[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ATE424455T1 - Ligationsvermittelnde codierung von kleinen molekülen - Google Patents

Ligationsvermittelnde codierung von kleinen molekülen

Info

Publication number
ATE424455T1
ATE424455T1 AT04722237T AT04722237T ATE424455T1 AT E424455 T1 ATE424455 T1 AT E424455T1 AT 04722237 T AT04722237 T AT 04722237T AT 04722237 T AT04722237 T AT 04722237T AT E424455 T1 ATE424455 T1 AT E424455T1
Authority
AT
Austria
Prior art keywords
chemical entities
template
encoded molecule
codon
identifier polynucleotide
Prior art date
Application number
AT04722237T
Other languages
English (en)
Inventor
Thomas Franch
Soeren Jacobsen
Torben Rasmussen
Soeren Neve
Henrik Pedersen
Alex Gouliaev
Original Assignee
Nuevolution As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nuevolution As filed Critical Nuevolution As
Application granted granted Critical
Publication of ATE424455T1 publication Critical patent/ATE424455T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/04—Methods of creating libraries, e.g. combinatorial synthesis using dynamic combinatorial chemistry techniques

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT04722237T 2003-03-20 2004-03-22 Ligationsvermittelnde codierung von kleinen molekülen ATE424455T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45585803P 2003-03-20 2003-03-20
DKPA200300430 2003-03-20

Publications (1)

Publication Number Publication Date
ATE424455T1 true ATE424455T1 (de) 2009-03-15

Family

ID=33031172

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04722237T ATE424455T1 (de) 2003-03-20 2004-03-22 Ligationsvermittelnde codierung von kleinen molekülen

Country Status (6)

Country Link
US (1) US7915201B2 (de)
EP (2) EP2236606B1 (de)
AT (1) ATE424455T1 (de)
DE (1) DE602004019764D1 (de)
DK (2) DK2236606T3 (de)
WO (1) WO2004083427A2 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7727713B2 (en) 2001-06-20 2010-06-01 Nuevolution A/S Templated molecules and methods for using such molecules
IL163822A0 (en) 2002-03-15 2005-12-18 Nuevolution As An improved method for synthesising templated molecules
WO2004013070A2 (en) 2002-08-01 2004-02-12 Nuevolution A/S Multi-step synthesis of templated molecules
JP4657919B2 (ja) * 2002-08-19 2011-03-23 プレジデント アンド フェローズ オブ ハーバード カレッジ 進化する新しい分子機能
US8791053B2 (en) 2002-09-27 2014-07-29 Mpm-Holding Aps Spatially encoded polymer matrix
EP1558744B1 (de) * 2002-10-30 2011-06-15 Nuevolution A/S Enzymatisches codieren
US9121110B2 (en) 2002-12-19 2015-09-01 Nuevolution A/S Quasirandom structure and function guided synthesis methods
EP1597395A2 (de) 2003-02-21 2005-11-23 Nuevolution A/S Methode zur herstellung einer bibliothek der zweiten generation
ATE424455T1 (de) 2003-03-20 2009-03-15 Nuevolution As Ligationsvermittelnde codierung von kleinen molekülen
US8017323B2 (en) * 2003-03-26 2011-09-13 President And Fellows Of Harvard College Free reactant use in nucleic acid-templated synthesis
EP1670939B1 (de) * 2003-09-18 2009-11-04 Nuevolution A/S Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
US7972994B2 (en) 2003-12-17 2011-07-05 Glaxosmithkline Llc Methods for synthesis of encoded libraries
NZ547723A (en) 2003-12-17 2009-09-25 Praecis Pharm Inc Methods for synthesis of encoded libraries
EP1723255B1 (de) * 2004-02-17 2010-12-29 Nuevolution A/S Anreicherungsverfahren mit eliminierung durch fehlpaarungshybridisierung
DE602005017370D1 (de) * 2004-03-22 2009-12-10 Nuevolution As Ligationscodierung unter verwendung von oligonukleotidbausteinen
US8168381B2 (en) 2004-11-22 2012-05-01 Peter Birk Rasmussen Template directed split and mix systhesis of small molecule libraries
NZ564545A (en) * 2005-06-09 2011-03-31 Praecis Pharm Inc Methods for synthesis of encoded libraries
US7883848B2 (en) * 2005-07-08 2011-02-08 Olink Ab Regulation analysis by cis reactivity, RACR
EP2368868A1 (de) * 2005-10-28 2011-09-28 Praecis Pharmaceuticals Inc. Verfahren zur Identifikation von Verbindungen von Interesse mithilfe kodierter Bibliotheken
SI2336315T1 (sl) 2005-12-01 2017-12-29 Nuevolution A/S Postopki encimskega kodiranja za učinkovito sintezo velikih knjižnic
US7727745B2 (en) 2006-08-14 2010-06-01 Bio-Id Diagnostic Inc. Synthesis of single-stranded DNA
WO2009077173A2 (en) * 2007-12-19 2009-06-25 Philochem Ag Dna-encoded chemical libraries
WO2009097673A1 (en) * 2008-02-07 2009-08-13 Bio-Id Diagnostic Inc. Synthesis of single-stranded dna
NZ611886A (en) 2009-02-13 2014-10-31 Chem Inc X Methods of creating and screening dna-encoded libraries
EP2558577B1 (de) 2010-04-16 2018-12-12 Nuevolution A/S Bifunktionelle komplexe und verfahren zur herstellung sowie verwendung derartiger komplexe
EP2405000A1 (de) * 2010-07-06 2012-01-11 Alacris Theranostics GmbH Synthese chemischer Bibliotheken
ES2675111T3 (es) 2011-09-07 2018-07-06 X-Chem, Inc. Métodos para etiquetar bibliotecas con codificación de ADN
EA034141B1 (ru) 2012-07-13 2020-01-09 Икс-Чем, Инк. Днк-кодированные библиотеки, содержащие связи кодирующих олигонуклеотидов, не доступные для считывания полимеразами
US9765375B2 (en) 2013-06-28 2017-09-19 General Electric Company Methods for developing binding-elements and uses thereof
GB201322692D0 (en) 2013-12-20 2014-02-05 Philochem Ag Production of encoded chemical libraries
GB201603789D0 (en) * 2016-03-04 2016-04-20 Apta Biosciences Ltd Oligonucleotides and methods for preparing
WO2017218293A1 (en) 2016-06-16 2017-12-21 Richard Edward Watts Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules
WO2018204420A1 (en) 2017-05-02 2018-11-08 Haystack Sciences Corporation Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same
CN107802276B (zh) * 2017-09-01 2020-11-27 深圳市菲森科技有限公司 头颅影像的描迹图绘制装置和方法
AU2020361681A1 (en) 2019-10-10 2022-05-05 1859, Inc. Methods and systems for microfluidic screening
EP4065723A4 (de) * 2019-11-29 2024-01-17 MGI Holdings Co., Limited Enzymatische synthese von oligonukleotiden

