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AU2001278696A1 - Aqueous pharmaceutical compositions - Google Patents

Aqueous pharmaceutical compositions

Info

Publication number
AU2001278696A1
AU2001278696A1 AU2001278696A AU7869601A AU2001278696A1 AU 2001278696 A1 AU2001278696 A1 AU 2001278696A1 AU 2001278696 A AU2001278696 A AU 2001278696A AU 7869601 A AU7869601 A AU 7869601A AU 2001278696 A1 AU2001278696 A1 AU 2001278696A1
Authority
AU
Australia
Prior art keywords
aqueous pharmaceutical
pharmaceutical composition
administration
ofloxacin
antibacterial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001278696A
Inventor
Masanobu Kirita
Hidekazu Suzuki
Masanobu Takeuchi
Takahiro Wada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wakamoto Pharmaceutical Co Ltd
Original Assignee
Wakamoto Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wakamoto Pharmaceutical Co Ltd filed Critical Wakamoto Pharmaceutical Co Ltd
Publication of AU2001278696A1 publication Critical patent/AU2001278696A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention has an object to provide an antibacterial aqueous pharmaceutical composition and an aqueous pharmaceutical composition which have a sufficiently low gelation temperature even when new quinolone antibacterial agents such as ofloxacin as the active ingredient and can be retained at the administration site for a long time by virtue of rapid viscosity increase after administration in spite of their being liquid at administration, thereby attaining high availability of a pharmaceutical agent. The present invention relates to an antibacterial aqueous pharmaceutical composition which comprises: 2.8 to 4 w/v% of methylcellulose, the 2 w/v% aqueous solution of which has a viscosity of 12 mPa.s or below at 20 DEG C; 1.5 to 2.3 w/v% of citric acid; 2 to 4 w/v% of polyethylene glycol; and 0.1 to 0.5 w/v% of ofloxacin.
AU2001278696A 2000-08-08 2001-08-08 Aqueous pharmaceutical compositions Abandoned AU2001278696A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000240455A JP3450805B2 (en) 2000-08-08 2000-08-08 Aqueous pharmaceutical composition
JP2000-240455 2000-08-08
PCT/JP2001/006805 WO2002011734A1 (en) 2000-08-08 2001-08-08 Aqueous pharmaceutical compositions

Publications (1)

Publication Number Publication Date
AU2001278696A1 true AU2001278696A1 (en) 2002-02-18

Family

ID=18731808

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001278696A Abandoned AU2001278696A1 (en) 2000-08-08 2001-08-08 Aqueous pharmaceutical compositions

Country Status (13)

