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ATE75947T1 - Pharmazeutische zusammensetzung fuer die kombinationstherapie von hormonabhaengigem krebs. - Google Patents

Pharmazeutische zusammensetzung fuer die kombinationstherapie von hormonabhaengigem krebs.

Info

Publication number
ATE75947T1
ATE75947T1 AT85904034T AT85904034T ATE75947T1 AT E75947 T1 ATE75947 T1 AT E75947T1 AT 85904034 T AT85904034 T AT 85904034T AT 85904034 T AT85904034 T AT 85904034T AT E75947 T1 ATE75947 T1 AT E75947T1
Authority
AT
Austria
Prior art keywords
sex steroid
antiandrogen
inhibitor
combination therapy
pharmaceutical composition
Prior art date
Application number
AT85904034T
Other languages
English (en)
Inventor
Alain Belanger
Andre Dupont
Original Assignee
Labrie Fernand
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/636,883 external-priority patent/US4775660A/en
Priority claimed from US06/699,711 external-priority patent/US4659695A/en
Priority claimed from US06/699,710 external-priority patent/US5023234A/en
Priority claimed from US06/699,702 external-priority patent/US4666885A/en
Application filed by Labrie Fernand filed Critical Labrie Fernand
Application granted granted Critical
Publication of ATE75947T1 publication Critical patent/ATE75947T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
AT85904034T 1984-08-02 1985-08-02 Pharmazeutische zusammensetzung fuer die kombinationstherapie von hormonabhaengigem krebs. ATE75947T1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US06/636,883 US4775660A (en) 1984-08-02 1984-08-02 Treatment of breast cancer by combination therapy
US06/699,711 US4659695A (en) 1985-02-08 1985-02-08 Method of treatment of prostate cancer
US06/699,710 US5023234A (en) 1985-02-08 1985-02-08 Combination male breast cancer therapy
US06/699,702 US4666885A (en) 1985-02-08 1985-02-08 Combination therapy for treatment of female breast cancer
EP85904034A EP0195015B1 (de) 1984-08-02 1985-08-02 Pharmazeutische zusammensetzung für die kombinationstherapie von hormonabhängigem krebs
PCT/US1985/001454 WO1986001105A1 (en) 1984-08-02 1985-08-02 Pharmaceutical composition for combination therapy of hormone dependent cancers

Publications (1)

Publication Number Publication Date
ATE75947T1 true ATE75947T1 (de) 1992-05-15

Family

ID=27505215

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85904034T ATE75947T1 (de) 1984-08-02 1985-08-02 Pharmazeutische zusammensetzung fuer die kombinationstherapie von hormonabhaengigem krebs.

Country Status (8)

