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AU2001286976A1 - Novel autoinducer molecules and uses therefor - Google Patents

Novel autoinducer molecules and uses therefor

Info

Publication number
AU2001286976A1
AU2001286976A1 AU2001286976A AU8697601A AU2001286976A1 AU 2001286976 A1 AU2001286976 A1 AU 2001286976A1 AU 2001286976 A AU2001286976 A AU 2001286976A AU 8697601 A AU8697601 A AU 8697601A AU 2001286976 A1 AU2001286976 A1 AU 2001286976A1
Authority
AU
Australia
Prior art keywords
uses therefor
autoinducer molecules
novel
novel autoinducer
molecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001286976A
Inventor
Everett Peter Greenberg
Barbara H. Iglewski
Andrew S. Kende
Jared B J Milbank
James P. Pearson
Everett C Pesci
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Iowa Research Foundation UIRF
East Carolina University
University of Rochester
Original Assignee
University of Iowa Research Foundation UIRF
University of North Carolina at Chapel Hill
East Carolina University
University of Rochester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Iowa Research Foundation UIRF, University of North Carolina at Chapel Hill, East Carolina University, University of Rochester filed Critical University of Iowa Research Foundation UIRF
Publication of AU2001286976A1 publication Critical patent/AU2001286976A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • C07D215/233Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10Nitrogen as only ring hetero atom
    • C12P17/12Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/045Culture media therefor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2001286976A 2000-08-31 2001-08-31 Novel autoinducer molecules and uses therefor Abandoned AU2001286976A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22971500P 2000-08-31 2000-08-31
US60229715 2000-08-31
PCT/US2001/027165 WO2002018342A2 (en) 2000-08-31 2001-08-31 Novel autoinducer molecules and uses therefor

Publications (1)

Publication Number Publication Date
AU2001286976A1 true AU2001286976A1 (en) 2002-03-13

Family

ID=22862409

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001286976A Abandoned AU2001286976A1 (en) 2000-08-31 2001-08-31 Novel autoinducer molecules and uses therefor

Country Status (3)

Country Link
US (2) US20020177715A1 (en)
AU (1) AU2001286976A1 (en)
WO (1) WO2002018342A2 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1450802A2 (en) * 2001-10-30 2004-09-01 The General Hospital Corporation Methods for the prevention or treatment of bacterial and fungal infections
KR20110124375A (en) 2002-08-13 2011-11-16 햅토젠 리미티드 Methods for the treatment of an infectious bacterial disease with an anti-lactone or lactone derived signal molecules antibody
US7498292B2 (en) 2002-08-15 2009-03-03 The Research Foundation Of State University Of New York Combinatorial libraries of autoinducer analogs, autoinducer agonists and antagonists, and methods of use thereof
US20050032093A1 (en) * 2003-04-17 2005-02-10 Tony Romeo Novel genes involved in the escherichia coli biofilm formation and uses thereof
US20050074827A1 (en) * 2003-07-18 2005-04-07 Ute Muh Methods for identifying modulators of quorum-sensing signaling in bacteria
GB0326194D0 (en) * 2003-11-10 2003-12-17 Univ Kent Canterbury Proteins involved in signal transduction
US7122700B2 (en) 2004-07-30 2006-10-17 Xerox Corporation Arylamine processes
WO2006084056A2 (en) 2005-02-04 2006-08-10 Wisconsin Alumni Research Foundation Compounds and methods for modulating communication and virulence in quorum sensing bacteria
CN100387586C (en) * 2005-03-18 2008-05-14 中国科学院理化技术研究所 Synthesis method of chiral 2-amino-1- (6-fluoro-3, 4-dihydrobenzopyranyl) ethanol
WO2007008769A2 (en) * 2005-07-08 2007-01-18 George Mason University Use of pseudan and pseudan inclusion bodies
EP1782826A1 (en) * 2005-11-08 2007-05-09 GBF Gesellschaft für Biotechnologische Forschung mbH PQS and c-diGMP and its conjugates as adjuvants and their uses in pharmaceutical compositions
US7910622B2 (en) * 2007-03-19 2011-03-22 Wisconsin Alumni Research Foundation Modulation of bacterial quorum sensing with synthetic ligands
WO2009036081A1 (en) * 2007-09-10 2009-03-19 University Of Kentucky Research Foundation Systems and methods for diagnosis and monitoring of bacteria-related conditions
WO2009063901A1 (en) * 2007-11-13 2009-05-22 The University Of Tokyo Quorum sensing inhibitor
US8624063B2 (en) 2009-06-30 2014-01-07 Wisconsin Alumni Research Foundation Non-lactone carbocyclic and heterocyclic antagonists and agonists of bacterial quorum sensing
CN102706821B (en) * 2012-06-15 2014-11-12 广东工业大学 Method for quickly identifying food-borne pathogen bacterial biofilm formation inhibitor
GB201513614D0 (en) 2015-07-31 2015-09-16 Univ College Cork Nat Univ Ie Compositions, compounds and methods and uses relating thereto
EP3260445A1 (en) * 2016-06-24 2017-12-27 Universität Konstanz Compounds for use as an anti-bacterial or anti-fungal agent and as a zinc sensor
US10526278B2 (en) 2017-10-19 2020-01-07 Wisconsin Alumni Research Foundation Inhibitors of quorum sensing receptor LasR
EP3502095A1 (en) 2017-12-22 2019-06-26 Universität Konstanz Compound for use against pathogenic neisseria and haemophilus species and moraxella catarrhalis
US20220015363A1 (en) * 2020-07-14 2022-01-20 The Trustees Of Princeton University Small molecule pathogen dispersal agent
CN113201473B (en) 2021-04-22 2022-06-07 广东省科学院微生物研究所(广东省微生物分析检测中心) Application of citronellol in preparation of preparation for promoting pseudomonas aeruginosa virulence gene toxA expression

