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ATE415399T1 - Kondensierte ringe enthaltende 1,2-dihydro-7- hydroxychinolinderivate - Google Patents

Kondensierte ringe enthaltende 1,2-dihydro-7- hydroxychinolinderivate

Info

Publication number
ATE415399T1
ATE415399T1 AT01957438T AT01957438T ATE415399T1 AT E415399 T1 ATE415399 T1 AT E415399T1 AT 01957438 T AT01957438 T AT 01957438T AT 01957438 T AT01957438 T AT 01957438T AT E415399 T1 ATE415399 T1 AT E415399T1
Authority
AT
Austria
Prior art keywords
dyes
hydroxychinoline
dihydro
derivatives
rings containing
Prior art date
Application number
AT01957438T
Other languages
English (en)
Inventor
Zhenjun Diwu
Jiaxing Liu
Richard Haugland
Kyle Gee
Original Assignee
Molecular Probes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Probes Inc filed Critical Molecular Probes Inc
Application granted granted Critical
Publication of ATE415399T1 publication Critical patent/ATE415399T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
AT01957438T 2000-08-04 2001-08-04 Kondensierte ringe enthaltende 1,2-dihydro-7- hydroxychinolinderivate ATE415399T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22308600P 2000-08-04 2000-08-04

Publications (1)

Publication Number Publication Date
ATE415399T1 true ATE415399T1 (de) 2008-12-15

Family

ID=22834975

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01957438T ATE415399T1 (de) 2000-08-04 2001-08-04 Kondensierte ringe enthaltende 1,2-dihydro-7- hydroxychinolinderivate

Country Status (7)

Country Link
US (1) US6716979B2 (de)
EP (3) EP2045252B1 (de)
AT (1) ATE415399T1 (de)
AU (2) AU7918501A (de)
CA (1) CA2417816A1 (de)
DE (1) DE60136719D1 (de)
WO (1) WO2002012195A1 (de)

