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ATE508126T1 - Als kinaseinhibitoren geeignete aminopyrimidine - Google Patents

Als kinaseinhibitoren geeignete aminopyrimidine

Info

Publication number
ATE508126T1
ATE508126T1 AT06837883T AT06837883T ATE508126T1 AT E508126 T1 ATE508126 T1 AT E508126T1 AT 06837883 T AT06837883 T AT 06837883T AT 06837883 T AT06837883 T AT 06837883T AT E508126 T1 ATE508126 T1 AT E508126T1
Authority
AT
Austria
Prior art keywords
aminopyrimidines
compounds
kinase inhibitors
compositions
inhibitors
Prior art date
Application number
AT06837883T
Other languages
English (en)
Inventor
Damien Fraysse
Andrew Miller
Daniel Robinson
Joanne Pinder
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of ATE508126T1 publication Critical patent/ATE508126T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT06837883T 2005-11-16 2006-11-16 Als kinaseinhibitoren geeignete aminopyrimidine ATE508126T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73706405P 2005-11-16 2005-11-16
PCT/US2006/044636 WO2007059299A1 (en) 2005-11-16 2006-11-16 Aminopyrimidines useful as kinase inhibitors

Publications (1)

Publication Number Publication Date
ATE508126T1 true ATE508126T1 (de) 2011-05-15

Family

ID=37806123

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06837883T ATE508126T1 (de) 2005-11-16 2006-11-16 Als kinaseinhibitoren geeignete aminopyrimidine

Country Status (9)

Country Link
US (1) US20070179125A1 (de)
EP (1) EP1951716B1 (de)
JP (1) JP2009515992A (de)
CN (1) CN101360740A (de)
AT (1) ATE508126T1 (de)
AU (1) AU2006315334B2 (de)
CA (1) CA2629781A1 (de)
DE (1) DE602006021776D1 (de)
WO (1) WO2007059299A1 (de)

