[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ATE412409T1 - Verfahren zur reinigung von pravastatin - Google Patents

Verfahren zur reinigung von pravastatin

Info

Publication number
ATE412409T1
ATE412409T1 AT04811862T AT04811862T ATE412409T1 AT E412409 T1 ATE412409 T1 AT E412409T1 AT 04811862 T AT04811862 T AT 04811862T AT 04811862 T AT04811862 T AT 04811862T AT E412409 T1 ATE412409 T1 AT E412409T1
Authority
AT
Austria
Prior art keywords
pravastatin
purification
provides
present
purifying pravastatin
Prior art date
Application number
AT04811862T
Other languages
English (en)
Inventor
Vilmos Keri
Istvan Melczer
Original Assignee
Teva Gyogyszergyar Zartkoeruee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Gyogyszergyar Zartkoeruee filed Critical Teva Gyogyszergyar Zartkoeruee
Application granted granted Critical
Publication of ATE412409T1 publication Critical patent/ATE412409T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/56—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
AT04811862T 2003-11-24 2004-11-23 Verfahren zur reinigung von pravastatin ATE412409T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US52549403P 2003-11-24 2003-11-24
US53231403P 2003-12-22 2003-12-22
US55416504P 2004-03-18 2004-03-18

Publications (1)

Publication Number Publication Date
ATE412409T1 true ATE412409T1 (de) 2008-11-15

Family

ID=34637188

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04811862T ATE412409T1 (de) 2003-11-24 2004-11-23 Verfahren zur reinigung von pravastatin

Country Status (12)

Country Link
US (2) US7425644B2 (de)
EP (2) EP2033636A1 (de)
JP (2) JP2007512366A (de)
AT (1) ATE412409T1 (de)
CA (1) CA2546377A1 (de)
DE (3) DE602004017461D1 (de)
ES (1) ES2251894T3 (de)
HR (1) HRP20080686T3 (de)
PL (1) PL1641447T3 (de)
PT (1) PT1641447E (de)
TW (1) TWI319707B (de)
WO (1) WO2005051372A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005121062A2 (en) * 2004-06-09 2005-12-22 Ranbaxy Laboratories Limited Process for the preparation of pravastatin
JP4775727B1 (ja) * 2010-08-17 2011-09-21 貞宏 平山 印刷物の微小マークによる一般人が容易にできる真贋判定方法
JP6218287B2 (ja) * 2013-01-29 2017-10-25 学校法人産業医科大学 シスプラチン耐性がんの治療のためのＨＭＧ−ＣｏＡ還元酵素阻害薬の使用

