[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

AU2001259589A1 - Sulfonyl aryl or heteroaryl hydroxamic acid compounds - Google Patents

Sulfonyl aryl or heteroaryl hydroxamic acid compounds

Info

Publication number
AU2001259589A1
AU2001259589A1 AU2001259589A AU5958901A AU2001259589A1 AU 2001259589 A1 AU2001259589 A1 AU 2001259589A1 AU 2001259589 A AU2001259589 A AU 2001259589A AU 5958901 A AU5958901 A AU 5958901A AU 2001259589 A1 AU2001259589 A1 AU 2001259589A1
Authority
AU
Australia
Prior art keywords
acid compounds
hydroxamic acid
sulfonyl aryl
heteroaryl hydroxamic
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001259589A
Inventor
Thomas E Barta
Daniel P Becker
Louis J. Bedell
Gary A Decrescenzo
John N Freskos
Daniel P. Getman
Joseph Mcdonald
Brent V. Mischke
Shashidhar N Rao
Clara I Villamil
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia LLC
Original Assignee
Pharmacia LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia LLC filed Critical Pharmacia LLC
Publication of AU2001259589A1 publication Critical patent/AU2001259589A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2001259589A 2000-05-11 2001-05-07 Sulfonyl aryl or heteroaryl hydroxamic acid compounds Abandoned AU2001259589A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09569034 2000-05-11
US09/569,034 US7115632B1 (en) 1999-05-12 2000-05-11 Sulfonyl aryl or heteroaryl hydroxamic acid compounds
PCT/US2001/014706 WO2001085680A2 (en) 2000-05-11 2001-05-07 Sulfonyl aryl or heteroaryl hydroxamic acid compounds

Publications (1)

Publication Number Publication Date
AU2001259589A1 true AU2001259589A1 (en) 2001-11-20

Family

ID=24273821

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001259589A Abandoned AU2001259589A1 (en) 2000-05-11 2001-05-07 Sulfonyl aryl or heteroaryl hydroxamic acid compounds

Country Status (3)

Country Link
US (1) US7115632B1 (en)
AU (1) AU2001259589A1 (en)
WO (1) WO2001085680A2 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6696449B2 (en) 1997-03-04 2004-02-24 Pharmacia Corporation Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors
US6683078B2 (en) * 2001-07-19 2004-01-27 Pharmacia Corporation Use of sulfonyl aryl or heteroaryl hydroxamic acids and derivatives thereof as aggrecanase inhibitors
NZ536116A (en) 2002-04-03 2007-01-26 Topotarget Uk Ltd Carbamic acid compounds comprising a piperazine linkage as HDAC inhibitors
CA2513246A1 (en) 2003-01-17 2004-08-05 Topotarget Uk Limited Carbamic acid compounds comprising an ester or ketone linkage as hdac inhibitors
US8101799B2 (en) * 2005-07-21 2012-01-24 Ardea Biosciences Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK
EP1908751A1 (en) * 2006-10-03 2008-04-09 EOS S.p.A. N-hydroxy benzamides with antitumour activity
AP2817A (en) * 2007-07-30 2013-12-31 Ardea Biosciences Inc Derivatives of n-(arylamino)sulfonamides includingpolymorphs as inhibitors of mek as well as compos itions, methods of use and methods for preparing the same
CA2694646C (en) * 2007-07-30 2017-09-05 Ardea Biosciences, Inc. Combinations of mek inhibitors and raf kinase inhibitors and uses thereof
US8044240B2 (en) 2008-03-06 2011-10-25 Ardea Biosciences Inc. Polymorphic form of N-(S)-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide and uses thereof
MX2011012861A (en) 2009-06-04 2012-01-25 Schering Corp Active metabolite of a thrombin receptor antagonist.
JP5890312B2 (en) 2009-10-09 2016-03-22 ザフゲン，インコーポレイテッド Sulfone compounds used in the treatment of obesity
CA2806221A1 (en) 2010-07-22 2012-01-26 Zafgen, Inc. Tricyclic compounds and methods of making and using same
BR112013018771A2 (en) 2011-01-26 2019-09-17 Zafgen Inc tetrazole compounds and methods for making and using them
KR20140053013A (en) 2011-05-06 2014-05-07 자프겐 인크. Tricyclic sulfonamide compounds and methods of making and using same
BR112013028534A2 (en) 2011-05-06 2016-09-06 Zafgen Inc partially saturated tricyclic compounds and methods for their production and use
EP2705035B1 (en) 2011-05-06 2016-12-14 Zafgen, Inc. Tricyclic pyrazole sulfonamide compounds and methods of making and using same
US9359369B2 (en) 2012-01-18 2016-06-07 Zafgen, Inc. Tricyclic sulfonamide compounds and methods of making and using same
AU2013209719A1 (en) 2012-01-18 2014-08-07 Zafgen, Inc. Tricyclic sulfone compounds and methods of making and using same
WO2014071363A1 (en) 2012-11-05 2014-05-08 Zafgen, Inc. Tricyclic compounds and methods of making and using same
EA028367B1 (en) 2012-11-05 2017-11-30 Зафджен, Инк. Methods of treating liver diseases
CN104918928A (en) 2012-11-05 2015-09-16 扎夫根股份有限公司 Tricyclic compounds for use in the treatment and/or control of obesity
AU2015229258B2 (en) * 2014-03-12 2020-01-30 The Trustees Of Columbia University In The City Of New York A new class of Mu-Opioid receptor agonists
WO2017049158A1 (en) 2015-09-16 2017-03-23 The Trustees Of Columbia University In The City Of New York Carboxylic diarylthiazepineamines as mu-opioid receptor agonists
BR112021006407A8 (en) 2018-10-04 2022-12-06 Inst Nat Sante Rech Med use of egfr inhibitors for keratoderms

