 2 when it represents 2-haloethanoyl. A solution or suspension of an appropriate compound of Formula I (R2=COCH2Br) (leq) and an appropriate amine (3eq) were allow to stand at room temperature for 3 days. The mixture was allowed to evaporate to dryness, the residue lyophilised from 30% acetonitrile/water and the resultant crude product purified by preparative HPLC. 25 Method N This method was used to prepare compound 153. 0 N NN H

CI

WO 2005/061513 PCT/AU2004/001830 -37 Aluminium chloride (2.88mol) was added to a stirred suspension of 3,4-pyridine anhydride (1.31mol) in chlorobenzene (1.21) at RT to give an orange suspension and heated to 1 10 C for 5h. The mixture was cooled and carefully hydrolysed with water (21), 5 heated to reflux for lh, filtered when hot and dried to give a brown solid. The solid was suspended in water (3.51) and basified with 10% NaOH solution (350ml). The resulting solution was filtered, acidified to pH = 3.1 with 2N HCl. The precipitate formed was filtered and refluxed with ethanol (21) to give a white solid (67g). This material was dissolved in 10% NaOH (400ml), acidified to pH 6.3 with 2N HCI and filtered to yield 3 10 (4-Chloro-benzoyl)-isonicotinic acid (53g) as a white solid. 'H-NMR (400MHz, DMSO-d 6 ) 5 7.59 (d, J 8.6 Hz, 2H), 7.68 (d, J 8.6 Hz, 2H), 7.88 (dd, J 0.7, 5.0 Hz, 1H), 8.74 (d, J 0.7 Hz, 1H), 8.93 (d, J 5.0 Hz, 1H), 13.9 (bs, 1H) ppm. 15 3-(4-Chloro-benzoyl)-isonicotinic acid (53g) and ethylene diamine (67.7ml) in xylenes (1.81) were refluxed for 4h. The solution was filtered when hot and the filtrate evaporated under reduced pressure to give a yellow solid (58g). This material was recrystallised from ethanol to give Compound 153 as a white solid (46.4g). 20 'H-NMR (400MHz, CDCl 3 ) 5 2.12 (bs, 1H, NH), 3.19 (in, 1H), 3.21 (in, 1H), 3.71 (in, 1H), 3.83 (in, 1H), 7.36 (d, J 8.8 Hz, 2H), 7.63 (d, J 8.8 Hz, 2H), 7.66 (dd, J 1.1, 4.9Hz, 1H), 8.64 (d, J 1.1 Hz, 1H), 8.79 (d, J 4.9 Hz, 1H) ppm. MS m/z ([M+H]*) 286 The above described methods were used to make the compounds described in tables 1 to 3 25 below. All compounds depicted in the tables were obtained. The tables set out a compound reference number, structure, observed mass (not calculated) and the method used to make the compound (based on correspondingly varied starting materials). The observed mass for the two compounds marked with * has not been included.

WO 2005/061513 PCT/AU2004/001830 - 38 Table 1: Compounds of Formula III (Intermediates). No Structure MIZ Mtd No Structure dv Mtd C1 0 \H N N N 285 A 6 N 279 A NH \/H 0 0 0 N N 2 N 299 A 7 N 313 A \/H Cl CI 0 0 3 'D 265 A 8 N 252 A H N \ N H 0 N N 4 N 251A 9 N 286 A N H N CI oH 0 5 \/H 265 A 5\2C N \/ H N" CI 0 WO 2005/061513 PCT/AU2004/001830 -39 No Structure nvr Mtd No Structure wz Mtd 0 0 Br 11 N252 A 106 N 365 A H H N ci 0 0 96 N 331 A N N 107 Br - N 365 A BH H Ci 0 N 0 7 N 331 A N Br N -- \5--110 N ~ 279 A H 100 N 257 A H1N 296A o0 N~ 0 / \ N / N 0 102 N 281 A 0 -o 112 D 266 A H N NH 2 _ -N 103 H 341 F

\L

WO 2005/061513 PCT/AU2004/001830 -40 No Structure Mfg Mtd No Structure mfr Mtd 0 0 NN N 115 N 308 H 126 _ N 336 H H O 0 N 0 0 NN H 127 N OH 380 H 116 \ 388 H 0 N H N

CH

0 F N 0N. 128 1 N 0 366 H N H OH 120 'NND 375 F 7H N

H

0 CI F N 130 - ~414B F N H 121 F ND 429 F -~H N- /

H

0 CIl 0 0 NN N131 HN 350 H 122 N> 364 H H _ N

H

0 N OH _ _ _ _ _ _ _ _ _ _ _ _ H 0 WO 2005/061513 PCT/AU2004/001830 -41 No Structure MI Mtd No Structure I Mtd 0 0 N N 132 341 G N 142 N 307 A H\ / CI N F / HN" 133 J 362 F 150 N 269 A CI Cl NH OH H 151 N 267 A 134 N 285 A N 0 0 OHN 152 N-.) 339 A \ /H - H 136 N 267 A N Cl O 0

NH

2 0 153 N N 286 N NN 140 N 300 A / H Cl N N 154 'N 287 A .. N H Cl WO 2005/061513 PCT/AU2004/001830 -42 No Structure w Mtd No Structure w Mtd 0 0 N N I~ N 155 N2 A 160 ND 293 A H H 0 N O 156 N 279 A N H 161 N 329 A Br 157 O O * A 'N N 162 N I N 286 A HO HN N / H CI 0, +,O 0N 0 0 158 N 330 A N D N 163 N 319 A H H CI F F F 1 N 159 N 293 A N N NII N H 164 N 320 A H F F F WO 2005/061513 PCT/AU2004/001830 -43 No Structure wzH Mtd No Structure wz Mtd Cl 0 N 165 N 287 A 170 ND-- N 280 A N N H N N N 0 0 0 N N I NN 166 282 A 171 321 A \ H H 0 0 - 0 | N~ N 167 D 332 A 176 437 A Cl Br N N 0 1 ""177 437 A 168 . N 332 A N N_5\2- N ",/ H H CI Br 0 N 169 N N 286 A H Cl WO 2005/061513 PCT/AU2004/001830 -44 Table 2: Compounds of the Invention (Formula I where A is Aryl) No. Structure M/. Mtd No. Structure M'Z Mtd 0 CI N O 16 N 341 B 12 N0407 B N OC1 0 / \ CI CF C O 17 355 B IN 13 N 389 B NO 0 C1 -0 C1 18 N 397 B ONH N 14 \/404 E N O C 0 19 N 439 B NH |ND 15 N 418 E NC1 F 0 O F 20 N 381 B N 0 WO 2005/061513 PCT/AU2004/001830 -45 No. Structure M+. Mtd No. Structure M+HZ Mtd

-

' N 21 N 361 B 26 ND 389 D N cl 0 N> 22 ND 523 B 27 355 D 0 0 0 23 N 375 D N 0 0 N'N 00 0 'N 25 N D 355 D 30 N D 409 D WO 2005/061513 PCT/AU2004/001830 -46 No. Structure+ Mtd No. Structure M2. Mtd 0 0 O 31 389 D 36 N 355 D 0 0 NN 32 393 D I N N 37 N 369 D Cl 07 00 33 359 D N 38 N 407 D OFCI F N 0 N 34 373 D N - N39 373 D 0 7 F NN 35 N 389 D N 40 - ND 387 D cl F WO 2005/061513 PCT/AU2004/001830 - 47 No. Structure fl/Z Mtd No. Structure M/Z Mtd Ci BrN 0 IN 41 - N 469 C 46 N401 D N N 0 F 0 CI 42 N 515 C 47 N 6 N -a~N 0 CI B 0 0 43 - ND 423 D 4840N

N

W r48ND40N CI Cl 0 N Cl - Cl ND N9 N2D 423 C Cw F 0 0 N CI I N /0 N -5NDN 387 D 50 NN ~ 403 C F0 WO 2005/061513 PCT/AU2004/001830 -48 No. Structure rn/Z t No. Stucurn/Z t Structure M+H+ t \1 / 51 49 56 N 431 C N 0 0 o 'F 52 N 473 C 435C F 0 CI 53 -N 457 C 58 ND 439 D Cl I 0 CI 0 CI N oN ' N 0 0 - F \\0 55 /\ I481 C 60 -N> 373 C N NN ND 0 0 WO 2005/061513 PCT/AU2004/001830 - 49 No. Structure M/. Mtd No. Structure rn 0 - F N0N 61 F 387 C ND N 66 O 413 C o0 o 0N 0 N 62 486 D N Cl 0 N O 67 O 433 C 00C N /0 ~N 64 0 417 C 0 CI IN 68 417 C 0 0 NN N CI 65 0 397 C 69 \ 437 C Cl Cl WO 2005/061513 PCT/AU2004/001830 -50 No. Structure Mtd No Structure M/Z t M+H Mt No eM+H" t 0 0 NN N 70 428 C 0cI1 9 0 0N N N75 N 415 C 71 /448 C CI 0 C 'NN N > 0 76 425 C N 0/ N' 77 445 C 'NN N 0N 73 421 CN CI 79 -N ~ 374 C FN 01 'N WO 2005/061513 PCT/AU2004/001830 -51 No. Structure MZ Mtd No. Structure / Mtd 0 0 80 N 374 C 85 H 434 E N 85F434 E N C3 /0 \/- Fi 0N 0 /P N 0 81 384 EN 86 N414 E N 82 N 398 E 81H 38E ~Nl 15 00/-87 ND 436 E 00 C F 83 N D477 E N 87 N 416 E Br 0 84 D497 EN 'NN N89 N 432 E /1 Br ci 0ld1 WO 2005/061513 PCT/AU2004/001830 - 52 No. Structure M'" Mtd No. Structure M+ Mtd 00 N 91 365 D N 104 N 418 B 0 F Cl C F 0 00 N N 94 N 429 B N32 105 463 B Cl N H0 0 98 453 B0 BO F 108 Br N 487 C N Cl I N 9Br -ND 453 B 0 N) F109 0551 H 0 C F N F F 101 N379 B F \s 0 o la F114 ND327 H

CI

WO 2005/061513 PCT/AU2004/001830 - 53 No. Structure Ml . Mtd No. Structure MZ Mtd O Cl N - 0 N p 117 ND 321 B 135 N 341 H 00 N 0 118 N 307 B 137 P 379 H O I N 00 N O 124 ND 335 H OH 138 N 323 L 0N N 0 N 125 N0406 H N 0 ci IN F N0 129 NH 562 H 0 N /143 350 H NH _ _ _ _ _ _

-K

0

O

WO 2005/061513 PCT/AU2004/001830 - 54 No. Structure fl. Mtd No. Structure M/. Mtd M+H+MtdM+H+ t O 0 144 N 407 H 173 | N0 461 C F CI Cl 0 N CI O 145 N 429 H 50 B -174 - ( 501 B O F N' O-< WC N 0 N O 146 455CI OH N 0 \ 0/ 175 /N501 B N 0 N 0 147 N 548 H N N 178 N H 412 E 00 FON 00 N~ N 172 N: > 447 D N N 179 N 428 E WO 2005/061513 PCT/AU2004/001830 -55 No. Structure M Mtd No. Structure /Zi+ Mtd Strutur M+H~ t C1 00 NN Cl

O

0 N N N3 181 ND 434 E 186 463 H Cl S //-N CI Cl F 0 O N N 181 N ~ 414 E 186 4973H /N CI SI F CI Cl - O N N 183 N380 H 188 N D410 H ND F O -0 Cl 0 SN N 184 N 411 H 189 389 L N HO IF D N 0 00 WO 2005/061513 PCT/AU2004/001830 -56 No. Structure fM.H Mtd No. Structure M2. Mtd 0 O N N 190 N 427 H 195 429 H 00 0- -O o 0 N NHN 191 N401 HN \ \/ F 196 - N 492 H \/ 0 0 Cl N 192 N'335 H 00 O NH O o 197 N 426 H N N 193 ND 337 H Cl -O 0 0 N 0 198 ND NH2 384 H 194 N 403 H N F Cl 0 -0 WO 2005/061513 PCT/AU2004/001830 - 57 No. Structure M+/ Mtd No. Structure mIz. Mtd 0 0 0 199 349 H N N 204 N 441 H \ 0 0 N Cl 200 N 415 H 0 0 205 N N s 473 C N N 0 N 0 0'N 201 N 441 H -o N N 206 456 C 0 0 N CI O N 202 N 349 H 207 N 475 C 0 cl - 0 203 N 4208 N NN 421 C 203 415 H'N F N 0 0 WO 2005/061513 PCT/AU2004/001830 - 58 No. Structure M+H. Mtd No. Structure M.+ Mtd H N CI H N 214 N 369 1 209 411 1 N N N 0 0 - 0 0 215 N 423 I 210 N 510 1 C 00C NN S216 N 3951 0 ND 211 D447 I N CI 217 0Y 449 1 00 CI -O 212 N 433 1 N C 218 N 415 I Cl 213 N 47 1 0 N O 0 WO 2005/061513 PCT/AU2004/001830 - 59 No. Structure Ml/Z Mtd No. Structure m/. Mtd Cl CI 219 N 379 I 224 N S 395 N 0 0 Cl O -0 220 N 3671 0 N N 3 0 I N ci 0 CIC \\- 0 0 221 N 353 N N 226 N 357 1 I N N 0 - - 0 ci - 0 222 383 1 227 N431 1 o N N 00 CI 0- 0 223 N 1 N 433 1 IN228 IN .4701 0 NH 00 WO 2005/061513 PCT/AU2004/001830 - 60 No. Structure M+HZ Mtd No. Structure M+ Mtd CI O 0N 229 N 401 1 234 N 453 H Br F Cl o -N 0 230 N 390 H N N I 0 235 / 479 H 0 Br N 231 N 391 H 0 F 0IF N o 236 N 387 H N Br 232 \ / 417 H 0 00 F N F 237 ~..N511 H O F 233 325 H 0 O N F F 238 N 447 L 0 0 0- WO 2005/061513 PCT/AU2004/001830 -61 No. Structure M+. Mtd No. Structure M Mtd 0 CI N F0 239 F 428 L 244 N 442 1 0 N H 0 0 Cl 0 -0 N F 245 N 447 1 240 N 428 L | N 0 0 NCl NHC 21N 352 N O Cl0 Nr 48 cN40i cI N 0 248 N C 34 I 241 ND 3521 N 3 N0 0 - -0 - 247 4 09 1 242 N D 481 1 N" N~ 0 -0 -C1248 N 455 1 243 N N 397N1 N D N 0 ___0 WO 2005/061513 PCT/AU2004/001830 - 62 No. Structure f. Mtd No. Structure M/+ Mtd Cl 0 C0 0 \ / <cl 249 N 397 1 0 N 254 \ 4431 O N 0 250 N 367 I N cl o 255 \ 451 I Cl - OND 251 N 423 I 0 N F F OCI~ 0 0 F 0 C0 256 N F F 509 1 \ /- N -jI% 252 N 405 I 0 N 0 o | N F c0 257 N : 389 L Cl 0 0-60 0 c HOO 253 N 453 I I N" 0 N F N-258 N 447 L 0 O | , WO 2005/061513 PCT/AU2004/001830 - 63 No. Structure M+. Mtd No. Structure MZ Mtd 0 0 N N NN 259 -- F 461 L 263 F 498 L 0 0 0 N 0- 0 0 0 N N 260 F 456 L 264 N 479 L 0 0 w0 a N O Cl 0 0 N 261 N 465 L 265 451 L \6 ON 0 0o S CI 0 0 0 N N D 262 F 479 L 266 F 446 L 0 0 o NH 2 WO 2005/061513 PCT/AU2004/001830 - 64 M/z m/Z No. Structure M+H Mtd No. Structure M+H+ Mtd O Cl H I- N NO N ~I~ii272 N439 M 267 N

-

443 L 2 N N N H 0 0 Cl H N 273 N 453 M N Nhl N\ 47 N 268 F 445 L - 0 N ccl 274 N 447 M N N N 269 N 447 L C' H - O N o276 OH 275 447 M N -N cl H 0 N__ 0__________ _ -N Ol 270 N N 454 M C1 N O 0 276 NN 467 M ON O clH 271 N N 439 M N 0 WO 2005/061513 PCT/AU2004/001830 - 65 No. Structure M1H Mtd No. Structure M2. Mtd cl O H 277 N 450 M 0 N~ N~ ci N 282 - NH 490 M 0 ClH N 0 N 0 278 N N 455 M N0 CI H o -0 N 283 433 M Cl ~ HN 0iN ND 279 N 469 M 0 N N 0N 0 N 284 O 433 M \ - ND 280 N N 447 M I N O N cl O0 0 - I N

-

o/ cl 285 N 419 M 281 N 433 M N 0 0 WO 2005/061513 PCT/AU2004/001830 - 66 No. Structure M/. Mtd No. Structure M/+ Mtd M+H+M+H+ t CH /- N Cl ON \/ O~,N~\N - 0 N 286 N 409 M 291 N 419 M N N 0 0 CI H NO N HN M--/ 287 N 426 M 292 N 420 M N N O N' NH 288 N N 469 M 293 N 409 M N N o 0 Cl N -- 0 N -//C1 289 N 425 M 294 \ 469 M 290 cl N 419 M 295 cl N 469 M N N 0