Families Citing this family (162)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7169922B2 (en) 2000-08-04 2007-01-30 Invitrogen Corporation Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings
AUPQ937100A0 (en) * 2000-08-15 2000-09-07 Food & Packaging Centre Management Limited Odour sensor
JP3607695B2 (ja) * 2000-08-24 2005-01-05 バイオ−ラッド ラボラトリーズ，インコーポレイティド タンパク質を標識する為の乾燥粉末製剤
US7579463B2 (en) * 2000-12-20 2009-08-25 Life Technologies Corporation Crown ether derivatives
US7129346B2 (en) * 2000-12-20 2006-10-31 Molecular Probes, Inc. Crown ether derivatives
US8323903B2 (en) 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
US7445894B2 (en) * 2002-05-03 2008-11-04 Molecular Probes, Inc. Compositions and methods for detection and isolation of phosphorylated molecules
WO2004042347A2 (en) * 2002-05-03 2004-05-21 Molecular Probes, Inc. Compositions and methods for detection and isolation of phosphorylated molecules
US20040171034A1 (en) * 2002-05-03 2004-09-02 Brian Agnew Compositions and methods for detection and isolation of phosphorylated molecules
US20050233307A1 (en) 2002-09-12 2005-10-20 Kyle Gee Site-specific labeling of affinity tags in fusion proteins
US20050250214A1 (en) * 2004-05-05 2005-11-10 Gee Kyle R Zinc binding compounds and their method of use
DE10329860A1 (de) * 2003-07-02 2005-01-20 Atto-Tec Gmbh Sulfonamidderivate polycyclischer Farbstoffe für analytische Anwendungen
US7727752B2 (en) * 2003-07-29 2010-06-01 Life Technologies Corporation Kinase and phosphatase assays
CA2445420A1 (en) * 2003-07-29 2005-01-29 Invitrogen Corporation Kinase and phosphatase assays
US7619059B2 (en) * 2003-07-29 2009-11-17 Life Technologies Corporation Bimolecular optical probes
US7271265B2 (en) * 2003-08-11 2007-09-18 Invitrogen Corporation Cyanine compounds and their application as quenching compounds
CA2538797A1 (en) * 2003-09-12 2005-03-24 Invitrogen Corporation Multiplex binding and activity assays
WO2005038460A2 (en) * 2003-10-14 2005-04-28 Molecular Probes, Inc. Site-specific labeling of affinity tags in fusion proteins
US20050214807A1 (en) * 2003-11-19 2005-09-29 Iain Johnson Environmental sensitive fluorogenic compounds and their application for singlet oxygen and protein detection
US7776529B2 (en) * 2003-12-05 2010-08-17 Life Technologies Corporation Methine-substituted cyanine dye compounds
EP2607431B1 (de) * 2003-12-05 2016-08-24 Life Technologies Corporation Cyanin Farbstoffverbindungen
WO2005071096A2 (en) 2004-01-21 2005-08-04 Molecular Probes, Inc. Derivatives of cephalosporin and clavulanic acid for detecting beta-lacamase in a sample
WO2006023231A2 (en) 2004-07-27 2006-03-02 Molecular Probes, Inc. Fluorescent metal ion indicators with large stokes shift
ITBO20040697A1 (it) * 2004-11-11 2005-02-11 Consiglio Nazionale Ricerche Sonde oligonucleotidiche
US7598390B2 (en) * 2005-05-11 2009-10-06 Life Technologies Corporation Fluorescent chemical compounds having high selectivity for double stranded DNA, and methods for their use
EP1915607A1 (de) * 2005-07-19 2008-04-30 Physical Sciences, Inc. Microwell-array mit bilderstellung in seitenansicht
WO2007030521A1 (en) * 2005-09-06 2007-03-15 Invitrogen Corporation Control of chemical modification
US8093012B2 (en) * 2005-10-13 2012-01-10 Aureon Laboratories, Inc. Multiplex in situ immunohistochemical analysis
US7521577B2 (en) 2006-01-12 2009-04-21 Molecular Probes, Inc. Heavy metal binding compounds and their method of use
US20070196860A1 (en) * 2006-01-18 2007-08-23 Invitrogen Corporation Methods for Measuring Real Time Kinase Activity
WO2007087582A1 (en) 2006-01-24 2007-08-02 Invitrogen Corporation Device and methods for quantifying analytes
EP1987361A4 (de) * 2006-01-30 2009-03-04 Invitrogen Corp Zusammensetzungen und verfahren zur erkennung und quantifizierung toxischer substanzen in krankheitsstadien
EP2623986B1 (de) * 2006-02-10 2017-06-14 Life Technologies Corporation Markierung und Detektion von posttranslational modifizierten Proteinen
US8562802B1 (en) 2006-02-13 2013-10-22 Life Technologies Corporation Transilluminator base and scanner for imaging fluorescent gels, charging devices and portable electrophoresis systems
MX2008012167A (es) 2006-03-23 2009-01-07 Absorber Ab Antigenos de grupo sanguineo de diferentes tipos para aplicaciones de diagnostico y terapeuticas.
AU2007240316A1 (en) 2006-04-20 2007-11-01 Becton, Dickinson And Company Thermostable proteins and methods of making and using thereof
