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AU2001280438A1 - Substituted heterocyclic amides - Google Patents

Substituted heterocyclic amides

Info

Publication number
AU2001280438A1
AU2001280438A1 AU2001280438A AU8043801A AU2001280438A1 AU 2001280438 A1 AU2001280438 A1 AU 2001280438A1 AU 2001280438 A AU2001280438 A AU 2001280438A AU 8043801 A AU8043801 A AU 8043801A AU 2001280438 A1 AU2001280438 A1 AU 2001280438A1
Authority
AU
Australia
Prior art keywords
substituted heterocyclic
heterocyclic amides
amides
inhibitor
factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001280438A
Inventor
David Kent Herron
Sajan Joseph
Angela Lynn Marquart
John Joseph Masters
David Mendel
Gerald Floyd Smith
Philip Parker Waid
Michael Robert Wiley
Ying Kwong Yee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of AU2001280438A1 publication Critical patent/AU2001280438A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
AU2001280438A 2000-07-27 2001-07-18 Substituted heterocyclic amides Abandoned AU2001280438A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22109200P 2000-07-27 2000-07-27
US60221092 2000-07-27
PCT/US2001/016528 WO2002010154A2 (en) 2000-07-27 2001-07-18 Substituted heterocyclic amides

Publications (1)

Publication Number Publication Date
AU2001280438A1 true AU2001280438A1 (en) 2002-02-13

Family

ID=22826311

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001280438A Abandoned AU2001280438A1 (en) 2000-07-27 2001-07-18 Substituted heterocyclic amides

Country Status (7)

Country Link
US (1) US7160878B2 (en)
EP (1) EP1307444B1 (en)
AT (1) ATE374765T1 (en)
AU (1) AU2001280438A1 (en)
DE (1) DE60130771T2 (en)
ES (1) ES2292607T3 (en)
WO (1) WO2002010154A2 (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU776053B2 (en) 2000-03-31 2004-08-26 Astellas Pharma Inc. Diazepan derivatives or salts thereof
EP1311501B1 (en) 2000-08-17 2005-11-02 Eli Lilly And Company Antithrombotic agents
ES2260336T3 (en) * 2000-11-22 2006-11-01 Astellas Pharma Inc. PHENOL DERIVATIVES SUBSTITUTED OR SALTS OF THE SAME AS INHIBITORS OF THE COAGULATION FACTOR X.
WO2002064567A2 (en) 2000-11-28 2002-08-22 Eli Lilly And Company Substituted carboxamides as inhibitors of factor xa
PT2266558T (en) * 2001-06-07 2017-07-21 Analgesic Neuropharmaceuticals Llc Treatment of neuropathic pain with the n-methyl-d-aspartate (nmda) receptor antagonist dextromethorphan
EP1456175A1 (en) * 2001-12-07 2004-09-15 Eli Lilly And Company Substituted heterocyclic carboxamides with antithrombotic activity
US20050119251A1 (en) * 2001-12-21 2005-06-02 Jian-Min Fu Nicotinamide derivatives and their use as therapeutic agents
US7390813B1 (en) 2001-12-21 2008-06-24 Xenon Pharmaceuticals Inc. Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents
US7262194B2 (en) * 2002-07-26 2007-08-28 Euro-Celtique S.A. Therapeutic agents useful for treating pain
DE602004011064T2 (en) 2003-05-30 2008-12-11 Eli Lilly And Co., Indianapolis ANTIBROMOTIC AETHER
BRPI0413059A (en) 2003-07-29 2006-10-31 Xenon Pharmaceuticals Inc pyridyl derivatives and their use as therapeutic agents
US7759348B2 (en) 2003-07-30 2010-07-20 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
KR100934554B1 (en) * 2003-07-30 2009-12-29 제논 파마슈티칼스 인크. Pyridazine Derivatives and Uses As Therapeutic Agents
US7754711B2 (en) * 2003-07-30 2010-07-13 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
CN101712653A (en) * 2003-07-30 2010-05-26 泽农医药公司 Pyridazine derivatives and their use as therapeutic agents
PL1651620T3 (en) * 2003-07-30 2012-04-30 Xenon Pharmaceuticals Inc Piperazine derivatives and their use as therapeutic agents
US7511066B2 (en) 2003-09-30 2009-03-31 Eli Lilly And Company Antithrombotic aromatic ethers
US7371743B2 (en) 2004-02-28 2008-05-13 Boehringer Ingelheim International Gmbh Carboxylic acid amides, the preparation thereof and their use as medicaments
SE0401342D0 (en) * 2004-05-25 2004-05-25 Astrazeneca Ab Therapeutic compounds
ATE537830T1 (en) * 2004-07-06 2012-01-15 Xenon Pharmaceuticals Inc NICOTINAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTICS
EP2266569A3 (en) 2004-09-20 2011-03-09 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
CA2580787A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
US7951805B2 (en) * 2004-09-20 2011-05-31 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
TW200626139A (en) * 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
CN101084211A (en) * 2004-09-20 2007-12-05 泽农医药公司 Heterocyclic derivatives and their use as therapeutic agents
AU2005286790A1 (en) * 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-CoA-desaturase (SCD)
CN101090724A (en) * 2004-09-20 2007-12-19 泽农医药公司 Heterocyclic derivatives and their use as therapeutic agents
CA2580845A1 (en) * 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase
TW200624427A (en) * 2004-09-20 2006-07-16 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
ATE457302T1 (en) 2004-11-24 2010-02-15 Lilly Co Eli AROMATIC ETHER DERIVATIVES AS THROMBIN INHIBITORS
ES2330461T3 (en) * 2004-11-29 2009-12-10 Eli Lilly And Company ANTHROMBOTIC DIAMIDS.
US7264402B2 (en) * 2005-03-10 2007-09-04 Corning Cable Systems Llc Multi-fiber optic receptacle and plug assembly
EP2029138A1 (en) * 2005-06-03 2009-03-04 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
EP2197873B1 (en) 2007-09-20 2014-07-16 Irm Llc Compounds and compositions as modulators of gpr119 activity
EP2635559A2 (en) * 2010-11-01 2013-09-11 Neurotune AG Neurotrypsin inhibitors

