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AU1782301A - 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p39 kinase inhibitors - Google Patents

3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p39 kinase inhibitors

Info

Publication number
AU1782301A
AU1782301A AU17823/01A AU1782301A AU1782301A AU 1782301 A AU1782301 A AU 1782301A AU 17823/01 A AU17823/01 A AU 17823/01A AU 1782301 A AU1782301 A AU 1782301A AU 1782301 A AU1782301 A AU 1782301A
Authority
AU
Australia
Prior art keywords
csbp
kinase inhibitors
compounds
quinazolin
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU17823/01A
Inventor
Jerry L. Adams
Jeffrey Charles Boehm
Michael J. Bower
Don E. Griswold
David C. Underwood
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of AU1782301A publication Critical patent/AU1782301A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract

Substituted quinazolinone compounds of formula (I) and compositions thereof for use in therapy as CSBP/p38 kinase inhibitors.
AU17823/01A 1999-11-23 2000-11-21 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p39 kinase inhibitors Abandoned AU1782301A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16697299P 1999-11-23 1999-11-23
US60166972 1999-11-23
PCT/US2000/031874 WO2001038313A1 (en) 1999-11-23 2000-11-21 3,4-DIHYDRO-(1H)QUINAZOLIN-2-ONE COMPOUNDS AS CSBP/p39 kINASE INHIBITORS

Publications (1)

Publication Number Publication Date
AU1782301A true AU1782301A (en) 2001-06-04

Family

ID=22605414

Family Applications (1)

Application Number Title Priority Date Filing Date
AU17823/01A Abandoned AU1782301A (en) 1999-11-23 2000-11-21 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p39 kinase inhibitors

Country Status (8)

Country Link
US (1) US6982270B1 (en)
EP (1) EP1233950B1 (en)
JP (1) JP2003528043A (en)
AT (1) ATE305787T1 (en)
AU (1) AU1782301A (en)
DE (1) DE60023025T2 (en)
ES (1) ES2249309T3 (en)
WO (1) WO2001038313A1 (en)

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AU2003250475A1 (en) * 2002-08-13 2004-02-25 Warner-Lambert Company Llc 5,6-fused 3,4-dihydropyrimidine-2-one derivatives as matrix metalloproteinase inhibitors
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AU2007275696B2 (en) * 2006-07-17 2011-11-10 Amgen Inc. Quinazoline and pyridopyrimidine derivatives as p38 kinase inhibitors
JP2010522155A (en) * 2007-03-20 2010-07-01 カディラ ファーマシューティカルズ リミテッド P38 inhibitor
EP1992344A1 (en) 2007-05-18 2008-11-19 Institut Curie P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
US20190060286A1 (en) 2016-02-29 2019-02-28 University Of Florida Research Foundation, Incorpo Chemotherapeutic Methods
CA3077499C (en) 2017-10-05 2021-09-21 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
GB201721793D0 (en) 2017-12-22 2018-02-07 Hvivo Services Ltd Methods and compunds for the treatment or prevention of hypercytokinemia and severe influenza

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