WO2007135368A2 (en) 2006-05-18 2007-11-29 Solexa Limited Dye compounds and the use of their labelled conjugates
EP2727965B1 (de) 2006-10-27 2019-03-06 Life Technologies Corporation FLUOROGENE pH-SENSITIVE FARBSTOFFE UND IHRE VERWENDUNG
US8586743B2 (en) 2007-01-30 2013-11-19 Life Technologies Corporation Labeling reagents and methods of their use
WO2008151089A2 (en) * 2007-05-30 2008-12-11 Invitrogen Corporation Fluorescent phospholipase a2 indicators
MY148484A (en) 2007-08-03 2013-04-30 Sanofi Aventis Caspase imaging probes
CN101946171B (zh) * 2007-12-14 2014-03-12 拜奥蒂乌姆股份有限公司 荧光化合物
EP2262783A2 (de) * 2008-02-21 2010-12-22 Sanofi-Aventis Kovalent bindende sonden zur bilddarstellung
EP2297344B1 (de) 2008-05-16 2018-03-14 Life Technologies Corporation Doppelmarkierungsverfahren zur messung von zellproliferation
US20110171124A1 (en) 2009-02-26 2011-07-14 Osi Pharmaceuticals, Inc. In situ methods for monitoring the EMT status of tumor cells in vivo
US8658434B2 (en) * 2009-10-28 2014-02-25 Biotium, Inc. Fluorescent pyrene compounds
JP5838169B2 (ja) 2009-12-31 2016-01-06 ヴェンタナ メディカル システムズ， インク． 一意的に特異的核酸プローブを生成するための方法
JP2013520961A (ja) 2010-02-26 2013-06-10 ヴェンタナ メディカル システムズ， インク． 中期染色体の細胞遺伝学的解析
DK2539355T3 (da) 2010-02-26 2017-01-02 Ventana Med Syst Inc IN-SITU-hybridisering med polytag-prober
US8974651B2 (en) 2010-04-17 2015-03-10 C.C. Imex Illuminator for visualization of fluorophores
WO2012123387A1 (en) 2011-03-14 2012-09-20 F. Hoffmann-La Roche Ag A method of analyzing chromosomal translocations and a system therefore
ES2597032T3 (es) 2011-05-04 2017-01-13 HTG Molecular Diagnostics, Inc Mejoras en un ensayo cuantitativo de protección contra la nucleasa (qNPA) y secuenciación (qNPS)
US10294515B2 (en) 2011-07-01 2019-05-21 Htg Molecular Diagnostics, Inc. Methods of detecting gene fusions
WO2013057586A1 (en) 2011-10-19 2013-04-25 Oslo Universitetssykehus Hf Compositions and methods for producing soluble t - cell receptors
WO2013108126A2 (en) 2012-01-16 2013-07-25 University Of Oslo Methyltransferases and uses thereof
WO2013167387A1 (en) 2012-05-10 2013-11-14 Ventana Medical Systems, Inc. Uniquely specific probes for pten, pik3ca, met, top2a, and mdm2
PL2872646T3 (pl) 2012-07-12 2018-03-30 Institut National De La Santé Et De La Recherche Médicale (Inserm) Sposoby przewidywania czasu przeżycia i responsywności na leczenie pacjenta cierpiącego na nowotwór lity z sygnaturą przynajmniej 7 genów
WO2014048942A1 (en) 2012-09-25 2014-04-03 Ventana Medical Systems, Inc. Probes for pten, pik3ca, met, and top2a, and method for using the probes
US9360474B2 (en) 2012-11-29 2016-06-07 Opti Medical Systems, Inc. Multi-layer device for selectively determining magnesium ion
WO2015041729A2 (en) 2013-06-03 2015-03-26 The Research Foundation Of State University Of New York SITE-SPECIFIC ORTHOGONAL LABELING OF THE CARBOXY TERMINUS OF α-TUBULIN IN LIVE CELLS
WO2015036405A1 (en) 2013-09-10 2015-03-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing and treating basal cell carcinoma
EP2848696A1 (de) 2013-09-13 2015-03-18 Sanofi-Aventis Deutschland GmbH Caspase-1-Bildgebungssonden
US9504405B2 (en) 2013-10-23 2016-11-29 Verily Life Sciences Llc Spatial modulation of magnetic particles in vasculature by external magnetic field
US10542918B2 (en) 2013-10-23 2020-01-28 Verily Life Sciences Llc Modulation of a response signal to distinguish between analyte and background signals
WO2015069787A1 (en) 2013-11-05 2015-05-14 Htg Molecular Diagnostics, Inc. Methods for detecting nucleic acids
EP3110966A1 (de) 2014-02-24 2017-01-04 Ventana Medical Systems, Inc. Automatisierter rna-nachweis mit markierten 2'-o-methyl-rns-oligonukleotidsonden und signalverstärkungssystemen
US9835587B2 (en) 2014-04-01 2017-12-05 C.C. Imex Electrophoresis running tank assembly
EP3143400B1 (de) 2014-05-16 2019-03-06 Life Technologies Corporation Zellverfolgungsreagenzien und deren verwendungsverfahren
EP3009147A1 (de) 2014-10-16 2016-04-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren zur Behandlung von resistenten Glioblastomen
US10383957B2 (en) 2015-01-06 2019-08-20 Anthony H. de Haas Near-infrared fluorescent surgical dye markers
EP3247803A1 (de) 2015-01-12 2017-11-29 INSERM - Institut National de la Santé et de la Recherche Médicale Verfahren zur diagnose von bauchspeicheldrüsenkrebs
