ATE542922T1 - 2'-terminator-assoziierte pyrophosphorolyse- aktivierte polymerisierung - Google Patents
2'-terminator-assoziierte pyrophosphorolyse- aktivierte polymerisierungInfo
- Publication number
- ATE542922T1 ATE542922T1 AT07819065T AT07819065T ATE542922T1 AT E542922 T1 ATE542922 T1 AT E542922T1 AT 07819065 T AT07819065 T AT 07819065T AT 07819065 T AT07819065 T AT 07819065T AT E542922 T1 ATE542922 T1 AT E542922T1
- Authority
- AT
- Austria
- Prior art keywords
- reaction mixtures
- pyrophosphorolysis
- terminator
- activated polymerization
- oligonucleotides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6848—Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/583,606 US7745125B2 (en) | 2004-06-28 | 2006-10-18 | 2′-terminator related pyrophosphorolysis activated polymerization |
| PCT/EP2007/008997 WO2008046602A2 (en) | 2006-10-18 | 2007-10-17 | 2'-terminator related pyrophosphorolysis activated polymerization |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE542922T1 true ATE542922T1 (de) | 2012-02-15 |
Family
ID=39283915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07819065T ATE542922T1 (de) | 2006-10-18 | 2007-10-17 | 2'-terminator-assoziierte pyrophosphorolyse- aktivierte polymerisierung |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7745125B2 (de) |
| EP (1) | EP2076606B1 (de) |
| JP (1) | JP5421112B2 (de) |
| CN (2) | CN105274169A (de) |
| AT (1) | ATE542922T1 (de) |
| CA (1) | CA2664229C (de) |
| ES (1) | ES2381505T3 (de) |
| HK (1) | HK1220733A1 (de) |
| WO (1) | WO2008046602A2 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7399590B2 (en) | 2002-02-21 | 2008-07-15 | Asm Scientific, Inc. | Recombinase polymerase amplification |
| US8030000B2 (en) | 2002-02-21 | 2011-10-04 | Alere San Diego, Inc. | Recombinase polymerase amplification |
| EP1992706B1 (de) | 2002-02-21 | 2014-11-19 | Alere San Diego, Inc. | Rekombinase-Polymerase-Verstärkung |
| US7947817B2 (en) * | 2003-06-30 | 2011-05-24 | Roche Molecular Systems, Inc. | Synthesis and compositions of 2'-terminator nucleotides |
| US7572581B2 (en) * | 2003-06-30 | 2009-08-11 | Roche Molecular Systems, Inc. | 2′-terminator nucleotide-related methods and systems |
| US7745125B2 (en) * | 2004-06-28 | 2010-06-29 | Roche Molecular Systems, Inc. | 2′-terminator related pyrophosphorolysis activated polymerization |
| US7928207B2 (en) * | 2004-06-28 | 2011-04-19 | Roche Molecular Systems, Inc | Synthesis and compositions of nucleic acids comprising 2′-terminator nucleotides |
| JP5027126B2 (ja) * | 2005-07-25 | 2012-09-19 | アリーア サン ディエゴ， インコーポレイテッド | リコンビナーゼポリメラーゼ増幅を多重化するための方法 |
| ES2388722T3 (es) * | 2005-12-21 | 2012-10-18 | F. Hoffmann-La Roche Ag | Secuenciación y genotipado utilizando nucleótidos modificados en 2' de forma reversible |
| EP3088533B1 (de) | 2006-05-04 | 2018-01-17 | Alere San Diego, Inc. | Rekombinase-polymerase-amplifikation |
| US8962293B2 (en) * | 2006-10-18 | 2015-02-24 | Roche Molecular Systems, Inc. | DNA polymerases and related methods |
| EP2215222B1 (de) * | 2007-11-28 | 2015-09-16 | Roche Diagnostics GmbH | Mutante dna-polymerasen mit verbesserter fähigkeit zur pyrophosphorolyse-aktivierten polymerisierung (pap) |