Country Link
US (2) US20030194441A1 (en)
EP (1) EP1312366B1 (en)
JP (1) JP3450805B2 (en)
KR (1) KR20030040384A (en)
CN (1) CN1446092A (en)
AT (1) ATE376423T1 (en)
AU (1) AU2001278696A1 (en)
CA (1) CA2421787A1 (en)
DE (1) DE60131088T2 (en)
HU (1) HUP0302690A3 (en)
NO (1) NO20030533L (en)
RU (1) RU2003106395A (en)
WO (1) WO2002011734A1 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005018646A1 (en) * 2003-08-21 2005-03-03 Sucampo Ag Ophthalmic composition
JPWO2004026953A1 (en) * 2002-09-18 2006-01-19 わかもと製薬株式会社 Transparent reversible thermogelled aqueous composition
US7220431B2 (en) 2002-11-27 2007-05-22 Regents Of The University Of Minnesota Methods and compositions for applying pharmacologic agents to the ear
US20050085446A1 (en) * 2003-04-14 2005-04-21 Babu M.K. M. Fluoroquinolone formulations and methods of making and using the same
JP2005008625A (en) * 2003-05-23 2005-01-13 Santen Pharmaceut Co Ltd Eye lotion containing quinolone-based antibacterial compound
KR101144647B1 (en) * 2003-10-31 2012-05-08 와카모토 세이야꾸 가부시끼가이샤 Water-based composition undergoing reversible thermogelation
WO2005079809A1 (en) * 2004-02-19 2005-09-01 Santen Pharmaceutical Co., Ltd. Transparent latanoprost eye drops
JP2005263792A (en) * 2004-02-19 2005-09-29 Santen Pharmaceut Co Ltd Clear latanoprost eye lotion
US7658947B2 (en) * 2004-06-25 2010-02-09 Kimberly-Clark Worldwide, Inc. Thermo-gelling composition
JP2007277095A (en) * 2004-07-02 2007-10-25 Wakamoto Pharmaceut Co Ltd Azithromycin-containing reversible heat-gellable aqueous composition
JP2006036660A (en) * 2004-07-23 2006-02-09 Wakamoto Pharmaceut Co Ltd Hardly soluble pharmaceutical-containing aqueously suspended thermogelling preparation
WO2006047418A1 (en) * 2004-10-25 2006-05-04 Alimera Sciences, Inc. Ophthalmic compositions and methods of using the same
US20060089384A1 (en) * 2004-10-25 2006-04-27 Minno George E Ophthalmic compositions and methods of using the same
US20080014274A1 (en) * 2006-07-14 2008-01-17 Wyeth Enhanced stability phenylephrine liquid compositions
CN101130083B (en) * 2007-08-07 2010-05-19 山东博士伦福瑞达制药有限公司 Ophthalmic composition, producing method and use of the same
ITMI20080289A1 (en) * 2008-02-22 2009-08-23 S I F I Societa Industria Farmaceutica Italia COMPOSITIONS OF GEMIFLOXACINE WITH HIGH EFFICIENCY ON EYE DISEASES
EP2143422A1 (en) * 2008-07-11 2010-01-13 S.I.F.I - Società Industria Farmaceutica Italiana - S.P.A. Ophthalmic compositions containing gemifloxacin for the treatment of ocular infections
US7842725B2 (en) 2008-07-24 2010-11-30 Ecolab USA, Inc. Foaming alcohol compositions with selected dimethicone surfactants
TW201023912A (en) * 2008-12-05 2010-07-01 Alcon Res Ltd Pharmaceutical suspension
CN102340993A (en) * 2009-03-03 2012-02-01 爱尔康研究有限公司 Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (RTKi) compounds to the eye
US8912236B2 (en) * 2009-03-03 2014-12-16 Alcon Research, Ltd. Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (RTKi) compounds to the eye
DE102009021372A1 (en) * 2009-05-14 2010-11-18 Ursapharm Arzneimittel Gmbh Phosphate-free pharmaceutical composition for glaucoma treatment
DK2521547T3 (en) * 2010-01-07 2017-11-20 Novartis Ag METHODS AND COMPOSITIONS FOR APPLYING MOXIFLOXACIN TO EARS
CN101843625B (en) * 2010-03-30 2012-02-08 重庆巴仕迪动物药业有限公司 Compound ofloxacin injection for livestock and preparation method thereof
WO2012012476A1 (en) * 2010-07-21 2012-01-26 Alcon Research, Ltd. Pharmaceutical composition with enhanced solubility characteristics