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4822731A (en) 1986-01-09 1989-04-18 Cetus Corporation Process for labeling single-stranded nucleic acids and hybridizaiton probes
US5449602A (en) 1988-01-13 1995-09-12 Amoco Corporation Template-directed photoligation
WO1990005785A1 (en) 1988-11-18 1990-05-31 The Regents Of The University Of California Method for site-specifically incorporating unnatural amino acids into proteins
AU638762B2 (en) 1989-10-05 1993-07-08 Optein Inc Cell-free synthesis and isolation of novel genes and polypeptides
US5723289A (en) 1990-06-11 1998-03-03 Nexstar Pharmaceuticals, Inc. Parallel selex
WO1993003172A1 (en) 1991-08-01 1993-02-18 University Research Corporation Systematic polypeptide evolution by reverse translation
DE69217497T2 (de) 1991-09-18 1997-06-12 Affymax Tech Nv Verfahren zur synthese der verschiedenen sammlungen von oligomeren
US5639603A (en) 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
ATE246702T1 (de) 1993-04-12 2003-08-15 Univ Northwestern Verfahren zur darstellung von oligonukleotiden
US5681943A (en) 1993-04-12 1997-10-28 Northwestern University Method for covalently linking adjacent oligonucleotides
US5840485A (en) * 1993-05-27 1998-11-24 Selectide Corporation Topologically segregated, encoded solid phase libraries
US5473060A (en) 1993-07-02 1995-12-05 Lynx Therapeutics, Inc. Oligonucleotide clamps having diagnostic applications
US5571903A (en) 1993-07-09 1996-11-05 Lynx Therapeutics, Inc. Auto-ligating oligonucleotide compounds
GB9315847D0 (en) * 1993-07-30 1993-09-15 Isis Innovation Tag reagent and assay method
US6165778A (en) 1993-11-02 2000-12-26 Affymax Technologies N.V. Reaction vessel agitation apparatus
US5503805A (en) 1993-11-02 1996-04-02 Affymax Technologies N.V. Apparatus and method for parallel coupling reactions
AU703472B2 (en) 1993-11-02 1999-03-25 Affymax Technologies N.V. Synthesizing and screening molecular diversity
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
WO1996000378A1 (en) 1994-06-23 1996-01-04 Affymax Technologies N.V. Photolabile compounds and methods for their use
US5604097A (en) 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US5843650A (en) 1995-05-01 1998-12-01 Segev; David Nucleic acid detection and amplification by chemical linkage of oligonucleotides
US5830658A (en) 1995-05-31 1998-11-03 Lynx Therapeutics, Inc. Convergent synthesis of branched and multiply connected macromolecular structures
US5780613A (en) 1995-08-01 1998-07-14 Northwestern University Covalent lock for self-assembled oligonucleotide constructs
DE19646372C1 (de) * 1995-11-11 1997-06-19 Evotec Biosystems Gmbh Genotyp und Phänotyp koppelnde Verbindung
JP3692542B2 (ja) * 1997-01-21 2005-09-07 ザ ジェネラル ホスピタル コーポレーション Ｒｎａ−蛋白質の融合体を用いた蛋白質の選抜
US6261804B1 (en) 1997-01-21 2001-07-17 The General Hospital Corporation Selection of proteins using RNA-protein fusions
DK0985032T4 (da) 1997-05-28 2009-08-31 Crescendo Biolog Ltd Ribosom-komplekser som selektionspartikler til in vitro fremvisning og evolution af proteiner
US6969584B2 (en) 1997-06-12 2005-11-29 Rigel Pharmaceuticals, Inc. Combinatorial enzymatic complexes
US20030004122A1 (en) 1997-11-05 2003-01-02 Leonid Beigelman Nucleotide triphosphates and their incorporation into oligonucleotides
US6537749B2 (en) 1998-04-03 2003-03-25 Phylos, Inc. Addressable protein arrays
EP1073730A1 (de) 1998-04-17 2001-02-07 Whitehead For Biomedical Research Verwendung von ribozym zum verbinden von nukleinsäuren mit polypeptiden
WO2000021909A2 (en) 1998-10-09 2000-04-20 Pharmacopeia, Inc. Selecting codes to be used for encoding combinatorial libraries