| US10150990B2 (en) | 2008-04-21 | 2018-12-11 | Roche Molecular Systems, Inc. | Ribonucleotide tag nucleic acid detection |
| US9469867B2 (en) * | 2009-05-20 | 2016-10-18 | Alere San Diego, Inc. | DNA glycosylase/lyase and AP endonuclease substrates |
| US9057097B2 (en) | 2009-06-05 | 2015-06-16 | Alere San Diego Inc. | Recombinase polymerase amplification reagents and kits |
| EP2464751B1 (de) * | 2009-08-11 | 2017-05-24 | Response Genetics, Inc. | Verfahren, primer, sonden und kits zur erkennung von braf-mutationen |
| US8409802B2 (en) * | 2009-08-14 | 2013-04-02 | Roche Molecular Systems, Inc. | Format of probes to detect nucleic acid differences |
| CN104694628B (zh) * | 2010-12-13 | 2017-06-06 | 生命技术公司 | 利用通过多磷酸分解作用(app)反应的活化聚合核酸 |
| EP3978620A1 (de) | 2011-04-07 | 2022-04-06 | Abbott Diagnostics Scarborough, Inc. | Überwachung von rekombinase-polymerase-verstärkungsmischungen |
| PL2697397T3 (pl) | 2011-04-15 | 2017-08-31 | The Johns Hopkins University | System bezpiecznego sekwencjonowania |
| AU2012335220B2 (en) | 2011-11-11 | 2017-06-01 | Pfizer Inc. | 2-thiopyrimidinones |
| KR101545848B1 (ko) * | 2012-04-09 | 2015-08-21 | (주)바이오니아 | 핵산중합효소로 핵산을 검출하는데 사용되는 고민감도 핵산준비방법 |
| AU2013338393C1 (en) | 2012-10-29 | 2024-07-25 | The Johns Hopkins University | Papanicolaou test for ovarian and endometrial cancers |
| US11384377B2 (en) | 2013-04-02 | 2022-07-12 | Molecular Assemblies, Inc. | Reusable initiators for synthesizing nucleic acids |
| US9279149B2 (en) | 2013-04-02 | 2016-03-08 | Molecular Assemblies, Inc. | Methods and apparatus for synthesizing nucleic acids |
| US11331643B2 (en) | 2013-04-02 | 2022-05-17 | Molecular Assemblies, Inc. | Reusable initiators for synthesizing nucleic acids |
| US8808989B1 (en) * | 2013-04-02 | 2014-08-19 | Molecular Assemblies, Inc. | Methods and apparatus for synthesizing nucleic acids |
| US9771613B2 (en) | 2013-04-02 | 2017-09-26 | Molecular Assemblies, Inc. | Methods and apparatus for synthesizing nucleic acid |
| US10683536B2 (en) | 2013-04-02 | 2020-06-16 | Molecular Assemblies, Inc. | Reusable initiators for synthesizing nucleic acids |
| EA034985B1 (ru) | 2015-05-05 | 2020-04-14 | Пфайзер Инк. | 2-тиопиримидиноны |
| CN104862401B (zh) * | 2015-05-29 | 2017-10-31 | 沈阳优吉诺生物科技有限公司 | 检测kras基因热点突变位点的引物、试剂盒及其pcr方法 |
| US11286531B2 (en) | 2015-08-11 | 2022-03-29 | The Johns Hopkins University | Assaying ovarian cyst fluid |
| CA3072195A1 (en) | 2017-08-07 | 2019-04-04 | The Johns Hopkins University | Methods and materials for assessing and treating cancer |
| JP6947464B2 (ja) | 2018-07-19 | 2021-10-13 | バイオフィデリティ・リミテッド | 改善されたポリヌクレオチド配列検出法 |
| EP4004230A4 (de) * | 2019-07-31 | 2023-08-09 | Bioskryb Genomics, Inc. | Genetische mutationsanalyse |
| GB201919186D0 (en) | 2019-12-23 | 2020-02-05 | Biofidelity Ltd | Simplified polynucleotide sequence detection method |
| IL307733A (en) | 2021-04-15 | 2023-12-01 | Biofidelity | Enrichment and discovery of nucleic acids |
Family Cites Families (59)
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| NL41678C (de) | 1931-07-27 | |||
