AU2001294258A1 - Method of purifying plavastatin - Google Patents

Method of purifying plavastatin

Info

Publication number: AU2001294258A1
Authority: AU; Australia
Prior art keywords: plavastatin; purifying; purifying plavastatin
Prior art date: 2000-10-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU2001294258A

Inventor

Minoru Hagisawa

Kiyoshi Hamano

Shunshi Kojima

Nobunari Sugio

Mutsuo Suzuki

Yasuyuki Takamatsu

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sankyo Co Ltd

Original Assignee

Sankyo Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-16

Filing date

2001-10-15

Publication date

2002-04-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18794392&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2001294258(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-10-15 Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd

2002-04-29 Publication of AU2001294258A1 publication Critical patent/AU2001294258A1/en

Status Abandoned legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/58—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/60—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
- C07C69/33—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with hydroxy compounds having more than three hydroxy groups
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
- C07C2602/28—Hydrogenated naphthalenes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Microbiology (AREA)
Obesity (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Hematology (AREA)
Diabetes (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AU2001294258A 2000-10-16 2001-10-15 Method of purifying plavastatin Abandoned AU2001294258A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP2000-315256		2000-10-16
JP2000315256A JP3236282B1 (en)	2000-10-16	2000-10-16	How to purify pravastatin
PCT/JP2001/009045 WO2002032848A1 (en)	2000-10-16	2001-10-15	Method of purifying plavastatin

Publications (1)

Publication Number	Publication Date
AU2001294258A1 true AU2001294258A1 (en)	2002-04-29

Family

ID=18794392

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU2001294258A Abandoned AU2001294258A1 (en)	2000-10-16	2001-10-15	Method of purifying plavastatin

Country Status (19)

Country	Link
US (1)	US20030216596A1 (en)
EP (4)	EP1514862A1 (en)
JP (1)	JP3236282B1 (en)
KR (1)	KR20030042018A (en)
CN (4)	CN1868996A (en)
AU (1)	AU2001294258A1 (en)
BR (1)	BR0114681A (en)
CA (1)	CA2425883A1 (en)
CZ (1)	CZ20031052A3 (en)
HU (1)	HUP0303106A3 (en)
IL (1)	IL155360A0 (en)
MX (1)	MXPA03003347A (en)
NO (1)	NO20031739L (en)
NZ (3)	NZ536892A (en)
PL (1)	PL360934A1 (en)
RU (2)	RU2260582C2 (en)
SK (1)	SK4532003A3 (en)
WO (1)	WO2002032848A1 (en)
ZA (1)	ZA200302966B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3422791B2 (en)	2002-08-06	2003-06-30	三共株式会社	Method for isolation and purification of pravastatin
TW589178B (en) *	2003-02-21	2004-06-01	China Chemical & Pharmaceutica	A novel industrial process to obtain pravastatin sodium of high purity
EP1452519A1 (en) *	2003-02-25	2004-09-01	Balkanpharma-Razgrad AD	Method for the isolation and purification of pravastatin sodium
US20090042979A1 (en) *	2004-08-06	2009-02-12	Transform Pharmaceuticals Inc.	Novel Statin Pharmaceutical Compositions and Related Methods of Treatment
NZ552390A (en) *	2004-08-06	2010-01-29	Transform Pharmaceuticals Inc	Novel fenofibrate formulations and related methods of treatment
JP2008509154A (en) *	2004-08-06	2008-03-27	トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド	Novel statin drug compositions and related treatment methods
CN100361954C (en) *	2005-05-16	2008-01-16	天津市冠东科技有限公司	Drying method of prepared pravastatin crystal
JP4813841B2 (en) *	2005-07-25	2011-11-09	キユーピー株式会社	Method for producing pravastatin sodium
WO2010051502A2 (en) *	2008-10-31	2010-05-06	Biogen Idec Ma Inc.	Light targeting molecules and uses thereof
CN109796333B (en) *	2019-01-25	2021-04-09	北大方正集团有限公司	A kind of method for extracting and purifying pravastatin sodium from fermentation broth
CN112778120B (en) *	2019-11-08	2024-05-17	上海现代制药股份有限公司	A method for preparing oxidized impurities of lipid-lowering drugs