WO2000023458A1 (en) * 1998-10-19 2000-04-27 The Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library chemistry
IL143238A0 (en) 1998-12-02 2002-04-21 Phylos Inc Dna-protein fusions and uses thereof
EP1208219A1 (de) 1999-04-08 2002-05-29 Pavel Sergeev Synthese von biologisch-aktiven zusammensetzungen in zellen
DE60045739D1 (de) 1999-06-25 2011-04-28 Nanosphere Inc Nanopartikel mit gebundenen oligonukleotiden und deren verwendungen
ATE551352T1 (de) 1999-07-27 2012-04-15 Bristol Myers Squibb Co Peptidakzeptorbindungsverfahren
US6593088B1 (en) 1999-08-27 2003-07-15 Japan Science And Technology Corporation Reversible photocoupling nucleic acid and phosphoroamidite
IL158000A0 (en) 2001-03-19 2004-03-28 Harvard College Evolving new molecular function
US7727713B2 (en) 2001-06-20 2010-06-01 Nuevolution A/S Templated molecules and methods for using such molecules
DE60221986D1 (de) * 2001-06-20 2007-10-04 Nuevolution As Eine methode zur synthese von matrizenabhängigen molekülen
EP1487851A2 (de) 2002-03-15 2004-12-22 Nuevolution A/S Ein baustein geeignet zur funktionellen gruppe übertragung zum nucleophil
US20050247001A1 (en) 2002-03-15 2005-11-10 Nuevolution A/S Building block forming a c-c or a c-hetero atom bond uponreaction
AU2003214032A1 (en) 2002-03-15 2003-09-29 Nuevolution A/S A building block forming a c=c double bond upon reaction
IL163822A0 (en) 2002-03-15 2005-12-18 Nuevolution As An improved method for synthesising templated molecules
AU2003253069A1 (en) 2002-03-15 2003-09-29 Nuevolution A/S A building block forming a c-c bond upon reaction
AU2003226008A1 (en) 2002-03-22 2003-10-13 Emory University Template-driven processes for synthesizing polymers and components related to such processes
EP1520040A2 (de) 2002-06-20 2005-04-06 Nuevolution A/S Mikroarrays zur darstellung von kodierten molekülen
US20060099589A1 (en) 2002-07-23 2006-05-11 Nuevolution A/S Gene shuffling by template switching
WO2004013070A2 (en) 2002-08-01 2004-02-12 Nuevolution A/S Multi-step synthesis of templated molecules
JP4657919B2 (ja) 2002-08-19 2011-03-23 プレジデント アンド フェローズ オブ ハーバード カレッジ 進化する新しい分子機能
AU2003260291A1 (en) 2002-09-12 2004-04-30 Nuevolution A/S Proximity-aided synthesis of templated molecules
EP1558744B1 (de) 2002-10-30 2011-06-15 Nuevolution A/S Enzymatisches codieren
US9121110B2 (en) 2002-12-19 2015-09-01 Nuevolution A/S Quasirandom structure and function guided synthesis methods
WO2004074501A2 (en) 2003-02-21 2004-09-02 Nuevolution A/S A method for obtaining structural information about an encoded molecule
EP1597395A2 (de) 2003-02-21 2005-11-23 Nuevolution A/S Methode zur herstellung einer bibliothek der zweiten generation
ATE424455T1 (de) 2003-03-20 2009-03-15 Nuevolution As Ligationsvermittelnde codierung von kleinen molekülen
WO2004099441A2 (en) 2003-05-09 2004-11-18 Hyscite Discovery As Selection and evolution of chemical libraries
WO2004110964A2 (en) 2003-06-16 2004-12-23 Nuevolution A/S Encoded molecules by translation (emt)
WO2005003778A2 (en) 2003-07-02 2005-01-13 Nuevolution A/S A method for identifying a synthetic molecule having affinity towards a target
EP1533385A1 (de) 2003-09-05 2005-05-25 Nuevolution A/S Matrizenabhängigen Verbindungen zur Herstellung von kodierten Molekülen und gesteuerten Verfahren unter Verwendung dieser Verbindungen
EP1670939B1 (de) 2003-09-18 2009-11-04 Nuevolution A/S Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
CN101914528B (zh) 2004-11-08 2013-04-03 威泊根私人有限公司 结构型核酸指导的化学合成
US8168381B2 (en) 2004-11-22 2012-05-01 Peter Birk Rasmussen Template directed split and mix systhesis of small molecule libraries

