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ATE432272T1 - Aminophenylderivate als neue inhibitoren von histondeacetylase - Google Patents

Aminophenylderivate als neue inhibitoren von histondeacetylase

Info

Publication number
ATE432272T1
ATE432272T1 AT07703891T AT07703891T ATE432272T1 AT E432272 T1 ATE432272 T1 AT E432272T1 AT 07703891 T AT07703891 T AT 07703891T AT 07703891 T AT07703891 T AT 07703891T AT E432272 T1 ATE432272 T1 AT E432272T1
Authority
AT
Austria
Prior art keywords
histone deacetylase
new inhibitors
aminophenyl derivatives
aminophenyl
derivatives
Prior art date
Application number
AT07703891T
Other languages
English (en)
Inventor
Patrick Angibaud
Isabelle Pilatte
Bruno Roux
Janine Arts
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE432272T1 publication Critical patent/ATE432272T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT07703891T 2006-01-19 2007-01-16 Aminophenylderivate als neue inhibitoren von histondeacetylase ATE432272T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06100584 2006-01-19
PCT/EP2007/050376 WO2007082878A1 (en) 2006-01-19 2007-01-16 Aminophenyl derivatives as novel inhibitors of histone deacetylase

Publications (1)

Publication Number Publication Date
ATE432272T1 true ATE432272T1 (de) 2009-06-15

Family

ID=36579211

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07703891T ATE432272T1 (de) 2006-01-19 2007-01-16 Aminophenylderivate als neue inhibitoren von histondeacetylase

Country Status (19)

Country Link
US (1) US8119650B2 (de)
EP (1) EP1981874B1 (de)
JP (1) JP5225104B2 (de)
CN (1) CN101370804B (de)
AT (1) ATE432272T1 (de)
AU (1) AU2007206946B2 (de)
CA (1) CA2631876C (de)
CY (1) CY1109331T1 (de)
DE (1) DE602007001190D1 (de)
DK (1) DK1981874T3 (de)
ES (1) ES2327972T3 (de)
HK (1) HK1128283A1 (de)
HR (1) HRP20090459T1 (de)
ME (1) ME01060B (de)
PL (1) PL1981874T3 (de)
PT (1) PT1981874E (de)
RS (1) RS51191B (de)
SI (1) SI1981874T1 (de)
WO (1) WO2007082878A1 (de)

Families Citing this family (23)

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PL208401B1 (pl) 2002-03-13 2011-04-29 Janssen Pharmaceutica Nv Pochodne piperazynylowe, piperydynylowe i morfolinylowe, sposób ich wytwarzania, kompozycja je zawierająca oraz ich zastosowanie
OA12789A (en) * 2002-03-13 2006-07-10 Janssen Pharmaceutica Nv Carbonylamino-derivatives as novel inhibitors of histone deacetylase.
BR0308081A (pt) 2002-03-13 2004-12-21 Janssen Pharmaceutica Nv Inibidores de histona desacetilase
CA2476186C (en) 2002-03-13 2011-07-19 Janssen Pharmaceutica N.V. Sulfonylamino-derivatives as novel inhibitors of histone deacetylase
UA86066C2 (ru) * 2004-07-28 2009-03-25 Янссен Фармацевтика Н.В. Производные замещенного пропенилпиперазина как ингибиторы гистондеацетилазы
CA2572833C (en) 2004-07-28 2013-04-09 Janssen Pharmaceutica N.V. Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
US8138198B2 (en) 2005-05-18 2012-03-20 Angibaud Patrick Rene Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase
DK1943232T3 (da) * 2005-10-27 2011-08-29 Janssen Pharmaceutica Nv Kvadratsyrederivater som inhibitorer af histondeacetylase
CN101370790B (zh) 2006-01-19 2015-10-21 詹森药业有限公司 作为组蛋白去乙酰化酶抑制剂的吡啶和嘧啶衍生物
PL1981874T3 (pl) 2006-01-19 2009-10-30 Janssen Pharmaceutica Nv Pochodne aminofenylowe jako nowe inhibitory deacetylazy histonowej
AU2007206948B2 (en) * 2006-01-19 2012-08-23 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
US8101616B2 (en) 2006-01-19 2012-01-24 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
WO2007082882A1 (en) 2006-01-19 2007-07-26 Janssen Pharmaceutica N.V. Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase
WO2009118370A1 (en) * 2008-03-27 2009-10-01 Janssen Pharmaceutica Nv Aza-bicyclohexyl substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
CN102118969B (zh) * 2008-06-12 2017-03-08 詹森药业有限公司 组胺h4受体的二氨基吡啶、二氨基嘧啶和二氨基哒嗪调节剂
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Also Published As

Publication number Publication date
CA2631876A1 (en) 2007-07-26
DK1981874T3 (da) 2009-09-28
EP1981874B1 (de) 2009-05-27
RS51191B (sr) 2010-10-31
ES2327972T3 (es) 2009-11-05
PT1981874E (pt) 2009-09-02
SI1981874T1 (sl) 2009-10-31
AU2007206946B2 (en) 2011-12-15
HK1128283A1 (en) 2009-10-23
CN101370804A (zh) 2009-02-18
JP2009523760A (ja) 2009-06-25
JP5225104B2 (ja) 2013-07-03
AU2007206946A1 (en) 2007-07-26
CY1109331T1 (el) 2014-07-02
ME01060B (me) 2012-10-20
WO2007082878A1 (en) 2007-07-26
US20090018152A1 (en) 2009-01-15
DE602007001190D1 (de) 2009-07-09
CA2631876C (en) 2014-05-27
EP1981874A1 (de) 2008-10-22
US8119650B2 (en) 2012-02-21
HRP20090459T1 (hr) 2009-09-30
PL1981874T3 (pl) 2009-10-30
CN101370804B (zh) 2013-05-29

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