O

WO 2005/061513 PCT/AU2004/001830 - 67 No. Structure '". Mtd No. Structure r"-i Mtd Cl O NCI N-H 296 NH 469 M 301 /N 492 M N N 0 N 0 CI N CI N O, -O S-/ 297 N475 M 302 N 425 M N N 0 0 C! -O CI -o \/N'N N 298 N 408 M 303 N 437 M N N o 0 CI N 0 -OS-O N 299 N 436 M _0 N46H N 304 .._. N75 H 0 FW F F F IC F FI WO 2005/061513 PCT/AU2004/001830 - 68 No. Structure M'.f Mtd No. Structure M+H Mtd 0 N 0 N 306 408 H N N N 311 431 L C\ F F CI 0O 00 CI N 0 -N 307 N 441 H CI F O312 N 424 H FW FF CC N O = Cl 308 N \ 417 L 313 N 425 H oN O0 0 0 N N 0D 1 314 392 H 309 F 459 L N315 O N 513 H 0 0 310 ___431 L O 0 F F 0 WO 2005/061513 PCT/AU2004/001830 - 69 No. Structure M+H. Mtd No. Structure M+H+ Mtd 0 0 N 320 N H2N 448 K 316 N 444 H N N 0 0i N O 321 HO 449 K 317 N 419 K N N cl \ CI cN N 0 322 N N 473 H N N 0N 318 0 445 K C I I O 0 N_ c N C 323 /s 480 H NH ND 0 0 0 319 | N 405 K | N 324 -3S 478 H \/ NH 2 N/ c 0 c WO 2005/061513 PCT/AU2004/001830 - 70 No. Structure M+H. Mtd No. Structure M+H Mtd 0 0 N N 325 407 H 330 424 H N- l N42 H CI CI o 0 N N 326 379 H 331 - 466 H \N CI wo 0 CI CI o 0 N IN 327 395 H - N N D N1 s 332 o 486 H Cl CI N O 328 429 H -N C- 333 N 461 H 0- N N N CI 329 - N> s 439 H 0 0 N C I ro 334 N N 396 H CIs

CI

WO 2005/061513 PCT/AU2004/001830 -71 No. Structure Mf.H* Mtd No. Structure fl.H Mtd 0 C1 N O 335N N 395 H N S O 503 489 J CI N N 0 Table 3: Compounds of the Invention (Formula I where A is Heteroaryl) No. Structure M+H. Mtd No. Structure M+H+ Mtd 0 o N N N N F 63 N 408 C 337 N 342 H N F 0 CI FI 0 0 F N N 78 N 408 C 338 N 388 H NN o 1I1 C1 F 0 0 0 N 0 NN 123 - N342 H 339- 322 H N N N N 336 N 408 C 340 N-. N 409 H CI o F \ 0 C IF WO 2005/061513 PCT/AU2004/001830 - 72 No. Structure M+H. Mtd No. Structure M+H. Mtd 0 0 N N | N N N ..N 341 435 H 346 434 H o, 0 CI Cl 1-10 0 0 N N N 342 N N 343 H 347 N 442 H cio F C I F F F -0 0 N 343 /\414 HN 3 N N 0 348 N 468 H F N- F F 0 0 344 N 408 H N N NN 10 F 349 468 H F F F N. 345 N N 342 H Cl0 WO 2005/061513 PCT/AU2004/001830 - 73 No. Structure M/. Mtd No. Structure M+ Mtd 0 N N -O F 350 N 376 H 355 N N 389 H O1 N F 0 F F 0 -0 N N 356 N 323 H 351 434 H N 0 Ci 0 Os N N Cl 357 404 H -F O F 0 F 352 N 424 J -O I N O 0 WC O | N Cl 358 N 452 H O F O -oo 353 N N 409 H Br F N 0 o N N 354 ND 343 H Br F N- rN N O 0 WO 2005/061513 PCT/AU2004/001830 - 74 No. Structure M/. Mtd No. Structure M2. Mtd 0 Cl f- O N=N N> Cl 360 N N 408 H 365 N 426 H N~ 01 CI F 0 0 0 N 361 N 402 H 366 N 455 H FN 0 Br O F 0 0 N 'N N> 362 336 H 367 N 455 H Br F CI 0 - 0 -N \ NN 363 N 391 H 368 N 409 H N N 0 Cl F CI 0 O /CI N> 364 N 425 H 369 N N 409 H NN N \ / N 0 Cl F WO 2005/061513 PCT/AU2004/001830 - 75 No. Structure M/Z Mtd No. Structure M+ Mtd 0 N O N> 370 ND 409 H 375 N N N F 403 H N 00 CI F 00 0 N N N 371 N N 428 H N N 376 C N 483 H CI ~0 0 __ _ _ __ _ _ _ __ _ _ _ 0_ 372 O +-N N 418 J CI N F 377 0 N 479 H N N S s N 0 0 373 0 o-N+ N 444 J \ 378 0 N 450 H ON |+N 374 0j-N / 352 J C1 ---- N 379 0N 446 H NN S 0 WO 2005/061513 PCT/AU2004/001830 - 76 No. Structure M+ Mtd No. Structure M+. Mtd Cl CI F FF 380 N 441 H 385 / N 462 H N O N N C 0 0 CI N N N 381 N 474 H 386 N 412 H 0 s~ N N O' N N Cl/ N N/oN 0 Ol Cl N 0 'N 38338 N H 3 388 C N 4H472 H \0 / N0 CCI 0 0 C N N 0N 384 ND464 H 38 N47 H Ci 0 IS ,,N s __0

N

WO 2005/061513 PCT/AU2004/001830 - 77 No. Structure M+. Mtd No. Structure MH. Mtd Ny 0 0 N N N N394 N 470 H 390 Cl IN 488 H cl on N F CI 0 / N\ 0 N N N 395 N 517 H 391 ND 473 H No 0 CI Cl CI 0 N\ 392 N 409 H 39 N 396 N 501 H N, N,0 ,N O 0 CI F 393 H C N O N" N 0 397 451 H NN 0 WO 2005/061513 PCT/AU2004/001830 - 78 No. Structure M+H. Mtd No. Structure M+H. Mtd Cl C1 N N 0 N 0 N 98N 43402 N 513 H N S0 N S0 CI O\ N\ 399 N 493 H C N N N S N O / N 0 403 425 H O N N N c4 N Cl O N CI 400 N 499 H 0 N N N S 404 B N 483 H N N N 0 Cl N CI 401 'N N 465 H N 405 0 \/ N 471 H N 0 WO 2005/061513 PCT/AU2004/001830 - 79 No. Structure M+H Mtd No. Structure M+H. Mtd 0 0 N- N N .3 D 406 \N 491 H 410 0489H F F> CI CI 0 N0I 407 449 H 411 N 493 H N N N0 NN N N O 408 40 N -N 47N N 408 -471 H N CI CI O N cl- 413 0 380 H 0 N ,N 0 NZ 409 ~ N 473 H CI 414 0 \/ 380 H / N ___ ____ ___ ____ ____ __0 WO 2005/061513 PCT/AU2004/001830 - 80 No. Structure MZ Mtd No. Structure M/H, Mtd CI CI 415 0 408 H N N 419 N% N 500H N 416 \/ / 480 H 420 0\ N ii N2 408 H NN 0 _ CI 0 N N 421 o/ N 408 H 417 -N 501 HN 0 0 NIN N CI 422 0 \/ 422 H o0 / N N N N N N ~ 504 H0 418 N, N , 0 CI 'NN Cl423 0 N 5 IC2N 0 WO 2005/061513 PCT/AU2004/001830 - 81 No. Structure M+. Mtd No. Structure M. Mtd CI CI 424 N 498 H 429 N 470 H N N N ~ N CI CI N 425 \ Q N 450 H 430 N 396 H ,NN NN ON CI CI 426 IO /~ N 488 H 431 / N\ 396 H N N Br 0 Cl CI 427 / o 502 H 42452 H | N N Oi N 428 N 484H 433 N 473H O L B 00 WO 2005/061513 PCT/AU2004/001830 - 82 No. Structure M+HZ Mtd No. Structure M"i Mtd CI CI 434 N 441 H 439 , N 474 H s s N N 0 N S N N 01 00 00 0 N N NN 435 491 H N 440 0 493 H ci s cO Cl N CI 436 0 N 460 H N N N N C s N 441 N 426 H 0l CI 0--~ IN Br1 f\ 47N N NN 0 442 CI 0\ N 43 H 43843 H BI N 438 0\ 1 N 506 H Br S Il NN 443 N 508 H IN Cl cl~ ss/ O -S- WO 2005/061513 PCT/AU2004/001830 - 83 No. Structure M+. Mtd No. Structure M+H Mtd CI CI 444 N 411 H 449 440 H N4 476 H 450 44N N s N 0 0 CI 44 BrO 476 H 450 444 H N N 452 449H N N cl 47N 446SHN O Cc 4 'NN I N 0-'~ \ , N ." 451 I 471 H 446 -N478 H N.. N 0 0 78 0 N N 0N 452 ND449 H N CI 0 ' 447 -N 446 H N 0 C I 8/ C I Cl ~~453 0 2 C I N 42H N N 448 381 H ~ N L- N N 0

N

WO 2005/061513 PCT/AU2004/001830 - 84 No. Structure M+H+ Mtd No. Structure M+H. Mtd o 0 | N | N 454 N 472 H N N 458 N 489 H o -W N Cl N CI s S N CI N 0 N 455 391 H N N N 459 -- N 430 H 0// / CI C1 456 N 398 H N 0 N NO S N N 0 460 N N 431 H

-O-

N N Cl 457 474 H CIC 0C

C

WO 2005/061513 PCT/AU2004/001830 - 85 M/Z M/Z No. Structure M+H+ Mtd No. Structure M+H+ Mtd 0 0 CI N 462 0\/ N 487 H N QoN N 466 -- N 491 H N N CI 0 CI CI 463 0 N 457 H CI O N N N 467 F 3 C 0 N 462 H N CI N N / o 464/ N 440 H C N N 0 N S N N-S N N 'NN N 0 465 / \N 487H H CI NZ C N| 6469 \ 487 H C CI N 0 0 / ci WO 2005/061513 PCT/AU2004/001830 - 86 No. Structure M+H+ Mtd No. Structure M+H, Mtd CI CI 470 N N 493 H 474 / 473 H N O CN N O 3,J__________ 0 0 N N 'N

N

Ni Ia N 475 I'- 516H 471 \s 507 H C1 NClO o 0 N N N N N N 472N N 457 H 476 s 503 H

\

1 W 6 47 / -S53 CI Cl N 0 N N7 NQ QN -487 H

IC

WO 2005/061513 PCT/AU2004/001830 - 87 MlZ M/ZMd No. Structure M+H. Mtd No. Structure Mf. Mtd CI Cl 478 O\/ 394 H 483 N 397 H N N N -N N S N H 0 0 0 C O N 484 N N 396 H 479 0 a 491 H 0 N 8 N . N 45N CI F0C 0 NN Cl CI C - o N N 481 N N N 392 H N N | N ~486 --. NH CIl c c 0N N N 482 N N 506 J N 487 N 447 H 0 +c N %~ 50CJNI 0 0 0 0 __N 7+C WO 2005/061513 PCT/AU2004/001830 - 88 No. Structure M+H. Mtd No. Structure M+H. Mtd CI 0 0 N N 488 o\ N 435 H Ne N 492 - N 512 H N \ /N 0 Ci CC CCI Cl N 489 N 460 3 9 48N 493 N 394 A 0 N N--N 00 Cl N N'N 494 0 366 A -Nh.IN | N 490 / N, * H 0 CI Cl CI C1 495 N N 342 A I ND 0 N 491 ,N N - 457 H N 497 N N 377 A | N' N 0 WO 2005/061513 PCT/AU2004/001830 - 89 m/Z No. Structure M+H+ Mtd 0 NN 498 N 419 H \/ CI 0 |NN N 499 N 405 H \ /O CI 0 | N 500 N _N 435 H H CI 0 | N N 501 N 421 H \

/>

CI 0 IN 502 N 440 D \ /09 \ / Ci 0

CI

WO 2005/061513 PCT/AU2004/001830 - 90 Method 0: Separation of Stereoisomers by Chiral Chromatography 5 Selected compounds of the invention may be separated into single stereoisomers by HPLC using chromatographic columns with a chiral stationary phase. For example, the following racemic compounds were separated into enantiomers under the conditions detailed below. 10 Column: Chirex 3014 (Chirex (S)-VAL and (R)-NEA)) 250 x 10.0mm Detector wavelength: 220nm Separation of Compound 12 Mobile Phase A: Hexane 15 Mobile Phase B: Isopropanol Flow Rate: 4mL/min Isocratic Elution: 93% Mobile Phase A, 7% Mobile Phase B Run Time: 20mins Column Temperature: 35'C 20 Injection Volume: 20tl Separation of Compound 188 Mobile Phase A: Hexane Mobile Phase B: Isopropanol 25 Flow Rate: 4mL/min Isocratic Elution: 93% Mobile Phase A, 7% Mobile Phase B Run Time: 26mins Column Temperature: 35'C Injection Volume: 15pl 30 Separation of Compound 306 Mobile Phase A: Hexane Mobile Phase B: Ethanol Flow Rate: 4mL/min 35 Column Temperature: 25'C Injection Volume: 20pd Gradient Timetable: WO 2005/061513 PCT/AU2004/001830 - 91 Time (min) % Mobile Phase B 0 5 15 25 15 25 17 5 22 5 Separation of Compound 336 Mobile Phase A: Hexane Mobile Phase B: Isopropanol 5 Flow Rate: 4mL/min Isocratic Elution: 93% Mobile Phase A, 7% Mobile Phase B Run Time: 50mins Column Temperature: 35'C Injection Volume: 25 pLI 10 Separation of Compound 352 Mobile Phase A: Hexane Mobile Phase B: Ethanol Flow Rate: 4mL/min 15 Column Temperature: 25'C Injection Volume: 15 tl Gradient Timetable: Time (min) % Mobile Phase B 0 15 15 20 23 20 24 15 29 15 20 Separation of Compound 363 Mobile Phase A: Hexane Mobile Phase B: Isopropanol Flow Rate: 4mL/min 25 Column Temperature: 50'C WO 2005/061513 PCT/AU2004/001830 - 92 Injection Volume: 15 pl Gradient Timetable: Time (min) % Mobile Phase B 0 17 25 35 26 17 31 17 5 Separation of Compound 368 Mobile Phase A: Hexane Mobile Phase B: Ethanol Flow Rate: 4mL/min 10 Column Temperature: 25*C Injection Volume: 15 1 Gradient Timetable: Time (min) % Mobile Phase B 0 5 15 25 24 25 25 5 30 5 15 Separation of Compound 381 Mobile Phase A: Hexane Mobile Phase B: Ethanol Flow Rate: 4mL/min 20 Column Temperature: 30'C Injection Volume: 20pl Gradient Timetable: Time (min) % Mobile WO 2005/061513 PCT/AU2004/001830 - 93 Phase B 0 3 15 20 24 20 25 3 30 3 Separation of Compound 414 Mobile Phase A: Hexane Mobile Phase B: Ethanol 5 Flow Rate: 4mL/min Isocratic Elution: 92% Mobile Phase A, 8% Mobile Phase B Run Time: 25mins Column Temperature: 40'C Injection Volume: 20pl 10 Table 4: Separation of Enantiomers Using Chirex 3014 Column Compound Retention Time of Enantiomer A Retention Time of Enantiomer B Number (mins) (mins) 12 13.1 14.6 188 13.4 14.8 306 12.9 13.7 336 6.7 7.4 352 20.4 21.3 363 17.6 19.5 368 15.8 16.9 381 20.8 21.9 414 21.5 22.3 Column: Chiracel OD-H (250 mm x 4.6 mm) 15 Isocratic Elution: hexane:ethanol (70:30) Detector wavelength: 254 nm WO 2005/061513 PCT/AU2004/001830 - 94 Flow rate: 0.7ml/min Injection Volume: 20pl Column Temperature: 25*C 5 Table 5: Separation of Enantiomers Using Chiracel OD-H Column Compound Retention Time of Enantiomer A Retention Time of Enantiomer B Number (mins) (mins) 153 15.4 12.4 363 89.6 55.1 414 23.8 17.6 Method P: Resolution of Compounds of Type III by Diastereomeric Salt Formation 10 A mixture of Compound 153 (1.0 g, 3.5 mmol) and (R)-(-)-1,1'-Binaphthyl-2,2'-diyl hydrogen phosphate (0.85 g, 2.44 mmol, 0.7 eq) in ethanol (90 ml) was refluxed until a clear solution was formed. After 15 minutes, the mixture was allowed to cool to room temperature for lh and then continued stirring under ice cooling for 1.5h. The white crystalline salt was filtered, rinsed with ethanol (5 ml) and dried under suction for 30 15 minutes to yield 1.09g of salt. The white salt was suspended in water (25 ml) and basified with 10% NaOH solution (0.7 ml) to pH 11. The aqueous phase was extracted with ethyl acetate (100 ml then 2 x 75 ml). The combined organic extracts were washed with saturated NaCl solution, dried (MgS04) 20 and concentrated to yield Compound 153B (0.49 g) as a white powder. The (R)-(-)-1,1'-Binaphthyl-2,2'-diyl hydrogen phosphate was recovered from the acidified aqueous layer (pH 2) by extraction with ethyl acetate (2 x 100 ml). The combined organic phases were washed with saturated NaCl solution, dried (MgSO 4 ) and 25 concentrated to afford a white powder (0.54 g). RSV Antiviral Assays Method Q: RSV Antiviral Assay Protocol 30 Compounds of the invention were tested for their antiviral activity against respiratory syncytial virus. Cytopathic effect (CPE) assays were performed essentially as described in WO 2005/061513 PCT/AU2004/001830 - 95 the literature (see for example Watanabe et al, J. Virological Methods, 1994, 48, 257). Serial dilutions of the test compounds were made in assay medium. HEp2 cells (1.0 x 10 4 cells/well) were infected with RSV at a low multiplicity of infection (e.g. RSV A2 at an moi of 0.01) and 100 ptL added to cultures assessing antiviral activity and cells without 5 virus added to those assessing compound cytotoxicity. Assays were incubated for approximately 5 days at 37'C in a 5% CO 2 atmosphere. The extent of CPE was determined via metabolism of the vital dye 3-(4,5-dimethylthiaxol-2-yl)-2,5 diphenyltetrazolium bromide (MTT). A 3 mg/ml stock of MTT was made in assay medium and 100 pL added to each well, taking the final MTT concentration to 1 mg/ml. 10 After 2 hours incubation at 37'C, the media-MTT solution was removed and 200 LL of isopropanol was added to dissolve the vital dye crystals. Plates were shaken and the absorbance read at 540 nm. The compound concentrations that inhibited CPE by 50% (EC50) and developed cytotoxicity (CC50) were calculated using an Excel curve fitting program. 15 Representative data for compounds of the invention against RSV A2 is show in Tables 6 8 where EC50 values lie in the ranges A: <100 ng/ml, B: 100-250 ng/ml and C: 250-1000 ng/ml. 20 Table 6: RSV A2 Antiviral Data for Compounds of Table 2 Activity Activity Cpd No. Range Cpd No. Range 12 B 200 A 66 B 201 C 82 C 203 C 85 B 205 A 86 B 211 C 87 B 214 C 88 A 216 C 117 C 217 B 144 B 218 C 178 C 219 A 179 C 224 A 180 C 227 C 183 B 228 C 184 A 230 A 188 C 231 C 190 C 232 C 191 A 234 A 192 C 235 B 199 C 236 B WO 2005/061513 PCT/AU2004/001830 - 96 Activity Activity Cpd No. Range Cpd No. Range 237 C 309 C 238 B 310 C 239 B 311 B 242 B 312 C 243 A 314 B 245 C 316 A 250 C 319 C 260 B 320 C 261 B 323 C 262 B 324 B 263 B 325 A 264 C 326 B 265 B 327 B 266 C 328 B 267 A 329 B 268 C 330 B 299 C 331 C 303 C 332 A 304 C 333 A 305 C 334 B 306 A 335 A 307 B 308 B Table 7: RSV A2 Antiviral Data for Compounds of Table 3 Activity Activity Cpd No. Range Cpd No. Range 336 B 369 B 344 C 370 C 351 C 371 C 352 B 372 C 358 B 377 A 360 C 379 B 361 B 381 A 363 A 382 C 364 C 385 A 366 A 386 B 367 C 387 B 368 A 391 A WO 2005/061513 PCT/AU2004/001830 - 97 Activity Activity Cpd No. Range Cpd No. Range 392 B 441 B 394 C 442 A 395 C 444 B 397 B 445 A 398 B 448 B 399 C 449 A 401 B 450 B 404 C 453 A 405 B 454 B 406 C 455 C 408 C 456 A 409 B 457 C 412 A 458 B 413 A 461 A 414 A 462 A 415 C 463 A 416 C 464 C 420 C 465 C 421 C 467 A 422 C 468 C 423 C 474 B 430 A 480 A 431 A 481 C 434 C 482 A 436 B 483 A 437 C 484 A 438 C WO 2005/061513 PCT/AU2004/001830 - 98 Table 8: RSV A2 Antiviral Data for Compounds of Tables 4 and 5 (the B enantiomer) Activity Cpd No. Range 12B A 188B B 306B A 336B A 352B A 363B A 368B A 381B A 414B A Method R: RSV Fusion Assay 5 Selected compounds of the invention were tested for their ability to inhibit the essential fusion processes of the respiratory syncytial virus. Generation of RSV-F constructs 10 Single-stranded synthetic DNA oligonucleotides encoding the portions of RSV A2 F glycoprotein incorporating optimal codons and without potential poly(A) addition or splice sites were generated synthetically (Mason et al, WO0242326). A membrane anchored full-length F was generated essentially according to the method described therein and in Morton et al, Virology, 2003, 311, 275. 15 Syncytium formation assay Fusion activity of the RSV-F constructs was measured in 293 cells essentially according to the method described in Morton et al, Virology, 2003, 311, 275. For example: cells in six 20 well plates at approximately 80% confluency were transfected by adding plasmid DNA (2 pg/well) carrying the constructs of interest in CaPO 4 solution for 4 hours. After glycerol shock and wash, the transfected cells were trypsinized and 1.5 x 104 cells/well added to 96-well plates containing half-log serial dilutions of the test compound. Syncytium formation was evaluated by visual inspection and quantified at 48 hours post-transfection 25 by addition of 20 piL of CellTiter 96 One Solution (Promega) followed by incubation for 4 hours at 37'C. The colour reaction was then stopped by addition of 25 [iL 10% SDS to each well and absorbance measured at 492 nm. The compound concentration that reduced WO 2005/061513 PCT/AU2004/001830 - 99 absorbance relative to untreated control cultures by 50% (EC50) was calculated using an Excel curve fitting program. Representative data for compounds of the invention is show in Table 9 where EC50 values 5 lie in the ranges A: <750 ng/ml, B: 750-1500 ng/ml and C: 1500-2250 ng/ml. Table 9: RSV Fusion Assay Data Compound Number RSV Fusion Assay EC50 12 C 16 B 66 13 336 A 10 Method S: RSV Cotton Rat Model The cotton rat model was performed essentially as described in the literature (Wyde et al, Antiviral Res. 2003, 60, 221). Briefly, cotton rats weighing 50-100 g were lightly anesthetized with isoflurane and dosed orally with 100 mg/kg/day of compound or vehicle 15 control. Viral infection followed 2 hours post-treatment in similarly anesthetized rats by intranasal instillation with approximately 1000 TCID50 of RSV A2 per animal. Four days after virus inoculation, each cotton rat was sacrificed and their lungs removed and RSV titres determined by plaque assay. 20 Table 10: RSV Cotton Rat Model Data Compound Number % Reduction of virus Control 352 68 306 72 336 96 Method T: RSV Balb/c Mouse Model 25 The mouse model was performed essentially as described by Cianci et al (Antimicrobial Agents and Chemotherapy. 2004, 48, 413). Briefly, eight week old female Balb/c mice were weighed, anesthetized intraperitoneally with AvertinTm and compound or vehicle administered orally 6 hours preinfection. Mice were inoculated intranasally with approximately 10000 TCID50 RSV A2 per animal. Three days after virus inoculation, WO 2005/061513 PCT/AU2004/001830 - 100 each mouse was sacrificed and their lungs removed and RSV titres determined by plaque assay. Table 11: RSV Balb/c Mouse Model Data 5 Compound Number % reduction of virus control 336 80 It would be appreciated by a person skilled in the art the numerous variations and/or modifications may be made to the invention as shown the specific embodiments without departing from the spirit or scope of the invention as broadly described. The present 10 embodiments are, therefore, to be considered in all respects as illustrative and not restrictive. Throughout this specification and the claims which follow, unless the context requires otherwise, the word "comprise", and variations such as "comprises" and "comprising", 15 will be understood to imply the inclusion of a stated integer or step or group of integers or steps but not the exclusion of any other integer or step or group of integers or steps. The reference to any prior art in this specification is not, and should not be taken as an acknowledgment or any form or suggestion that that prior art forms part of the common 20 general knowledge in Australia.