US9861710B1 (en) 2015-01-16 2018-01-09 Verily Life Sciences Llc Composite particles, methods, and in vivo diagnostic system
US10028659B2 (en) 2015-03-26 2018-07-24 Verily Life Sciences Llc Aptamer-based sensors, implantable devices and detection system
WO2017029391A1 (en) 2015-08-20 2017-02-23 INSERM (Institut National de la Santé et de la Recherche Médicale) New method for treating cancer
WO2017055327A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of endothelial cells in a tissue sample
WO2017055324A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of cells of monocytic origin in a tissue sample
WO2017055319A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of b cells in a tissue sample
WO2017055326A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of myeloid dendritic cells in a tissue sample
WO2017055322A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of neutrophils in a tissue sample
WO2017055325A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of nk cells in a tissue sample
WO2017055320A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of cytotoxic lymphocytes in a tissue sample
WO2017055321A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of fibroblasts in a tissue sample
WO2017060397A1 (en) 2015-10-09 2017-04-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of subjects suffering from melanoma metastases
WO2017067944A1 (en) 2015-10-19 2017-04-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of subjects suffering from triple negative breast cancer
JP7094880B2 (ja) 2015-11-06 2022-07-04 ヴェンタナ メディカル システムズ， インク． 代表診断法
US10793909B2 (en) 2015-11-10 2020-10-06 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for predicting the survival time of patients with decompensated alcoholic cirrhosis
US10760135B2 (en) 2016-01-13 2020-09-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for predicting pancreatic cancer treatment response
JP6882331B2 (ja) 2016-04-15 2021-06-02 ベックマン コールター， インコーポレイテッド 光活性巨大分子及びその使用
WO2017182834A1 (en) 2016-04-19 2017-10-26 INSERM (Institut National de la Santé et de la Recherche Médicale) New method for treating resistant glioblastoma
WO2017202962A1 (en) 2016-05-24 2017-11-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of non small cell lung cancer (nsclc) that coexists with chronic obstructive pulmonary disease (copd)
WO2017216206A1 (en) 2016-06-14 2017-12-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting acute severe colitis treatment response
WO2018011107A1 (en) 2016-07-11 2018-01-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of er-alpha 46 in methods and kits for assessing the status of breast cancer
WO2018011166A2 (en) 2016-07-12 2018-01-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of myeloid dendritic cells in a tissue sample
WO2018046738A1 (en) 2016-09-12 2018-03-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of patients suffering from cancer
WO2018046736A1 (en) 2016-09-12 2018-03-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of patients suffering from cancer
WO2018054960A1 (en) 2016-09-21 2018-03-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting and treating resistance to chemotherapy in npm-alk(+) alcl
US20200016177A1 (en) 2016-09-22 2020-01-16 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for reprograming immune environment in a subject in need thereof
WO2018122249A1 (en) 2016-12-28 2018-07-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of patients suffering from a microsatellite stable colorectal cancer
WO2018122245A1 (en) 2016-12-28 2018-07-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting the survival time of patients suffering from cms3 colorectal cancer
WO2018146239A1 (en) 2017-02-10 2018-08-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Biomarker for outcome in aml patients
WO2018162404A1 (en) 2017-03-06 2018-09-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Biomarker for outcome in aml patients
WO2018172540A1 (en) 2017-03-24 2018-09-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Method to predict the progression of alzheimer's disease
EP3601613B1 (de) 2017-03-29 2021-12-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren zur beurteilung eines schwangerschaftsergebnisses
WO2018183621A1 (en) 2017-03-30 2018-10-04 Life Technologies Corporation Quantification of ngs dna by adapter sequence