Country Link
EP (1) EP0195015B1 (de)
JP (1) JPH0680016B2 (de)
AT (1) ATE75947T1 (de)
AU (1) AU594309B2 (de)
DE (2) DE3590389T1 (de)
DK (1) DK168516B1 (de)
IE (1) IE58836B1 (de)
WO (1) WO1986001105A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0301850A3 (de) * 1987-07-31 1990-10-31 Syntex (U.S.A.) Inc. LHRH-Analoge und 19-NOR-progestationäle Steroide für eine therapeutische Anwendung
DE3733478A1 (de) * 1987-10-01 1989-04-13 Schering Ag Antigestagen- und antioestrogenwirksame verbindungen zur geburtseinleitung und zum schwangerschaftsabbruch sowie zur behandlung gynaekologischer stoerungen und hormonabhaengiger tumore
HU199694B (en) * 1988-05-10 1990-03-28 Innofinance Altalanos Innovaci Process for producing citostatic pharmaceutical compositions containing gonadoliberin derivatives
US5686465A (en) * 1988-10-31 1997-11-11 Endorecherche Inc. Sex steroid activity inhibitors
US5395842A (en) * 1988-10-31 1995-03-07 Endorecherche Inc. Anti-estrogenic compounds and compositions
US5204337A (en) * 1988-10-31 1993-04-20 Endorecherche Inc. Estrogen nucleus derivatives for use in inhibition of sex steroid activity
US5372996A (en) * 1989-03-10 1994-12-13 Endorecherche, Inc. Method of treatment of androgen-related diseases
US5595985A (en) 1989-03-10 1997-01-21 Endorecherche Inc. Combination therapy for prophylaxis and/or treatment of benign prostatic hyperplasia
ZA901847B (en) * 1989-03-10 1991-10-30 Endorecherche Inc Combination therapy for the treatment of estrogen sensitive diseases
US5364847A (en) * 1989-03-10 1994-11-15 Endorecherche Inhibitors of sex steroid biosynthesis and methods for their production and use
DE3921059A1 (de) * 1989-06-23 1991-01-10 Schering Ag 11(beta)-aryl-4-estrene, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel
ATE230994T1 (de) * 1989-07-07 2003-02-15 Endorech Inc Methode zur behandlung androgenbedingter krankheiten
DE69033020T2 (de) * 1989-07-07 1999-08-05 Endorecherche Inc., Ste-Foy, Quebec Kombinationstherapie zur prophylaxe und/oder behandlung benigner prostatahyperplasie
US4990538A (en) * 1989-08-23 1991-02-05 Harris Adrian L Use of toremifene and its metabolites for the reversal of multidrug resistance of cancer cells against cytotoxic drugs
ZA924811B (en) * 1991-06-28 1993-12-29 Endorecherche Inc Controlled release systems and low dose androgens
HU222501B1 (hu) * 1991-06-28 2003-07-28 Endorecherche Inc. MPA-t vagy MGA-t tartalmazó nyújtott hatóanyag-felszabadulású gyógyászati készítmény és eljárás előállítására
US6060503A (en) * 1991-12-02 2000-05-09 Endorecherche, Inc. Benzopyran-containing compounds and method for their use
JPH07506575A (ja) * 1992-05-21 1995-07-20 アンドルシェルシュ・インコーポレイテッド テストステロン５α−レダクターゼ活性の阻害剤
CA2170480A1 (en) * 1995-02-28 1996-08-29 Robin Sharon Lee Fuchs-Young Methods of inhibiting estrogen positive tumors of the brain or cns
ZA961564B (en) * 1995-02-28 1997-08-27 Lilly Co Eli Methods of inhibiting ovarian cancer.
PL343862A1 (en) 1998-03-11 2001-09-10 Endorech Inhibitors of type 5 and type 3 17β−hydroxysteroid dehydrogenase and methods for their use
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
WO2003015820A1 (fr) * 2001-08-10 2003-02-27 Takeda Chemical Industries, Ltd. Medicaments combines d'agoniste de la gnrh
NZ530810A (en) 2001-09-06 2006-05-26 Schering Corp 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
EP1436281B1 (de) 2001-10-17 2010-06-16 Schering Corporation Piperidin- und piperazinacetamide als inhibitoren der 17beta-hydroxysteroiddehydrogenase des typs 3 zur behandlung androgenabhängiger krankheiten
CA2506290C (en) 2002-11-18 2012-04-24 Schering Corporation 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
JP4585320B2 (ja) 2002-12-17 2010-11-24 シェーリング コーポレイション 男性ホルモン依存性疾患の処置のための１７β−ヒドロキシステロイドデヒドロゲナーゼ３型インヒビター
GB0513702D0 (en) 2005-07-04 2005-08-10 Sterix Ltd Compound
GB0722779D0 (en) 2007-11-20 2008-01-02 Sterix Ltd Compound
CN115862804B (zh) * 2022-11-25 2023-12-19 成都诺医德医学检验实验室有限公司 双药联用的联合用药的推荐方法及装置

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4329364A (en) * 1974-09-11 1982-05-11 Schering Corporation Antiandrogenic agents and methods for the treatment of androgen dependent disease states
FR2329276A1 (fr) * 1975-10-29 1977-05-27 Roussel Uclaf Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant
DE2921593C2 (de) * 1979-05-28 1984-02-02 Gränges Nyby AB, Nybybruk Verfahren und Vorrichtung zum Weiterzerkleinern von hydriertem, grobstückigem Material, insbes. Schrott aus Titan oder dessen Legierungen
ZA822247B (en) * 1981-04-03 1983-11-30 Lilly Co Eli Benzothiophene compounds and process for preparing them

Also Published As

Publication number Publication date
AU594309B2 (en) 1990-03-08
EP0195015A1 (de) 1986-09-24
DK147086D0 (da) 1986-04-01
AU4728285A (en) 1986-03-07
DK168516B1 (da) 1994-04-11
WO1986001105A1 (en) 1986-02-27
IE851929L (en) 1986-02-02
DK147086A (da) 1986-04-01
DE3586053D1 (de) 1992-06-17
EP0195015B1 (de) 1992-05-13
IE58836B1 (en) 1993-11-17
JPH0680016B2 (ja) 1994-10-12
JPS62500451A (ja) 1987-02-26
DE3590389T1 (de) 1986-08-28

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time