AU2001284354A1 - Immunological adjuvant compounds, compositions, and methods of use thereof - Google Patents
Immunological adjuvant compounds, compositions, and methods of use thereofInfo
- Publication number
- AU2001284354A1 AU2001284354A1 AU2001284354A AU8435401A AU2001284354A1 AU 2001284354 A1 AU2001284354 A1 AU 2001284354A1 AU 2001284354 A AU2001284354 A AU 2001284354A AU 8435401 A AU8435401 A AU 8435401A AU 2001284354 A1 AU2001284354 A1 AU 2001284354A1
- Authority
- AU
- Australia
- Prior art keywords
- methods
- compositions
- immunological adjuvant
- adjuvant compounds
- novel compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000000568 immunological adjuvant Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 239000002671 adjuvant Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 238000002255 vaccination Methods 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/113—Esters of phosphoric acids with unsaturated acyclic alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Abstract
The present invention provides novel compounds that function as immunological adjuvants when co-administered with antigens, including, antigens used as vaccines for any disease or condition amenable to vaccination. The invention also provides adjuvant formulations comprising the novel compounds of the invention and methods for immunizing humans and non-human animals.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22175200P | 2000-07-31 | 2000-07-31 | |
US60221752 | 2000-07-31 | ||
PCT/IB2001/001658 WO2002009752A2 (en) | 2000-07-31 | 2001-07-27 | Immunological adjuvant compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001284354A1 true AU2001284354A1 (en) | 2002-02-13 |
Family
ID=22829213
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001284354A Abandoned AU2001284354A1 (en) | 2000-07-31 | 2001-07-27 | Immunological adjuvant compounds, compositions, and methods of use thereof |
Country Status (8)
Country | Link |
---|---|
US (1) | US6521776B2 (en) |
EP (1) | EP1307466B1 (en) |
JP (1) | JP4230765B2 (en) |
AT (1) | ATE310008T1 (en) |
AU (1) | AU2001284354A1 (en) |
DE (1) | DE60115051T2 (en) |
TW (1) | TWI305775B (en) |
WO (1) | WO2002009752A2 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6835721B2 (en) | 1999-02-01 | 2004-12-28 | Eisai Co., Ltd. | Immunomodulatory compounds and methods of use thereof |
US20040006242A1 (en) * | 1999-02-01 | 2004-01-08 | Hawkins Lynn D. | Immunomodulatory compounds and method of use thereof |
US6551600B2 (en) * | 1999-02-01 | 2003-04-22 | Eisai Co., Ltd. | Immunological adjuvant compounds compositions and methods of use thereof |
US7915238B2 (en) | 1999-02-01 | 2011-03-29 | Eisai R & D Management Co., Ltd. | Immunomodulatory compounds and methods of use thereof |
TW200523235A (en) * | 2003-10-15 | 2005-07-16 | Gtx Inc | Anti-cancer compounds and methods of use thereof |
US20070292418A1 (en) * | 2005-04-26 | 2007-12-20 | Eisai Co., Ltd. | Compositions and methods for immunotherapy |
CN103285392A (en) | 2005-04-26 | 2013-09-11 | 卫材R&D管理株式会社 | Compositions for cancer immunotherapy and use thereof |
KR101294455B1 (en) * | 2005-06-30 | 2013-08-07 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | Compounds for preparing immunological adjuvant |
KR20080066712A (en) * | 2005-09-30 | 2008-07-16 | 티티아이 엘뷰 가부시키가이샤 | Functionalized microneedles transdermal drug delivery systems, devices, and methods |
WO2007041314A2 (en) * | 2005-09-30 | 2007-04-12 | Tti Ellebeau, Inc. | Transdermal drug delivery systems, devices, and methods employing novel pharmaceutical vehicles |
JP2009509634A (en) * | 2005-09-30 | 2009-03-12 | Tti・エルビュー株式会社 | Functionalized microneedle transdermal drug delivery system, apparatus and method |
WO2007079190A2 (en) * | 2005-12-29 | 2007-07-12 | Tti Ellebeau, Inc. | Device and method for enhancing immune response by electrical stimulation |
RU2494091C2 (en) * | 2007-12-18 | 2013-09-27 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Reagents and methods for beta-keto amide synthesis of synthetic precursor to immunological adjuvant e6020 |
JPWO2018070543A1 (en) * | 2016-10-14 | 2019-07-25 | 株式会社ボナック | Novel glycoside compound and method for producing the same |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2583892A (en) | 1991-09-11 | 1993-04-05 | Pitman-Moore, Inc. | Method for enhancing the immune system in a host employing liposome-encapsulated polypeptides |
US5961970A (en) | 1993-10-29 | 1999-10-05 | Pharmos Corporation | Submicron emulsions as vaccine adjuvants |
WO1995011700A1 (en) | 1993-10-29 | 1995-05-04 | Pharmos Corp. | Submicron emulsions as vaccine adjuvants |
WO1995015768A1 (en) | 1993-12-09 | 1995-06-15 | Heinrich Exner | Adjuvant for antigens, process for producing the same and its use |
GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
DE19511276C2 (en) * | 1995-03-27 | 1999-02-18 | Immuno Ag | Adjuvant based on colloidal iron compounds |
US5834015A (en) | 1996-09-11 | 1998-11-10 | Albany Medical College | Protein-lipid vesicles and autogenous vaccine comprising the same |
US6306404B1 (en) * | 1998-07-14 | 2001-10-23 | American Cyanamid Company | Adjuvant and vaccine compositions containing monophosphoryl lipid A |
JP4698027B2 (en) | 1999-02-01 | 2011-06-08 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Immune adjuvant compounds |
-
2001
- 2001-07-27 WO PCT/IB2001/001658 patent/WO2002009752A2/en active IP Right Grant
- 2001-07-27 JP JP2002515305A patent/JP4230765B2/en not_active Expired - Lifetime
- 2001-07-27 AU AU2001284354A patent/AU2001284354A1/en not_active Abandoned
- 2001-07-27 AT AT01963334T patent/ATE310008T1/en not_active IP Right Cessation
- 2001-07-27 EP EP01963334A patent/EP1307466B1/en not_active Expired - Lifetime
- 2001-07-27 DE DE60115051T patent/DE60115051T2/en not_active Expired - Lifetime
- 2001-07-30 US US09/919,049 patent/US6521776B2/en not_active Expired - Lifetime
- 2001-07-31 TW TW090118694A patent/TWI305775B/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP2004505059A (en) | 2004-02-19 |
TWI305775B (en) | 2009-02-01 |
ATE310008T1 (en) | 2005-12-15 |
JP4230765B2 (en) | 2009-02-25 |
US6521776B2 (en) | 2003-02-18 |
WO2002009752A3 (en) | 2002-06-27 |
EP1307466B1 (en) | 2005-11-16 |
WO2002009752A2 (en) | 2002-02-07 |
US20020049314A1 (en) | 2002-04-25 |
DE60115051D1 (en) | 2005-12-22 |
EP1307466A2 (en) | 2003-05-07 |
DE60115051T2 (en) | 2006-08-24 |
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