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WO2004072029A2 (en) 2003-02-06 2004-08-26 Vertex Pharmaceuticals Incorporated Pyrazolopyridazines useful as inhibitors of protein kinases
EP1951234A2 (de) * 2005-10-18 2008-08-06 Janssen Pharmaceutica N.V. Verfahren zur hemmung von flt3-kinase
NZ606259A (en) 2005-11-03 2014-06-27 Vertex Pharma Aminopyrimidines useful as kinase inhibitors
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US8697716B2 (en) 2006-04-20 2014-04-15 Janssen Pharmaceutica Nv Method of inhibiting C-KIT kinase
WO2007124319A1 (en) 2006-04-20 2007-11-01 Janssen Pharmaceutica N.V. Inhibitors of c-fms kinase
EP2086965B1 (de) 2006-11-02 2010-02-10 Vertex Pharmaceuticals, Inc. Als inhibitoren von proteinkinasen geeignete aminopyridine und aminopyrimidine
JP2010513567A (ja) * 2006-12-19 2010-04-30 バーテックス ファーマシューティカルズ インコーポレイテッド プロテインキナーゼの阻害剤として有用なアミノピリミジン
NZ579446A (en) 2007-03-09 2012-02-24 Vertex Pharma Aminopyrimidines useful as inhibitors of protein kinases
CA2679701A1 (en) 2007-03-09 2008-09-18 Vertex Pharmaceuticals Incorporated Aminopyridines useful as inhibitors of protein kinases
CA2680029A1 (en) 2007-03-09 2008-09-18 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as inhibitors of protein kinases
WO2008128009A2 (en) 2007-04-13 2008-10-23 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as kinase inhibitors
MX2009011812A (es) 2007-05-02 2010-01-14 Vertex Pharma Aminopirimidinas utiles como inhibidores de cinasa.
MX2009011810A (es) 2007-05-02 2010-01-14 Vertex Pharma Tiazoles y pirazoles utiles como inhibidores de cinasa.
CA2683152A1 (en) * 2007-06-11 2008-12-18 Miikana Therapeutics, Inc. Substituted pyrazole compounds
WO2009018415A1 (en) 2007-07-31 2009-02-05 Vertex Pharmaceuticals Incorporated Process for preparing 5-fluoro-1h-pyrazolo [3, 4-b] pyridin-3-amine and derivatives thereof
US20110190280A1 (en) * 2007-08-29 2011-08-04 George Adjabeng Thiazole And Oxazole Kinase Inhibitors
PT2209778E (pt) * 2007-09-21 2012-12-06 Array Biopharma Inc Derivados de piridin-2-il-amino-1,2,4-tiadiazole como activadores de glucoquinase para o tratamento de diabetes mellitus
WO2009073224A1 (en) * 2007-12-07 2009-06-11 Ambit Biosciences Corp. Methods of treating certain diseases using pyrimidine derivatives
UA103319C2 (en) 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds
ES2415907T3 (es) * 2008-07-24 2013-07-29 Nerviano Medical Sciences S.R.L. Combinación terapéutica que comprende un inhibidor de cinasas aurora y agentes antiproliferativos
US20100136097A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
US20100137787A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Delivery devices for modulating inflammation
US20100137246A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Anti-inflammatory compositions and methods
US20100136096A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
US20100136095A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
US20100135983A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Anti-inflammatory compositions and methods
US20100136094A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
US20100135984A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Anti-inflammatory compositions and methods
US20120058984A1 (en) 2009-03-17 2012-03-08 Catherine Mary Alder Pyrimidine derivatives used as itk inhibitors
WO2010111056A1 (en) * 2009-03-24 2010-09-30 Banyu Pharmaceutical Co., Ltd. Novel aminopyridine derivatives having aurora a selective inhibitory action
BR112014003997A2 (pt) 2011-08-25 2017-03-21 Hoffmann La Roche composto, método para inibição da atividade de pak1 em uma célula e paciente, método para o tratamento ou melhoria da gravidade do câncer ou de um distúrbio hiperproliferativo em um paciente, utilização do composto e composição
RU2014129740A (ru) 2011-12-22 2016-02-10 Ф.Хоффманн-Ля Рош Аг Производные 2,4-диаминопиримидина в качестве ингибиторов серин/треонин киназы
JP6120941B2 (ja) 2012-03-16 2017-04-26 アクシキン ファーマシューティカルズ インコーポレーテッド ３，５−ジアミノピラゾールキナーゼ阻害剤
LT2841428T (lt) 2012-04-24 2018-12-10 Vertex Pharmaceuticals Incorporated Dnr-pk inhibitoriai
JP6211072B2 (ja) * 2012-06-15 2017-10-11 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ ダサチニブと、選択された共結晶形成剤とを含んでなる多成分結晶
EP3527563B1 (de) 2013-03-12 2021-09-01 Vertex Pharmaceuticals Incorporated Dna-pk-hemmer
NZ631142A (en) 2013-09-18 2016-03-31 Axikin Pharmaceuticals Inc Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors
CN105814036B (zh) 2013-10-17 2018-10-26 沃泰克斯药物股份有限公司 作为dna-pk抑制剂的共晶
TWI703133B (zh) 2014-12-23 2020-09-01 美商艾克斯基製藥公司 ３,５-二胺基吡唑激酶抑制劑
US10118904B2 (en) 2015-06-05 2018-11-06 Vertex Pharmaceuticals Incorporated Triazoles for the treatment of Demyelinating Diseases
KR101726648B1 (ko) * 2016-02-29 2017-04-14 한국화학연구원 신규한 피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 drak 관련 질환의 예방 또는 치료용 약학적 조성물
SG11201809342YA (en) 2016-04-28 2018-11-29 Theravance Biopharma R&D Ip Llc Pyrimidine compounds as jak kinase inhibitors
KR20190062485A (ko) 2016-09-27 2019-06-05 버텍스 파마슈티칼스 인코포레이티드 Dna-손상제 및 dna-pk 저해제의 조합을 사용한 암 치료 방법
CN110494432B (zh) 2016-12-28 2022-08-12 米尼奥尔克斯治疗有限公司 异喹啉化合物，其制备方法及其在与β-半乳糖苷酶活性改变相关的病症中的治疗用途
CN106841420A (zh) * 2016-12-30 2017-06-13 广州中大南沙科技创新产业园有限公司 一种LC‑MS/MS测定大鼠血浆中Ly‑7u浓度的方法
EA202091016A1 (ru) 2017-10-27 2020-07-17 ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи Пиримидиновое соединение в качестве ингибитора jak киназы
EP3856349A1 (de) * 2018-09-25 2021-08-04 Black Diamond Therapeutics, Inc. Tyrosinkinase-inhibitorzusammensetzungen, verfahren zu ihrer herstellung und ihre verwendung
TW202106682A (zh) 2019-04-24 2021-02-16 美商施萬生物製藥研發Ｉｐ有限責任公司 作為jak激酶抑制劑之酯類及碳酸酯類嘧啶化合物
JP7482152B2 (ja) 2019-04-24 2024-05-13 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー 皮膚疾患の処置のためのピリミジンｊａｋ阻害剤 発明の背景
KR20230074733A (ko) * 2020-08-26 2023-05-31 날로 테라퓨틱스 Myc 패밀리 원종양유전자 단백질의 조정제
US12084453B2 (en) 2021-12-10 2024-09-10 Incyte Corporation Bicyclic amines as CDK12 inhibitors
WO2023164612A1 (en) * 2022-02-25 2023-08-31 Nalo Therapeutics Modulators of myc family proto-oncogene protein

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WO2001047921A1 (en) * 1999-12-28 2001-07-05 Pharmacopeia, Inc. Pyrimidine and triazine kinase inhibitors
AU2002234047A1 (en) * 2000-12-21 2002-07-01 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
EP1397142A4 (de) * 2001-06-19 2004-11-03 Bristol Myers Squibb Co Pyrimidin-hemmer der phosphodiesterase (pde) 7
MY141867A (en) * 2002-06-20 2010-07-16 Vertex Pharma Substituted pyrimidines useful as protein kinase inhibitors
BRPI0415398A (pt) * 2003-10-17 2006-12-19 Astrazeneca Ab composto, composição farmacêutica, processo para a preparação da mesma, uso de um composto, método de tratamento de cáncer, e, processo para preparação de um composto
NZ606259A (en) * 2005-11-03 2014-06-27 Vertex Pharma Aminopyrimidines useful as kinase inhibitors

Also Published As

Publication number Publication date
DE602006021776D1 (de) 2011-06-16
AU2006315334A1 (en) 2007-05-24
EP1951716A1 (de) 2008-08-06
CN101360740A (zh) 2009-02-04
US20070179125A1 (en) 2007-08-02
AU2006315334B2 (en) 2011-05-19
WO2007059299A1 (en) 2007-05-24
JP2009515992A (ja) 2009-04-16
CA2629781A1 (en) 2007-05-24
EP1951716B1 (de) 2011-05-04

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Legal Events

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