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Publication number Priority date Publication date Assignee Title
JPS5842869B2 (en) 1981-11-30 1983-09-22 三菱瓦斯化学株式会社 Homoserine lactone derivative
US4650750A (en) * 1982-02-01 1987-03-17 Giese Roger W Method of chemical analysis employing molecular release tag compounds
US4709016A (en) * 1982-02-01 1987-11-24 Northeastern University Molecular analytical release tags and their use in chemical analysis
JPS5951267A (en) * 1982-09-14 1984-03-24 Nippon Redarii Kk Quinoline-n-oxide derivative
JPS6045568A (en) 1983-08-23 1985-03-12 Mitsubishi Gas Chem Co Inc Production of homoserine lactone derivative
JPS6165869A (en) * 1984-09-07 1986-04-04 Kyowa Hakko Kogyo Co Ltd Quinoline-n-oxide derivative
JPH04360884A (en) * 1991-02-08 1992-12-14 Hoechst Ag Method for manufacturing homoserine lactone
GB9108307D0 (en) 1991-04-18 1991-06-05 Univ Nottingham Autoinducer
US5320805A (en) * 1991-05-15 1994-06-14 Sterilex Corporation Methods of using a cleaner, sanitizer, disinfectant, fungicide, sporicide, chemical sterilizer
US5536750A (en) * 1992-10-29 1996-07-16 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5686472A (en) * 1992-10-29 1997-11-11 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
AU7077894A (en) * 1993-07-02 1995-01-24 University Of Nottingham, The Immunosuppressant and antiallergic compounds, e.g. n-(3-oxohexanoyl) homoserine lactone
US5591872A (en) * 1993-08-09 1997-01-07 The University Of Iowa Research Foundation Autoinducer molecule
JP3071990B2 (en) * 1993-12-27 2000-07-31 花王株式会社 External preparation for skin
GB9407869D0 (en) * 1994-04-20 1994-06-15 Caduceus Ltd Antimicrobial compounds
AUPN191295A0 (en) 1995-03-23 1995-04-27 Unisearch Limited Microbiocide or microbial regulator
US5942619A (en) * 1995-09-29 1999-08-24 Pfizer Inc. Quinolone compounds for the treatment of disorders caused by helicobacter pylori
WO1997027851A1 (en) 1996-02-01 1997-08-07 The Johns-Hopkins University L-homoserine and l-homoserine lactone as bacteriostatic agents for m. tuberculosis and m. bovis
JP3592918B2 (en) * 1997-05-14 2004-11-24 花王株式会社 Cosmetics
EP0994961B1 (en) 1997-06-18 2006-10-18 Montana State University - Bozeman Homoserine lactones biofilm regulating compounds and their methods of use
US6455031B1 (en) * 1997-06-18 2002-09-24 David G Davies Methods and compositions for controlling biofilm development
JP3669818B2 (en) 1997-07-09 2005-07-13 電気化学工業株式会社 Hexagonal boron nitride powder
JPH1192307A (en) * 1997-09-24 1999-04-06 Marine Biotechnol Inst Co Ltd Antifouling agent
US6337347B1 (en) * 1998-06-18 2002-01-08 The Research & Development Institute, Inc. Autoinducer compounds
JP2000302682A (en) * 1999-04-23 2000-10-31 Yamanouchi Pharmaceut Co Ltd Anti-helicobacter pylori agent
EP1250450A2 (en) 1999-09-03 2002-10-23 University of Iowa Research Foundation Inc. Quorum sensing signaling in bacteria

Also Published As

Publication number Publication date
US20050009869A1 (en) 2005-01-13
WO2002018342A2 (en) 2002-03-07
US20020177715A1 (en) 2002-11-28
WO2002018342A3 (en) 2002-05-10
US7442798B2 (en) 2008-10-28

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