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2664238B2 (en) * 1989-03-01 1997-10-15 日清製粉株式会社 Nicotinic acid or its ester derivatives
US4994456A (en) 1989-03-01 1991-02-19 Nisshin Flour Milling Co., Ltd. Pyridinecarboxylic acid amide derivatives and pharmaceutical compositions comprising same
GB9816837D0 (en) * 1998-08-04 1998-09-30 Zeneca Ltd Amide derivatives
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
HUP9601331A3 (en) * 1996-05-17 2000-06-28 Egyt Gyogyszervegyeszeti Gyar Piperazine- and homopiperazine-derivatives, process for producing them and pharmaceutical compositions containing them
US6359134B1 (en) 1997-05-30 2002-03-19 Takeda Chemical Industries, Ltd. Sulfonamide derivatives, their production and use
IL133625A0 (en) 1997-06-26 2001-04-30 Lilly Co Eli Antithrombotic agents
WO1999000126A1 (en) 1997-06-26 1999-01-07 Eli Lilly And Company Antithrombotic agents
EP1014962A4 (en) 1997-06-26 2007-06-27 Lilly Co Eli Antithrombotic agents
ES2241151T3 (en) 1997-06-26 2005-10-16 Eli Lilly And Company ANTITROMBOTIC AGENTS.
AU735144B2 (en) 1997-07-23 2001-07-05 Yamanouchi Pharmaceutical Co., Ltd. Novel hexahydro-1,4-diazepine derivatives or their salts
EP1031563B1 (en) 1997-09-30 2005-12-28 Daiichi Pharmaceutical Co., Ltd. Sulfonyl derivatives
AU3352899A (en) 1997-12-11 1999-07-12 American Home Products Corporation 2,4,6-trisubstituted pyridines with estrogenic activity and methods for the solid phase synthesis thereof
US6140351A (en) 1997-12-19 2000-10-31 Berlex Laboratories, Inc. Ortho-anthranilamide derivatives as anti-coagulants
ES2215337T3 (en) 1997-12-19 2004-10-01 Schering Aktiengesellschaft ORTO-ANTRANILAMIDE DERIVATIVES AS ANTICOAGULANTS.
EP1057818A4 (en) * 1998-01-30 2003-01-29 Meiji Seika Kaisha PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS
TR200100300T2 (en) 1998-08-04 2001-07-23 Astrazeneca Ab Amide derivatives useful as inhibitors in the production of cytokines
ES2226485T3 (en) 1998-12-23 2005-03-16 Eli Lilly And Company AROMATIC AMIDAS.
ATE240316T1 (en) 1998-12-23 2003-05-15 Lilly Co Eli HETEROAROMATIC AMIDES AS INHIBITORS OF FACTOR XA
US6610704B1 (en) 1998-12-23 2003-08-26 Eli Lilly And Company Antithrombotic amides
JP2002533442A (en) 1998-12-24 2002-10-08 イーライ・リリー・アンド・カンパニー Heterocyclic amides as factor Xa inhibitors
JP4390024B2 (en) * 1999-04-23 2009-12-24 アステラス製薬株式会社 Novel diazepane derivatives or salts thereof
US6844367B1 (en) 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
WO2001019798A2 (en) 1999-09-17 2001-03-22 Cor Therapeutics Inc. INHIBITORS OF FACTOR Xa
DE60040676D1 (en) 1999-09-17 2008-12-11 Millennium Pharm Inc BENZAMIDES AND SIMILAR INHIBITORS OF FACTOR Xa
ATE311366T1 (en) 2000-02-29 2005-12-15 Millennium Pharm Inc BENZAMIDE AND SIMILAR FACTOR XA INHIBITORS
AU776053B2 (en) 2000-03-31 2004-08-26 Astellas Pharma Inc. Diazepan derivatives or salts thereof

Also Published As

Publication number Publication date
WO2002010154A2 (en) 2002-02-07
ES2292607T3 (en) 2008-03-16
EP1307444B1 (en) 2007-10-03
EP1307444A2 (en) 2003-05-07
US7160878B2 (en) 2007-01-09
US20040097491A1 (en) 2004-05-20
DE60130771T2 (en) 2008-07-17
ATE374765T1 (en) 2007-10-15
DE60130771D1 (en) 2007-11-15
WO2002010154A3 (en) 2002-06-27

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