ATE7655T1 - Arzneizubereitung mit verzoegerter wirkstoffabgabe und verfahren zu deren herstellung. - Google Patents
Arzneizubereitung mit verzoegerter wirkstoffabgabe und verfahren zu deren herstellung.Info
- Publication number
- ATE7655T1 ATE7655T1 AT81302895T AT81302895T ATE7655T1 AT E7655 T1 ATE7655 T1 AT E7655T1 AT 81302895 T AT81302895 T AT 81302895T AT 81302895 T AT81302895 T AT 81302895T AT E7655 T1 ATE7655 T1 AT E7655T1
- Authority
- AT
- Austria
- Prior art keywords
- component
- melting
- finely divided
- manufacture
- melting point
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3024416A DE3024416C2 (de) | 1980-06-28 | 1980-06-28 | Verfahren zur Herstellung von Arzneimitteln mit retardierter Wirkstoff-Freisetzung |
EP81302895A EP0043254B1 (de) | 1980-06-28 | 1981-06-26 | Arzneizubereitung mit verzögerter Wirkstoffabgabe und Verfahren zu deren Herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE7655T1 true ATE7655T1 (de) | 1984-06-15 |
Family
ID=6105792
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT81302895T ATE7655T1 (de) | 1980-06-28 | 1981-06-26 | Arzneizubereitung mit verzoegerter wirkstoffabgabe und verfahren zu deren herstellung. |
Country Status (15)
Country | Link |
---|---|
US (1) | US4483847A (de) |
EP (1) | EP0043254B1 (de) |
JP (1) | JPS5738711A (de) |
AT (1) | ATE7655T1 (de) |
AU (1) | AU545279B2 (de) |
CA (1) | CA1165691A (de) |
DD (1) | DD159966A5 (de) |
DE (2) | DE3024416C2 (de) |
DK (1) | DK155711C (de) |
ES (1) | ES503414A0 (de) |
FI (1) | FI76928C (de) |
HU (1) | HU184862B (de) |
IE (1) | IE51353B1 (de) |
SU (1) | SU1360575A3 (de) |
ZA (1) | ZA814094B (de) |
Families Citing this family (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5959632A (ja) * | 1982-09-28 | 1984-04-05 | Teikoku Chem Ind Corp Ltd | 徐放性組成物 |
US4713245A (en) * | 1984-06-04 | 1987-12-15 | Mitsui Toatsu Chemicals, Incorporated | Granule containing physiologically-active substance, method for preparing same and use thereof |
JPS6150912A (ja) * | 1984-08-16 | 1986-03-13 | Shionogi & Co Ltd | リポソ−ム製剤の製造法 |
US4755387A (en) * | 1985-03-21 | 1988-07-05 | The Procter & Gamble Company | Therapeutic particles |
FR2581541B1 (fr) * | 1985-05-09 | 1988-05-20 | Rhone Poulenc Sante | Nouvelles compositions pharmaceutiques permettant la liberation prolongee d'un principe actif et leur procede de preparation |
US4820523A (en) * | 1986-04-15 | 1989-04-11 | Warner-Lambert Company | Pharmaceutical composition |
US4837381A (en) * | 1986-08-11 | 1989-06-06 | American Cyanamid Company | Compositions for parenteral administration and their use |
US4822619A (en) * | 1987-02-18 | 1989-04-18 | Ionor, Inc. | Controlled release pharmaceutical preparation containing a gastrointestinal irritant drug |
JP2668880B2 (ja) * | 1987-06-23 | 1997-10-27 | 日本油脂株式会社 | 被覆アミノ酸類の製造方法 |
DE3737741A1 (de) * | 1987-11-06 | 1989-05-18 | Goedecke Ag | Oral anzuwendende arzneiform zur einmal taeglichen behandlung der hypertonie mit diltiazemhydrochlorid |
JP2681373B2 (ja) * | 1988-07-18 | 1997-11-26 | 塩野義製薬株式会社 | 徐放性製剤の製造法 |