Claims (18)

1. Use of a compound of formula I R 2 R1 N B A NC 5 X Formula I or a pharmaceutically acceptable salt or derivative thereof, in the treatment of infections involving viruses of the Pneumovirinae sub-family, wherein 10 A together with the atoms to which it is attached, forms an optionally substituted aryl or heteroaryl ring; linker B-C together with the atoms to which it is attached, forms an optionally substituted heterocyclic ring having from 5 to 8 ring atoms; 15 R 1 is selected from C 1 - 1 2 alkyl, C 2 - 1 2 alkenyl, C 2 - 1 2 alkynyl, -(CH 2 )nC 3 . 7 cycloalkyl, -(CH 2 ),C 4 . 7 cycloalkenyl, -(CH-2)n aryl, -(CH-2)n arylC1.12 alkyl, 4-(C2). arylC2-12 alkenyl, -(CH2)n arylC2.12 alkynyl. and -(ClH 2 ), heterocyclyl; n is 0-6 and the alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl and heterocyclyl groups are optionally substituted; 20 R 2 is selected from -CH 2 R 3 , -C(Y)R 3 , -C(Y)OR 3 , -C(Y)N(R 4 )R 3 , -C(Y)CI-1 2 N(R4)R 3 , -C(Y)CI-12SR 3 and S(O),Rs, where R 3 is selected from hydrogen, CI- 12 alkyl, C 2 - 12 alkenyl, C 2 - 1 2 alkynyl, -(CH-l 2 )mC3. 7 cycloalkyl, -(CH 2 )mC 4 . 7 cycloalkenyl, -(CH 2 )m aryl, -(ClH 2 )m arylCI. 1 2 alkyl, -(CIH 2 )m arylC 2 1 2 alkenyl, (CI1 2 )m arylC 2 . 1 2 alkynyl and -(CH 2 )m heterocyclyl; and when R 2 is -CH1 2 R 3 , or -C(Y)R 3 . R 3 is further 25 selected from -S-R 5 and -O-Rs; m is 0-6; R4 is hydrogen or C 1 . 6 alkyl; R 5 is C 1 . 6 alkyl, C 2 - 6 alkenyl, C 2 -6 alkynyl, C 3 . 7 cycloalkyl, C 4 . 7 cycloalkenyl, benzyl, aryl or heterocyclyl; w is 0, 1 or 2; and the alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl and heterocyclyl groups are optionally substituted; and X and Y are independently selected from 0, S and N&. where R is independently selected from 30 hydrogen, lower alkyl, hydroxy and lower alkoxy.

2. Use according to claim I, wherein R 2 is not an unsubstituted -C 1 . 6 alkyl or unsubstituted -C(O) CI- 6 alkyl. 35 3. Use according to claim I or claim 2, wherein ring A is an optionally substituted phenyl ring. 2334232_2 (GHMatters) 9/07110 -102

4. Use according to claim I or claim 2 wherein ring A represents an optionally substituted pyridyl, optionally substituted pyridazinyl, optionally substituted pyrimidinyl, optionally substituted pyrazinyl, optionally substituted pyrrolyl, optionally substituted furyl, optionally substituted thienyl, optionally 5 substituted imidazolyl, optionally substituted oxazolyl or optionally substituted isoxazolyl ring.

5. Use of a compound of formula I as defined in any one of claims I to 4. or a pharmaceutically acceptable salt or derivative thereof, in the manufacture of a medicament for the treatment of infections involving viruses of the Pneumovirinae sub-family. 10

6. The use according to any one of claims I to 5, in the treatment of respiratory syncytial virus (RSV).

7. A method for treating mammals infected with viruses of the Pneumovirinae sub-family, which 15 comprises administering to the mammal a therapeutically effective amount of a compound of formula I as defined in any one of claims I to 4, or a pharmaceutically acceptable salt or derivative thereof.

8. A method for preventing the infection of mammals with viruses of the Pneumovirinae sub family, which comprises administering to the mammal a therapeutically effective amount of a compound 20 of formula I as defined in any one of claims I to 4, or a pharmaceutically acceptable salt or derivative thereof.

9. A compound of formula I R2 R1 N ___ A N 25 X Formula I its salts, and pharmaceutically acceptable derivatives thereof, wherein 30 A together with the atoms to which it is attached, represents an optionally substituted phenyl, optionally substituted pyridyl, optionally substituted pyridazinyl, optionally substituted pyrimidinyl or optionally substituted pyrazinyl ring; B-C is an optionally substituted link of the formula -C-1 2 -(C1 2 ),-, where z is 1-4; 35 2334232_2 (GHMatters) 9/07110 -103 RI is selected from C 1 . 1 2 alkyl, C 2 . 12 alkenyl, C 2 . 1 2 alkynyl, -(CH 2 )nC 3 . 7 cycloalkyl, -(CH 2 )nC 4 . 7 cycloalkenyl, -(CH 2 ). aryl, -(CH 2 ), arylCI. 1 2 alkyl, -(CH 2 )n arylC 2 - 1 2 alkenyl, -(Cl-I 2 )n arylC 2 12 alkynyl, and -(CH 2 )n heterocyclyl; n is 0-6 and the alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl. aryl and heterocyclyl groups are optionally substituted; 5 R, is selected from -CH 2 R 3 , -C(Y)R 3 , -C(Y)OR 3 , -C(Y)N(R 4 )R 3 S(0)o R 5 , S(O),R', S(0) 2 -C 2 . 6 alkenyl, S(O) 2 -C 2 .3 alkynyl, S(0) 2 -C 3 . 7 cycloalkyl, S(0) 2 -C 4 . 7 cycloalkenyl, S(0) 2 -benzyl and S(O) 2 -heterocyclyl; where R 3 is selected from hydrogen, CI. 1 2 alkyl, C 2 . 1 2 alkenyl, C 2 - 12 alkynyl, -(C-1 2 )mC 3 . 7 cycloalkyl, -(CH 2 )mC 4 .7 cycloalkenyl, -(CH 2 )m aryl, -(CH 2 )m arylCI- 1 2 alkyl, -(CHl 2 )m arylC 2 . 1 2 alkenyl, -(CH1 2 )m 10 arylC 2 . 1 2 alkynyl and -(CH 2 )m heterocyclyl; and when R 2 is -CH 2 R 3 , or -C(Y)R 3 R3 is further selected from -S-R 5 and -O-R 5 ; m is 0-6; R 4 is hydrogen or C 1 . 6 alkyl; R 5 is C 1 . 6 alkyl, C 2 . 6 alkenyl, C 2 - 6 alkynyl, C3.7 cycloalkyl, C 4 . 7 cycloalkenyl, benzyl, aryl or heterocyclyl; and the alkyl, alkenyl, alkynyl, cycloalkyl. cycloalkenyl, aryl and heterocyclyl groups are optionally substituted; provided that R 2 is not unsubstituted C 1 .,alkyl; and 15 X and Y are independently selected from 0, S and NR 6 . where R 6 is independently selected from hydrogen, lower alkyl, hydroxy and lower alkoxy; with the provisos that when A is phenyl and RI is 4-chlorophenyl or unsubstituted phenyl 20 (i) R3 is not unsubstituted cyclopropyl, halomethyl, unsubstituted phenyl or phenyl with only halo, Cl- 3 and/or -OCH 3 substituents when R 2 is COR 3 ; (ii) R 3 is not unsubstituted phenyl or phenyl with only halo, -CH 3 , -OCH 3 and/or -C(O)OCH 2 CH 3 substituents when R 2 is C(O)NI-HR 3 ; (iii) R 3 is not unsubstituted phenyl or phenyl with only halo, -CH1 3 , -OCH 3 and/or -C(0)OC 2 C-1 3 25 substituents when R 2 is C(S)NHR 3 ; and with the provisos (iv) when A is phenyl and R 2 is CH 2 R 3 , R 3 is not hydrogen, unsubstituted C 1 . 6 alkyl or C 1 .- alkyl only substituted with NI-I 2 , mono or di CI- 6 alkyl amino groups; 30 (v) when A is phenyl and R, is 4-methoxyphenyl, R 2 is not CHO; (vi) when A is phenyl and R, is phenyl optionally substituted with only halo. C1, alkyl and / or C 1 ., alkoxy and R 2 is COR 3 , R 3 is not methylene substituted with N-1 2 , mono or di C 1 . 6 alkyl amino, N-piperidinyl or N-morpholinyl; (vii) when A is phenyl and RI is 3-C1 3 ,4-C-1 3 CH 2 CH 2 NH-IC(O)CH 2 O-phenyl, R 2 is not 35 -S(O)2CH 2 SO2CH 3 , -CHO, -COCH 2 CH3. -CI-1 2 CH 2 01-, -ClHl 2 CH 2 0CHI 3 , -CH 2 CO 2 C(CI-H3)3 or C,. 6 alkyl; (viii) when A is pyridyl and R, is 3-CH 3 ,4-CH 3 CH 2 CH 2 NHC(O)C1 2 0-phenyl, R 2 is not CH 3 ; and (ix) wherein A is phenyl and R 2 is -C(O)R 3 , and R 3 is alkyl then alkyl is C 7 - 1 2 alkyl. 40 10. The compound according to claim 9, wherein ring A is an optionally substituted phenyl. 2334232_2 (GHMattes) 9107/10 -104 II. The compound according to claim 9, wherein ring A is an optionally substituted pyridyl.

12. The compound according to claim I1, of the formula IV R2 R 1 N_ N N C N_, 5 X Formula IV wherein RI, R 2 , X and -B-C- are as defined in claim 9. or an N-oxide form or pyridium salt thereof. 10 13. The compound according to any one of claims 9 to 12, or a salt or pharmaceutically acceptable derivative thereof, wherein R 2 is -CH2-R 3 , and R 3 is -(CH 2 )maryl or -(CHl 2 )m heterocyclyl and m is 0 to 3 and the aryl or heterocyclyl ring is optionally substituted.

14. The compound according to any one of claims 9 to 12, or a salt or pharmaceutically acceptable 15 derivative thereof, wherein R 2 is -COR 3 and R 3 is (CH 2 )m aryl or (CI1 2 )m heterocyclyl where m is 0 to 3 and is optionally substituted.

15. '[he compound according to any one of claims 9 to 12, or a salt or pharmaceutically acceptable derivative thereof, wherein R 2 is -CON(H)R 3 , and R 3 is -(CH 2 )m aryl or -(CH 2 )m heteroaryl and m is 0 to 20 2 and the aryl or heteroaryl ring is optionally substituted with one or more substituents independently selected from halo, lower alkyl, hydroxy, lower alkoxy and phenyl.

16. The compound according to any one of claims 9 to 15, or a salt or pharmaceutically acceptable derivative thereof, wherein -B-C- is a linker of the formula -CH 2 CI- 2 -. 25

17. The compound according to any one of claims 9 to 15, or a salt or pharmaceutically acceptable derivative thereof, wherein X is oxygen.

18. The compound according to any one of claims 9 to 17, or a salt or pharmaceutically acceptable 30 derivative thereof, wherein R, is an optionally substituted aryl or optionally substituted heterocyclyl group.

19. The compound according to any one of claims 9 to 17, or a salt or pharmaceutically acceptable derivative thereof, wherein R, is phenyl optionally substituted with a substituent selected from halo. -C 1 . 35 6 alkyl, -C 1 . 6 alkylhalo, -C . 6 alkylCN, -OCI. 6 alkyl, -OCI. 6 alkylhalo, -OC 1 . 6 alkylCO 2 NH 2 , -OCI. 6 alkylCN, OC1. 6 alkyIC 3 . 7 cycloalkyl, -OCI. 6 alkylC 6 H 5 , -OC 1 . 6 alkylOCH 3 , -OC 6 H 5 , -OC 6 1H 4 halo, -CF 3 , -OCF 3 , 23342322 (GHMatters) 9107/10 -105 NR'R", -CO 2 H, -CO 2 CI. 6 alkyl, -NO 2 , -OH, -C 6 11 5 , -C 6 H 4 CI_6alkyl, -C 6 H 4 halo and -OC(O)CI. 6 alkyl; where R' and R" are independently selected from hydrogen, -C(O)C 1 . 6 alkyl, -C(O)C 6 -l5, -C(O)CH=CHCO 2 l, C(O)CI. 6 alkylCO 2 H, -C(O)CI. 6 alkylCO 2 CH 3 , -C(O)CI_6alkylCl-I 5 , -C(O)CI. 6 alkyIC 6 H 4 CH 3 . -C(O)C. 6 aIkylC 6 H 4 0C1 3 and -C(O)CI. 6 alkylC 6 l-l 4 halo.. 5

20. The compound according to any one of claims 9 to 17, or a salt or pharmaceutically acceptable derivative thereof, wherein R, is 4-chlorophenyl.

