ATE507839T1 - Kombinationstherapie - Google Patents
KombinationstherapieInfo
- Publication number
- ATE507839T1 ATE507839T1 AT02719260T AT02719260T ATE507839T1 AT E507839 T1 ATE507839 T1 AT E507839T1 AT 02719260 T AT02719260 T AT 02719260T AT 02719260 T AT02719260 T AT 02719260T AT E507839 T1 ATE507839 T1 AT E507839T1
- Authority
- AT
- Austria
- Prior art keywords
- cells expressing
- combination therapy
- depletion
- treatment
- disorders characterized
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28080501P | 2001-04-02 | 2001-04-02 | |
PCT/US2002/008057 WO2002078766A2 (en) | 2001-04-02 | 2002-03-14 | Combination therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE507839T1 true ATE507839T1 (de) | 2011-05-15 |
Family
ID=23074728
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02719260T ATE507839T1 (de) | 2001-04-02 | 2002-03-14 | Kombinationstherapie |
Country Status (11)
Country | Link |
---|---|
US (5) | US20020197256A1 (de) |
EP (2) | EP1383532B1 (de) |
JP (2) | JP4679035B2 (de) |
AT (1) | ATE507839T1 (de) |
AU (2) | AU2002250352C1 (de) |
CA (1) | CA2440831C (de) |
DE (1) | DE60239931D1 (de) |
ES (1) | ES2364816T3 (de) |
HK (1) | HK1062636A1 (de) |
IL (3) | IL157946A0 (de) |
WO (1) | WO2002078766A2 (de) |
Families Citing this family (79)
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ATE538794T1 (de) | 1999-01-13 | 2012-01-15 | Bayer Healthcare Llc | Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
US6737056B1 (en) * | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
US7183387B1 (en) | 1999-01-15 | 2007-02-27 | Genentech, Inc. | Polypeptide variants with altered effector function |
CA2904259C (en) | 1999-05-07 | 2016-11-15 | Genentech, Inc. | Use of rituximab to treat vasculitis |
BR0013201A (pt) * | 1999-07-12 | 2002-04-30 | Genentech Inc | Método de bloqueio de uma resposta imunológica a um antigeno externo em mamìferos através da utilização de um antagonista que se liga ao cd20, método de tratamento de mamìferos, método de tratamento de uma doença de enxerto contra hospedeiro ou hospedeiro contra enxerto em mamìferos, método de insensibilização de mamìferos que aguardam transplante e artigo industrializado |
DK1255558T3 (da) * | 2000-02-16 | 2006-10-23 | Genentech Inc | Anti-april antistoffer og hybridomaceller |
JP2002016181A (ja) * | 2000-04-25 | 2002-01-18 | Torex Semiconductor Ltd | 半導体装置、その製造方法、及び電着フレーム |
US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
EP1383532B1 (de) * | 2001-04-02 | 2011-05-04 | Genentech, Inc. | Kombinationstherapie |
FR2828104B1 (fr) * | 2001-08-01 | 2005-06-24 | Chu Montpellier | Utilisation d'inhibiteurs du facteur de croissance epidermique liant l'heparine ou d'inhibiteurs de ses recepteurs pour la preparation de medicaments utiles pour traiter le myelome |
CN100423777C (zh) * | 2001-10-25 | 2008-10-08 | 杰南技术公司 | 糖蛋白组合物 |
US7838541B2 (en) | 2002-02-11 | 2010-11-23 | Bayer Healthcare, Llc | Aryl ureas with angiogenesis inhibiting activity |
DK2289936T3 (en) * | 2002-12-16 | 2017-07-31 | Genentech Inc | IMMUNGLOBULIN VARIATIONS AND APPLICATIONS THEREOF |
WO2004060317A2 (en) * | 2002-12-31 | 2004-07-22 | Genta Incorporated | Combination of gallium compounds with nonchemotherapeutic anticancer agents in the treatment of neoplasia |
UY28213A1 (es) | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
SI1613350T1 (sl) * | 2003-04-09 | 2009-08-31 | Genentech Inc | Zdravljenje avtoimunske bolezni pri bolniku z neustreznim odzivom na inhibitor TNF-alfa |
