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ATE424821T1 - Pyrrolopyridin-2-karbonsäureamide - Google Patents

Pyrrolopyridin-2-karbonsäureamide

Info

Publication number
ATE424821T1
ATE424821T1 AT05821654T AT05821654T ATE424821T1 AT E424821 T1 ATE424821 T1 AT E424821T1 AT 05821654 T AT05821654 T AT 05821654T AT 05821654 T AT05821654 T AT 05821654T AT E424821 T1 ATE424821 T1 AT E424821T1
Authority
AT
Austria
Prior art keywords
pyrrolopyridine
carbonic acid
acid amides
ischemia
cardioprotectants
Prior art date
Application number
AT05821654T
Other languages
English (en)
Inventor
Thomas Martin Krulle
Robert John Rowley
Gerard Hugh Thomas
Original Assignee
Prosidion Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prosidion Ltd filed Critical Prosidion Ltd
Application granted granted Critical
Publication of ATE424821T1 publication Critical patent/ATE424821T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT05821654T 2004-12-02 2005-12-02 Pyrrolopyridin-2-karbonsäureamide ATE424821T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63246104P 2004-12-02 2004-12-02

Publications (1)

Publication Number Publication Date
ATE424821T1 true ATE424821T1 (de) 2009-03-15

Family

ID=36201419

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05821654T ATE424821T1 (de) 2004-12-02 2005-12-02 Pyrrolopyridin-2-karbonsäureamide

Country Status (7)

Country Link
US (1) US20090099176A1 (de)
EP (1) EP1819332B1 (de)
JP (1) JP2008521873A (de)
AT (1) ATE424821T1 (de)
DE (1) DE602005013275D1 (de)
ES (1) ES2324173T3 (de)
WO (1) WO2006059164A2 (de)

Families Citing this family (13)

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JP5398984B2 (ja) * 2005-06-24 2014-01-29 富山化学工業株式会社 新規な含窒素複素環化合物およびその塩
EP1829867A1 (de) * 2006-03-03 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Gegenüber dem Sigmarezeptor pharmazeutisch aktive Imidazolverbindungen
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
CN103497181B (zh) 2013-09-30 2016-03-30 承德医学院 作为糖原磷酸化酶抑制剂的苯并氮杂卓酮类化合物、其制备方法及医药用途
CN104744353B (zh) * 2015-03-31 2017-11-24 山东友帮生化科技有限公司 2‑氨基‑3‑碘‑5‑氯吡啶的合成方法
US9815850B2 (en) 2016-02-05 2017-11-14 Denali Therapeutics Inc. Compounds, compositions and methods
EP3552017B1 (de) 2016-12-09 2022-02-23 Denali Therapeutics Inc. Verbindungen zur verwendung als ripk1-hemmer
US20220236237A1 (en) * 2019-05-31 2022-07-28 Shin Nippon Biomedical Laboratories, Ltd. Mass spectrometry method using chromatography-mass spectrometry device
CN112442022B (zh) * 2019-09-02 2022-05-20 承德医学院 苯并嗪-4-酮类化合物、其制备方法及医药用途
CN114057716B (zh) * 2020-08-04 2023-06-09 承德医学院 苯并氮杂卓酮类化合物及其盐、其制备方法及医药用途
AU2021353009A1 (en) 2020-09-30 2023-06-08 Katholieke Universiteit Leuven 1,2,3,4-tetrahydroquinoline derivatives as inhibitors of the yap/taz-tead activation for treating cancer
WO2022160138A1 (zh) * 2021-01-27 2022-08-04 承德医学院 苯并嗪-4-酮类化合物、其制备方法及医药用途
US11999750B2 (en) 2022-01-12 2024-06-04 Denali Therapeutics Inc. Crystalline forms of (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydropyrido [3,2-B][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide

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US5672582A (en) 1993-04-30 1997-09-30 Merck & Co., Inc. Thrombin inhibitors
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Also Published As

Publication number Publication date
JP2008521873A (ja) 2008-06-26
EP1819332A2 (de) 2007-08-22
DE602005013275D1 (de) 2009-04-23
WO2006059164A2 (en) 2006-06-08
ES2324173T3 (es) 2009-07-31
EP1819332B1 (de) 2009-03-11
WO2006059164A3 (en) 2006-08-17
US20090099176A1 (en) 2009-04-16

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Legal Events

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