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4148801A (en) 1978-07-03 1979-04-10 American Home Products Corporation 3-[(Chlorophenylsulfonyl)methyl]-1,2,4-oxadiazole-5-carboxylic acid derivatives
US4595700A (en) 1984-12-21 1986-06-17 G. D. Searle & Co. Thiol based collagenase inhibitors
US5103014A (en) 1987-09-30 1992-04-07 American Home Products Corporation Certain 3,3'-[[[(2-phenyl-4-thiazolyl)methoxy]phenyl]methylene]dithiobis-propanoic acid derivatives
GB2212153B (en) 1987-11-16 1992-01-15 Squibb & Sons Inc Phenyl hydroxamic acids
GB8827305D0 (en) 1988-11-23 1988-12-29 British Bio Technology Compounds
TW224459B (en) 1990-12-17 1994-06-01 Sankyo Co
EP0634998B1 (en) 1992-04-07 1997-03-19 British Biotech Pharmaceuticals Limited Hydroxamic acid based collagenase and cytokine inhibitors
US5376664A (en) 1992-07-27 1994-12-27 The Du Pont Merck Pharmaceutical Company Unsymmetrical mono-3-nitro bis-naphthalimides as anticancer agents
US5455258A (en) 1993-01-06 1995-10-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
US5646167A (en) 1993-01-06 1997-07-08 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamix acids
US5506242A (en) 1993-01-06 1996-04-09 Ciba-Geigy Corporation Arylsufonamido-substituted hydroxamic acids
US5552419A (en) 1993-01-06 1996-09-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
GB9307956D0 (en) 1993-04-17 1993-06-02 Walls Alan J Hydroxamic acid derivatives
GB9320660D0 (en) 1993-10-07 1993-11-24 British Bio Technology Inhibition of cytokine production
GB9323165D0 (en) 1993-11-10 1994-01-05 Chiros Ltd Compounds
WO1995029892A1 (en) 1994-04-28 1995-11-09 The Du Pont Merck Pharmaceutical Company Hydroxamic acid and amino acid derivatives and their use as anti-arthritic agents
GB9416897D0 (en) 1994-08-20 1994-10-12 British Biotech Pharm Metalloproteinase inhibitors
EP0784629B1 (en) 1994-10-05 1999-04-28 Darwin Discovery Limited Peptidyl compounds and their therapeutic use as inhibitors of metalloproteases
SK73898A3 (en) 1995-12-08 1999-01-11 Agouron Pharma Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation
EP0780386B1 (en) 1995-12-20 2002-10-02 F. Hoffmann-La Roche Ag Matrix metalloprotease inhibitors
AU1529897A (en) 1996-01-02 1997-07-28 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted (aryl, heteroaryl, arylmethyl or heteroarylmethyl) hydroxamic acid compounds
KR20000022532A (en) 1996-06-27 2000-04-25 오노 야꾸힝 고교 가부시키가이샤 Aryl (sulfide, sulfoxide and sulfone) derivatives and drugs containing the same as the active ingredient
EP0939628B1 (en) 1996-07-22 2003-03-05 Monsanto Company Thiol sulfone metalloprotease inhibitors
BR9711027A (en) 1996-08-07 1999-08-17 Darwin Discovery Ltd Hydroxic and carboxylic acid derivatives having mmp and tnf inhibitory activity
PL331599A1 (en) 1996-08-14 1999-08-02 Zeneca Ltd Substituted derivatives of pyrimidine and their pharmaceutical application
DE69801530T2 (en) 1997-01-13 2002-05-08 Fuji Photo Film Co., Ltd. Heat-developable, photosensitive color material
ATE263554T1 (en) 1997-02-27 2004-04-15 Wyeth Corp N-HYDROXY-2-(ALKYL, ARYL OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED ALKYL, ARYL OR HETEROARYL AMIDES AS MATRIX METALLOPROTEINASE INHIBITORS
US6197791B1 (en) * 1997-02-27 2001-03-06 American Cyanamid Company N-hdroxy-2-(alkyl, aryl, or heteroaryl, sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
CA2283272A1 (en) 1997-03-04 1998-09-11 Monsanto Company Aromatic sulfonyl alpha-cycloamino hydroxamic acid compounds
US6794511B2 (en) * 1997-03-04 2004-09-21 G. D. Searle Sulfonyl aryl or heteroaryl hydroxamic acid compounds
US6576664B1 (en) 1997-08-18 2003-06-10 Bristol-Myers Squibb Pharma Company Inhibitors of aggrecanase and matrix metalloproteinases for the treatment of arthritis
US20010039287A1 (en) 1997-11-14 2001-11-08 Thomas E Barta Aromatic sulfone hydroxamic acid metalloprotease inhibitor
US6750228B1 (en) 1997-11-14 2004-06-15 Pharmacia Corporation Aromatic sulfone hydroxamic acid metalloprotease inhibitor
IL135106A0 (en) 1997-11-14 2001-05-20 Searle & Co Aromatic sulfone hydroxamic acid metalloprotease inhibitor
CA2356606A1 (en) * 1998-12-23 2000-07-06 G.D. Searle & Co. Method of using a cyclooxygenase-2 inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
EP1157021A1 (en) 1999-02-08 2001-11-28 G.D. SEARLE & CO. Sulfamato hydroxamic acid metalloprotease inhibitor
US6465468B1 (en) * 1999-03-22 2002-10-15 Darwin Discovery Limited Hydroxamic and carboxylic acid derivatives
WO2000059874A1 (en) 1999-04-02 2000-10-12 Du Pont Pharmaceuticals Company NOVEL AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE
CN1360577A (en) 1999-05-12 2002-07-24 G.D.瑟尔公司 Hydroxamic acid derivs. as matrix metalloprotease inhibitors
EP1081137A1 (en) 1999-08-12 2001-03-07 Pfizer Products Inc. Selective inhibitors of aggrecanase in osteoarthritis treatment
AU7514700A (en) * 1999-09-07 2001-04-10 Syngenta Participations Ag Cyanopiperidines