EP1626993B1 (de) * | 2003-05-09 | 2015-03-11 | Duke University | Cd20-spezifische antikörper und verfahren zur anwendung derselben |
AR044388A1 (es) * | 2003-05-20 | 2005-09-07 | Applied Molecular Evolution | Moleculas de union a cd20 |
MXPA05012486A (es) | 2003-05-20 | 2006-07-03 | Bayer Pharmaceuticals Corp | Diaril ureas para enfermedades mediadas por pdgfr. |
NZ543712A (en) | 2003-06-05 | 2008-06-30 | Genentech Inc | Combination therapy for B cell disorders |
ZA200600798B (en) * | 2003-07-29 | 2007-06-27 | Genentech Inc | Assay for human anti CD20 antibodies and uses therefor |
JP2007504138A (ja) * | 2003-08-29 | 2007-03-01 | ジェネンテック・インコーポレーテッド | 眼疾患の治療法 |
US20070031406A1 (en) * | 2003-10-22 | 2007-02-08 | Zand Martin S | Anti-thymocyte antiserum and use thereof to trigger b cell apoptosis |
US8277810B2 (en) | 2003-11-04 | 2012-10-02 | Novartis Vaccines & Diagnostics, Inc. | Antagonist anti-CD40 antibodies |
ES2341009T3 (es) | 2003-11-05 | 2010-06-14 | Roche Glycart Ag | Anticuerpos cd20 con afinidad de union a receptores fc y funcion efectora. |
AU2004303848A1 (en) * | 2003-12-19 | 2005-07-07 | Genentech, Inc. | Detection of CD20 in transplant rejection |
KR20060109494A (ko) * | 2003-12-19 | 2006-10-20 | 제넨테크, 인크. | 자가면역 질환의 치료에 있어서 cd20의 검출 |
KR20070012408A (ko) * | 2004-04-16 | 2007-01-25 | 제넨테크, 인크. | B 세포 고갈을 증대시키는 방법 |
CN1980697A (zh) * | 2004-05-05 | 2007-06-13 | 健泰科生物技术公司 | 通过使用抗cd20抗体预防自身免疫病 |
ZA200610158B (en) * | 2004-06-04 | 2008-07-30 | Genentech Inc | Method for treating multiple sclerosis |
MXPA06014067A (es) * | 2004-06-04 | 2007-02-15 | Genentech Inc | Metodo para tratar lupus. |
EP1781378A2 (de) * | 2004-07-22 | 2007-05-09 | Genentech, Inc. | Verfahren zur behandlung des sjögren-syndroms |
PL2213683T3 (pl) | 2004-08-04 | 2013-10-31 | Mentrik Biotech Llc | WARIANTY REGIONÓW Fc |
US8017151B2 (en) * | 2004-09-07 | 2011-09-13 | Board Of Regents Of The University Of Nebraska By And Behalf Of The University Of Nebraska Medical Center | Amphiphilic polymer-protein conjugates and methods of use thereof |
US8168222B2 (en) | 2004-09-07 | 2012-05-01 | Board Of Regents Of The University Of Nebraska | Amphiphilic polymer-protein conjugates and methods of use thereof |
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RU2478384C2 (ru) * | 2004-11-29 | 2013-04-10 | Новартис Аг | Курс лечения с использованием агониста рецептора s1p |
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UA97469C2 (uk) | 2005-07-25 | 2012-02-27 | Емерджент Продакт Дівелопмент Сіетл, Елелсі | Гуманізована специфічна до cd37 зв'язувальна молекула імуноглобуліну |
BRPI0614183A2 (pt) | 2005-07-25 | 2011-03-15 | Trubion Pharmaceuticals Inc | uso de dose única de moléculas de ligação especìficas para cd20 |
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MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
EP1952150B1 (de) | 2005-11-23 | 2016-12-14 | Genentech, Inc. | Verfahren und zusammensetzungen in verbindung mit b-zellen-testverfahren |
BRPI0619586A2 (pt) * | 2005-12-09 | 2018-08-28 | Seattle Genetics Inc | método para o tratamento ou prevenção de um distúrbio associado com cd40 |
JP5075130B2 (ja) * | 2006-01-24 | 2012-11-14 | バイオコンパティブルズ ユーケー リミテッド | ポリマー粒子を薬物で負荷する方法 |
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EP2200631A1 (de) | 2007-10-16 | 2010-06-30 | Zymogenetics, Inc. | Kombination aus blys-hemmung und anti-cd20-wirkstoffen zur behandlung von autoimmunerkrankungen |
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CN104447990B (zh) * | 2008-10-14 | 2019-07-19 | 霍夫曼-拉罗奇有限公司 | 免疫球蛋白变体及其用途 |
