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ATE438620T1 - Azetidin-derivate als ccr-3-rezeptor-antagonisten - Google Patents

Azetidin-derivate als ccr-3-rezeptor-antagonisten

Info

Publication number
ATE438620T1
ATE438620T1 AT05776965T AT05776965T ATE438620T1 AT E438620 T1 ATE438620 T1 AT E438620T1 AT 05776965 T AT05776965 T AT 05776965T AT 05776965 T AT05776965 T AT 05776965T AT E438620 T1 ATE438620 T1 AT E438620T1
Authority
AT
Austria
Prior art keywords
ccr
receptor antagonists
compounds
azetidine derivatives
inflammatory
Prior art date
Application number
AT05776965T
Other languages
English (en)
Inventor
Darren Mark Legrand
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE438620T1 publication Critical patent/ATE438620T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT05776965T 2004-08-10 2005-08-09 Azetidin-derivate als ccr-3-rezeptor-antagonisten ATE438620T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0417801.8A GB0417801D0 (en) 2004-08-10 2004-08-10 Organic compounds
PCT/EP2005/008654 WO2006015854A2 (en) 2004-08-10 2005-08-09 Azetidine derivatives as ccr-3 receptor antagonists

Publications (1)

Publication Number Publication Date
ATE438620T1 true ATE438620T1 (de) 2009-08-15

Family

ID=33017254

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05776965T ATE438620T1 (de) 2004-08-10 2005-08-09 Azetidin-derivate als ccr-3-rezeptor-antagonisten

Country Status (17)

Country Link
US (1) US7691841B2 (de)
EP (1) EP1781606B1 (de)
JP (1) JP2008509185A (de)
KR (1) KR20070045242A (de)
CN (1) CN101175722B (de)
AT (1) ATE438620T1 (de)
AU (1) AU2005270308B2 (de)
BR (1) BRPI0514248A (de)
CA (1) CA2572748A1 (de)
DE (1) DE602005015866D1 (de)
ES (1) ES2330125T3 (de)
GB (1) GB0417801D0 (de)
MX (1) MX2007001646A (de)
PL (1) PL1781606T3 (de)
PT (1) PT1781606E (de)
RU (1) RU2007108657A (de)
WO (1) WO2006015854A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2934265B1 (fr) * 2008-07-23 2010-07-30 Sanofi Aventis Derives de carbamates d'alkylthiazoles, leur preparation et leur application en therapeutique
WO2010121011A1 (en) * 2009-04-16 2010-10-21 Janssen Pharmaceutica Nv 4-azetidinyl-1-heteroaryl-cyclohexane antagonists of ccr2
ES2541607T3 (es) * 2009-04-17 2015-07-22 Janssen Pharmaceutica Nv Antagonistas de CCR2 de ciclohexano unido a 4-azetidinilo-1-heteroátomo

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9609374D0 (en) 1996-05-03 1996-07-10 Merck Sharp & Dohme Therapeutic agents
KR100667645B1 (ko) * 1999-08-04 2007-02-28 데이진 가부시키가이샤 환상 아민 ccr3 길항제
GB0117387D0 (en) * 2001-07-17 2001-09-05 Novartis Ag Organic compounds
JP2003155285A (ja) * 2001-11-19 2003-05-27 Toray Ind Inc 環状含窒素誘導体
TW200305395A (en) 2002-03-15 2003-11-01 Novartis Ag Organic compounds
AU2003293129B2 (en) * 2002-11-27 2009-03-12 Incyte Holdings Corporation 3-aminopyrrolidine derivatives as modulators of chemokine receptors
JP2006511552A (ja) * 2002-12-13 2006-04-06 スミスクライン ビーチャム コーポレーション Ccr5拮抗薬としてのピロリジンおよびアゼチジン化合物
JP2007505080A (ja) * 2003-09-15 2007-03-08 ノバルティス アクチエンゲゼルシャフト 炎症性およびアレルギー性疾患の処置における、ccr−3受容体アンタゴニストとして使用するための1,3−二置換アゼチジン誘導体

Also Published As

Publication number Publication date
EP1781606B1 (de) 2009-08-05
ES2330125T3 (es) 2009-12-04
WO2006015854A2 (en) 2006-02-16
AU2005270308B2 (en) 2009-10-22
JP2008509185A (ja) 2008-03-27
PL1781606T3 (pl) 2010-01-29
MX2007001646A (es) 2007-04-10
WO2006015854A3 (en) 2007-08-30
BRPI0514248A (pt) 2008-06-03
GB0417801D0 (en) 2004-09-15
US20070259848A1 (en) 2007-11-08
PT1781606E (pt) 2009-10-26
EP1781606A2 (de) 2007-05-09
KR20070045242A (ko) 2007-05-02
CN101175722B (zh) 2010-11-24
CA2572748A1 (en) 2006-02-16
RU2007108657A (ru) 2008-09-20
CN101175722A (zh) 2008-05-07
DE602005015866D1 (de) 2009-09-17
AU2005270308A1 (en) 2006-02-16
US7691841B2 (en) 2010-04-06

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