WO2018189215A1 (en) 2017-04-12 2018-10-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for predicting the survival time of a patient suffering from hepatocellular carcinoma
CA3061429A1 (en) 2017-05-05 2018-11-08 Inserm (Institut National De La Sante Et De La Recherche Medicale) Microtubule-targeting drugs as immune checkpoint inhibitors and methods of screening novel immune checkpoint inhibitors for the treatment of cancers and infectious diseases
WO2019038219A1 (en) 2017-08-21 2019-02-28 INSERM (Institut National de la Santé et de la Recherche Médicale) NEW PROGNOSTIC METHOD OF PANCREATIC CANCER
WO2019043138A1 (en) 2017-09-01 2019-03-07 INSERM (Institut National de la Santé et de la Recherche Médicale) METHOD FOR PREDICTING OUTCOME OF CANCER
WO2019057995A1 (en) 2017-09-25 2019-03-28 INSERM (Institut National de la Santé et de la Recherche Médicale) USE OF VNN1 AS A BIOMARKER AND THERAPEUTIC TARGET IN SARCOMES
WO2019077123A1 (en) 2017-10-20 2019-04-25 INSERM (Institut National de la Santé et de la Recherche Médicale) METHODS AND KITS FOR IDENTIFYING WHETHER A SUBJECT IS REACHED OR RISK OF BEING WITH AUTOIMMUNE MYOPATHY
US11691141B2 (en) 2017-11-13 2023-07-04 Roche Sequencing Solutions, Inc. Devices for sample analysis using epitachophoresis
WO2019207030A1 (en) 2018-04-26 2019-10-31 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting a response with an immune checkpoint inhibitor in a patient suffering from a lung cancer
WO2019229489A1 (en) 2018-05-31 2019-12-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of mir-146a-5p and mir-186 as biomarkers of osteoarthritis
WO2020089428A1 (en) 2018-11-02 2020-05-07 INSERM (Institut National de la Santé et de la Recherche Médicale) New prognostic method of pancreatic cancer
WO2020089432A1 (en) 2018-11-02 2020-05-07 INSERM (Institut National de la Santé et de la Recherche Médicale) New prognostic method of pancreatic cancer
US11584825B2 (en) 2018-12-14 2023-02-21 Beckman Coulter, Inc. Polymer dye modification and applications
AU2020205150A1 (en) 2019-01-03 2021-07-22 Assistance Publique-Hôpitaux De Paris (Aphp) Methods and pharmaceutical compositions for enhancing CD8+ T cell-dependent immune responses in subjects suffering from cancer
EP3911669A1 (de) 2019-01-16 2021-11-24 INSERM (Institut National de la Santé et de la Recherche Médicale) Varianten von erythroferron und deren verwendung
US20220098674A1 (en) 2019-02-13 2022-03-31 Inserm (Institut National De La Santé Et Dr La Recherch Médicale) Methods and compositions for selecting a cancer treatment in a subject suffering from cancer
WO2020182932A1 (en) 2019-03-13 2020-09-17 INSERM (Institut National de la Santé et de la Recherche Médicale) New gene signatures for predicting survival time in patients suffering from renal cell carcinoma
WO2020193740A1 (en) 2019-03-28 2020-10-01 INSERM (Institut National de la Santé et de la Recherche Médicale) New strategy for treating pancreatic cancer
WO2020201362A2 (en) 2019-04-02 2020-10-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting and preventing cancer in patients having premalignant lesions
WO2020212362A1 (en) 2019-04-15 2020-10-22 INSERM (Institut National de la Santé et de la Recherche Médicale) A method of profiling the energetic metabolism of a population of cells
EP3956474A1 (de) 2019-04-18 2022-02-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren zur behandlung und prognose von krebs
WO2020216832A1 (en) 2019-04-24 2020-10-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for predicting the response of antipsychotic drugs
EP3969583A1 (de) 2019-05-14 2022-03-23 F. Hoffmann-La Roche AG Vorrichtungen und verfahren zur probenanalyse
WO2020229521A1 (en) 2019-05-14 2020-11-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for inhibiting or reducing bacterial biofilms on a surface
WO2021001539A1 (en) 2019-07-04 2021-01-07 INSERM (Institut National de la Santé et de la Recherche Médicale) New strategy to detect and treat eosinophilic fasciitis
WO2021044012A1 (en) 2019-09-05 2021-03-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Method of treatment and pronostic of acute myeloid leukemia
WO2021063968A1 (en) 2019-09-30 2021-04-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Method and composition for diagnosing chronic obstructive pulmonary disease
EP4045686A1 (de) 2019-10-17 2022-08-24 Institut National de la Santé et de la Recherche Médicale (INSERM) Verfahren zur diagnose von nasalen adenokarzinomen vom intestinalen typ