EP0418596A3 (en) * | 1989-09-21 | 1991-10-23 | American Cyanamid Company | Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form |
US5213810A (en) * | 1990-03-30 | 1993-05-25 | American Cyanamid Company | Stable compositions for parenteral administration and method of making same |
IE61651B1 (en) * | 1990-07-04 | 1994-11-16 | Zambon Spa | Programmed release oral solid pharmaceutical dosage form |
US5134016A (en) * | 1990-10-31 | 1992-07-28 | E. I. Du Pont De Nemours And Company | Fiber reinforced porous sheets |
US5266331A (en) * | 1991-11-27 | 1993-11-30 | Euroceltique, S.A. | Controlled release oxycodone compositions |
US5958459A (en) * | 1991-12-24 | 1999-09-28 | Purdue Pharma L.P. | Opioid formulations having extended controlled released |
US5968551A (en) * | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
US5478577A (en) * | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
EP0641195B1 (de) * | 1992-05-22 | 1996-04-10 | Gödecke Aktiengesellschaft | Verfahren zur herstellung retardierter arzneimittelzubereitungen |
IL119660A (en) | 1993-05-10 | 2002-09-12 | Euro Celtique Sa | Controlled release formulation comprising tramadol |
IL110014A (en) * | 1993-07-01 | 1999-11-30 | Euro Celtique Sa | Solid controlled-release oral dosage forms of opioid analgesics |
US7740881B1 (en) | 1993-07-01 | 2010-06-22 | Purdue Pharma Lp | Method of treating humans with opioid formulations having extended controlled release |
US5879705A (en) * | 1993-07-27 | 1999-03-09 | Euro-Celtique S.A. | Sustained release compositions of morphine and a method of preparing pharmaceutical compositions |
KR100354702B1 (ko) * | 1993-11-23 | 2002-12-28 | 유로-셀티크 소시에떼 아노뉨 | 약학조성물의제조방법및서방형조성물 |
US5891471A (en) * | 1993-11-23 | 1999-04-06 | Euro-Celtique, S.A. | Pharmaceutical multiparticulates |
US5843480A (en) * | 1994-03-14 | 1998-12-01 | Euro-Celtique, S.A. | Controlled release diamorphine formulation |
GB9422154D0 (en) | 1994-11-03 | 1994-12-21 | Euro Celtique Sa | Pharmaceutical compositions and method of producing the same |
US5965161A (en) | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
WO1996031197A1 (en) * | 1995-04-03 | 1996-10-10 | Abbott Laboratories | Homogeneous mixtures of low temperature-melting drugs and additives for controlled release |
DE19522899C1 (de) * | 1995-06-23 | 1996-12-19 | Hexal Pharmaforschung Gmbh | Verfahren zum kontinuierlichen Ersintern eines Granulats |
DE69637441T2 (de) | 1995-10-17 | 2009-03-05 | Jagotec Ag | Verabreichung unlöslicher arzneistoffe |
US7255877B2 (en) | 1996-08-22 | 2007-08-14 | Jagotec Ag | Fenofibrate microparticles |
US6465016B2 (en) | 1996-08-22 | 2002-10-15 | Research Triangle Pharmaceuticals | Cyclosporiine particles |
DE19705538C1 (de) * | 1997-02-14 | 1998-08-27 | Goedecke Ag | Verfahren zur Trennung von Wirkstoffen in festen pharmazeutischen Zubereitungen |
US5891476A (en) * | 1997-12-22 | 1999-04-06 | Reo; Joe P. | Tastemasked pharmaceutical system |
IL137734A0 (en) * | 1998-02-11 | 2001-10-31 | Res Triangle Pharm Ltd | Method and composition for treatment of inflammatory conditions |