Also Published As

Publication number Publication date
EP2236606A3 (de) 2010-10-20
US20060246450A1 (en) 2006-11-02
DK1608748T3 (da) 2009-06-29
EP2236606B1 (de) 2013-11-06
EP2236606A2 (de) 2010-10-06
EP1608748A2 (de) 2005-12-28
US7915201B2 (en) 2011-03-29
EP1608748B1 (de) 2009-03-04
DK2236606T3 (da) 2014-02-10
WO2004083427A2 (en) 2004-09-30
WO2004083427A3 (en) 2005-02-17
DE602004019764D1 (de) 2009-04-16

Similar Documents

Publication Publication Date Title
ATE424455T1 (de) Ligationsvermittelnde codierung von kleinen molekülen
ATE447020T1 (de) Ligationscodierung unter verwendung von oligonukleotidbausteinen
ATE420170T1 (de) Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle
DK3018206T3 (da) Enzymatic encoding methods for efficient synthesis of large libraries
AU2003291962A1 (en) Polypeptides having cellobiohydrolase ii activity and polynucleotides encoding same
WO2004074429A3 (en) Method for producing second-generation library
ATE448301T1 (de) Sammlung von proteinen mit sich wiederholenden sequenzen (repeat proteins), die repetitive sequenzmodule enthalten
ATE239090T1 (de) Methode zum generieren von einzelsträngigen dna molekülen
DK0876509T4 (da) Fremgangsmåder til dannelse af polynukleotider med ønskede egenskaber ved hjælp af gentagen selektion og rekombination
WO2005051970A3 (de) Hochparalleler dna-synthesizer auf matrizenbasis
ATE399771T1 (de) Verfahren zur herstellung von 1,2-epoxy-3- chlorpropan
DE602004025624D1 (de) Verfahren zur nukleinsäureamplifikation
DE69616525D1 (de) Verfahren zur herstellung von tetrabrombisphenol-a
JP2004533259A5 (de)
GB2421950B (en) Method of mutagenesis
ATE223499T1 (de) Von kreisförmiger matrize abhängige kettenreaktion
ATE478105T1 (de) Elektroaktiver komplex, elektroaktive sonde und verfahren zur herstellung
DE69931759D1 (de) Methode zur erstellung von genexpressionsprofilen
DE50203919D1 (de) Verfahren zur herstellung von grignard-verbindungen
SE0103249D0 (sv) Generation of compound libraries utilizing molecular imprints including a double or anti-idiotypic imprinting
DE50001638D1 (de) Verfahren zur herstellung von 4,6-dichlorpyrimidin

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties