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AU2002213099A1 - Novel dyes for organ function monitoring - Google Patents

Novel dyes for organ function monitoring

Info

Publication number
AU2002213099A1
AU2002213099A1 AU2002213099A AU1309902A AU2002213099A1 AU 2002213099 A1 AU2002213099 A1 AU 2002213099A1 AU 2002213099 A AU2002213099 A AU 2002213099A AU 1309902 A AU1309902 A AU 1309902A AU 2002213099 A1 AU2002213099 A1 AU 2002213099A1
Authority
AU
Australia
Prior art keywords
organ function
function monitoring
novel dyes
dyes
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002213099A
Inventor
Samuel Achilefu
Joseph E. Bugaj
Richard B. Dorshow
Raghavan Rajagopalan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of AU2002213099A1 publication Critical patent/AU2002213099A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0066—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0075—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of an heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2002213099A 2000-10-16 2001-10-05 Novel dyes for organ function monitoring Abandoned AU2002213099A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/688,947 US6656451B1 (en) 2000-10-16 2000-10-16 Indole compounds as novel dyes for organ function monitoring
US09688947 2000-10-16
PCT/US2001/031718 WO2002032464A1 (en) 2000-10-16 2001-10-05 Novel dyes for organ function monitoring

Publications (1)

Publication Number Publication Date
AU2002213099A1 true AU2002213099A1 (en) 2002-04-29

Family

ID=24766445

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002213099A Abandoned AU2002213099A1 (en) 2000-10-16 2001-10-05 Novel dyes for organ function monitoring

Country Status (6)

Country Link
US (3) US6656451B1 (en)
EP (1) EP1326648A4 (en)
JP (1) JP2004513893A (en)
AU (1) AU2002213099A1 (en)
CA (1) CA2425703C (en)
WO (1) WO2002032464A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10023051B4 (en) * 2000-05-11 2004-02-19 Roche Diagnostics Gmbh Process for the preparation of fluorescein isothiocyanate sinistrin, its use and diagnostic preparation containing fluorescein isothiocyanate sinistrin
US6656451B1 (en) * 2000-10-16 2003-12-02 Mallinckrodt, Inc. Indole compounds as novel dyes for organ function monitoring
US7556797B2 (en) * 2000-10-16 2009-07-07 Mallinckrodt Inc. Minimally invasive physiological function monitoring agents
US20030105300A1 (en) * 2001-10-17 2003-06-05 Mallinckrodt Inc. Tumor targeted photodiagnostic-phototherapeutic agents
US20030105299A1 (en) * 2001-10-17 2003-06-05 Mallinckrodt Inc. Carbocyanine dyes for tandem, photodiagnostic and therapeutic applications
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
NO20034350D0 (en) * 2003-09-29 2003-09-29 Amersham Health As Optical imaging of colorectal cancer
US8906354B2 (en) 2007-02-28 2014-12-09 Bruker Biospin Corporation Loaded latex optical molecular imaging probes containing lipophilic large stokes shift dyes
US8017104B2 (en) 2007-02-28 2011-09-13 Carestream Health, Inc. Large stoke shift dye used for optical imaging
KR101473320B1 (en) 2008-01-08 2014-12-16 삼성에스디아이 주식회사 Benzoindole compound and dye-sensitized solar cell using the same
US20100062093A1 (en) * 2008-09-11 2010-03-11 Wenger Manufacturing, Inc. Method and apparatus for producing fully cooked extrudates with significantly reduced specific mechanical energy inputs
US9433700B2 (en) 2009-04-27 2016-09-06 Medibeacon Inc. Tissue sealant compositions, vascular closure devices, and uses thereof
JP5817073B2 (en) * 2010-01-28 2015-11-18 国立大学法人三重大学 Diagnostic composition and analysis method using novel indocyanine compound
EP2530093B1 (en) 2010-01-28 2018-11-21 National UniversityCorporation Mie University Indocyanine compound, synthesis method thereof, purification method thereof, diagnostic composition using indocyanine compound, and device for measuring in vivo kinetics and device for visualizing circulation using diagnostic composition
CN103038629B (en) 2010-05-31 2015-07-08 卫材R&D管理有限公司 Fluorescent probe for imaging lymph nodes
US9862682B2 (en) 2016-01-08 2018-01-09 BroadPharm Functionalized pegylated cyanine compounds, pharmaceutical compositions, and methods of use thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5395619A (en) 1993-03-03 1995-03-07 Liposome Technology, Inc. Lipid-polymer conjugates and liposomes
WO1996000902A1 (en) * 1994-06-30 1996-01-11 Biometric Imaging, Inc. N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels
US5453505A (en) * 1994-06-30 1995-09-26 Biometric Imaging, Inc. N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels
DE4445065A1 (en) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Methods for in-vivo diagnostics using NIR radiation
IT1276833B1 (en) * 1995-10-09 1997-11-03 Sorin Biomedica Cardio Spa FLUORESCENT DYES OF THE SULFUR BENZ AND INDOCYANINE FAMILY
US5928625A (en) * 1997-03-13 1999-07-27 Mallinckrodt Inc. Method of measuring physiological function
US6228344B1 (en) * 1997-03-13 2001-05-08 Mallinckrodt Inc. Method of measuring physiological function
EP0979103B1 (en) * 1997-04-29 2004-01-02 Amersham Health AS Light imaging contrast agents
JPH11185836A (en) * 1997-12-16 1999-07-09 Fuji Photo Film Co Ltd Photoelectric conversion element and photoregeneration type photoelectrochemical cell
CA2319433C (en) 1998-02-09 2008-04-22 Bracco Research S.A. Targeted delivery of biologically active media
JP2000095758A (en) * 1998-09-18 2000-04-04 Schering Ag Near-infrared, fluorescent contrast medium, and its production
AU4784200A (en) 1999-05-27 2000-12-18 Jong-Ki Kim Beverage container
ATE260764T1 (en) * 1999-08-09 2004-03-15 Fuji Photo Film Co Ltd PHOTO SENSITIVE LITHOGRAPHIC PLATE PREPARATOR CONTAINING METAL OXIDE
US6180087B1 (en) * 2000-01-18 2001-01-30 Mallinckrodt Inc. Tunable indocyanine dyes for biomedical applications
US6395257B1 (en) * 2000-01-18 2002-05-28 Mallinckrodt Inc. Dendrimer precursor dyes for imaging
US7198778B2 (en) * 2000-01-18 2007-04-03 Mallinckrodt Inc. Tumor-targeted optical contrast agents
US6656451B1 (en) * 2000-10-16 2003-12-02 Mallinckrodt, Inc. Indole compounds as novel dyes for organ function monitoring
US6610322B1 (en) 2000-12-20 2003-08-26 Brian Charles Keller Self forming, thermodynamically stable liposomes and their applications

Also Published As

Publication number Publication date
US6656451B1 (en) 2003-12-02
EP1326648A4 (en) 2007-03-21
CA2425703A1 (en) 2002-04-25
JP2004513893A (en) 2004-05-13
US20080056989A1 (en) 2008-03-06
CA2425703C (en) 2010-05-25
EP1326648A1 (en) 2003-07-16
US20040202611A1 (en) 2004-10-14
WO2002032464A1 (en) 2002-04-25
US7438894B2 (en) 2008-10-21

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