EP4110955A1 (de) 2020-02-28 2023-01-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren zur diagnose, prognose und verwaltung der behandlung von brustkrebs
WO2021186014A1 (en) 2020-03-20 2021-09-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for predicting the survival time of a patient suffering from a cancer
JP2023528978A (ja) 2020-06-10 2023-07-06 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 悪性膠芽腫のような癌の治療及び予防方法
EP4168006A1 (de) 2020-06-18 2023-04-26 Institut National de la Santé et de la Recherche Médicale (INSERM) Neue strategie zur behandlung von bauchspeicheldrüsenkrebs
EP4175967A2 (de) 2020-07-02 2023-05-10 Life Technologies Corporation Trinukleotid-kappenanaloga, herstellung und verwendungen davon
WO2022018163A1 (en) 2020-07-22 2022-01-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for predicting survival time in patients suffering from cancer
WO2022064049A1 (en) 2020-09-28 2022-03-31 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for diagnosing brucella infection
US20230383350A1 (en) 2020-10-20 2023-11-30 Institut National De La Sante Et De La Recherche Medicale Method for predicting the response to tnf inhibitors
CN116917502A (zh) 2020-11-06 2023-10-20 Inserm(法国国家健康医学研究院) 诊断和治疗多囊卵巢综合征（pcos）的方法
WO2022135753A1 (en) 2020-12-21 2022-06-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for prognosis the humoral response of a subject prior to vaccination
WO2022136252A1 (en) 2020-12-21 2022-06-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for prognosis the humoral response of a subject prior to vaccination
WO2022152698A1 (en) 2021-01-12 2022-07-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of npdk-d to evaluate cancer prognosis
CN117015711A (zh) 2021-02-05 2023-11-07 贝克曼库尔特有限公司 用于阻止聚合物染料-抗体缀合物之间的非特异性相互作用的组合物和方法
WO2022171611A1 (en) 2021-02-09 2022-08-18 INSERM (Institut National de la Santé et de la Recherche Médicale) New method to pronostic lung cancer
US20240159760A1 (en) 2021-03-17 2024-05-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for diagnosing pancreatic cancer
WO2022207566A1 (en) 2021-03-29 2022-10-06 INSERM (Institut National de la Santé et de la Recherche Médicale) New method to evaluate pancreatic cancer prognosis
WO2022223791A1 (en) 2021-04-23 2022-10-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treating cell senescence accumulation related disease
WO2022263451A1 (en) 2021-06-15 2022-12-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Peptides derived from the spike protein of sars-cov-2 and uses thereof for diagnosis and vaccine purposes
EP4367269A1 (de) 2021-07-05 2024-05-15 Inserm (Institut National De La Sante Et De La Recherche Medicale) Gensignaturen zur vorhersage der überlebenszeit bei patienten mit nierenzellkarzinom
WO2023004400A1 (en) 2021-07-21 2023-01-26 Life Technologies Corporation Dibenzoxanthene quenchers, uses, and methods of preparation
WO2023056460A1 (en) 2021-09-30 2023-04-06 Beckman Coulter, Inc. Water-soluble tetrahydropyrene based fluorescent polymers
MX2024005772A (es) 2021-11-12 2024-07-22 Beckman Coulter Inc Novedosa formulación para la tinción de anticuerpos conjugados con polímeros.
WO2023089159A1 (en) 2021-11-22 2023-05-25 INSERM (Institut National de la Santé et de la Recherche Médicale) New strategy targeting stroma/tumor cell crosstalk to treat a cancer
WO2023144303A1 (en) 2022-01-31 2023-08-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Cd38 as a biomarker and biotarget in t-cell lymphomas
WO2023152133A1 (en) 2022-02-08 2023-08-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for diagnosing colorectal cancer
WO2024002924A2 (en) * 2022-06-28 2024-01-04 F. Hoffmann-La Roche Ag Fluorescent dyes with large stokes shift
WO2024007016A2 (en) 2022-07-01 2024-01-04 Beckman Coulter, Inc. Novel fluorescent dyes and polymers from dihydrophenanthrene derivatives
WO2024044327A1 (en) 2022-08-26 2024-02-29 Beckman Coulter, Inc. Dhnt monomers and polymer dyes with modified photophysical properties
WO2024061930A1 (en) 2022-09-22 2024-03-28 Institut National de la Santé et de la Recherche Médicale New method to treat and diagnose peripheral t-cell lymphoma (ptcl)
WO2024115935A1 (en) 2022-11-29 2024-06-06 Inserm Methods for the treatment of b-cell lymphoma using cd39 inhibitors
WO2024196805A1 (en) 2023-03-17 2024-09-26 Beckman Coulter, Inc. Benzothienopyrrole cyanine dyes

