[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

AU2001294824A1 - Piperazine based inhibitors of factor xa - Google Patents

Piperazine based inhibitors of factor xa

Info

Publication number
AU2001294824A1
AU2001294824A1 AU2001294824A AU9482401A AU2001294824A1 AU 2001294824 A1 AU2001294824 A1 AU 2001294824A1 AU 2001294824 A AU2001294824 A AU 2001294824A AU 9482401 A AU9482401 A AU 9482401A AU 2001294824 A1 AU2001294824 A1 AU 2001294824A1
Authority
AU
Australia
Prior art keywords
factor
based inhibitors
piperazine based
piperazine
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001294824A
Inventor
Erik A. Goldman
Wenrong Huang
Zhaozhong Jon Jia
Robert M. Scarborough Jr.
Yonghong Song
Lingyan Wang
Yanhong Wu
Penglie Zhang
Bing-Yan Zhu
Jingmei Fan Zuckett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
Original Assignee
Millennium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Publication of AU2001294824A1 publication Critical patent/AU2001294824A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/06Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2001294824A 2000-09-29 2001-10-01 Piperazine based inhibitors of factor xa Abandoned AU2001294824A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23616100P 2000-09-29 2000-09-29
US60/236,161 2000-09-29
PCT/US2001/030315 WO2002026720A2 (en) 2000-09-29 2001-10-01 PIPERAZINE BASED INHIBITORS OF FACTOR Xa

Publications (1)

Publication Number Publication Date
AU2001294824A1 true AU2001294824A1 (en) 2002-04-08

Family

ID=22888374

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001294824A Abandoned AU2001294824A1 (en) 2000-09-29 2001-10-01 Piperazine based inhibitors of factor xa

Country Status (4)

Country Link
US (1) US20040082786A1 (en)
EP (1) EP1322610A2 (en)
AU (1) AU2001294824A1 (en)
WO (1) WO2002026720A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI290136B (en) 2000-04-05 2007-11-21 Daiichi Seiyaku Co Ethylenediamine derivatives
US7365205B2 (en) 2001-06-20 2008-04-29 Daiichi Sankyo Company, Limited Diamine derivatives
CN1181065C (en) * 2002-05-08 2004-12-22 上海医药工业研究院 Aralkylformylalkyl piperazine derivative and its application as brain nerve protector
AU2003284596A1 (en) * 2002-11-22 2004-06-18 Takeda Pharmaceutical Company Limited Imidazole derivative, process for producing the same, and use
PE20040804A1 (en) 2002-12-19 2004-12-31 Boehringer Ingelheim Pharma CARBOXAMID DERIVATIVES AS INHIBITORS OF THE Xa FACTOR
ATE429228T1 (en) * 2003-02-14 2009-05-15 Serono Lab DERIVATIVES OF PIPERAZINE-2-CARBOXAMIDE
WO2005079799A1 (en) * 2004-02-13 2005-09-01 Glaxo Group Limited 4-acyl-piperazines as anti-viral agents
US7371743B2 (en) 2004-02-28 2008-05-13 Boehringer Ingelheim International Gmbh Carboxylic acid amides, the preparation thereof and their use as medicaments
TWI396686B (en) 2004-05-21 2013-05-21 Takeda Pharmaceutical Cyclic amide derivative, and its production and use
WO2006016237A2 (en) * 2004-08-04 2006-02-16 Ranbaxy Laboratories Limited Heterocyclic derivatives as anti-inflammatory agents
BRPI0515488A (en) 2004-09-20 2008-07-29 Xenon Pharmaceuticals Inc heterocyclic derivatives and their use as therapeutic agents
WO2007008145A1 (en) * 2005-07-08 2007-01-18 Astrazeneca Ab Heterocyclic sulfonamide derivatives as inhibitors of factor xa
SI2922845T1 (en) 2012-11-20 2018-10-30 Merial, Inc. Anthelmintic compounds and compositions and method of using thereof
BR112015023279B1 (en) 2013-03-13 2021-01-19 Forma Therapeutics, Inc. compounds for fasn inhibition
EP3873214A4 (en) 2018-10-29 2022-07-13 Forma Therapeutics, Inc. Solid forms of (4-(2-fluoro-4-(1-methyl-1 h-benzo[d]imidazol-5-yl)benzoyl) piperazin-1-yl)(1-hydroxycyclopropyl)methanone

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2287292A1 (en) * 1997-05-30 1998-12-03 Takeda Chemical Industries, Ltd. Sulfonamide derivatives, their production and use
ATE314347T1 (en) * 1997-09-30 2006-01-15 Daiichi Seiyaku Co SULFONYL DERIVATIVES
CA2340100A1 (en) * 1998-08-11 2000-02-24 Daiichi Pharmaceutical Co., Ltd. Novel sulfonyl derivatives

Also Published As

Publication number Publication date
WO2002026720A2 (en) 2002-04-04
US20040082786A1 (en) 2004-04-29
EP1322610A2 (en) 2003-07-02
WO2002026720A3 (en) 2002-10-31

Similar Documents

Publication Publication Date Title
AU2001273040A1 (en) Factor xa inhibitors
AU6762400A (en) Inhibitors of factor xa
AU5723500A (en) Inhibitors of factor xa
AU5283700A (en) Inhibitors of factor xa
AU5283900A (en) Inhibitors of factor xa
AU3857300A (en) Inhibitors of factor xa
AU2001249399A1 (en) Isoquinolone inhibitors of factor xa
IL148698A0 (en) INHIBITORS OF FACTOR Xa
AU2002351179A1 (en) Glycinamides as factor xa inhibitors
AU2001234689A1 (en) Bivalent phenylene inhibitors of factor xa
HRP20040453A2 (en) Indole-2-carboxamides as factor xa inhibitors
AU5283600A (en) Inhibitors of factor xa
AU2002365896A1 (en) SUBSTITUTED AMINO METHYL FACTOR Xa INHIBITORS
AU2001249397A1 (en) Oxindole inhibitors of factor xa
AU2001294824A1 (en) Piperazine based inhibitors of factor xa
AU2001297648A1 (en) Substituted carboxamides as inhibitors of factor xa
AU2002303264A1 (en) Fused heterocyclic inhibitors of factor xa
IL159195A0 (en) Pyrrolidine derivatives as factor xa inhibitors
IL162454A0 (en) Pyrrolidine-2-ones as factor xa inhibitors
AU2002222933A1 (en) Inhibitors of factor xa
AU2002338734A1 (en) Use of phosphorodiesterase IV inhibitors
PL350941A1 (en) Pyrazole-3-on-derivative as factor xa inhibitors
AU2002211281A1 (en) Quaternary amidino based inhibitors of factor xa
AU2003296393A1 (en) Factor xa inhibitors
AU2002348501A1 (en) Factor xa inhibitor