| US3338882A (en) | 1965-06-28 | 1967-08-29 | Upjohn Co | 2'-and 3'-phosphates of 1-beta-d-arabinofuranosylcytosine |
| JPS5290693A (en) | 1977-02-21 | 1977-07-30 | Kyowa Hakko Kogyo Co Ltd | Preparation of guanine nucleotide by fermentation |
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
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| JPS5985298A (ja) | 1982-11-04 | 1984-05-17 | Yamasa Shoyu Co Ltd | ３′−デオキシグアノシンの製造法 |
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| US7033763B2 (en) * | 2000-02-23 | 2006-04-25 | City Of Hope | Pyrophosphorolysis activated polymerization (PAP) |
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| CA2485596C (en) * | 2002-05-10 | 2013-04-16 | City Of Hope | Pyrophosphorolysis activated polymerization (pap) |
| JP3827629B2 (ja) | 2002-08-30 | 2006-09-27 | 住友大阪セメント株式会社 | 光変調器 |
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| US7947817B2 (en) | 2003-06-30 | 2011-05-24 | Roche Molecular Systems, Inc. | Synthesis and compositions of 2'-terminator nucleotides |
| US7572581B2 (en) | 2003-06-30 | 2009-08-11 | Roche Molecular Systems, Inc. | 2′-terminator nucleotide-related methods and systems |
| DE602005009693D1 (de) | 2004-06-02 | 2008-10-23 | Asm Scient Inc | 2"-nitrobenzyl-modifizierte ribonukleotide |
| US7745125B2 (en) | 2004-06-28 | 2010-06-29 | Roche Molecular Systems, Inc. | 2′-terminator related pyrophosphorolysis activated polymerization |
| JP4753066B2 (ja) | 2005-06-29 | 2011-08-17 | 独立行政法人産業技術総合研究所 | イオン複合型粘土組成物およびその固化物 |
| WO2007039301A2 (en) | 2005-10-05 | 2007-04-12 | Roche Diagnostics Gmbh | Non-fluorescent energy transfer |
| ES2388722T3 (es) | 2005-12-21 | 2012-10-18 | F. Hoffmann-La Roche Ag | Secuenciación y genotipado utilizando nucleótidos modificados en 2' de forma reversible |
-
2006
- 2006-10-18 US US11/583,606 patent/US7745125B2/en not_active Expired - Fee Related
-
2007
- 2007-10-17 WO PCT/EP2007/008997 patent/WO2008046602A2/en active Application Filing
- 2007-10-17 CA CA 2664229 patent/CA2664229C/en not_active Expired - Fee Related
- 2007-10-17 ES ES07819065T patent/ES2381505T3/es active Active
- 2007-10-17 EP EP20070819065 patent/EP2076606B1/de not_active Not-in-force
- 2007-10-17 AT AT07819065T patent/ATE542922T1/de active
- 2007-10-17 JP JP2009532720A patent/JP5421112B2/ja not_active Expired - Fee Related
- 2007-10-17 CN CN201510684383.3A patent/CN105274169A/zh active Pending
- 2007-10-17 CN CNA2007800386518A patent/CN101528945A/zh active Pending
-
2016
- 2016-07-22 HK HK16108797.0A patent/HK1220733A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2076606A2 (de) | 2009-07-08 |
| WO2008046602A2 (en) | 2008-04-24 |
| CA2664229A1 (en) | 2008-04-24 |
| JP2010506573A (ja) | 2010-03-04 |
| CN101528945A (zh) | 2009-09-09 |
| HK1220733A1 (zh) | 2017-05-12 |
| JP5421112B2 (ja) | 2014-02-19 |
| WO2008046602A3 (en) | 2008-06-26 |
| EP2076606B1 (de) | 2012-01-25 |
| ES2381505T3 (es) | 2012-05-28 |
| US20070154914A1 (en) | 2007-07-05 |
| CA2664229C (en) | 2012-12-18 |
| US7745125B2 (en) | 2010-06-29 |
| CN105274169A (zh) | 2016-01-27 |
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