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AU2001284769A1 - A member of the lysyl oxidase gene family - Google Patents

A member of the lysyl oxidase gene family

Info

Publication number
AU2001284769A1
AU2001284769A1 AU2001284769A AU8476901A AU2001284769A1 AU 2001284769 A1 AU2001284769 A1 AU 2001284769A1 AU 2001284769 A AU2001284769 A AU 2001284769A AU 8476901 A AU8476901 A AU 8476901A AU 2001284769 A1 AU2001284769 A1 AU 2001284769A1
Authority
AU
Australia
Prior art keywords
lysyl oxidase
gene family
oxidase gene
protein
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001284769A
Inventor
Ashok R. Bapat
Eric Beer
Ramesh A. Bhat
Mark J Evans
Elissa Ferris
Sotirios K. Karathanasis
Robert Mastroeni
Marshall S. Scicchitano
Jianziong Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Publication of AU2001284769A1 publication Critical patent/AU2001284769A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention relates to a novel lysyl oxidase genes, termed EER-7. The invention relates to the protein and nucleic acids encoding the protein. The invention further relates to an assay system to identify compounds that selectively modulate EER-7 protein activity by interaction with estrogen receptors.
AU2001284769A 2000-08-08 2001-08-08 A member of the lysyl oxidase gene family Abandoned AU2001284769A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US22376300P 2000-08-08 2000-08-08
US60/223,763 2000-08-08
US25583800P 2000-12-15 2000-12-15
US60/255,838 2000-12-15
PCT/US2001/024942 WO2002012470A2 (en) 2000-08-08 2001-08-08 A member of the lysyl oxidase gene family

Publications (1)

Publication Number Publication Date
AU2001284769A1 true AU2001284769A1 (en) 2002-02-18

Family

ID=26918106

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001284769A Abandoned AU2001284769A1 (en) 2000-08-08 2001-08-08 A member of the lysyl oxidase gene family

Country Status (12)

Country Link
US (2) US7208300B2 (en)
EP (1) EP1354046B1 (en)
JP (1) JP2004505631A (en)
AT (1) ATE364087T1 (en)
AU (1) AU2001284769A1 (en)
BR (1) BR0113257A (en)
CA (1) CA2418952A1 (en)
DE (1) DE60128830T2 (en)
HK (1) HK1060148A1 (en)
IL (1) IL154036A0 (en)
MX (1) MXPA03001196A (en)
WO (1) WO2002012470A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030114410A1 (en) 2000-08-08 2003-06-19 Technion Research And Development Foundation Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis
US8119599B2 (en) * 2001-08-31 2012-02-21 Orthopeutics, L.P. Direct application of non-toxic crosslinking reagents to resist progressive spinal degeneration and deformity
US20070021365A1 (en) * 2005-06-21 2007-01-25 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of Lysyl oxidase for treating tumor growth and diagnostics relating thereto
US20070225242A1 (en) * 2005-06-21 2007-09-27 The Board Of Trustees Of The Leland Stanford Junior University Method and composition for treating and preventing tumor metastasis in vivo
US9687262B2 (en) * 2005-11-30 2017-06-27 CARDINAL HEALTH SWITZERLAND 515 GmbH Methods and devices for treating vulnerable plaque
US10278947B2 (en) 2007-02-28 2019-05-07 Orthopeutics, L.P. Crosslinker enhanced repair of connective tissues
AU2008299784B9 (en) 2007-08-02 2015-06-18 Gilead Biologics, Inc. LOX and LOXL2 inhibitors and uses thereof
US9107935B2 (en) * 2009-01-06 2015-08-18 Gilead Biologics, Inc. Chemotherapeutic methods and compositions
WO2011022709A1 (en) * 2009-08-21 2011-02-24 Arresto Biosciences, Inc In vitro screening assays
NZ625850A (en) * 2009-08-21 2015-12-24 Gilead Biologics Inc Methods and compositions for treatment of pulmonary fibrotic disorders
AU2010284001A1 (en) * 2009-08-21 2012-03-22 Gilead Biologics, Inc. Therapeutic methods and compositions
BR112012008054A2 (en) * 2009-08-21 2017-05-23 Gilead Biologics Inc catalytic domains of lysyl oxidase and loxl2
WO2011022670A1 (en) * 2009-08-21 2011-02-24 Arresto Biosciences, Inc In vivo screening assays
JP6134142B2 (en) 2010-02-04 2017-05-24 ギリアド バイオロジクス, インク.Gilead Biologics, Inc. Antibody binding to lysyl oxidase-like 2 (LOXL2) and method of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5834213A (en) 1991-05-02 1998-11-10 Baylor College Of Medicine Screening system and assay for identifying compounds that regulate steroid and orphan receptors mediation of DNA transcription
CA2352203A1 (en) * 1998-12-18 2000-06-29 American Home Products Corporation Bioassay for identifying estrogen receptor-.beta./.alpha. selective modulators
JP2003527076A (en) 1999-04-09 2003-09-16 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド Bone morphogenetic protein
US7264926B2 (en) * 2000-04-18 2007-09-04 Millennium Pharmaceuticals, Inc. Nucleoside Phosphatase
AU2001261194A1 (en) 2000-05-03 2001-11-12 University Of Hawaii Novel members of the lysyl oxidases family of amine oxidases related applications
WO2001092495A2 (en) * 2000-05-26 2001-12-06 Millennium Pharmaceuticals, Inc. A human lysyl ixodase (47765) and uses thereof

Also Published As

Publication number Publication date
EP1354046A2 (en) 2003-10-22
IL154036A0 (en) 2003-07-31
HK1060148A1 (en) 2004-07-30
US7445920B2 (en) 2008-11-04
BR0113257A (en) 2003-10-28
WO2002012470A3 (en) 2003-08-28
DE60128830D1 (en) 2007-07-19
MXPA03001196A (en) 2004-04-05
EP1354046B1 (en) 2007-06-06
CA2418952A1 (en) 2002-02-14
JP2004505631A (en) 2004-02-26
ATE364087T1 (en) 2007-06-15
WO2002012470A2 (en) 2002-02-14
US20040171110A1 (en) 2004-09-02
US20020102645A1 (en) 2002-08-01
DE60128830T2 (en) 2008-01-31
US7208300B2 (en) 2007-04-24

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