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AU2001284354A1 - Immunological adjuvant compounds, compositions, and methods of use thereof - Google Patents

Immunological adjuvant compounds, compositions, and methods of use thereof

Info

Publication number
AU2001284354A1
AU2001284354A1 AU2001284354A AU8435401A AU2001284354A1 AU 2001284354 A1 AU2001284354 A1 AU 2001284354A1 AU 2001284354 A AU2001284354 A AU 2001284354A AU 8435401 A AU8435401 A AU 8435401A AU 2001284354 A1 AU2001284354 A1 AU 2001284354A1
Authority
AU
Australia
Prior art keywords
methods
compositions
immunological adjuvant
adjuvant compounds
novel compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001284354A
Inventor
Lynn D Hawkins
Sally T. Ishizaka
Michael Lewis
Pamela Mcguiness
Jeffrey Rose
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of AU2001284354A1 publication Critical patent/AU2001284354A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • C07F9/091Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • C07F9/113Esters of phosphoric acids with unsaturated acyclic alcohols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55572Lipopolysaccharides; Lipid A; Monophosphoryl lipid A

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

The present invention provides novel compounds that function as immunological adjuvants when co-administered with antigens, including, antigens used as vaccines for any disease or condition amenable to vaccination. The invention also provides adjuvant formulations comprising the novel compounds of the invention and methods for immunizing humans and non-human animals.
AU2001284354A 2000-07-31 2001-07-27 Immunological adjuvant compounds, compositions, and methods of use thereof Abandoned AU2001284354A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22175200P 2000-07-31 2000-07-31
US60221752 2000-07-31
PCT/IB2001/001658 WO2002009752A2 (en) 2000-07-31 2001-07-27 Immunological adjuvant compounds

Publications (1)

Publication Number Publication Date
AU2001284354A1 true AU2001284354A1 (en) 2002-02-13

Family

ID=22829213

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001284354A Abandoned AU2001284354A1 (en) 2000-07-31 2001-07-27 Immunological adjuvant compounds, compositions, and methods of use thereof

Country Status (8)

Country Link
US (1) US6521776B2 (en)
EP (1) EP1307466B1 (en)
JP (1) JP4230765B2 (en)
AT (1) ATE310008T1 (en)
AU (1) AU2001284354A1 (en)
DE (1) DE60115051T2 (en)
TW (1) TWI305775B (en)
WO (1) WO2002009752A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6835721B2 (en) 1999-02-01 2004-12-28 Eisai Co., Ltd. Immunomodulatory compounds and methods of use thereof
US20040006242A1 (en) * 1999-02-01 2004-01-08 Hawkins Lynn D. Immunomodulatory compounds and method of use thereof
US6551600B2 (en) * 1999-02-01 2003-04-22 Eisai Co., Ltd. Immunological adjuvant compounds compositions and methods of use thereof
US7915238B2 (en) 1999-02-01 2011-03-29 Eisai R & D Management Co., Ltd. Immunomodulatory compounds and methods of use thereof
TW200523235A (en) * 2003-10-15 2005-07-16 Gtx Inc Anti-cancer compounds and methods of use thereof
US20070292418A1 (en) * 2005-04-26 2007-12-20 Eisai Co., Ltd. Compositions and methods for immunotherapy
CN103285392A (en) 2005-04-26 2013-09-11 卫材R&D管理株式会社 Compositions for cancer immunotherapy and use thereof
KR101294455B1 (en) * 2005-06-30 2013-08-07 에자이 알앤드디 매니지먼트 가부시키가이샤 Compounds for preparing immunological adjuvant
KR20080066712A (en) * 2005-09-30 2008-07-16 티티아이 엘뷰 가부시키가이샤 Functionalized microneedles transdermal drug delivery systems, devices, and methods
WO2007041314A2 (en) * 2005-09-30 2007-04-12 Tti Ellebeau, Inc. Transdermal drug delivery systems, devices, and methods employing novel pharmaceutical vehicles
JP2009509634A (en) * 2005-09-30 2009-03-12 Tti・エルビュー株式会社 Functionalized microneedle transdermal drug delivery system, apparatus and method
WO2007079190A2 (en) * 2005-12-29 2007-07-12 Tti Ellebeau, Inc. Device and method for enhancing immune response by electrical stimulation
RU2494091C2 (en) * 2007-12-18 2013-09-27 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Reagents and methods for beta-keto amide synthesis of synthetic precursor to immunological adjuvant e6020
JPWO2018070543A1 (en) * 2016-10-14 2019-07-25 株式会社ボナック Novel glycoside compound and method for producing the same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2583892A (en) 1991-09-11 1993-04-05 Pitman-Moore, Inc. Method for enhancing the immune system in a host employing liposome-encapsulated polypeptides
US5961970A (en) 1993-10-29 1999-10-05 Pharmos Corporation Submicron emulsions as vaccine adjuvants
WO1995011700A1 (en) 1993-10-29 1995-05-04 Pharmos Corp. Submicron emulsions as vaccine adjuvants
WO1995015768A1 (en) 1993-12-09 1995-06-15 Heinrich Exner Adjuvant for antigens, process for producing the same and its use
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
DE19511276C2 (en) * 1995-03-27 1999-02-18 Immuno Ag Adjuvant based on colloidal iron compounds
US5834015A (en) 1996-09-11 1998-11-10 Albany Medical College Protein-lipid vesicles and autogenous vaccine comprising the same
US6306404B1 (en) * 1998-07-14 2001-10-23 American Cyanamid Company Adjuvant and vaccine compositions containing monophosphoryl lipid A
JP4698027B2 (en) 1999-02-01 2011-06-08 エーザイ・アール・アンド・ディー・マネジメント株式会社 Immune adjuvant compounds

Also Published As

Publication number Publication date
JP2004505059A (en) 2004-02-19
TWI305775B (en) 2009-02-01
ATE310008T1 (en) 2005-12-15
JP4230765B2 (en) 2009-02-25
US6521776B2 (en) 2003-02-18
WO2002009752A3 (en) 2002-06-27
EP1307466B1 (en) 2005-11-16
WO2002009752A2 (en) 2002-02-07
US20020049314A1 (en) 2002-04-25
DE60115051D1 (en) 2005-12-22
EP1307466A2 (en) 2003-05-07
DE60115051T2 (en) 2006-08-24

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