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JP5930542B2 (ja) | 2009-08-11 | 2016-06-08 | ジェネンテック, インコーポレイテッド | グルタミンフリー細胞培養培地におけるタンパク質の生産 |
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CN102933231B (zh) | 2010-02-10 | 2015-07-29 | 伊缪诺金公司 | Cd20抗体及其用途 |
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EP3431993A1 (de) * | 2010-12-20 | 2019-01-23 | The Rockefeller University | Modulation agonistischer tnfr-antikörper |
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CA2997801A1 (en) | 2015-10-02 | 2017-04-06 | F. Hoffmann-La Roche Ag | Bispecific anti-human cd20/human transferrin receptor antibodies and methods of use |
CA3042867A1 (en) * | 2016-11-04 | 2018-05-11 | Memorial Sloan Kettering Cancer Center | Bi-specific activators for tumor therapy |
CN110090228A (zh) * | 2018-04-18 | 2019-08-06 | 浙江大学 | 人羊膜上皮细胞在自身免疫性疾病中的治疗用途 |
EP4051321A4 (de) * | 2019-10-30 | 2023-11-22 | Duke University | Immuntherapie mit kombinationstherapie mit einem immuntoxin |
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-
2002
- 2002-03-14 EP EP02719260A patent/EP1383532B1/de not_active Revoked
- 2002-03-14 CA CA2440831A patent/CA2440831C/en not_active Expired - Lifetime
- 2002-03-14 JP JP2002577030A patent/JP4679035B2/ja not_active Expired - Lifetime
- 2002-03-14 WO PCT/US2002/008057 patent/WO2002078766A2/en active Application Filing
- 2002-03-14 IL IL15794602A patent/IL157946A0/xx unknown
- 2002-03-14 ES ES02719260T patent/ES2364816T3/es not_active Expired - Lifetime
- 2002-03-14 DE DE60239931T patent/DE60239931D1/de not_active Expired - Lifetime
- 2002-03-14 AU AU2002250352A patent/AU2002250352C1/en not_active Expired
- 2002-03-14 EP EP10176041A patent/EP2359849A1/de not_active Withdrawn
- 2002-03-14 US US10/099,818 patent/US20020197256A1/en not_active Abandoned
- 2002-03-14 AT AT02719260T patent/ATE507839T1/de active
-
2003
- 2003-09-16 IL IL157946A patent/IL157946A/en active IP Right Grant
-
2004
- 2004-07-09 HK HK04105003.0A patent/HK1062636A1/xx not_active IP Right Cessation
-
2006
- 2006-09-29 US US11/537,559 patent/US20070178091A1/en not_active Abandoned
-
2008
- 2008-06-26 AU AU2008202838A patent/AU2008202838A1/en not_active Abandoned
-
2009
- 2009-10-28 JP JP2009247791A patent/JP5587589B2/ja not_active Expired - Lifetime
-
2010
- 2010-02-18 IL IL204031A patent/IL204031A/en active IP Right Grant
-
2011
- 2011-02-01 US US13/019,183 patent/US20110123531A1/en not_active Abandoned
-
2013
- 2013-11-05 US US14/072,703 patent/US20140065160A1/en not_active Abandoned
-
2016
- 2016-09-26 US US15/276,591 patent/US20170233482A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
IL157946A (en) | 2013-11-28 |
CA2440831A1 (en) | 2002-10-10 |
JP2005508844A (ja) | 2005-04-07 |
EP1383532B1 (de) | 2011-05-04 |
AU2002250352C1 (en) | 2009-04-30 |
WO2002078766A2 (en) | 2002-10-10 |
HK1062636A1 (en) | 2004-11-19 |
IL157946A0 (en) | 2004-03-28 |
ES2364816T3 (es) | 2011-09-14 |
US20070178091A1 (en) | 2007-08-02 |
US20020197256A1 (en) | 2002-12-26 |
JP5587589B2 (ja) | 2014-09-10 |
IL204031A (en) | 2015-05-31 |
CA2440831C (en) | 2013-05-28 |
US20170233482A1 (en) | 2017-08-17 |
US20110123531A1 (en) | 2011-05-26 |
EP1383532A2 (de) | 2004-01-28 |
AU2002250352B2 (en) | 2008-04-03 |
EP1383532A4 (de) | 2004-10-06 |
JP4679035B2 (ja) | 2011-04-27 |
DE60239931D1 (de) | 2011-06-16 |
EP2359849A1 (de) | 2011-08-24 |
AU2008202838A1 (en) | 2008-07-24 |
JP2010077134A (ja) | 2010-04-08 |
US20140065160A1 (en) | 2014-03-06 |
WO2002078766A3 (en) | 2003-05-22 |
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