US6979456B1 (en) | 1998-04-01 | 2005-12-27 | Jagotec Ag | Anticancer compositions |
CN1245955C (zh) | 1998-05-29 | 2006-03-22 | 斯凯伊药品加拿大公司 | 热保护微粒组合物及其最终蒸汽灭菌的方法 |
IL141095A0 (en) | 1998-08-19 | 2002-02-10 | Rtp Pharma Inc | Injectable aqueous dispersions of propofol |
US6806294B2 (en) | 1998-10-15 | 2004-10-19 | Euro-Celtique S.A. | Opioid analgesic |
RU2233654C2 (ru) | 1998-11-20 | 2004-08-10 | Ртп Фарма Инк. | Диспергируемые стабилизированные фосфолипидом микрочастицы |
DE19918325A1 (de) | 1999-04-22 | 2000-10-26 | Euro Celtique Sa | Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion |
KR20020011985A (ko) * | 1999-05-07 | 2002-02-09 | 파르마솔 게엠베하 | 액상 및 고체상 지질 혼합물에 기초한 지질입자들 및 그의제조방법 |
ES2374717T3 (es) * | 1999-10-29 | 2012-02-21 | Euro-Celtique S.A. | Formulaciones de hidrocodona de liberación controlada. |
US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
JP5102423B2 (ja) | 2000-04-20 | 2012-12-19 | オバン・エナジー・リミテッド | 改善された水不溶性薬剤粒子の処理 |
WO2002017883A2 (en) | 2000-08-31 | 2002-03-07 | Rtp Pharma Inc. | Milled particles |
US8586094B2 (en) | 2000-09-20 | 2013-11-19 | Jagotec Ag | Coated tablets |
EP2295042A1 (de) | 2000-10-30 | 2011-03-16 | Euro-Celtique S.A. | Hydrocodon-Formulierungen mit gesteuerter Freisetzung |
ES2290095T3 (es) * | 2000-12-27 | 2008-02-16 | Ares Trading S.A. | Microparticulas lipidicas por micronizacion criogenica. |
US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
DE10300325A1 (de) | 2003-01-09 | 2004-07-22 | Hexal Ag | Granulat mit öliger Substanz, Herstellungsverfahren und Tablette |
CA2509958A1 (en) | 2003-02-03 | 2004-08-19 | Novartis Ag | Pharmaceutical formulation |
DE102004032051A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
US8075872B2 (en) | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
ES2653568T3 (es) | 2004-06-12 | 2018-02-07 | Collegium Pharmaceutical, Inc. | Formulaciones de fármacos para la prevención del abuso |
DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
CA2671200A1 (en) * | 2006-07-21 | 2008-01-24 | Lab International Srl | Hydrophilic abuse deterrent delivery system |
DE102007011485A1 (de) | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
US20110059140A1 (en) * | 2007-12-21 | 2011-03-10 | Gerhard Winter | Extruded rod-shaped devices for controlled release of biological substances to humans and animals |
EP2249811A1 (de) | 2008-01-25 | 2010-11-17 | Grünenthal GmbH | Pharmazeutische dosierform |
CN102123701B (zh) | 2008-05-09 | 2013-03-27 | 格吕伦塔尔有限公司 | 使用喷雾冻凝步骤制备中间粉末制剂以及最终固体剂型的方法 |
EP2997965B1 (de) | 2009-07-22 | 2019-01-02 | Grünenthal GmbH | Manipulationssichere darreichungsform für oxidationsempfindliche opioide |
WO2011009602A1 (en) | 2009-07-22 | 2011-01-27 | Grünenthal GmbH | Hot-melt extruded controlled release dosage form |
US10668060B2 (en) | 2009-12-10 | 2020-06-02 | Collegium Pharmaceutical, Inc. | Tamper-resistant pharmaceutical compositions of opioids and other drugs |
WO2011095314A2 (en) | 2010-02-03 | 2011-08-11 | Grünenthal GmbH | Preparation of a powdery pharmaceutical composition by means of an extruder |
