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ATE533750T1 - Verfahren zur herstellung einer 4- aminochinazolinverbindung - Google Patents

Verfahren zur herstellung einer 4- aminochinazolinverbindung

Info

Publication number
ATE533750T1
ATE533750T1 AT03703218T AT03703218T ATE533750T1 AT E533750 T1 ATE533750 T1 AT E533750T1 AT 03703218 T AT03703218 T AT 03703218T AT 03703218 T AT03703218 T AT 03703218T AT E533750 T1 ATE533750 T1 AT E533750T1
Authority
AT
Austria
Prior art keywords
formula
compound
reacting
organic solvent
halo
Prior art date
Application number
AT03703218T
Other languages
English (en)
Inventor
Shigeyoshi Nishino
Kenji Hirotsu
Hidetaka Shima
Takashi Harada
Hiroyuki Oda
Original Assignee
Ube Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ube Industries filed Critical Ube Industries
Application granted granted Critical
Publication of ATE533750T1 publication Critical patent/ATE533750T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT03703218T 2002-02-06 2003-02-06 Verfahren zur herstellung einer 4- aminochinazolinverbindung ATE533750T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2002029745 2002-02-06
JP2002246656 2002-08-27
JP2002272893 2002-09-19
JP2002272892 2002-09-19
PCT/JP2003/001254 WO2003066602A1 (fr) 2002-02-06 2003-02-06 Procede relatif a l'elaboration d'un compose 4-aminoquinazoline

Publications (1)

Publication Number Publication Date
ATE533750T1 true ATE533750T1 (de) 2011-12-15

Family

ID=27739271

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03703218T ATE533750T1 (de) 2002-02-06 2003-02-06 Verfahren zur herstellung einer 4- aminochinazolinverbindung

Country Status (6)

Country Link
US (3) US20050130995A1 (de)
EP (1) EP1481971B1 (de)
JP (1) JP4389205B2 (de)
AT (1) ATE533750T1 (de)
AU (1) AU2003207291A1 (de)
WO (1) WO2003066602A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002217999A1 (en) 2000-11-01 2002-05-15 Cor Therapeutics, Inc. Process for the production of 4-quinazolinylpiperazin-1-carboxylic acid phenylamides
TWI324597B (en) * 2002-03-28 2010-05-11 Astrazeneca Ab Quinazoline derivatives
GB0221245D0 (en) 2002-09-13 2002-10-23 Astrazeneca Ab Chemical process
WO2006074147A2 (en) 2005-01-03 2006-07-13 Myriad Genetics, Inc. Nitrogen containing bicyclic compounds and therapeutical use thereof
US8309562B2 (en) 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
SI1667992T1 (sl) * 2003-09-19 2007-06-30 Astrazeneca Ab Kinazolinski derivati
US8258145B2 (en) 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
GB0519879D0 (en) 2005-09-30 2005-11-09 Astrazeneca Ab Chemical process
US20090124642A1 (en) * 2007-08-23 2009-05-14 Augusto Canavesi Crystalline forms of Erlotinib HCI and formulations thereof
BRPI0912170A2 (pt) * 2008-05-13 2015-10-13 Astrazeneca Ab composto, forma a, processo para a preparação da mesma, composição farmacêutica, uso de um composto, e, método para tratar um câncer em um animal de sangue quente
EP2307386A1 (de) * 2008-07-07 2011-04-13 Plus Chemicals S.A. Kristalline formen von erlotinib-base und erlotinib-hcl
EP2411373B1 (de) 2009-03-26 2015-10-21 Ranbaxy Laboratories Limited Verfahren zur herstellung von erlotinib oder dessen pharmazeutisch unbedenklichen salzen
PH12012500097A1 (en) * 2009-07-21 2011-01-27 Shanghai Inst Organic Chem Potent small molecule inhibitors of autophagy, and methods of use thereof
WO2011058525A2 (en) 2009-11-12 2011-05-19 Ranbaxy Laboratories Limited Processes for the preparation of erlotinib hydrochloride form a and erlotinib hydrochloride form b
WO2014037961A1 (en) 2012-09-04 2014-03-13 Shilpa Medicare Limited Crystalline erlotinib hydrochloride process
WO2014118737A1 (en) 2013-01-31 2014-08-07 Ranbaxy Laboratories Limited Erlotinib salts

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ243082A (en) 1991-06-28 1995-02-24 Ici Plc 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
US5256781A (en) * 1991-10-24 1993-10-26 American Home Products Corporation Substituted quinazolines as angiotensin II antagonists
US5661147A (en) * 1993-09-03 1997-08-26 Kyowa Hakko Kogyo Co., Ltd. Imidazoquinazoline derivatives
GB9510757D0 (en) * 1994-09-19 1995-07-19 Wellcome Found Therapeuticaly active compounds
GB9508538D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
US5747498A (en) * 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
ES2169355T3 (es) * 1996-03-05 2002-07-01 Astrazeneca Ab Derivados de 4-anilinoquinazolina.
US5747798A (en) * 1996-07-19 1998-05-05 Hughey & Phillips, Inc. Photocell checker
EP0837063A1 (de) * 1996-10-17 1998-04-22 Pfizer Inc. 4-Aminoquinazolinderivate
RS49779B (sr) * 1998-01-12 2008-06-05 Glaxo Group Limited, Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze
ATE482946T1 (de) 1999-02-10 2010-10-15 Astrazeneca Ab Chinazolinderivate als angiogenesehemmer und zwischenprodukte dafür
DE19911509A1 (de) * 1999-03-15 2000-09-21 Boehringer Ingelheim Pharma Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
GB0408308D0 (en) * 2004-04-14 2004-05-19 Vectura Ltd Pharmaceutical compositions

Also Published As

Publication number Publication date
WO2003066602A1 (fr) 2003-08-14
US20050130995A1 (en) 2005-06-16
JP4389205B2 (ja) 2009-12-24
US20080177069A1 (en) 2008-07-24
EP1481971B1 (de) 2011-11-16
US20090171083A1 (en) 2009-07-02
US8318932B2 (en) 2012-11-27
EP1481971A1 (de) 2004-12-01
AU2003207291A1 (en) 2003-09-02
JPWO2003066602A1 (ja) 2005-05-26
EP1481971A4 (de) 2006-03-08

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