JP6356795B2 (en) * 2013-07-17 2018-07-11 ダウ グローバル テクノロジーズ エルエルシー Mucosal composition containing methylcellulose
CN104000777B (en) * 2014-05-21 2016-06-01 丽珠医药集团股份有限公司 A kind of levofloxacin preparation
CN104784101A (en) * 2015-03-05 2015-07-22 中国药科大学制药有限公司 Prescription and preparation method for tranilast gel and ointment
WO2018199180A1 (en) 2017-04-25 2018-11-01 わかもと製薬株式会社 Thermogelling artificial tears
US20180318319A1 (en) 2017-05-04 2018-11-08 Ocular Science, Inc. Compositions and Methods for Treating Eyes and Methods of Preparation
CN109260152A (en) * 2018-11-13 2019-01-25 禹州市中医院 A kind of lomefloxacin hydrochloride auristilla
US11071724B2 (en) 2019-05-17 2021-07-27 Ocular Science, Inc. Compositions and methods for treating presbyopia
RS62932B1 (en) * 2019-07-23 2022-03-31 Nicox Ophthalmics Inc Process for the preparation of sterile ophthalmic aqueous fluticasone propionate form a nanocrystals suspensions
CN117338787A (en) * 2023-11-24 2024-01-05 南京恒道医药科技股份有限公司 Ophthalmic pharmaceutical composition and preparation method thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE84968T1 (en) * 1987-11-13 1993-02-15 Asta Medica Ag MEDICATIONS CONTAINING AZELASTINE FOR NOSE AND/OR EYE USE.
CA2153234C (en) * 1993-04-16 1999-02-16 Masanobu Takeuchi Aqueous drug composition having property of reversible thermosetting gelation
KR100215739B1 (en) * 1994-10-13 1999-08-16 오쿠다 기요아키 Lyophilized preparation providing reversibly thermogelling water-base medicinal composition
ATE215821T1 (en) * 1995-01-20 2002-04-15 Wakamoto Pharma Co Ltd ANTI-INFLAMMATORY EYE DROPS
ZA966579B (en) * 1995-08-04 1998-02-02 Wakamoto Pharma Co Ltd O/W emulsion composition for eye drops.
WO1998030221A1 (en) * 1997-01-10 1998-07-16 Wakamoto Pharmaceutical Co., Ltd. Difluprednate-containing ophthalmic o/w emulsion composition
EP1020194A4 (en) * 1997-10-01 2003-05-21 Wakamoto Pharma Co Ltd O/w emulsion compositions
US6171616B1 (en) * 1998-04-13 2001-01-09 Shin-Etsu Chemical Co., Ltd. Solid preparation and a method of manufacturing it
EP1082966A4 (en) * 1998-05-15 2004-07-21 Wakamoto Pharma Co Ltd Anti-inflammatory eye drops
WO1999063968A1 (en) * 1998-06-10 1999-12-16 Wakamoto Pharmaceutical Co., Ltd. Aqueous preparations containing hardly soluble drug
JP2001048807A (en) * 1999-08-04 2001-02-20 Wakamoto Pharmaceut Co Ltd Pharmaceutical preparation formed by dissolving slightly soluble medicament in water
WO2001037838A1 (en) * 1999-11-24 2001-05-31 Wakamoto Pharmaceutical Co., Ltd. Ophthalmic aqueous preparation
JP4541504B2 (en) * 2000-06-14 2010-09-08 沢井製薬株式会社 A stable aqueous solution formulation containing tranilast or a pharmacologically acceptable salt thereof as an active ingredient
JP2002097129A (en) * 2000-07-21 2002-04-02 Rohto Pharmaceut Co Ltd Eye lotion

Also Published As

Publication number Publication date
EP1312366A4 (en) 2006-04-26
JP3450805B2 (en) 2003-09-29
DE60131088D1 (en) 2007-12-06
KR20030040384A (en) 2003-05-22
NO20030533D0 (en) 2003-02-03
EP1312366B1 (en) 2007-10-24
JP2003160473A (en) 2003-06-03
HUP0302690A2 (en) 2003-11-28
NO20030533L (en) 2003-02-26
US20030194441A1 (en) 2003-10-16
DE60131088T2 (en) 2008-07-31
WO2002011734A1 (en) 2002-02-14
HUP0302690A3 (en) 2004-06-28
US20060172969A1 (en) 2006-08-03
CA2421787A1 (en) 2003-02-04
EP1312366A1 (en) 2003-05-21
EP1312366A8 (en) 2003-11-12
ATE376423T1 (en) 2007-11-15
RU2003106395A (en) 2004-07-27
US7612115B2 (en) 2009-11-03
CN1446092A (en) 2003-10-01

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