RU2607499C2 (ru) | 2010-09-02 | 2017-01-10 | Грюненталь Гмбх | Устойчивая к разрушению лекарственная форма, которая содержит анионный полимер |
RU2604676C2 (ru) | 2010-09-02 | 2016-12-10 | Грюненталь Гмбх | Устойчивая к разрушению лекарственная форма, содержащая неорганическую соль |
KR20140053158A (ko) | 2011-07-29 | 2014-05-07 | 그뤼넨탈 게엠베하 | 즉시 약물 방출을 제공하는 탬퍼-저항성 정제 |
CN103841964A (zh) | 2011-07-29 | 2014-06-04 | 格吕伦塔尔有限公司 | 提供药物立即释放的抗破碎片剂 |
US20130225697A1 (en) | 2012-02-28 | 2013-08-29 | Grunenthal Gmbh | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
RS57913B1 (sr) | 2012-04-18 | 2019-01-31 | Gruenenthal Gmbh | Farmaceutske dozne forme otporne na neovlašćenu upotrebu i naglo oslobađanje celokupne doze |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
MX371432B (es) | 2013-05-29 | 2020-01-30 | Gruenenthal Gmbh | Forma de dosificacion resistente al uso indebido que contiene una o mas particulas. |
EP3003283A1 (de) | 2013-05-29 | 2016-04-13 | Grünenthal GmbH | Manipulationssichere darreichungsform mit bimodalem freisetzungsprofil |
EP3019157A1 (de) | 2013-07-12 | 2016-05-18 | Grünenthal GmbH | Manipulationssichere darreichungsform mit ethylenvinylacetatpolymer |
MX371372B (es) | 2013-11-26 | 2020-01-28 | Gruenenthal Gmbh | Preparacion de una composicion farmaceutica en polvo por medio de criomolienda. |
CN106572980A (zh) | 2014-05-12 | 2017-04-19 | 格吕伦塔尔有限公司 | 包含他喷他多的防篡改即释胶囊制剂 |
MX2016015417A (es) | 2014-05-26 | 2017-02-22 | Gruenenthal Gmbh | Multiparticulas protegidas contra vertido de dosis etanolico. |
JP2017524014A (ja) * | 2014-08-11 | 2017-08-24 | ペロラ ゲーエムベーハーPerora Gmbh | 満腹感を誘発する方法 |
JP2018517676A (ja) | 2015-04-24 | 2018-07-05 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 即時放出および溶媒抽出に対する耐性を有する改変防止製剤 |
CA2998259A1 (en) | 2015-09-10 | 2017-03-16 | Grunenthal Gmbh | Protecting oral overdose with abuse deterrent immediate release formulations |
US9737530B1 (en) | 2016-06-23 | 2017-08-22 | Collegium Pharmaceutical, Inc. | Process of making stable abuse-deterrent oral formulations |
EP3492070A1 (de) | 2017-11-30 | 2019-06-05 | BIT Pharma GmbH | Verfahren und vorrichtung zur herstellung einer festen dispersion |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2875130A (en) * | 1956-11-20 | 1959-02-24 | Smith Kline French Lab | Method of preparing sustained release particles and the product of the method |
GB906422A (en) * | 1958-05-02 | 1962-09-19 | Wellcome Found | Improvements in and relating to prolonged acting pharmaceutical preparations |
US3108046A (en) * | 1960-11-25 | 1963-10-22 | Smith Kline French Lab | Method of preparing high dosage sustained release tablet and product of this method |
US3146167A (en) * | 1961-10-05 | 1964-08-25 | Smith Kline French Lab | Method of preparing sustained release pellets and products thereof |
GB1021924A (en) * | 1962-06-22 | 1966-03-09 | Smith Kline French Lab | Improvements in or relating to method of preparing sustained release tablets |
