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ATE540122T1 - Cluster-deletion und humanisierung in zwei schritten - Google Patents

Cluster-deletion und humanisierung in zwei schritten

Info

Publication number
ATE540122T1
ATE540122T1 AT08806243T AT08806243T ATE540122T1 AT E540122 T1 ATE540122 T1 AT E540122T1 AT 08806243 T AT08806243 T AT 08806243T AT 08806243 T AT08806243 T AT 08806243T AT E540122 T1 ATE540122 T1 AT E540122T1
Authority
AT
Austria
Prior art keywords
humanization
steps
cluster
cluster deletion
relates
Prior art date
Application number
AT08806243T
Other languages
English (en)
Inventor
Nico Scheer
Original Assignee
Iti Scotland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iti Scotland Ltd filed Critical Iti Scotland Ltd
Application granted granted Critical
Publication of ATE540122T1 publication Critical patent/ATE540122T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Environmental Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Animal Husbandry (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Electrotherapy Devices (AREA)
  • Oscillators With Electromechanical Resonators (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT08806243T 2007-09-14 2008-09-12 Cluster-deletion und humanisierung in zwei schritten ATE540122T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0718029.2A GB0718029D0 (en) 2007-09-14 2007-09-14 Two step cluster deletion and humanisation
PCT/GB2008/003084 WO2009034328A2 (en) 2007-09-14 2008-09-12 Two step cluster deletion and humanisation

Publications (1)

Publication Number Publication Date
ATE540122T1 true ATE540122T1 (de) 2012-01-15

Family

ID=38659025

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08806243T ATE540122T1 (de) 2007-09-14 2008-09-12 Cluster-deletion und humanisierung in zwei schritten

Country Status (10)

Country Link
US (1) US20100281554A1 (de)
EP (1) EP2209898B8 (de)
JP (1) JP2010538632A (de)
CN (1) CN101855356A (de)
AT (1) ATE540122T1 (de)
AU (1) AU2008299636A1 (de)
CA (1) CA2699547A1 (de)
ES (1) ES2384760T3 (de)
GB (1) GB0718029D0 (de)
WO (1) WO2009034328A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011044050A2 (en) 2009-10-06 2011-04-14 Regeneron Pharmaceuticals, Inc. Genetically modified mice and engraftment
US8847004B2 (en) 2011-02-15 2014-09-30 Regeneron Pharmaceuticals, Inc. Humanized M-CSF mice
IL307969A (en) 2012-09-07 2023-12-01 Regeneron Pharma Genetically modified non-human animals and methods of their use
RU2673156C2 (ru) 2012-11-05 2018-11-22 Ридженерон Фармасьютикалз, Инк. Генетически модифицированные не относящиеся к человеческому роду животные и способы их применения
EP3145307B1 (de) 2014-05-19 2019-02-06 Regeneron Pharmaceuticals, Inc. Genetisch modifizierte nichtmenschliche tiere zur expression von menschlichem epo
KR20240060648A (ko) 2015-04-13 2024-05-08 리제너론 파마슈티칼스 인코포레이티드 인간화된 sirpa-il15 녹인 마우스 및 이의 이용 방법
EP3474662A1 (de) 2016-06-27 2019-05-01 Baylor College of Medicine Nichtmenschliches chimäres tier mit menschlicher leber mit defizienter p450-oxidoreduktase und verfahren zur verwendung davon
CN107779462B (zh) * 2016-08-29 2021-06-04 中国科学院分子细胞科学卓越创新中心 双同源重组谱系示踪技术
CN110129346A (zh) * 2018-02-02 2019-08-16 杭州菁因康生物科技有限公司 一种高效的基因工程载体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5149655A (en) * 1990-06-21 1992-09-22 Agracetus, Inc. Apparatus for genetic transformation
AU6476000A (en) * 1999-08-13 2001-03-13 Kirin Beer Kabushiki Kaisha Mouse having human cytochrome p450 transferred therein
US6596541B2 (en) * 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
WO2005019463A1 (en) * 2003-08-11 2005-03-03 Therapeutic Human Polyclonals, Inc. Improved transgenesis with humanized immunoglobulin loci
SG158115A1 (en) * 2004-12-13 2010-01-29 Iti Scotland Ltd Transgenic animals for assessing drug metabolism and toxicity
GB0700194D0 (en) * 2007-01-05 2007-02-14 Univ Edinburgh Humanisation of animals

Also Published As

Publication number Publication date
JP2010538632A (ja) 2010-12-16
WO2009034328A3 (en) 2009-04-30
EP2209898B1 (de) 2012-01-04
US20100281554A1 (en) 2010-11-04
AU2008299636A1 (en) 2009-03-19
EP2209898B8 (de) 2012-03-21
GB0718029D0 (en) 2007-10-24
CN101855356A (zh) 2010-10-06
WO2009034328A2 (en) 2009-03-19
CA2699547A1 (en) 2009-03-19
EP2209898A2 (de) 2010-07-28
ES2384760T3 (es) 2012-07-12

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