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK149080C (en) *	1980-06-06	1986-07-28	Sankyo Co	METHOD FOR PREPARING ML-236B CARBOXYLIC ACID DERIVATIVES
JPS5889191A (en) *	1981-11-20	1983-05-27	Sankyo Co Ltd	Preparation of 3-hydroxy-ml-236b derivative
US5202029A (en)	1991-03-13	1993-04-13	Caron Kabushiki Kaisha	Process for purification of hmg-coa reductase inhibitors
NZ250609A (en) *	1992-12-28	1995-07-26	Sankyo Co	Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments
IL108432A (en) *	1993-01-29	1997-09-30	Sankyo Co	DERIVATIVES OF 3, 5-DIHYDROXY-7- £1, 2, 6, 7, 8, 8a-HEXAHYDRO-2- METHYL-8- (SUBSTITUTED ALKANOYLOXY)-1-NAPHTHYL\| HEPTANOIC ACID AND THEIR LACTONES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
MX9702403A (en) *	1995-08-03	1997-06-28	Gist Brocades Bv	Selective process for the deacylation of acylated compounds.
SI9800046A (en)	1998-02-18	1999-08-31	LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.	Process for obtaining of HMG-CoA reductase inhibitors of high purity
SI20072A (en)	1998-09-18	2000-04-30	LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.	PROCEDURE OF PREPARATION OF INHIBITORS OF HMG-CoA REDUCTASE
SI20305A (en) *	1999-08-06	2001-02-28	LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.	Pravastatin sodium salt crystals
JP2000279174A (en)	1999-03-30	2000-10-10	Bml Inc	Monoclonal antibody against human LDL receptor and method for determining familial hyperlipidemia using the same
HUP9902352A1 (en) *	1999-07-12	2000-09-28	Gyógyszerkutató Intézet Kft.	Process for producing pravastatin by microbiological way
CN1468098A (en) *	2000-10-05	2004-01-14	�ݰ¸Ƕ�ҩ��޹�˾	Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same

2000
- 2000-10-16 JP JP2000315256A patent/JP3236282B1/en not_active Expired - Lifetime
2001
- 2001-10-15 NZ NZ536892A patent/NZ536892A/en unknown
- 2001-10-15 NZ NZ525256A patent/NZ525256A/en unknown
- 2001-10-15 HU HU0303106A patent/HUP0303106A3/en unknown
- 2001-10-15 AU AU2001294258A patent/AU2001294258A1/en not_active Abandoned
- 2001-10-15 NZ NZ536891A patent/NZ536891A/en unknown
- 2001-10-15 CN CNA2005100700673A patent/CN1868996A/en active Pending
- 2001-10-15 EP EP04027245A patent/EP1514862A1/en not_active Withdrawn
- 2001-10-15 CN CNA01820712XA patent/CN1481353A/en active Pending
- 2001-10-15 EP EP04027246A patent/EP1514863A1/en not_active Withdrawn
- 2001-10-15 MX MXPA03003347A patent/MXPA03003347A/en unknown
- 2001-10-15 BR BR0114681-5A patent/BR0114681A/en not_active IP Right Cessation
- 2001-10-15 KR KR10-2003-7005271A patent/KR20030042018A/en not_active Withdrawn
- 2001-10-15 EP EP01974858A patent/EP1327626A4/en not_active Withdrawn
- 2001-10-15 CA CA002425883A patent/CA2425883A1/en not_active Abandoned
- 2001-10-15 RU RU2003110580/04A patent/RU2260582C2/en not_active IP Right Cessation
- 2001-10-15 CN CNA2005100712967A patent/CN1690037A/en active Pending
- 2001-10-15 WO PCT/JP2001/009045 patent/WO2002032848A1/en not_active Application Discontinuation
- 2001-10-15 PL PL01360934A patent/PL360934A1/en not_active Application Discontinuation
- 2001-10-15 CZ CZ20031052A patent/CZ20031052A3/en unknown
- 2001-10-15 CN CNA2005100700688A patent/CN1679535A/en active Pending
- 2001-10-15 IL IL15536001A patent/IL155360A0/en unknown
- 2001-10-15 SK SK453-2003A patent/SK4532003A3/en unknown
- 2001-10-15 EP EP04027244A patent/EP1522589A1/en not_active Withdrawn
2003
- 2003-04-15 NO NO20031739A patent/NO20031739L/en not_active Application Discontinuation
- 2003-04-15 ZA ZA200302966A patent/ZA200302966B/en unknown
- 2003-04-16 US US10/417,062 patent/US20030216596A1/en not_active Abandoned
2005
- 2005-05-04 RU RU2005113661/04A patent/RU2005113661A/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
CA2425883A1 (en)	2003-04-15
ZA200302966B (en)	2004-07-15
NZ536891A (en)	2005-05-27
KR20030042018A (en)	2003-05-27
HUP0303106A3 (en)	2004-10-28
JP3236282B1 (en)	2001-12-10
NO20031739L (en)	2003-06-13
CN1868996A (en)	2006-11-29
RU2005113661A (en)	2006-11-10
HUP0303106A2 (en)	2003-12-29
WO2002032848A1 (en)	2002-04-25
EP1522589A1 (en)	2005-04-13
NZ536892A (en)	2005-05-27
MXPA03003347A (en)	2003-06-19
RU2260582C2 (en)	2005-09-20
CN1690037A (en)	2005-11-02
BR0114681A (en)	2003-12-09
NO20031739D0 (en)	2003-04-15
CN1679535A (en)	2005-10-12
CN1481353A (en)	2004-03-10
PL360934A1 (en)	2004-09-20
US20030216596A1 (en)	2003-11-20
EP1514862A1 (en)	2005-03-16
EP1514863A1 (en)	2005-03-16
EP1327626A1 (en)	2003-07-16
SK4532003A3 (en)	2003-10-07
EP1327626A4 (en)	2004-08-18
NZ525256A (en)	2005-01-28
JP2002121174A (en)	2002-04-23
IL155360A0 (en)	2003-11-23
CZ20031052A3 (en)	2003-09-17

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