US3279998A (en) * | 1962-06-22 | 1966-10-18 | Smith Kline French Lab | Method of preparing sustained release tablets |
US3308217A (en) * | 1965-02-09 | 1967-03-07 | Lowy Lawrence | Method of granulating materials for subsequent forming into tablets |
US4132753A (en) * | 1965-02-12 | 1979-01-02 | American Cyanamid Company | Process for preparing oral sustained release granules |
US3374146A (en) * | 1966-04-18 | 1968-03-19 | American Cyanamid Co | Sustained release encapsulation |
US3487138A (en) * | 1966-11-23 | 1969-12-30 | Merck & Co Inc | Process for preparing a delayed release medicinal tablet |
DE1617418C3 (de) * | 1967-12-16 | 1980-01-24 | Hoechst Ag, 6000 Frankfurt | Herstellung von festen Arzneimittelformen mit verzögerter Wirkstoffabgabe |
NL6808619A (de) * | 1968-06-19 | 1969-12-23 | ||
GB1312918A (en) * | 1969-07-08 | 1973-04-11 | Beecham Group Ltd | Veterinary treatment |
DK121813B (da) * | 1969-12-10 | 1971-12-06 | C Mangen | Fremgangsmåde til fremstilling af tabletlignende doseringsenheder. |
DE2426811A1 (de) * | 1974-06-04 | 1976-01-08 | Klinge Co Chem Pharm Fab | Verfahren zur herstellung von retard-tabletten |
-
1980
- 1980-06-28 DE DE3024416A patent/DE3024416C2/de not_active Expired
-
1981
- 1981-06-17 ZA ZA814094A patent/ZA814094B/xx unknown
- 1981-06-22 FI FI811951A patent/FI76928C/fi not_active IP Right Cessation
- 1981-06-23 AU AU72069/81A patent/AU545279B2/en not_active Expired
- 1981-06-24 DK DK278381A patent/DK155711C/da not_active IP Right Cessation
- 1981-06-25 DD DD81231145A patent/DD159966A5/de unknown
- 1981-06-26 CA CA000380767A patent/CA1165691A/en not_active Expired
- 1981-06-26 IE IE1438/81A patent/IE51353B1/en not_active IP Right Cessation
- 1981-06-26 HU HU811873A patent/HU184862B/hu unknown
- 1981-06-26 ES ES503414A patent/ES503414A0/es active Granted
- 1981-06-26 SU SU813304330A patent/SU1360575A3/ru active
- 1981-06-26 DE DE8181302895T patent/DE3163868D1/de not_active Expired
- 1981-06-26 JP JP9846481A patent/JPS5738711A/ja active Granted
- 1981-06-26 AT AT81302895T patent/ATE7655T1/de not_active IP Right Cessation
- 1981-06-26 EP EP81302895A patent/EP0043254B1/de not_active Expired
-
1983
- 1983-09-20 US US06/534,020 patent/US4483847A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPS6140204B2 (de) | 1986-09-08 |
FI76928B (fi) | 1988-09-30 |
DK155711C (da) | 1989-10-23 |
EP0043254A1 (de) | 1982-01-06 |
IE51353B1 (en) | 1986-12-10 |
US4483847A (en) | 1984-11-20 |
ZA814094B (en) | 1982-07-28 |
ES8301625A1 (es) | 1983-01-01 |
DK155711B (da) | 1989-05-08 |
JPS5738711A (en) | 1982-03-03 |
IE811438L (en) | 1981-12-28 |
DE3024416A1 (de) | 1982-01-21 |
DD159966A5 (de) | 1983-04-20 |
AU7206981A (en) | 1982-01-07 |
FI76928C (fi) | 1989-01-10 |
CA1165691A (en) | 1984-04-17 |
SU1360575A3 (ru) | 1987-12-15 |
HU184862B (en) | 1984-10-29 |
ES503414A0 (es) | 1983-01-01 |
FI811951L (fi) | 1981-12-29 |
AU545279B2 (en) | 1985-07-11 |
DE3163868D1 (en) | 1984-07-05 |
DK278381A (da) | 1981-12-29 |
EP0043254B1 (de) | 1984-05-30 |
DE3024416C2 (de) | 1982-04-15 |
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