Also Published As

Publication number Publication date
WO2001085680A2 (en) 2001-11-15
WO2001085680A3 (en) 2002-03-07
US7115632B1 (en) 2006-10-03

Similar Documents

Publication Publication Date Title
AU2001259589A1 (en) Sulfonyl aryl or heteroaryl hydroxamic acid compounds
AU2002257076A1 (en) Nucleic acid shuffling
AU2002222228A1 (en) Chemical compounds
AU2001284584A1 (en) Chemical compounds
AU2001262886A1 (en) Chemical compounds
AU2001228638A1 (en) Chemical compounds
AU1704201A (en) Sulfonic acid or sulfonylamino n-(heteroaralkyl)-azaheterocyclylamide compounds
AU6542298A (en) Thioaryl sulfonamide hydroxamic acid compounds
AU2001280167A1 (en) Novel propenohydroxamic acid derivatives
AU2002366440A1 (en) Chemical compounds
AU7494100A (en) Charge-modified nucleic acid terminators
AU2002258502A1 (en) Nucleic acid labeling compounds
AU3006900A (en) Asymmetric cycloaddition reactions
AU2002350942A1 (en) Imidazolidineacetic acid derivatives
AU2001262111A1 (en) Aryl and heteroaryl sulfonates
AU2002256497A1 (en) Sulfonamides
AU2001261311A1 (en) Chemical structure identification
AU2001279648A1 (en) Organophosphorous hydroxamic acid derivatives used as herbicides
AU2002332299A1 (en) Reverse hydroxamic acid derivatives
AU5689400A (en) Chemical compounds
AU6685598A (en) Aromatic sulfonyl alpha-cycloamino hydroxamic acid compounds
AU2002349280A1 (en) Structure for erecting walls
GB0109554D0 (en) Hydroxamic acid derivatives
GB0109557D0 (en) Hydroxamic acid derivatives
GB0110770D0 (en) Hydroxamic acid derivatives