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3336293A (en) * 1964-11-06 1967-08-15 Searle & Co Complex amides of 5, 6-dihydrophenanthridine-5-carboxylic acid, 5, 6-dihydro-11h-dibenz[b, e]azepine-5-carboxylic acid, and related compounds
US4544546A (en) 1980-04-21 1985-10-01 Abbott Laboratories Fluorescent nucleic acid stains
SU926914A1 (ru) * 1980-05-26 1992-04-23 Научно-исследовательский институт фармакологии АМН СССР Производные 1,2,3,4-тетрагидробензофуро[3,2-с]-пиридина или хлоргидрат, обладающие р дом свойств анальгетиков и антагонистов морфина
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US5171534A (en) 1984-01-16 1992-12-15 California Institute Of Technology Automated DNA sequencing technique
CA1340806C (en) 1986-07-02 1999-11-02 James Merrill Prober Method, system and reagents for dna sequencing
US5047519A (en) 1986-07-02 1991-09-10 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
US4945171A (en) 1987-08-10 1990-07-31 Molecular Probes, Inc. Xanthene dyes having a fused (C) benzo ring
US5049673A (en) 1987-10-30 1991-09-17 The Regents Of The University Of California Fluorescent indicator dyes for calcium working at long wavelengths
AU3008289A (en) 1988-02-22 1989-08-24 Eastman Kodak Company Novel thiorhodamines and a novel method of preparation
US4997928A (en) 1988-09-15 1991-03-05 E. I. Du Pont De Nemours And Company Fluorescent reagents for the preparation of 5'-tagged oligonucleotides
US5137810A (en) 1989-04-26 1992-08-11 The University Of North Carolina Method of determining the gram sign of bacteria
US5453517A (en) 1992-02-25 1995-09-26 Molecular Probes, Inc. Reactive derivatives of bapta used to make ion-selective chelators
US5405975A (en) 1993-03-29 1995-04-11 Molecular Probes, Inc. Fluorescent ion-selective diaryldiaza crown ether conjugates
US5648270A (en) 1995-02-06 1997-07-15 Molecular Probes, Inc. Methods of sensing with fluorescent conjugates of metal-chelating nitrogen heterocycles
US5227487A (en) 1990-04-16 1993-07-13 Molecular Probes, Inc. Certain tricyclic and pentacyclic-hetero nitrogen rhodol dyes
US5567588A (en) 1990-06-11 1996-10-22 University Research Corporation Systematic evolution of ligands by exponential enrichment: Solution SELEX
US5714327A (en) 1990-07-19 1998-02-03 Kreatech Diagnostics Platinum-containing compounds, methods for their preparation and applications thereof
US5208148A (en) 1990-12-07 1993-05-04 Molecular Probes, Inc. Lipophilic fluorescent glycosidase substrates
US5750409A (en) * 1991-11-18 1998-05-12 Boehringer Mannheim Gmbh Pentacyclic compounds and their use as absorption or fluorescent dyes
EP0658167B1 (de) 1992-09-03 1999-04-14 The Perkin-Elmer Corporation 4,7-dichlorofluoroszein-farbestoffe als molekulare sonden
US5290706A (en) * 1992-11-10 1994-03-01 Camiener Gerald W Visualization system for retrieval, identification, and positioning of biological samples for subsequent microscopic examination
US5516911A (en) 1993-12-30 1996-05-14 The United States Of America As Represented By The Department Of Health And Human Services Fluorescent intracellular calcium indicators
US6080852A (en) * 1996-06-27 2000-06-27 The Perkin-Elmer Corporation 4,7-dichlororhodamine dyes
US5696157A (en) 1996-11-15 1997-12-09 Molecular Probes, Inc. Sulfonated derivatives of 7-aminocoumarin
US6130101A (en) 1997-09-23 2000-10-10 Molecular Probes, Inc. Sulfonated xanthene derivatives
US5936087A (en) 1997-11-25 1999-08-10 The Perkin-Elmer Corporation Dibenzorhodamine dyes
US6140500A (en) 1999-09-03 2000-10-31 Pe Corporation Red-emitting [8,9]benzophenoxazine nucleic acid dyes and methods for their use

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AU7918501A (en) 2002-02-18
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EP2045252A3 (de) 2009-06-24
AU2001279185B2 (en) 2005-07-07
WO2002012195A1 (en) 2002-02-14
EP2045252B1 (de) 2013-05-01
EP2322524A1 (de) 2011-05-18
US20020059684A1 (en) 2002-05-23
US6716979B2 (en) 2004-04-06
CA2417816A1 (en) 2002-02-14

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