21. A compound selected from the group consisting of: 10 9b-(4-Chloro-phenyl)- 1-(4-fluoro-benzoyl)- l,2,3,9b-tetrahydro-imidazo[ 1',2': 1,5]pyrrolo[3,4-b]pyridin-5 one 3a-(4-Chloro-phenyl)-3-(4-fluoro-benzoyl)-1,2,3,3a-tetrahydro-3,6,8a-triaza-cyclopenta[a jinden-8-one 3a-(4-Chloro-phenyl)-3-propionyl- 1,2,3,3a-tetrahydro-3,6,8a-triaza-cyclopentaa] inden-8-one 15 3a-(4-Chloro-phenyl)-3-(4-fluoro-benzoyl)- 1,2,3,3a-tetrahvdro-3,5.8a-triaza-cyclopenta[alinden-8-one 3a-(4-Chloro-phenyl)-3-propionyl- l,2,3,3a-tetrahydro-3,5,8a-triaza-cyclopenta[a jinden-8-one 3-(4-Fluoro-benzoyl)-3a-p-tolyl- 1,2,3,3a-tetrahydro-3,5,8a-triaza-cyclopenta[ajinden-8-one 3-Propionyl-3a-p-tolyl- 1,2,3,3a-tetrahydro-3,5,8a-triaza-cyclopenta[alinden-8-one 3a-(4-Chloro-phenyl)-3-(4-fluoro-benzoyl)- l,2,3,3a-tetrahydro-3,4,7,8a-tetraaza-cyclopenta[alinden-8 20 one 3a-(4-Chloro-phenyl)-3-[2-(4-methoxy-phenyl)-acetyll- 1,2,3,3a-tetrahydro-3,4,7,8a-tetraaza cyclopenta[alinden-8-one 3a-(4-Chloro-phenyl)-3-propionyl- 1,2,3,3a-tetrahydro-3,4,7,8a-tetraaza-cyclopenta[alinden-8-one 3-[2-(4-Methoxy-phenyl)-acetyll-3a-p-tolyl- 1,2,3,3a-tetrahydro-3,6,8a-triaza-cyclopentalalinden-8-one 25 3a-(2-Chloro-phenyl)-3-(4-fluoro-benzoyl)- 1,2,3,3a-tetrahydro-3,5,8a-triaza-cyclopentaajinden-8-one 3a-(2-Chloro-phenyl)-3-propionyl- 1,2.3,3a-tetrahydro-3,5,8a-triaza-cyclopenta[a]inden-8-one 3a-(4-Chloro-phenyl)-3-[2-(4-methoxy-phenyl)-acetyl 1-1,2,3,3a-tetrahydro-3,6,8a-triaza cyclopenta[alinden-8-one 3-(4-Fluoro-benzoyl)-3a-(4-trifluoromethyl-phenyl)- 1,2,3,3a-tetrahydro-3,6,8a-triaza-cyclopenta[ajinden 30 8-one 3-[2-(4-Methoxy-phcnyl)-acetylj-3a-(4-trifluoromethyl-phenyl)- l,2,3,3a-tetrahydro-3,6,8a-triaza cyclopenta[a]inden-8-one 3-[2-(4-Methoxy-phenyl)-acetyl]-3a-(4-trifluoromethyl-phenyl)- 1.2,3,3a-tetrahydro-3,5,8a-triaza cyclopentalajinden-8-one 35 3-Propionyl-3a-(4-trifluoromethyl-phenyl)- 1,2,3,3a-tetrahydro-3,6,8a-triaza-cyclopenta[a]inden-8-one 3a-(4-Chloro-phenyl)-3-[2-(4-methoxy-phenyl)-acetyl 1-1,2.3,3a-tetrahydro-3,5,8a-triaza cyclopentalaJinden-8-one 3a-(4-Chloro-phenyl)-3-(4-fluoro-benzoyl)-5-oxy- 1,2,3,3a-tetrahydro-3,5,8a-triaza-cyclopenta[ajinden-8 one 40 3a-(4-Chloro-phenyl)-3-(4-fluoro-benzoyl)- 1,2,3,3a-tetrahydro-3,5,6,8a-tetraaza-cyclopenta[alinden-8 one 3a-(4-Chloro-phenyl)-3-propionyl- 1,2,3,3a-tetrahydro-3,5,6,8a-tetraaza-cyclopenta[ajinden-8-one 2334232_2 (GHMatters) 9/07/10 -106 3-(4- F1uoro-bcnzoyl)-3a-p-tolyl - I ,2,3,3a-tetrahydro-3,5,6,8a-tctraaza-cyclopenta[ ajIinden-8-one 3-Propi on yl-3a-p-toly!- I ,2,3.3a-tetrahydro-3,5,6,8a-tetraaza-cyclIopenta[ a indcn-8-onc 3-(4-FlIuoro-benzoyl)-3a-(4-methoxy-phenyl)- I ,2,3.3a-tetrahydro-3.,6,8a-triaza-cyclopcntaI a Iinden-8-one 3a-(4-IBromo-phenyl)-3-(4-fluoro-benzoyl)- I ,2.3,3a-tetrahydro-3,5,8a-triaza-cyclopenta a I!inden-8-one 5 3a-(4-Bromo-phenyl)-3-(4-fluoro-benzoyl)- I ,2,3,3a-tetrahydro-3,6,8a-tria7za-cyclopcnta a I inden-8-one 9b-(4-Ch Ioro-phenyl)- I -(4-tluoro-benzoyl)- I ,2,3,9b-tetrahy'dro-imidazo[ 1',2': 1,2 Ipyrrolol 3,4-bipyridin-5 one 3a-(4- Ethyl -phenyl)-3-(4-fluoro-benzoyl)- I ,2,3,3a-tetrahydro-3,5,8a-triaza-cyclopenta~alinden-8-one 3a-(4-Ethyl-phenyl)-3-propionyl I ,2,3,3a-tetrahydro-3,5,8a-triaza-cyclopentaI a]indcn-8-one 10 3a-(4-Chloro-phenyl)-3-(pyridine-3-carbonyl)- I ,2,3,3a-tetrahydro-3,5,8a-triaza-cyclopentalinden-8-one 3a-(4-Chloro-phenyl)-3-(6-chloro-pyridi ne-3-carbonyl)- 1,2,3,3 a-tetrahydro-3,5,8a-triaza cyclopenta Ia] inden-8-one 3a-(4-Chloro-phenyl)-3-(6-chloro-pyridazine-3-carbonyl)- I ,2,3,3a-tctrahydro-3,5,8a-triaza cyclopenta[ajinden-8-one 15 3a-(4-IBromo-phenyl)-3-(6-fluoro-pyridine-3-carbonyl)- 1 ,2,3.3a-tetrahydro-3,5,8a-triaza cyclopenta[alinden-8-one 3a-(4.Bromo-phcnyl)-3-(6-tluoro-pyridine-3-carbonyl)- 1 ,2,3.3a-tetrahydro-3,6,8a-triaza cyclopentalaJinden-8-one 3a-(4-Chloro-phenyl)-3-(6-fluoro-pyridinc-3-carbonyl)- 1 ,2,3,3a-tetrahydro-3,5,8a-triaza 20 cyclopenta[a]indcn-8-one 9b-(4-Chloro-phcnyl)- ] -(6- fl uoro- pyri d ine-3 -carbon yl)- I ,2,3,9b-tetrahydro-imidazo[ 1',2': 1 ,2lpyrrolol3,4 bjpyridin-5-one 9b-(4-Chloro-phcnyl)- 1 -(6-fluoro-pyridine-3-carbonyl)- I ,2,3,9b-tetrahydro-imidazol 1',2': 1 ,5lpyrrolol3,4 bjpyridin-5-one 25 3 a-(4-IEthylI-phenyl)-3 -t2-(4-methoxy-phenyl)-acetyl] I I ,2,3,3a-tetrahydro-3,5,8a-triaza cyclopenta[alinden-8-one 3 a-(4- Ethyl -phenyl)-3 -(4- f1uoro-benzoyl).5 -oxy- I ,2,3,3a-tetrahydro-3,5,8a-triaza-cyclopcnta[ajinden.8 one 3 a-(4- Ethyl -phenyl)-3 -[2-(4-methoxy-phenyI)-acetyI]I-S-oxy- I ,2,3,3a-tetrahydro-3,5,8a-triaza 30 cyclopenta[ajinden-8-one 3a-(4-Ethyl-phenyl)-5-oxy-3-propionyl. I ,2,3,3a-tetrahydro-3,5,8a-triaza-cyclopentalaJindcn-8-one 3a-(4-Ethyl-phenyl)-3-(6-fluoro-pyridine-3-carbonyl)- 1,2,3 ,3a-tetrahydro-3 ,5,8a-triaza cyclopentafa]inden-8-one 3a-(4.Chloro-phenyl)-3-(6-phenoxy-pyridine-3-carbonyl)- I ,2,3,3a-tetrahydro-3,5,8a-triaza 35 cyclopenta[aJinden-8-one 3a-(4-Chloro-phenyl)-3-(2-thiophen-2-yI-thiazolc-4-carbonyl)- I .2.3,3a-tetrahydro-3,5,8a-triaza cyclopenta[alinden-8-one 3a-(4-Chloro-phenyl)-3-(4,5,6,7-tetrahydro-benzol cithiophene- I -carbonyl)- I ,2,3,3a-tetrahydro-3,5,8a triaza-cyclopental al indcn-8-one 40 3-( Benzo[blthiophene-3-carbonyl)-3a-(4-chloro-phenyl)- 1 ,2,3,3a-tctrahydro-3,5,8a-triaza cyclopental alinden-8-one 23342322 (GHMatters) W/7110 -107 3a-(4-Chloro-phcnyl)-3-(quinoline-2-carbonyl)- I ,2,3,3a-tetrahydro-3,5,8a-triaza-cyclopenta[alinden-8 one 3a-(4-Chloro-phenyl)-3-(2-pyridin-3-yI-thiazolc-4-carbonyl)- I .2,3,3a-tetrahydro-3,5,8a-triaza cyclopenta[alinden-8-one 5 3a-(4-Chloro-phenyl)-3-(5-methyl-isoxazole-3-carbonyl)- I ,2,3,3a-tetrahydro-3,5,8a-triaza cyclopental ajindcn-8-one 3a-(4-Chloro-phenvI)-3-(6-morpholin-4-yI-pyridinc-3-carbonyl)- I .2,3,3a-tetrahydro-3,5,8a-Iriaza cyclopcntalalinden-8-one 3a-(4-Chloro-phenyl)-3-(1I,3-dimethyl- I H-thieno[2,3-cJpyrazole.5-carbonyl)- I ,2,3,3a-tetrahydro-3.5,8a 10 triaza-cyclopenta[a]inden-8-one 3a-(4-Chloro-phenyl)-3-(5-methyl-2-trifluoromethyl-furan-3-carbonyl)- I ,2,3,3a-tetrahydro-3,5,8a-triaza cyclopentalalinden-8-onc 3a-(4-Chloro-phenyl)-3-(4-methyl-[ I ,2,3]thiadiazole-5-carbonyl)- I ,2,3,3a-tctrahydro-3,S,8a-triaza cyclopentafajinden-8-one 15 3a-(4-Chloro-phenyl)-3-(5-mcthyl-2-phenyl-2HI-[ I ,2,3]triazole-4-carbonyl)- I ,2,3,3a-tctrahydro-3,S,8a triaza-cyclopenta[ajinden-8-one 3a-(4-Chloro-phcnyl)-3-(5-phcnyl-thiophcnc-2-carbonyl)- I ,2,3,3a-tetrahydro-3,5,8a-triaza c),clopenta[alinden-8-one 3a-(4-Chloro-phenyl)-3-(4-phenyl-[ I ,2,3ithiadiazole-5-carbonyl)- I ,2,3,3a-tetrahydro-3,5,8a-triaza 20 cyclopcntaLaiinden-8-one 3a-(4-Chloro-phenyl)-3-[ I-(4-fluoro-phenyl )-5-methyl- I 1-1-pyrazole-4-carbonyl I-l ,2.3,3a-tctrahydro 3.5,8a-triaza-cyclopentalalinden-8-one 3a-(4-Chloro-phenyl)-3-(2-phenyl-thiazolc-4-carbonyl )- I ,2,3,3a-tetrahydro-3,5,8a-triaza cyclopental ajinden-8-one 25 3 a-(4-Ch loro-pheny l)-3 -(3,5 -d im ethyl -isoxazo le-4-carbonyl)- I ,2,3,3a-tetrahydro-3,5,8a-triaza cyclopcntal alinden-8-one 3a-(4-Chloro-phcnyl)-3-(1I,3,5-trimethyl- I Fi-pyrazole-4-carbonyl)- I ,2,3,3a-tctrahydro-3,5,8a-triaza cyclopenta[aJinden-8-one 3a-(4-Chloro-phcnyl)-3-(2-methyl-5-phenyl-furan-3-carbonyl)- I ,2,3,3a-tetrahydro-3,5,8a-triaza 30 cyclopenta[aJinden-8-one 3-[2-(4-Chloro-phenoxy)-pyridine-3-carbonyl j-3a-(4-chloro-phenyl)- I .2,3.3a-tetrahydro-3,5,8a-triaza cyclopenta[a]indcn-8-onc 3a-(4-Chloro-phenyl)-3-[2-(4-fluoro-phenoxy)-pyridi ne-3-carbonyl]- 1,2,3 ,3a-tctrahydro-3,5,8a-triaza cyclopentalajinden-8-one 35 3a-(4-Chloro-phenyl)-3-(2-cthylsul Ifanyl-pyridinc-3-carbonyl)- I ,2,3,3a-tetrahydro-3 ,5,8a-triaza cyclopentafalinden-8-one 3a-(4-Chloro-phenyl)-3-(2-methylsulfanyl-pyridine-3-carbonyl)- I ,2,3,3a-tetrahydro-3.5,8a-triaza cyclopenta[a Iinden-8-one 3a-(4-Chloro-phenyl )-3-(2-pentylsul fanyl-pyridine-3-carbonyl)- I ,2,3,3a-tetrahydro-3.5,8a-triaza 40 cyclopentaLalinden-8-onc 3a-(4-Chloro-phenyl)-3-(2-phenylsuI I'anyl-pyridine-3-carbonyl)- I ,2.3,3a-tetrahydro-3,5,8a-triaza cyclopcntata]inden-8-one 2334232_2 (GHMatters) M17110 -108 3a-(4-Chloro-phenyl)-3-(2-propyI su Ifanyi-pyridine-3-carbonyl)- I ,2,3,3a-tetrahydro-3,S,8a-triaza cyc lopenta [a] inden-8-one 3a-(4-Chloro-phenyl)-3-(2-p-tolylsul I anyi-pyridine-3-carbonyl )- I ,2,3,3a-tetrahydro-3,5,8a-triaza cyclopental alIinden-8-one 5 3a-(4-Ch Ioro-phcny!)-3-(2-ch loro-pyridi nc-3-carbonyl )- 1,2,3 ,3a-tetrahydro-3,5,8a-triaza cyclopenta [a] inden-8-one 3a-(4-Chloro-phenyi)-3-(2-phenoxy-pyridine-3-carbonyl)- I ,2,3,3a-tctrahydro-3,5,8a-triaza c),clopenta[al inden-8-one 3-(5-Bromo-pyridine-3-carbonyl)-3a-(4-chloro-phenyl)- I .2,3.3a-tctrahydro-3,5,8a-triaza 10 cyclopentalalinden-8-one 3a-(4-Chloro-phenyl)-3-(5-phenylethynyl-pyridine-3-carbonyl )- I ,2,3,3a-tetrahydro-3,5,8a-triaza cyclopenta[alinden-8-one 3-[3a-(4-Chioro-phenyl )-8-oxo- I ,2,3a,8-tetrahydro-3 ,5,8a-triaza-cyclopcntala~indene-3-carbonyl] isonicotinic acid methyl ester 15 3a-(4-Chloro;-phenyl)-3-(5-hex- I -ynyl-pyridine-3-carbonyl)- I ,2,3,3a-tetrahydro-3,5,8a-triaza cyclopenta[ajinden-8-one 3a-t4-Chloro-phenyl)-3-(5-thiophen-2-yI-pyridine-3-carbonyl)- I ,2,3,3a-tetrahydro-3,5,8a-triaza cyclopenta[alinden-8-one 3a-(4-Chloro-phenyl)-3-[6-(2,2,2-trifluoro-ethoxy)-pyridine-3-carbonyl]- I ,2,3,3a-tetrahydro-3,5.8a 20 triaza-cyclopenta[alindcn-8-one 3a-(4-Chloro-phenyl)-3-[3-methyl-5-(4-methyl-I 1,2,3 Ithiadiazol-5-yI)-isoxazole-4-carbonyl j- I ,2,3,3a tetrahydro-3,5,8a-triaza-cyclopentalinden-8-one 3a-(4-Chloro-phenyl)-3-(2,5-dimethyl-furan-3-carbonyl)- I ,2.3,3a-tetrahydro-3,5,8a-triaza cvclopentalajinden-8-one 25 3a-(4-Chloro-phenyl)-3-(furan-2-carbonyl)- I ,2,3,3a-tctrahydro-3,S.8a-tria7za-cyclopenta[alinden-8-onc 3a-(4-Chloro-phenyl)-3-(lburan-3-carbonyl)- I ,2,3,3a-tetrahydro-3.5.8a-triaza-cyclopental a inden-8-one 3a-(4-Chloro-phenyl)-3-(4.5-dimethyl-f'uran-2-carbonyl )- I .2.3,3a-tetrahydro-3,5.8a-triaza cyclopentalalinden-8-one 3a-(4-Chloro-phenyl)-3-(5-phenylethynyl-'uran-2-carbonyl )- I ,2,3,3a-tetrahydro-3,5,8a-triaza 30 c)'clopcntalalindcn-8-one 4-I 3a-(4-Chloro-phenyl )-8-oxo- I .2,3a,8-tetrahydro-3,5,8a-triaza-cyclopentalaindene-3-carbonyl]-5 methyl-fUuran-2-sulfonic acid dimethylamide 3a-(4-Chloro-phenyl)-3-11I-(4-chloro-phcnyl)-5-methyl- I li-pyrazole-4-carbonyt]- I ,2.3,3a-tetrahydro 3,5,8a-triaza-cyclopentalinden-8-one 35 3a-(4-Chloro-phenyl)-3-[ I-(4-methoxy-phenyl)-5-methyl- I H-pyrazole-4-carbonyl]- I ,2,3,3a-tetrahydro 3,5,8a-triaza-cyclopentalinden-8-one 3a-(4-Chloro-phenyl)-3-(2,5-dimethyl-21-I-pyrazole-3-carbonyl)- I ,2,3,3a-tetrahydro-3,S,8a-triaza cyclopenta[a]inden-8-one 3a-(4-Ch loro-phenyl)-3-(1I,5 -d imet hylI- I I--pyrazole-3-carbonyl)-1I,2,3,3a-tetrahydro-3,5,8a-triaza 40 cyclopenta[alinden-8-one 3a-(4-Chloro-phenyl)-3-(2-cthyl-5-methyl-21-I-pyrazole-3-carbonyl)- I ,2,3,3a-tctrahydro-3,5,8a-triaza cyclopentala]inden-8-onc 2334232_2 (GHMatters) 9107/10 - 109 3a-(4-Ch Ioro-phenyl)-3-(2-phenyl-21-1-pyrazole-3-carbonyl)- I ,2,3,3a-tetrahydro-3 ,5,8a-triaza cyc lopenta[ a] inden-8-one 3a-(4-ChlIoro-phenyi)-3 -( I -phenyl-5-propyi- I H-pyrazole-4-carbonyl)- I ,2,3,3a-tctrahydro-3,5,8a-triaza cyc lopenta[a] inden- 8-orie 5 3-(5-tert-Butyl-2-methyl-2H-pyrazolc-3-carbonyl)-3a-(4-chloro-phenyl)- I ,2.3,3a-tetrahydro-3,5,8a triaza-cyclopcntal a]inden-8-one 3-(4-Bromo-2,5-dimethyl-2H-pyrazolc-3-carbonyl)-3a-(4-chloro-phenyl )- I ,2.3,3a-tetrahydro-3,5,8a triaza-cyclopenta[a]inden-8-onc 3-(4-Bromo-2-cthyI-5-methyl-21-1-pyrazole-3-carbonyl)-3a-t4-chloro-phenylI)- I .2.3,3a-tetrahydro-3,5.8a 10 triaza-cyclopcnta[alinden-8-one 3a-(4-Chloro-phenyl)-3-(5-methyl- I -o-tolyl- I fi-pyrazole-4-carbonyl )- 1 .2,3.3a-tetrahydro-3,5,8a-triaza cyclopentaialinden-8-one 3a-(4-Chloro-phcnyl)-3-(5-mcthyl- I -phenyl- I 1-1-pyrazole-4-carbonyl)- I ,2,3,3a-tetrah),dro-3,5,8a-triaza cyclopental ajinden-8-one 15 3a-(4-Chloro-phenyl)-3-(thiophcne-3-carbonyl)- I ,2,3,3a-tetrahydro-3,5,8a-triaza-cyclopentalajindcn-8 one 3a-(4-Chloro-phenyl)-3-(thiophene-2-carbonyl)- I ,2,3,3a-tctrahydro-3,5,8a-triaza-cyclopental a] inden-8 one 3a-(4-Chloro-phenyl)-3-(thienof3,2-bJthiophene-2-carbonyl)- I ,2,3,3a-tctrahydro-3.5,8a-triaza 20 cyclopenta[alinden-8-one 3a-(4-Chloro-phenyl)-3-( 5-pyridin-2-yI-thiophene-2-carbony 1)-I ,2,3,3a-tetrahydro-3,5,Ba-triaza cyclopental a]inden-8-one 3a-(4-Chloro-phcnyl)-3-(5-nitro-thiophene-3-carbonyl )- I ,2,3,3a-tctrahydro-3,5,8a-triaza cyclopentalajindcn-8-onc 25 3a-(4-Chloro-phenyl)-3-(S-nitro-benzol bjthiophenc-2-carbonyl)- I ,2,3,3a-tetrahydro-3,5,8a-triaza cyclopenta[aJinden-8-one 3-(5-Chloro-4-methoxy-thiophene-3-carbony'I)-3a-(4-chloro-phenyl)- I ,2,3,3a-tetrahydro-3,5,8a-triaza cyclopenta[alinden-8-one 3-(5-FBromo-thiophene-2-carbonyl)-3a-(4-chloro-phenyl)- I .2,3,3a-tetrahydro-3,5,8a-triaza 30 cyclopenta[a linden-8-one 3-(5-Bromo-4-mcthoxy-thiophene-3-carbonyl)-3a-(4-chloro-phenyl)- I ,2,3,3a-tctrahydro-3 ,5.8a-triaza cyclopental alinden-8-one 3a-(4-Chloro-phenyl)-3-(5-methanesuI fonyl-thiophene-2-carbonyl )- I ,2,3,3a-tetrahydro-3,S,8a-triaza cyclopental aiinden-8-one 35 3a-(4-Chloro-phenyl)-3-15-(2-mcthyl-thiazol-4-yI)-thiophene-2-carbonyll- I ,2,3,3a-teirahydro-3,5,8a triaza-cyclopental alinden-8-one 3a-(4-Chloro-phenyl).3-(4-methoxy-thiophene-3-carbonyl)- I ,2,3,3a-tetrahydro-3,5,8a-triaza cyclopenta[a]inden-8-one 3a-(4-Chloro-phenyl)-3-(3-chloro-thiophene-2-carbonyl)- I ,2,3,3a-tetrahydro-3,5,8a-triaza 40 cyclopcntalalinden-8-one 2334232_2 (GHMatters) 9107/10 -110 3-(3-Chloro-4-methanesulIfony I-thiophene-2-carbonyl)-3a-(4-chloro-phenyl)- I ,2,3,3a-tctrahydro-3,5,8a triaza-cyc lopenta[ a] i nden- 8-one 3 a-(4-Ch loro-pheny l)-3 -(2-mcthyl-th iazol e-4-carbony 1)- 1,2,3,3 a-tetrahydro-3,5,8a-tri aza cyc Iope nta[aminden- 8-onc 5 3-(3-Bromo-thiophenc-2-carbonyl)-3a-(4-chloro-phenyl)- I ,2,3,3a-tetrahydro-3,5,8a-triaza cyciopental aJinden-8-one 3-([2,2']Bithiophenyl-5-carbonyl)-3a-(4-chloro-phenyl)-1I,2,3,3a-tctrahydro-3,5,8a-triaza cyclopentaialinden-8-one 3-(Benzo[b]thiophene-2-carbonyl)-3a-(4-chloro-phenyl)- I ,2,3,3a-tetrahydro-3,5,8a-triaza 10 cyclopenta[aJinden-8-one 3a-(4-Chloro-phenyl)-3-(isoxazole-5-carbonyl)- I ,2,3,3a-tetrahydro-3.5,8a-triaza-cyclopcntalinden-8 one 3a-(4-Chloro-phenyl)-3-(3-ethoxy-thiophene-2-carbonyl)- I ,2,3,3a-tetrahydro-3,5,8a-triaza cyclopentafalinden-8-onc 15 3-(3-Chloro-4-methyl-thiophene-2-carbonyl)-3a-(4-chloro-phenyl )- I ,2.3,3a-tetrahydro-3,5,8a-triaza cyclopental a inden-S-one 3a-(4-Chloro-phenyl)-3-(3-methyl-5-phenyl-isoxazolc-4-carbonyl)- I ,2,3,3a-tctrahydro-3,5,8a-triaza cyclopenta[alinden-8-one 6-I 3a-(4-Ch loro-phenyl )-8-oxo- I ,2,3a,8-tetrahydro-3 ,5,8a-triaza-cyclopenta[a] indenc-3-carbonylJ 20 nicotinic acid methyl ester 3a-(4-Chloro-phenyl)-3-(6-ch loro-pyridi ne-2-carbonyl)- 1,2,3 .3a-tetrahydro-3,5,8a-triaza cyclopenta[a]inden-8-one 3-(5-Chloro-2-methylsulfanyl-pyrimidine-4-earbonyl)-3a-(4-chloro-phenyl)- I ,2.3,3a-tetrahydro-3,5,8a triaza-cyclopenta~aj inden-8-one 25 3a-(4-Chloro-phenyl)-3-(pyridine-2-carbonyl )- 1,2,3 ,3 a-tetrah yd ro- 3,5,8a-tri aza-cyclIopen ta [a] inden -8-o ne 3a-(4-Chloro-phenyl)-3-(( 1,2,3 ithiadiazole-4-carbonyl)- I ,2,3,3a-tetrahydro-3,5,8a-triaza cyclopenta[a]inden-8-one 3a-(4-Chloro-phenyl)-3-(2-pyridin-4-yI-thiazole-4-carbonyl)- I ,2,3,3a-tetrahydro-3,5.8a-triaza cyclopenta[a]inden-8-one 30 3a-(4-Chloro-phenyl)-3-(4-methyl-2-pyrazin-2-yI-thiazolc-S-carbonyl )- I ,2.i3,3a-tetrahydro-3,5.8a-triaza cyclopentalalinden-8-one 3-(Benzofuran-2-carbonyl)-3a-(4-chloro-phenyl)- 1 ,2,3,3a-tetrahydro-3.5,8a-triaza-cyclopenta[ajinden-8 one 3-(Benzo[cjisoxazolc-3-carbonyl)-3a-(4-chloro-phenyl)- I ,2,3,3a-tetrahydro-3,5,8a-triaza 35 cyclopentalalinden-8-one 3a-(4-Chloro-phenyl)-3-(4,5-dichloro-isothiazole-3-carbonyl )* I,2,3,3a-tetrahydro-3,5,8a-triaza cyclopenta[alinden-8-one 3a-(4-Chloro-phenyl)-3-[5-(4-methoxy-phenyl)-oxazole-4-carbonyl]- 1 ,2,3,3a-tetrahydro-3,5,8a-triaza cyclopenta[a]inden-8-one 40 3a-(4-Chloro-phenyl)-3-(5-phenyl-oxazole-4-carbonyl)- 1 ,2,3,3a-tetrahydro-3,5,8a-triaza cyclopenta[alinden-8-one 2334232_2 (GHMetIO(3) 9/07/10 - III 3a-(4-Chloro-phenyl).3-(4-isopropyl-[ I ,2,3]thiadiazolc-5-carbonyl)- I ,2,3,3a-tetrahydro-3,5,8a-triaza cyclopenta[ajinden-8-one 3a-(4-Chloro-phenyl)-3-[3-(4-mcthoxy-phenyl)-isoxazole-5-carbonyl]- I ,2,3,3a-tetrahydro-3,5,8a-triaza cyclopenta~a]inden-8-one 5 3a-(4-Chloro-pheny!)-3-[3-(4-chloro-phenyl)-isoxazole-5-carbonyll- I ,2,3,3a-tetrahydro-3,5,8a-triaza cyclopental aJinden-8-one 3a-(4-Chloro-phenyl)-3-( I-methyl-3-tri fluoromethyl- I Fi-pyrazole-4-carbonyl)- I ,2,3,3a-tetrahydro-3,5,8a triaza-cyclopenta[ai inden-8-one 3a-(4-Chloro-phcnyl)-3-(4-methyl-2-pyridin-2-yI-thiazole-5-carbonyl)- 1 ,2,3,3a-tetrahydro-3,5,8a-triaza 10 cyclopenta[alinden-8-one 3a-(4-Chloro-phenyl)-3-(2-p-tolyl-thiazole-4-carbonyl)- 1,2,3 ,3a-tetrahydro-3,5,8a-triaza cyclopcnta[alinden-8-onc 3a-(4-Chloro-phenyl)-3-(4-methyl-2-thiophen-2-y-thiazole-5-carbonyl)- 1 ,2,3,3a-tetrahydro-3,5,8a triaza-cyc Iopenta[aJ inden-8-one 15 3a-(4-Chloro-phenyl)-3-12-(4-chloro-phenyl)-thiazole-4-carbonyll- I ,2,3,3a-tctrahydro-3.S.8a-triaza cyclopentalalinden-8-one 3a-(4.Chloro-phenyl)-3-(3-phenyl-isoxazolc-5-carboiyl )- I ,2,3,3a-tctrahydro-3,5,8a-triaza cyclopenta[aJinden-8-one 3a-(4-Chloro-phenyl)-3-(4-methyl-2-pyridin-3-yI-thiazole-5-carbonyl)- I ,2,3,3a-tetrahydro-3,S,8a-triaza 20 cyclopenta[ajinden-8-one 3-(2-Chloro-5-isopropyl-thiazole-4-carbonyl)-3a-(4-chloro-phenyl)- I ,2,3,3a-tetrahydro-3.5,8a-triaza cyclopental al inden-8-one 3a-(4-Chloro-phenyl)-3-[5-mcthyl- I -(4-nitro-phenyl )- I H-[! ,2,4ltriazole-3-carbonyll- I .2,3,3a-tetrahydro 3.5 ,8a-triaza-cyclopenta[aJ inden-8-one 25 3a-(4-Chloro-phenyl)-3-[2-(4-methoxy-phenyl)-thiazole-4-carbonyl]- I ,2,3,3a-tetrahydro-3,5,8a-triaza cyclopentafalinden-8-onc 3a-(4-Chloro-phenyl)-3-(4-methyl-2-phenyl-thiazole-5-carbonyl )- 1,2,3,3a-tetrahydro-3.5,8a-triaza cyclopental alinden-8-one 3a-(4-Chloro-phcnyl)-3-(5-mcthyl- I Hi-pyrazolc-3-carbonyl)- I ,2,3,3a-tetrahydro-3,5,8a-triaza 30 cyclopentalalindcn-8-onc 3a-(4-Chloro-phcnyl)-3-[3-(2-chloro-phcnyl)-isoxazolc-5-carbonyl]- I ,2,3,3a-tetrahydro-3.5,8a-triaza cyclopental ajinden-8-one 3a-(4-Chloro-phenyl)-3-(6-fluoro-pyridinc-3-carbonyl)-5-oxy- I ,2,3.3a-tetrahydro-3,5.8a-triaza cyclopentalalinden-8-onc 35 3a-(4-Chloro-phenyl)-3-(pyrimidine-5-carbonyl )- I ,2,3.3a-tetrahydro-3,5,8a-triaza-cyclopenta[aJinden-8 one 3a-(4-Chloro-phenyl)-5-oxy-3-I 2-( I -oxy-pyridin-3-yI)-thiazolc-4-carbonylJ- I ,2,3,3a-tetrahydro-3.5,8a triaza-cyclopental ajinden-8-one 3a-(4-Chloro-phenyl)-3-(thiazole-4-carbonyl)- I .2,3,3a-tetrahvdro-3,5,8a-triaza-cyclopentalalinden-8-one 40 3a-(4-Chloro-phenyl)-3-(4-methyl-furazan-3-carbonyl)- I ,2,3,3a-tetrahydro-3,5,8a-triaza cyclopcnta[alinden-8-one 3a-(4-Chloro-phenyl)-3-(5-isobutyl-isoxazole-3-carbonyl)- I ,2,3.3a-tetrahydro-3,5,8a-triaza cyclopenta[alinden-8-one 23342322 (GHMatters) 9/07/10 -112 3 a-(4-ChlIoro-phcnyl)-3 -(5- isopropyl-2-phenyl -2 H-pyrazole-3 -carbon yl)- I ,2,3,3a-tetrahydro-3,5,8a triaza-cyclopenta[alinden-8-one 3a-(4-Chloro-phenyl)-3-(5-f'uran-2-yI-isoxazole-3-carbonyl )- I ,2,3,3a-tetrahydro-3,5.8a-triaza cyclopcntalaiinden-8-one 5 3a-(4-Chloro-phcnyl)-3-(4,5,.6,7-tetrahydro-bcnzo[djisoxazolc-3-carbonyl)- I ,2,3,3a-tetrahydro-3,5,8a triaza-cyciopental a] inden-8-one 3a-(4-Chloro-phenyl)-3-(5-pyrazol- I -ylmethyl-furan-2-carbonyl)- I ,2,3,3a-tctrahydro-3.5,8a-triaza cyclopentalalinden-8-one 3a-(4-Chioro-phcnyl)-3-[5-(4-chloro-phenyl)-isoxazole-3-carbony I-I ,2.3,3a-tetrahydro-3.5.8a-triaza 10 cyclopentajalinden-8-one 3a-(4-Chloro-phcnyl)-3-(5-phenyl-isoxazole-3-carbonyl)- I ,2,3,3a-tctrahydro-3,5,8a-triaza cyclopenta[alinden-8-one 3-(5-tert-Butyl-2-phcnyl-2H-pyrazolc-3-carbonyl)-3a-(4-chloro-phnyl)- I ,2,3,3a-tetrahydro-3,5,8a triaza-cyclopenta[ajinden-8-one 15 3a-(4-Chloro-phenyl)-3-(4-fluoro-bcnzyl)- I ,2,3,3a-tetrahydro-3,5,8a-triaza-cyclopcnta[ajinden-8-one 3a-(4-Chloro-phenyl)-3-furan-2-ylmethyl- I ,2,3,3a-tetrahydro-3,5,8a-triaza-cyclopcnta[ajinden-8-onc 3-Butyl-3a-(4-chloro-phcny! )- I ,2,3,3a-tetrahydro-3,5,8a-triaza-cyclopcnta[aJ inden-8-onc 3a-(4-Chloro-phcnyl)-3-pyridin-3-ylmethyl- I ,2,3,3a-tctrahydro-3,5,8a-triaza-cyclopental a linden-8-one 3a-(4-Chloro-phenyl)-8-oxo-1I,2,3a,8-tetrahydro-3,5,8a-triaza-cyclopcntal alindcnc-3-carboxvl ic acid 20 benzylamide 3a-(4-Chloro-phenyl)-8-oxo- I ,2,3a,8-tctrahydro-3,5,8a-triaza-cyclopcntal alindcnc-3-carboxylic acid phenylamide 3a-(4-Chloro-phcnyl)-8-oxo- I ,2,3a,8-tetrahydro-3,5,8a-triaza-cyclopenta[ajindene-3-carbothioic acid bcnzylamide 25 3a-(4-Chloro-phenyl)-8-oxo- I ,2,3a,8-tetrahydro-3,5,8a-triaza-cyclopenta[alindene-3-carbothioic acid phenylamide 3a-(4-Chloro-phenyl)-3-(toluene-4-sul fonyl)-1I,2,3,3a-tetrahydro-3,5,8a-triaza-cyclopenta[alinden-8-one 9b-(4-Chloro-phenyl)- I -(4-fluoro-bcnzoyl)- I ,2,3,9b-tetrahydro-imidazo[2, I -alisoindol-5-one; I -Benzoyl-9b-(4-chloro-phcnyl)- I ,2,3,9b-Letrahydro-imidazo[2, I -alisoindol-5-one; 30 9b-(4-Chloro-phenyl)-5-oxo-2,3,5,9b-tetrahydro-imidazo[2, I-alisoindole- I-carboxylic acid phenylamnide; 9b-(4-Chloro-phenyl)-5-oxo-2,3,5,9b-tctrahydro-imidazo[2,1I-ajisoindoic-lI-carboxylic acid benzylamide; 9b-(4-Chloro-phenyl)- I-propionyl-1I 2,3,9b-tctrahydro-imidazol 2,! -alisoindol-5-one; I -Iutyryl-9b-(4-chloro-phenyl)-1I,2,3,9b-tetrahydro-imidazo[2, I-ajisoindol-5-onc; 9b-(4-Chloro-phenyl)- I-heptanoyl-1I,2,3,9b-tctrahydro-imidazo[2,1I-ajisoindol-5-one; 35 9b-(4-Chloro-phenyl)-lI-decanoyl-1I,2,3,9b-tetrahydro-imidazo[2, I-aJisoindol-5-one; 9b-(4-C hlIoro-phcnylI)- I -(2,2,2-tri fl uoro-acetyl)- I ,2,3,9b-tetrahydro- imi cazol 2,1 )-a] isoi ndol -5 -one; I -(2-Chloro-acetyl)-9b-(4-chloro-phenyl)-1I,2,3,9b-tetrahydro-imidazo[2,1I-alisoindol-5-one; 9b-(4-Chloro-phenyl)- I-hexadecanoyl-1I,2,3,9b-tetrahydro-imidazol 2,1 -alisoindol-5-one; I -I3cnzyl1-9b-(4-chloro-phcnyl)-1I,2,3,9b-tctrahydro-imidazo 2.1 -a jisoi ndol-5-one; 40 1 -BenzylI-9b-phcny I ,2,3,9b-tetrahydro- im idazo[2, I -a] isoi ndol -5-one; I -Ienzyl-9b-p-tolyI-1I,2,3,9b-tetrahydro-imidazo[2,1I-ajisoindol-5-one; 23342322 (GHMatters) 9/07/10 -113 9b-(4-Chloro-pheny!)- I -(4-methyl-bcnzyl )- 1 ,2,3,9b-tetrahydro-imidazol 2,1I -a]lisoindol-5-one; I -(4-MethyI-benzyl)-9b-phcnyl- I ,2,3,9b-tetrahydro-imidazo 12. 1-a jisoindol-5-one; I -(4-Methyl-benzyl)-9b-p-tolyl I ,2,3,9b-tetrahydro-imidazol2, I1-a jisoindol-5-one; I -(4-Chloro-benzyl)-9b-phcnyl- I ,2,3,9b-tetrahydro-imidazo[2, I -a jisoindol-5 -one; 5 I -(4-ChlIoro-bcnzyl)-9b-(4-chloro-phenyl)- I ,2,3,9b-tetrahydro-imidazo[2, I -a] isoindol-5-one; 1 -(4-ChlIoro-bcnzyl)-9b-p-tolIyl- 1 .2,3,9b-tetrahydro-imidazot2, I -a] isoindol-5-one; 9b-(4-Ch Ioro-phenyl)- I -(4-fluoro-benzyl)- 1 ,2,3,9b-tetrahydro-imidazo[2, I -a] isoindol-5-one; 1 -(4-FlI uoro-bcnzyl)-9b-phenyl- I ,2,3,9b-tetrahydro-imidazo[2, I -a] isoindol-5-one; I -(4-F'luoro-benzyl)-9b-p-totyI- I ,2,3,9b-tetrahydro-imidazo[2, I -a] isoindol-5-one; 10 1 -Benzyl- I Ob-(4-chloro-phenyl)- 1,3,4, I Ob-tetrahydro-21-l-pyrimido[2, I -a] isoindol-6-one; I -Benzyl- I Ob-phenyl- 1,3,4.,1 Ob-tctrahydro-211-pyrimi do[ 2, 1 -a] isoindol-6-one; I -Ben zyl- I Ob-p-tolylI- 1,3,4, 1 Ob-tetrahydro-2Hi-pyrim idol[2, 1 -a] isoindol-6-one; I Ob-(4-ChlIoro-phenyl)- I -(4-fluoro-bcnzyl)- 1,3,4, 1 Ob-tetrahydro-21-I-pyrimido[2, I -a] isoindol-6-one; I -(4-Fluoro-benzyl)- I Ob-phenyl- 1,3,4, 1 Ob-tetrahydro-21 I-pyrimido[2, 1 -ajisoindol-6-onc; 15 1 -(4-Fluoro-benzyl)- I Ob-p-tolyl- 1,3,4, 1 Ob-tetrahydro-2H-pyrimido[2, 1 -a jisoindol-6-one; I -(4-Bromo-benzoyl)-9b-(4-chloro-phenyl)- I ,2,3,9b-tetrahydro-imidazo[2, ] -a] isoindol-5-onc; 9b-(4-Chloro-phenyl)- I -(4-iodo-benzoyl)- I ,2,3,9b-tetrahydro-imidazo[2, I -a] isoindol-5-onc; I -(4-ChlIoro-benzyl)- I Ob-(4-chloro-phenyl)- 1,3,4, 1 Ob-tetrahydro-2F1-pyrimi do[l2, 1 -ajIi so indol-6-one; I I b-(4-ChlIoro-phenyl)-1I-(4-fluoro-benzyl)- 1,2,3,4.5,1 I b-hexahydro-I I 1,3 idiazepinol 2, I -a] isoindol-7-one; 20 I -(4-Fluoro-benzyl )-l IIb-phenyl- 1,2,3,4,5,11 b-hexahydro-[1I,3 jdiazepino[2, I-ajisoindol-7-one; I -(4-Fluoro-benzyl)-I lb-p-to!'!- 1,2,3,4,5,11 b-hexahydro-I I ,31diazepinot2, I-a]isoindol-7-one; I -(4-Bromo-benzyl)- IOb-(4-chloro-phcnyl)- 1,3,4,1 Ob-tetrahydro-2H-pyrimido[2,1I-a]isoindol-6-one; I Ob-(4-ChlIoro-phenylI)- I -(4-m ethyl- bcnzyl1)- 1,3,4. 1 Ob-tetrahydro-211-pyri mido[2, I -a] iso indol -6-one: I -(4-Chloro-benzoyl)-9h-(4-chloro-phcnyl)-1I,2,3,9b-tetrahydro-imidazol2,1I-alisoindol-5-onc; 25 9b-(4-Chloro-phenyl)- I-(4-mcthyl-benzoyl)- I,2,3,9b-tctrahydro-imidazo[2,1I-alisoindol-5-one; 9b-(4-Chloro-phcnyl)- I -(4-methoxy-benzoyl)- I ,2,3,9b-tetrahydro-imidazo[2, I -alisoindol-5-one; 9b-(4-Chloro-phcnyl)- I -(4-trit'Iuoromcthoxy-bcnzoyl)- I ,2,3,9b-tetrahydro-imidazo[2, I -alisoindol-5-one; 9b-(4-Chloro-phenyl)- I -(4-trifluoromethyl-bcnzoyl)- I ,2,3,9b-tetrahydro-imidazo[2, I -ajisoindol-5-one; I -(4-IBcnzyloxy-benzoyl)-9b-(4-chloro-phenyl )- I ,2,3,9b-tetrahydro-imidazo[2, I -a] isoindol-5-onc; 30 9b-(4-Chloro-phenyl)- I -(4-phenoxy-benzoyl)- I ,2,3,9b-tetrahydro-imidazo[2, I -alisoindol-5-one; 9b-(4-Chloro-phcnyl)- I -(2,4,6-trimethyl-benzoyl)- I ,2,3,9b-tctrahydro-imidazo[2, I -alisoindol-5-one; I I b-(4-Chloro-phenyl)-1I-(4-fluoro-benzoyl)- 1,2,3,4,5,1 I b- hexahydro-[ 1,3ldiazepino[2,1 -alisoindol-7 one; 9b-(4-Chloro-phcnyl)- I -(toluene-4-sul fonyl)- I ,2,3,9b-tetrahydro-imidazol2, I -alisoindol-5-one; 35 9b-(4-Chloro-phenyl)- I -(pyridinc-4-carbonyl)- I ,2,3,9b-tetrahydro-imidazol 2.1 -a Iisoindol-5-one: I -(4-Fl uoro-benzoyl)-9b-phcnyl- I.2,3,9b-tctrahydro-imidazo[2, I -ajisoindol-5-one; I -(4-Fluoro-bcnzoyl)-9b-p-tolyl- I ,2,3,9b-tetrahydro-imidazol 2, 1 -ajisoindol-5-one; 9b-(4-Chloro-phenyl)- I -[5-(3-nitro-phenyl )-furan-2-ylmcthyl I-I ,2,3,9b-tetrahydro-imidazol 2, 1 a jisoindol-5-one; 2334232_2 (GHMatter3) 9107110 -114 9b-(4-Chloro-phenyl)- 1 -(2-p-tolyl-acetyl)- I ,2,3,9b-tetrahydro-imidazo[2, 1 -alisoindol-5-one; 9b-p-Tolyl- I -(2-p-tolyl-acetyl)- I ,2,3.9b-tetrahydro-imidazot2. I -alisoindol-5-one; 11 2-(4-Mcthoxy-phenyI )-acetyl J-9b-p-tol yl- I ,2,3,9b-tctrahydro-imidazo[2, I -ajisoindol-5-one; 9b-(4-Chioro-phcnyl)- 1 -1 2-(4-methoxy-phenyl)-acetyl]- 1,2,3 ,9b-tetrahydro-imidazol 2, 1 -aJisoindol-5 5 one; I -[2-(4-Chloro-phenyl)-acetyl ]-9b-p-tolyI- I ,2,3,9b-tetrahydro-imidazol 2,!1 -alisoindol-5-one; 9b-(4-Chloro-phenyl)- I -[2-(4-chloro-phenyl)-acctylJ- I ,2,3,9b-tctrahydro-imidazo[2, I -alisoindol-5-one; 1 -[2-(4-Nitro-phenyl)-acety J-9b-p-tolyl- I ,2,3,9b-tctrahydro-imidazof 2,1I -alisoindol-5-one; 9b-(4-Chioro-phenyl)- I -12-(4-nitro-phcnyl)-acetyll- I ,2,3,9b-tctrahydro-imidazo[2, I -a]isoindol-5-one; 10 I- -2-(4-1Fluoro-phenyl)-acetyl]-9b-p-tolyl- I .2,3,9b-tctrahydro-imidazo[2, I -a]isoindol-5-one; 9b-(4-Chloro-phenyl)- I -[2-(4-fluoro-phenyl)-acctyl]- I ,2,3,9b-tctrahydro-imidazo[2, I -ajisoindol-5-one: I -[(E)-(3-Phenyl-acryloyl)I-9b-p-tolyl- I ,2,3,9b-tctrahydro-imidazo[2, I -alisoindoI-5-one; 9b-(4-Chloro-phenyl)- I -[E)-(3-phcnyl-acryloyl)] I ,2,3,9b-tetrahydro-imidazo[2, I -alisoindol-5-one; I -(5-Phenyl-pentanoyl)-9b-p-tolyl- I ,2,3,9b-tetrahydro-imidazol 2, 1 -aJisoindol-5-one; 15 9b-(4-Chloro-phenyl)- I -(5-phenyl-pentanoyl)- I ,2,3,9b-tetrahydro-imidazo[2, I -a] isoindol-5-onc; I -(4--Iuoro-benzoyl)-9b-pyridin-3-y- I ,2,3,9b-tetrahydro-imidazo[2, I -alisoindol-5-one; I -(4-Fluoro-benzoyl)-9b-pyridin-2-yI- 1 ,2,3,9b-tctrahydro-imidazo[2, I -alisoindoI-5-onc; 5-Oxo-9b-p-tolyl-2,3,5,9b-tetrahydro-imidazo[2,]I-ajisoindole-1I-carboxylic acid phenylamide; 5-Oxo-9b-p-tolyl-2,3,5,9b-tetrahydro-imidazo[2, 1 -alisoindlole- I -carboxylic acid benzylamide; 20 5-Oxo-9b-p-tolyl-2,3,5,9b-tetrahydro-imidazo[2, I-a jisoindole-lI-carboxylic acid 4-bromo-benzylamide, 9b-(4-Chloro-phenyl)-5-oxo-2,3,5,9b-tetrahydro-imidazo 2.1-al isoindole-lI-carboxylic acid 4-bromo bcnzylamnice; 9b-(4-Chloro-phenyl)-5-oxo-2,3,5,9b-tetrahydro-imidazol 2,1-alisoindole- I-carboxylic acid (4-methoxy phenyl)-amide; 25 5-Oxo-9b-p-tolyl-2,3.5,9b-tetrahydro-imidazo[2, I -ajisoindoic- I -carboxylic acid (4-methoxy-phenyl) amnide; 9b-(4-Chloro-phenyl )-5-oxo-2,3,5.9b-tetrahydro-imidazol2, I -alisoindole- I -carboxylic acid 4-Iluoro benzylanic; 5-Oxo-9b-p-tolyl-2,3,5,9b-tetrahydro-imidazo[2, I -alisoindole- I -carboxylic acid 4-fluoro-bcnzylamide; 30 9b-(4-Chloro-phenyl)-5-oxo-2,3,5.9b-tctrahydro-imidazol2, I -a]isoindole- I -carboxylic acid 4-methyl benzylamide; 9b-(4-Chloro-phcnyl)- I -furan-2-ylmethyl- 1 ,2,3,9b-tetrahydro-imidazot2, I -a]isoindol-5-one; I -Benzothiazol-2-yI-9b-(4-chloro-phenyl)- I ,2,3,9b-tetrahydro-im idazol 2, 1 -alisoindol-5-onc; I -( I li-Benzoimidazole-5-carbonyl)-9b-(4-chloro-phenyl)- I ,2,3,9b-tetrahydro-imidazo[2, I -alisoindoi-5 35 one; 9b-(2-Bromo-phcnyl)- I -(4-fluoro-benzoyl)- I ,2,3,9b-tetrahydro-imidazof2, I -ajisoindol-5-one; 9b-(3-Bromo-phenyl)- 1 -(4-lluoro-benzoyl)- I ,2,3,9b-tetrahydro-imidazof 2, 1 -alisoindol-5-one; I -(4-Fluoro-benzoyl)-9b-thiophen-2-yI- I ,2,3,9b-tetrahydro-imidazol2, 1I-a jisoindol-5-one;. I -(4-Fl uoro-benzoyl )-9b-(3-nitro-phenyl)- I ,2,3,9b-tetrahydro-imidazol 2 1 -a jisoindol-5-one; 23342322 (GHmatters) 9107110 -115 I -(4-Fluoro-benzoyl)-9b-(4'-methyl-biphcnyl-4-yI)- 1 ,2,3,9b-tetrahydro-imidazo[2, I -a] isoindolI-5-one; 8-Bromo-9b-(4-chloro-phenyl)- I -(4-fluoro-benzoyl)- I ,2,3,9b-tetrahydro-imidazol 2,1I -ajIisoindol-5-one; 9b-(4-Chloro-phenyl)- 1 -(4-fl uoro-bcnzoyl)-8-(3-tri fluoromethyl-phenyl)- I ,2,3,9b-tetrahydro imidazol2, I -a] isoindol-5-onc; 5 1 -Acetyl-9b-(4-chloro-phenyl)- I ,2,3,9b-tetrahydro-imidazo[2, I -a] isoindol-5-one; I .Propionyl-9b-p-tolyl- I ,2,3,9b-tetrahydro-imidazo[2, 1 -aiisoindol-5-onc; 9b-Phenyl- I -propionyl-1I,2,3,9b-tetrahydro-imidazof 2,1I -a i so indol-5-one; 9b-Phenethyl- I -propionyl- 1 ,2,3,9b-tetrahydro-imidazol2, I -a] isoindol-5-one; N-[3-( I-Butyryl-5-oxo-2,23-dihydro- I1 hI,51--imidazo[2, I -a] isoindol-9b-yi)-phcnyl 1-butyramide; 10 2-(4-Methoxy-phenyI)-N-(3-j I -[2-(4-mcthoxy-phenyl)-acetylJ-5-oxo-2.3-dihydro- I H ,51-i-imidazo[2. I ajisoindol-9b-yI Fphenyl)-acetamide. 9b-(3-Chloro-phenyl)- I -propionyl- I ,2,3,9b-tetrahydro-imidazol 2, I -alisoindol-5-one; Propionic acid 3-(5-oxo-lI-propionyl-2.3-dihvdro- I H ,51i-imidazot 2.1-a Iisoindol-9b-yI )-phenyl ester. 9b-( 3-Hydroxy-phcnyl)-lI-propionyl- 1,2,3,9b-tetrahydro-imidazo[2,1I-alisoindol-5-one; 15 9b-(4-Chloro-phenyl)- I -(4-fluoro-benzoyl)-8-pyridin-4-y- I ,2,3,9b-tetrahydro-imidazol2, I -alisoindol-5 one; N-[3-( I-Acetyl-5-oxo-2,3-dihydro- I I-1,5F-imidazol2, I -a]isoindol-9b-yI)-phenyl]-acetamide; 9b-(3-Chloro-phenyl)- I -(4-fluoro-benzoyl)- I ,2,3,9b-tctrahydro-imidazo[2, 1 -a]isoindol-5-onc; 9b-(4-Butyl-phenyl)- I -(4-fluoro-bcnzoyl)- I ,2,3,9b-tetrahydro-imidazo[2, I -aJisoindol-5-one; 20 9b-(4-Butyl-phenyl)- I -[2-(4-methoxy-phenyl)-acetyl]- I ,2,3,9b-tetrahydro-imidazo[2, I -a]isoindol-5-onc; 9b-[4-((S)-4-Benzyl-2-oxo-oxazolidin-3-yI)-phenyl I-I -(4-fluoro-benzoyl)- I ,2,3,9b-tetrahydro imidazol 2, 1 -ajisoindol-5-one; 4b-(4-Chloro-phenyl)-5-(4-fluoro-benzyl)-4b, 5,5a,6,7,8,9,9a-octahydro-benzo[4,5 jimidazol 2, 1 alisoindol-I 1-one; 25 4b-(4-Chloro-phenyI)-5-(4-fluoro-benzoyl)-4b,5,5a,6.7,8,9,9a-octahydro-benzo[4.5]imidazo[2.1I ajisoindol- I 1 -one; (2S,3S)-2.3-Diacetoxy-4-I(R)-9b-(4-chloro-phenyl)-5-oxo-2,35,9b-tetrahydro-imidazol 2,1 -ajisoindol-lI yIj-4-oxo-butyric acid; (2S,3S)-2,3-Diacetoxy-4-((S)-9b-(4-chloro-phenyl)-5-oxo-2,3,5,9b-tetrahydro-iniidazo[2,1I-a]isoindol-lI 30 yl 1-4-oxo-butyric acid; 5-Oxo-9b-p-tolyl-2,3,5,9b-tetrahydro-imidazo[2 1 -alisoindole- I-carboxylic acid 4-methyl-benzylamide; 5-Oxo-9b-p-tolyl-2,3,5,9b-tetrahydro-imidazo[2,1I-alisoindole- I-carboxylic acid 4-mcthoxy benzylamide; 9b-(4-Chloro-phenyl)-5-oxo-2,3,5,9b-tetrahydro-imidazo[2 I-a] isoindole-lI-carboxyl ic acid 4-methoxy 35 benzylIamide; 9b-(4-Chloro-phenyl)-5-oxo-2,3,5,9b-tetrahydro-imidazol2, I-a] isoindole- I-carbothioic acid benzyiamide; 5-Oxo-9b-p-tolyl-2,3,5,9b-tetrahydro-imidazo[2, I-a jisoindoic- I-carbothioic acid benzylamide; 9b-(4-Chloro-phenyl)- I-(isoxazole-5-carbonyl)-1I,2,3,9b-tetrahydro-imidazo[2,1I alisoindol-5-one; 23342322 (GHMatters) 9/07/10 -116 9b-(4-Chloro-phcnyl)- 1 -(4-methyl-[ I ,2,3]thi ad iazole-5-carbonyl)- I ,2,3,9b-tetrahydro-imidazo[2, I a jisoindol-5-onc; 9b-(4-ChlIoro-phenyl)- 1 -(5-methyl-isoxazole-3-carbonyl)- 1,2,3.9b-tetrahydro-imidazo[2, 1 -a] isoindol-5 one; 5 8-IButy I-9b-(4-chloro-phenyl)- 1-(4-fluoro-benzoyl)- I ,2,3,9b-tetrahydro-imidazo[2, I -a] isoindol-5 -one; 9b-(4-Chloro-phenyl)- I -(4-fluoro-benzoyl)-8-p-tolyl- I ,2,3,9b-tetrahydro-imidazo[2, 1 -a] isoindol-5 -one; 9b-(4-Chloro-phenyl)- 1 -(2-mcthyl-thiazole-4-carbonyl)- 1 ,2,3,9b-tetrahydro-imidazo[2, 1 -ajisoindol-5 one; I -(4-FlIuoro-benzoyl)-9b-(3-hydroxy-phenyl)- 1 ,2,3,9b-tctrahydro-imidazo[2, I -a] isoindol-5-one; 10 9b-(4-Ethyl-phenyl)- I -[2-(4-methoxy-phenyl)-acetyl]- I ,2,3,9b-tetrahydro-imidazo[2, 1 -a Ijisoindol-5-one; 9b-(4-Ethyl-phenyl)- I -(4-fluoro-bcnzoyl)- I ,2,3,9b-tctrahydro-imidazol2, I -a] isoindol-5-one; 9b-(4-Ethy I-phenyl)- I -propionyl- I ,2,3,9b-tctrahydro-imidazol 2, 1-a] isoindol-5-one; 9b-(4-Mcthoxy-phenyl)- I -propionyl- I ,2,3,9b-tetrahydro-imidazo[2, I -ajIisoindol-5-one; I -(4-1Fluoro-benzoyl)-9b-(4-methoxy-phenyl)- I ,2,3,9b-tetrahydro-imidazoj 2,1I-a I isoindo I-5-one; 15 9b-(4-Methoxy-phcnyl)- 1 -1 2-(4-methoxy-phenyl)-acetyl I ,2.3,9b- tetra hydro-imidazol 2,1I-a Ijisoindol1-S one; N-I 9b-(4-Ch Ioro-phenyl)- I -(4-Iluoro-bcnzoyl)-5-oxo-2,3,5,9b-tctrahydro- I H-imidazo[2, I -a] isoindol-6 yiJ-butyramide; N-19b-(4Chloro-phenyl)-5-oxo- I -propionyl-2,3,5,9b-tctrahydro- I H-imidazol2, 1 -a] isoindol-6-yI] 20 butyramide; 4-19b-(4-Chloro-phenyl)-5-oxo-2,3,5,9b-tetrahydro-imidazo[2, I -a]jisoindol- I -yI]-4-oxo-butyramide; 1 -Propionyl-9b-(4-propyl-phenyl)- I ,2,3,9b-tetrahydro-imidazo[2, I -ajisoindol-S-onc; I -(4-Fluoro-benzoyl)-9b-(4-propyl-phenyl)- 1 ,2,3,9b-tetrahydro-imidazo[2, I -a]isoindol-5-one; I -12-(4-Methoxy-phenyl)-acctyl ]-9b-(4-propyl-phenyl)- I ,2,3,9b-tctrahvdro-imidazo[2, I -alisoindol-5 25 one; 9b-(4-Isopropyl-phcnyl)- I -propionyl- I ,2,3,9b-tetrahydro-imidazo[2, I -a~isoindol-5-one. 1 -(4-1-luoro-benzoyl)-9b-(4-isopropyl-phenyl)- I ,2,3.9b-tetrahydro-imidazol 2, 1 -ajisoindol-5-one. 9b-(4-Isopropyl-phenyl)- I -[2-(4-methoxy-plienyI)-acctyI]- I ,2,3.9b-tetrahydro-imidazoj 2, 1 -ajlisoindol-5 one; 30 9b-(4-Chloro-phenyl)- 1 -(2-pyridin-3-yl-thiazole-4-carbonyl )- I ,2,3,9b-tctrahydro-imidazo[2, I -alisoindol 5-onc; 9b-(4-Chloro-phenyl)- 1 -(4-[1,2,4 Jtriazol- I -yI-benzoyl)- I ,2,3,9b-tetrahydro-imidazo[2, I -alisoindol-5-one; 9b-(4-Chloro-phenyl)- I -(6-morpholin-4-yI-pyridinc-3-carbonyl)- I ,2,3,9b-tetrahydro-imidazo[2, I alisoindol-5-one; 35 9b-(4-Chloro-phenyl)- I -(2-cthyl-5-mcthyl-2H-pyrazolc-3-carbonyl)- I ,2,3,9b-tetrahydro-imidazo[2, I alisoindol-5 -one; IBenzo[c Jisoxazole-3-carboxyl ic acid I 3-(5-oxo-2,3-dihydro-1I -I ,51--imidazol 2,1-a jisoindol-9b-yI) phenyll-amide; 2334232_2 (GHMatters) 9107/10 -117 4-FlIuoro-N-{ 3-LI -(4-tluoro-benzoyl)-5-oxo-2,3-dihydro- I H,51--imidazo[2, 1 -a] isoindol-9b-yI]-phenyl } benzamide; 9b-(4-Chloro-phcnyl)- I -[3-(4-mcthoxy-phenyl)-propionylJ I -,2,3,9b-tctrahydro-imidazol2, 1 -a Iisoindol-5 one; 5 1 -(Benzo[ I ,3]dioxole-S-carbonyl)-9b-(4-chloro-phenyl)- I ,2,3,9b-tctrahydro-imidazo[2, I -a Iisoindol-5 one; I -(5-AcetylI-thiophenc-2-carbonyl)-9b-(4-chlIoro-phenyl)- I ,2,3,9b-tetrahydro-imidazo[2, I -a] isoindol-5 one; 9b-(4-Chloro-phenyl)- 1 -(3-methyl-butyryl)- 1 ,2,3,9b-tetrahydro-imidazo[2, I -a Iisoindol-5-one; 10 9b-(4-ChlIoro-phenyl)- I-1 2-(4-rnethyl-cyclIohexyl)-acetylJ- 1 ,2,3,9b-tetrahydro-imidazo[2, I -a] isoindol-5 one; 9b-(4-ChlIoro-phenyl)- I -(2-cyc Iopentyl-acetyl)-1I,2,3,9b-tetrahydro-imidazo[2, I -a] iso indoI-5-one; I -(2-IBenzylIsul fanylI-acetyl)-9b-(4-chloro-phenyl)- I .2,3,9b-tetrahydro-imidazol 2.1I -a Iisoi ndol-5-one; I -(Bicyclo[4.2.O]octa- I (6),2,4-triene-7-carbonyl)-9b-(4-chlIoro-phenyl)- I ,2,3,9b-tctrahydro-imidazo[2, I 15 ajisoindol-5-one; 9b-(4-ChlIoro-phenyl)- 1 -(furan-2-carbonyl)- I ,2,3,9b-tetrahydro-imidazol 2,1I-a I isoindol-5-one; 9b-(4-Chloro-phenyl)- 1 -cyclobutanecarbonyl- 1 ,2,3,9b-tetrahydro-imidazo[2, I -a Iisoindol-5-one; 9b-(4-Ch Ioro-phenyl)- 1 -cyclopropanecarbonyl- I ,2,3,9b-tetrahydro-imidazo[2, I -a] isoindol-S-onc;. 9b-(4-Ch Ioro-phenyl)- I -(tetrahydro-turan-3-carbonyl)- I ,2,3,9b-tetrahydro-imidazo[2, I -a]jisoindol-5-one: 20 9b-(4-Chloro-phcnyl)- I -(3-phcnoxy-propionyl)- I ,2,3,9b-tctrahydro-imidazo[2, I -ajisoindol-5-one; 9b-(4-Chloro-phcnyl)- I -(thiophene-2-carbonyl)- I ,2,3,9b-tetrahydro-imidazo[2, 1 -a~isoindol-5-one; 9b-(4-Chloro-phenyl)- 1 -(3,3 -d iphenylI-prop ionyl)- I ,2,3,9b-tetrahydro-imidazo[2, I -alisoindol-5-one; 9b-(4-Chloro-phenyl)- 1 -(2-methoxy-acetyl)- I ,2,3,9b-tctrahydro-imidazo[2, 1 -a]isoindol-5-one; 9b-(4-Chloro-phenyl)- I -(4-phenyl-butyryl)- 1 ,2,3,9b-tetrahydro-imidazo[2, I -a]isoindol-5-onc; 25 9b-(4-Chloro-phcnyl)- 1]-(4-1 I-I-indol-3-yI-butyryl)- 1 ,2,3,9b-tetrahydro-imidazo[2, I -alisoindol-5-onc; 9b-(4-Chloro-phenyl)- I -[2-(2-mcthoxy-cthoxy)-acetyll- I ,2,3,9b-tetrahydro-imidazo[2, I -ajisoindol-5 one; 9b-(4-Chloro-phenyl)- 1 -(pyridine-3-carbonyl)- I ,2,3,9b-tetrahydro-imidazol 2, 1 -a lisoindol-5-one; I -(4-Fluoro-benzoyl)-9b-(4-fl uoro-phenyl )- 1 ,2,3,9b-tetrahydro-imidazol 2, 1 -a lisoindol-5-one, 30 9b-(4-I:Iuoro-pheny)- I-1 2-(4-methoxy-phenyl )-acctyl I-I ,2,3,9b-tctrahydro-imidazol2. I -a lisoindol-5-one; 9b-(4-Fluoro-phenyl)- I -propionyl- I ,2,3,9b-tctrahydro-imidazol 2. 1 -a Iisoindol-5-one; 9b-(4-Bromo-phenyl)- 1 -(4-tluoro-bcnzoyl)- I .2,3,9b-tetrahydro-imidazo[2, I -a]isoi ndol-5-onc; 9b-(4-Bromo-phenyl)- 1 -[2-(4-methoxy-phenyl )-acctyl l-I ,2,3,9b-tetrahydro-imidazo[2, I -a jisoindol-5 one; 35 9b-(4-Bromo-phenyl)- I -propionyl- I ,2,3,9b-tctrahydro-imidazo[2, I -alisoindol-5-one; 4-Fluoro-benzoic acid 4-[ I-(4-tluoro-benzoyl )-5-oxo-2,3-dihydro- IH,5H-imidazo[2, 1-a Iisoindol-9b-yI I phenyl ester-, I -(4-Fl uoro-benzoyl )-9b-[4-(2-mcthoxy-ethoxy)-phenylJ-1I,2,3,9b-tetrahydro-imidazol 2,1 -a]isoindol-5 one; 23342322 (GHMatters) 9107/10 -118 -[I--Fuoro-bcnzoyl)-5-oxo-2,3-dihydro- I FH,51--imidazo[2, I -a] isoindol-9b-yl 1-phenoxy) acetonitrile; 3-1 1-(44-1luoro-bcnzoyl)-5-oxo-2,3-dihydro- I1 -,51--imidazol 2,1I -a Iisoindol-9b-yI -phenoxy) aceton itri le; 5 3-[9b-(4-ChlIoro-phcnyl)-5-oxo-2,3,5,9b-tetrahydro-imidazo12, 1]-a] isoindol- 1 -yI]-3-oxo-propi on itrilIe; 1 -12-(3-IBromo-phenyl)-acetylIl-9b-(4-chloro-phenyl)- I ,2,3,9b-tetrahydro-imidazot2, I -a] isoindol-5-one; 9b-(4-ChlIoro-phenyl)- I -([I ,2,3]thiadiazole-4-carbonyl)- 1 ,2,3,9b-tctrahydro-imidazo[2, I -a] isoindol-5 onc; 9b-(4-Chloro-phenyl)- 1 -(2- 1 H -indol-3-yi-acetyl)- I ,2,3,9b-tetrahydro-imidazo[2, 1 -a] isoindol-5-one: 10 9b-(4-Chloro-phenyl)- I -(2,3-dihydro-benzo[ I ,4Jdioxinc-5-carbonyl)- 1 ,2,3,9b-tetrahydro-imidazo[2, I1 ajisoindol-5-one; N-( 2-I 9b-(4-ChlIoro-phenyl)-5-oxo-2.3.5,9b-tetrahydro-imidazol2, I -a] isoindol- I -y I -2-oxo-ethy'I I acetam ide; 9b-(4-ChlIoro-phcnyl )- I -(2-cyclIohexyl-acetyl)- I ,2,3.,9b-tetrahydro-imidazo[2, I -a] isoindoI1-5 -one, 15 1 -12-(2-Chloro-6-fluoro-phenyl)-acetyI] -9b-(4-chloro-phenyl )- I ,2,3,9b-tctrahydro-imidazol 2,1I alisoindol-5-one; 9b-(4-Chloro-phenyl)- I -((S)-5-oxo-tetrahydro-furan-2-carbonyl)- I ,2,3,9b-tetrahydro-imidazol 2.1I alisoindol-5-onc; 9b-(4-ChlIoro-phcnyl)- I -pent-4-enoy- I ,2,3,9b-tetrahydro-imidazo 2,1I -a] isoindol-5-onc; 20 9b-(4-ChlIoro-phcnyl)- I -(3-cyclohcxyl-propionyl )- I ,2,3,9b-tetrahydro-imidazo[2, I -a] isoindol-5-one; 9b-(4-Ch Ioro-phcnyl)- I -(2-methanesulIfonylI-acetyl)- I ,2,3,9b-tetrahydro-imidazof 2, I -a] isoindol-5 -one; 1-I 2-(3-ChlIoro-phenoxy)-acetylIJ-9b-(4-chloro-phenyl )- I ,2,3,9b-tetrahydro-imidazol 2,1I-a I isoindol-5 -one; 9b-(4-Chloro-phenyl)- I .(2-indan-2-yl-acetyl)- I ,2,3.9b-tetrahydro-imidazo[2, I -a] isoin dol1-5 -one; 1].[2-((]1 S,3S)-3-Acetyl-2,2-dimethyl-cyclobutyl)-acetyli-9b-(4-chloro-phenyl)- I ,2,3,9b-tetrahydro 25 imidazol 2, 1-ailisoindol-5-one; 9b-(4-Chloro-phenyl)- I -(2-pentatluorophenyloxy-acetyl)- I ,2,3,9b-tetrahydro-imidazo[2, 1 -alisoindol-5 one; 1 -(4-Fl uoro-benzoyl)-9b-(4-hydroxy-phenyl)- 1,2,3 ,9b-tetrahydro-imidazo[2, 1 -a] isoindol-5-one; 1 -(4-Fluoro-benzoyl)-9b-I 3-(2-methoxy-ethoxy)-phenyl]- I ,2,3,9b-tetrahydro-imidazo[2, I -alisoindol-5 30 one; (4-LI -(4-Fluoro-benzoyl)-5-oxo-2,3-dihydro- I 1-,51--imidazo[2, I -alisoindol-9b-yl]-phenoxy) -acetic acid methyl ester; 4-14-lI -(4-luoro-benzoyl)-5-oxo-2,3-dihydro- 1 H,51-1-imidazol 2,1 -a]isoindol-9b-vl j-phenox'y butyronitrile; 35 9b-14-(3-Chloro-propoxy)-phenyl]-lI-(4-Iluoro-benzoyl)-1I,2,3,9b-tetrahydro-imidazo[2, I-a Iisoindol-5 one; 9b-(4- Benzy loxy- phenyl)- 1 -(4 -fl uoro- benzoylI)- I ,2,3,9b-tetrah ydro-i m idazot2, I -a] isoi ndol1-5 -one: 9b-14-(3,5-Dimethyl-isoxazol-4-ylmethoxy)-phenyll- 1-(4-fluoro-benzoyl)-1I,2,3,9b-tetrahydro imidazo[2,1I-a]isoindol-5-one;

2334232.2 (GHMatters) 9/07110 -119 9b-14-(4-Chloro-butoxy)-phenyl j-1-(4-fluoro-bcnzoyl)- 1,2,3 ,9b-tetrahydro-imidazol 2,1 -a Ijisoindol-5 -one: 9b-14-(2-ChlIoro-cthoxy)-phenyl i-I-(4-fluoro-benzoyl)- I ,2,3,9b-tetrahydro-imidazol 2,1I -a Iisoindol-5 -one; 2- I d1-4-Fluoro-benzoyl )-5-oxo-2,3-dihydro- I H,5H-imidazol 2.1 -a I isoindol-9b-y I I-phenoxy acetamnide 5 9b-(4-CyclIopropylImethoxy-phenyl)- I -(4-fluoro-benzoyl)- I ,2,3.9b-tetrahydro-imidazol 2,1 -a]jisoindol-5 one; 1 -(4- Fluoro-bcnzoyl)-9b-[4-(2-oxo-propoxy)-phenylI I- 1,2,3,9b-tctrahydro-i midazo[2, I -a] isoindol-5-one; (4-[ I-(4-Fluoro-benzoyl)-5-oxo-2,3-dihydro- I H,5H-imidazo[2, 1 -ajisoindol-9b-yI ]-phcnoxy) -acetic acid; 9b-(4-Chloro-phenyl)- I -[2-(2-pi perazin- I -yi-ethylamino).acetyl]- 1,2,3 ,9b-tetrahydro-imidazot2. 1 10 alisoindol-5-one; 9b-(4-Chloro-phcnyl)- I -[2-(2-pyrrolidin- I -yI-ethylamino)-acetyl]- I ,2,3,9b-tetrahydro-imidazo[2. I a] isoindol-5-one; 9b-(4-Chloro-phenyl)- 1- (2-1 (piperidin-4-ylmethyl).aminoj-acctyl }- I ,2,3,9b-tetrahydro-imidazo[2, I1 alisoi ndol-5-one; 15 9b-(4-Chloro-phenyl)- I -12-(3-pyrrol idin- I -yI-propylIamino)-acetyl I- I ,2,3,9b-tctrahydro-imidazol 2.1 a jisoindol-5-one; 9b-(4-Chloro-phenyl)- I -[2-(2-pyridin-4-yI-ethylamino)-acety I-I ,2,3,9b-tetrahydro-imidazo[2, I alisoindol-5-onc; 9b-(4-Chloro-phcnyl)- I -[2-(2-pyridin-3-yl-ethylamino)-acetyl]- I ,2,3,9b-tetrahydro-i midazo[2. 20 aJisoindol-5-one; 9b-(4-Chloro-phcnyl)- 1 -1 2-[3-(2-oxo-pyrrolidin- I -yI)-propylamino]-acetyl }- I ,2,3.9b-tctrahydro imidazol 2.1 -alisoindol-5-onc; 9b-(4-Chloro-phenyl)- I -12-(3-imidazoI- 1 -yI-propylamino)-acctyll- I ,2,3,9b-tctrahydro-imidazo[2, I ajisoindol-5-one; 25 9b-(4-Chloro-phenyl)- I .[2-(2-morphol in-4-yI-ethylamino)-acetyl]- I ,2,3,9b-tetrahydro-imidazo[2, I aJisoindol-5-one; 9b-(4-Chloro-phenyl)- I -[2-(3-morpholin-4-yI-propylamino)-acetyl]- I ,2,3,9b-tetrahydro-imidazo[2, I alisoindol-5-one; 9b-(4-Chloro-phcnyl)- I -[2-(2-pyri di n-2-yI -ethyl ami no)-acctyl] I I ,2,3,9b-tctrahydro-imidazo[2, I 30 aJisoindoI-5-one; 9b-(4-Chloro-phcnyl)- 1 -1 2-[(pyridin-4-ylmethyl)-aminoj-acetyl) 1,2,3,9b-tetrahydro-imidazo[2, I alisoindol-5-one; 9b-(4-Chloro-phenyl)- I - ( 2-[(2,3-dihydro-benzo[ I ,4]dioxin-2-ylmethyl)-amino]-acetyl )- I ,2,3,9b tetrahydro-imidazo[ 2, 1 -ajisoindol-5-one; 35 9b-(4-Chloro-phcnyl)- I- ( 2-[(pyridin-2-ylmethyl)-amino]-acetyI )- I ,2,3,9b-tetrahNydro-imidazo[2, I ajisoindol-5-one; 9b-(4-Chloro-phenyl)- I -I2-[(pyridin-3-ylmcthyl )-aminoJ-acctyl)-I 1.2,3,9b-tetrahydro-imidazol 2.1 a jisoindol-5-one; 2334232_2 (GHMatters) 9/07110 -120 9b-(4-Chloro-phenyl)- 1 -[2-(pyridin-4-y lam ino)-acetylJ I - ,2,3,9b-tetrahydro-imidazo[2, 1 -a] isoindol-5 one; 9b-(4-Chloro-phenyl)- I -[2-([1I,2,4]triazol-4-ylamino)-acetyl]- I ,2,3,9b-tctrahydro-imidazo[2, I -a]jisoindol 5-one; 5 9b-(4-Chloro-phenyl)- 1 -[2-([1I,3,4]thiadiazol-2-ylamino)-acetyli I I ,2,3,9b-tetrahydro-imidazo[2, I a]isoindol-5-one; 9b-(4-Ch Ioro-phenyl)- I -[2-(qui nolIin-8-y lam ino)-acety I ,2,3,9b-tctrahydro-imidazol2 21 -a] iso indol-5 one; 9b-(4-Ch Ioro-phenyl)- I-I 2-(thiazol-2-yl am ino)-acetylj 1,2,3 ,9b-tetrahydro-imidazo[2, I -a Iisoindol-5-one; 10 9b-(4-ChlIoro-phenyl)- I -[2-(pyridin-2-ylIam ino)-acety I]- 1,2.3,9b-tetrahydro-imidazo[2, I -a] isoindol-5 one; 9b-(4-Chloro-phenyl)- I -[2-(pyridin-3-yl am ino)-acctyI] - I ,2,3,9b-tetrahydro-imidazo[2, I -a Ijisoindol-S one; 9b-(4-ChlIoro-phenyl)- I -[2-(pyrimidin-2-yl am ino)-acetyI]- I ,2,3,9b-tetrahydro-imidazo[2, 1 -ajIi so indol-5 15 one; 9b-(4-Chloro-phcnyl)- 1 -[2-( I H-[ I ,2,4ltriazol-3-yl am ino)-acetylI I-I ,2,3,9b-tctrahydro-imidazol2, I aJisoindol-5-one; 9b-(4-ChlIoro-phenyl)- 1 -[2-(quinolin-3-yl am ino)-acctyl]- I ,2,3,9b-tetrahydro-imidazo[2, I -a] isoindol-5 one; 20 9b-(4-Chloro-phcnyl)- I -12-(isoqui nolIin-5-yl am ino)-acetyl]- I .2,3,9b-tetrahydro-imidazo[2, I -a] isoindol-5 one; 9b-(4-Chloro-phenyl)- I -[2-(qui nolIin-6-yl am ino)-acetyl]- I ,2,3,9b-tetrahydro-imidazol 2,1]-a I isoindol-5 one; I -[2-(Benzothiazol-2-yl am ino)-acetyl I -9b-(4-chloro-phenyl)- I ,2.3,9b-tctrahydro-imidazoj 2,1 )-a] isoindolI 25 5-one; 9b-(4-Chloro-phenyl)- I -[2-(lI 1--pyrazol-3-yl am ino)-acetyl]- I ,2,3,9b-tetrahydro-imidazo[2, I -a] isoindol-5 one; 9b-(4-Chloro-phcnyl)- I -[2-(pyridin-2-ylsullfanyI)-acetyI]- I ,2,3,9b-tetrahydro-imidaz.o[2, I -a Iisoindol-5 one; 30 1 -[2-(] I --Benzoimidazol-2-ylsullfanyl)-acetyl]-9b-(4-chloro-phenyl)- I ,2,3,9b-tetrahydro-imidazo[2. I a] isoindol-5-one; I -[2-(BenzothiazoI-2-ylsu IfanyI)-acetyIJ-9b-(4-chloro-phenyI)-1I,2,3,9b-tetrahydro-imidazo[2, I a] isoindol-5-one; 9b-(4-Ch Ioro-phenyl)- 1-1 2-( I 1--imidazol-2-ylIsulI fanyl)-acetylI] -I,2,3,9b-tetrahydro-imidazol2, I 35 alisoindoI-5-one; 9b-(4-ChlIoro-phenyl)- I -12-(pyrimidin-2-ylsulIftanyl)-acetyll- I ,2,3,9b-tetrahydro-imidazo['2, I -ajIisoindol 5-one; I -[2-(4-Methoxy-phenyl)-acetyI] -9b-(4-trifluoromethylI-phenyl)- I ,2,3,9b-tetrahydro-imidazo[2. I alisoindol-5-one; 2334232_2 (GHMatters) 9/07/10 -121 I -Propionyl-9b-(4-trifluoromethyl-phenyl )- I ,2,3,9b-tetrahydro-imidazo[2, I -ajIisoindol-5-one; 9b-(4-Chloro-phenyl)- I -(6-fluoro-pyridine-3-carbonyl )- I ,2,3,9b-tetrahydro-imidazo[2, I -a] isoindol-5 one; I-(4-Fluoro-benzoyl)-9b-(4-tri fluoromethyl-phenyl)- I ,2,3,9b-tetrahydro-imidazo[2, I1-a]jisol ndol-5 -one; 5 9b-(4-Ethoxy-phenyl)- I -(4-fluoro-benzoyl)- I ,2,3,9b-tctrahydro-imidazo[2, I -alIisoindol-5-one; I -(4-Fluoro-benzoyl)-9b-14-(3-methyl-butoxy)-phenyl]- I ,2,3,9b-tctrahydro-imidazo[2, I -a] isoindol-5 one; 1-(4-l-luoro-benzovl )-9b.(4-isopropoxy-phenyl)- I ,2,3,9b-tetrahydro-imidazo 12, 1-a Ijisoindol-5-one; 1-(4-fl'uoro-benzoyl)-9b-(4-propoxy-phenyl)- I.2.3,9b-tetrahydro-imidazo[2, I -a Ijisoindol-5-one;, 10 9b-(4-Chloro-phenyl)- I -(6-chlIoro-pyridine-3-carbonyl)- I ,2,3,9b-tetrahydro-imidazol 2,1I-a Ijisoindol-5 one. 9b-(4-ChlIoro-phenyl)- I -(6-chlIoro-pyridazine-3-carbonyl)- I ,2,3,9b-tetrahydro-imidazo 2,1I-a Ijisoindol-5 one; 9b-(4-l-luoro-phenyl )- I -(6-fluoro-pyridine-3-carbonyl)- I ,2,3,9b-tctrahydro-imidazol2. I -a I isoindol-S-one; 15 6-Fluoro-nicotinic acid 4-ji -(6-fluoro-pyridine-3-carbonyl )-5-oxo-2,3-dihydro- I H,51H-imidazo[2, I alisoindol-9b-yI]-phenyl ester; 9b-(4-Cyclopropylmethoxy-phenyl)- I-(6-tluoro-pyridine-3-carbonyl)-1I,2,3,9b-tctrahydro-imidazot2, I ajisoindol-5-one; 9b-(4-Ch Ioro-phcnylI)- I -(6-methyl am ino-pyri di ne-3 -carbon v )- 1 ,2,3,9b-tetrahydro- im idazo [2, 1I 20 ajisoindol-5-one; 9b-(4-Chloro-phenyl)- I-(6-cyclopropylamino-pyridine-3-carbonyl)-1I,2,3,9b-tetrahydro-imidazo[2, I alisoindol-5-one; 1 -(6-Amino-pyridine-3-carbonyl)-9b-(4-chloro-phenyl)-1I,2.3,9b-tetrahydro-imidazol2,1I-ajisoindol-5 one 25 I -[6-(2-Amino-ethylamino)-pyridine-3-carbonyl J-9b-(4-ehloro-phenyl )- I,2,3.9b-tetrahydro-imidazo 2.1 a jisoi ndol-5-one; 9b-(4-Chloro-phenyl)- I -[6-(2-hydroxy-ethylamino)-pyridine-3-carbonyli-i .2,3,95-tetrahydro imidazo[2, 1 -aJisoindol-5-one; 9b-(4-Chloro-phenyl)- I -(2-pyridin-4-yI-thiazole-4-carbonyl )- I ,2,3,9b-tetrahydro-imidazo[2, 1 -a]isoindol 30 5-one; 9b-(4-Chloro-phenyl)- I -((R)-2-th iophen-2-yI-4,5-dihydro-thiazole-4-carbonyl)- 1,2,3 ,9b-tetrahydro imidazo[2, I -ajisoindol-5-one; 9b-(4-Chloro-phenyl)- I -(2-thiophen-2-yI-thiazole-4-carbonyl )- I ,2,3,9b-tetrahydro-imidazo[2, I a jisoindol-5-one; 35 9b-(4-Chloro-phenyl)- I -(2,5-dimethyl-furan-3-carbonyl)- I ,2,3,9b-tetrahydro-imidazo[2, I -alisoindol-5 one; 9b-(4-Chloro-phenyl)- I -( furan-3-carbonyl)- I ,2.3.,9b-tetrahydro-imidazol 2,1I -ajisoindol-5-one; 9b-(4-Chloro-phenyl)- I -(thiophene-3-carbonyl)- I ,2,3,9b-tetrahydro-imidazo[2, I1-a jisoindol-S-one; 2334232_2 (GHMatters) 9/07110 -122 9b-(4-Chloro-phenyl)- I-(3-chloro-thiophene-2-carbonyl)- 1,2,3,9b-tetrahydro-imidazo[2,1 -a]isoindol-5 one; 9b-(4-Chloro-phenyl)- 1-(3-ethoxy-thiophene-2-carbonyl)- 1,2,3,9b-tetrahydro-imidazo[2, I -a]isoindol-5 one; 5 9b-(4-Chloro-phenyl)- I-(6-chloro-pyridine-2-carbonyl)- l,2,3,9b-tetrahydro-imidazo[2, I -a]isoindol-5 one; 9b-(4-Chloro-phenyl)- 1-(4,5-dichloro-isothiazole-3-carbonyl)- 1,2,3,9b-tetrahydro-imidazol 2,1 a]isoindol-5-one; 9b-(4-Chloro-phenyl)- 1-5-(4-methoxy-phenyl)-oxazole-4-carbonyl]- 1,2,3,9b-tetrahydro-imidazol 2,1 10 alisoindol-5-one; 9b-(4-Chloro-phenyl)- -( I-methyl-3-trifluoromethyl- I H-pyrazole-4-carbonyl)- 1,2,3,9b-tetrahydro imidazo[2, I -alisoindol-5-one; 9b-(4-Chloro-phenyl)- I -(thiazole-4-carbonyl)- I,2,3.9b-tetrahydro-imidazo[2. 1-a lisoindol-5-one; 9b-(4-Chloro-phenyl)- 1-(4-methyl-furazan-3-carbonyl)- 1,2.3,9b-tetrahydro-imidazo[2, I-a jisoindol-5 15 one; and 9b-(4-Chloro-phenyl)- l-[2-(I-oxy-pyridin-3-yl)-thiazole-4-carbonyll- 1,2,3,9b-tetrahydro-imidazol2, I alisoindol-5-one. 22. A pharmaceutical formulation for the treatment of infections involving viruses of 20 Pneumovirinae sub-family comprising a compound of formula I according to any one of claims I to 4 or 9 to 21, or a pharmaceutically acceptable salt or derivative thereof; and a pharmaceutically acceptable carrier. 23. A compound of formula III H R , N B AC 25 X Formula IllI or a salt thereof, wherein A, B, C, R' and X are as defined in claim 9. 30 24. The compound according to claim 23, wherein ring A is pyridyl with the proviso that when -B-C- is -Cl 2 C-I(CH(CH 3 ) 2 )-, R, is not 3-CH 3 ,4-Ci 3 CH 2 CH 2 NHC(O)CH 2 0-phenyl-. 25. Use of a compound of formula III, as defined in claim 23 or claim 24 2334232_2 (GHMatters) 9/07/10 -123 H R, N B A N-C X Formula Ill or a salt thereof, as an intermediate for the production of a compound of formula I as defined in any one of claims9 to 21. 5 26. The compound according to any one of claims 9 to 21, 23 or 24 in a single stereoisomeric form. 27. A compound of formula I or formula Ill, a pharmaceutical formulation comprising the compound of formula I, uses or methods involving the compounds of formula I or formula Ill, or 10 processes for preparing the compounds of formula I or formula Ill, substantially as herein described with reference to the Examples. 23342322 (GHMatters) 9/07/10