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4319039A (en) 1979-06-15 1982-03-09 Merck & Co., Inc. Preparation of ammonium salt of hypocholesteremic fermentation product
US4346277A (en) * 1979-10-29 1982-08-24 Eaton Corporation Packaged electrical heating element
MX7065E (es) 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
ATE69602T1 (de) 1985-09-13 1991-12-15 Sankyo Co Hydroxy-ml-236b-derivate, deren herstellung und anwendung.
US4857547A (en) 1988-01-07 1989-08-15 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US4857522A (en) 1988-03-21 1989-08-15 E. R. Squibb & Sons, Inc. Derivatives of pravastatin for inhibiting cholesterol biosynthesis
US5180589A (en) 1988-03-31 1993-01-19 E. R. Squibb & Sons, Inc. Pravastatin pharmaceuatical compositions having good stability
US5099035A (en) 1989-02-27 1992-03-24 E. R. Squibb & Sons, Inc. Mevinic acid derivatives useful as antihypercholesterolemic agents and method for preparing same
US5140012A (en) 1990-05-31 1992-08-18 E. R. Squibb & Sons, Inc. Method for preventing onset of restenosis after angioplasty employing pravastatin
US5202029A (en) 1991-03-13 1993-04-13 Caron Kabushiki Kaisha Process for purification of hmg-coa reductase inhibitors
US5157025A (en) 1991-04-01 1992-10-20 E. R. Squibb & Sons, Inc. Method for lowering serum cholesterol employing a phosphorus containing ace inhibitor alone or in combination with a cholesterol lowering drug
KR100286242B1 (ko) 1992-05-20 2001-04-16 스타르크, 카르크 돌라스타틴 유도체
NZ250609A (en) * 1992-12-28 1995-07-26 Sankyo Co Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments
SI9300303A (en) 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
IL112639A0 (en) 1994-03-11 1995-05-26 Bristol Myers Squibb Co A pharmaceutical composition containing pravastin
US5942423A (en) 1995-06-07 1999-08-24 Massachusetts Institute Of Technology Conversion of compactin to pravastatin by actinomadura
US5616595A (en) 1995-06-07 1997-04-01 Abbott Laboratories Process for recovering water insoluble compounds from a fermentation broth
PT784605E (pt) 1995-08-03 2000-08-31 Dsm Nv Processo selectivo para a desacilacao de compostos acetilados campo e antecedentes da invencao
US5883109A (en) 1996-07-24 1999-03-16 Bristol-Myers Squibb Company Method for lowering serum lipid levels employing an MTP inhibitor in combination with another cholesterol lowering drug
US6165757A (en) 1997-02-20 2000-12-26 Dsm N.V. Nitrogen feed in statin fermentation
KR100210482B1 (ko) 1997-04-10 1999-07-15 김종인 스트렙토마이세스엑스포리아투스(streptomycesexfoliatus)yj-118과이를이용한프라바스타틴나트륨의제조방법
AU9264598A (en) 1997-08-22 1999-03-16 Gist-Brocades B.V. Statin production by fermentation
SI9800046A (sl) 1998-02-18 1999-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti
JP2931971B1 (ja) 1998-02-23 1999-08-09 利夫 佐藤 プラバスタチンの製造法
SI20305A (sl) 1999-08-06 2001-02-28 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristali natrijeve soli pravastatina
SI20072A (sl) 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze
WO2000046175A1 (en) 1999-02-03 2000-08-10 Institute For Drug Research Ltd. Microbial process for preparing pravastatin
US6682913B1 (en) 1999-02-03 2004-01-27 Institute For Drug Research Ltd. Microbial process for preparing pravastatin
HUP9902352A1 (hu) 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
DK1265604T3 (da) 1999-11-30 2007-02-05 Teva Gyogyszergyar Zartkoeruee Proces til udvinding af statinforbindelser fra en gæringsvæske
WO2001081611A1 (en) 2000-04-27 2001-11-01 Biocon India Limited A novel process for the manufacture and purification of compactin
KR20030059173A (ko) * 2000-10-05 2003-07-07 비오갈 기오기스제르갸르 알티. 프라바스타틴 락톤과 에피-프라바스타틴을 실질적으로함유하지 않는 프라바스타틴 나트륨, 및 이를 포함하는조성물
JP3463881B2 (ja) * 2002-08-06 2003-11-05 三共株式会社 プラバスタチン又はその薬理上許容される塩の単離・精製方法
TW589178B (en) * 2003-02-21 2004-06-01 China Chemical & Pharmaceutica A novel industrial process to obtain pravastatin sodium of high purity

Also Published As

Publication number Publication date
US20050113446A1 (en) 2005-05-26
JP2009161542A (ja) 2009-07-23
JP2007512366A (ja) 2007-05-17
EP2033636A1 (de) 2009-03-11
TWI319707B (en) 2010-01-21
ES2251894T3 (es) 2009-04-01
DE202004020671U1 (de) 2005-12-08
HRP20080686T3 (en) 2009-03-31
US20080300305A1 (en) 2008-12-04
PT1641447E (pt) 2008-12-10
EP1641447A2 (de) 2006-04-05
ES2251894T1 (es) 2006-05-16
US7425644B2 (en) 2008-09-16
WO2005051372A2 (en) 2005-06-09
DE602004017461D1 (de) 2008-12-11
TW200518745A (en) 2005-06-16
WO2005051372A3 (en) 2005-08-11
CA2546377A1 (en) 2005-06-09
DE04811862T1 (de) 2006-03-02
EP1641447B1 (de) 2008-10-29
PL1641447T3 (pl) 2009-04-30

Similar Documents

Publication Publication Date Title
ATE369201T1 (de) Verfahren zur reinigung von synthesegas
ATE540962T1 (de) Extraktive verfahren zur aufreinigung von sucralose
DE50102926D1 (de) Verfahren zur oxidation von kohlenwasserstoffen
ATE298326T1 (de) Verfahren zur epoxidierung von olefinen
DE50213709D1 (de) Verfahren zur bereitstellung von zielführungshinweisen
DE60114348D1 (de) Verfahren zur Reinigung von Gasen
DE60209095D1 (de) Verfahren zur Rückgewinnung von Katalysatormetallen
DE602004023757D1 (de) Methode zur reinigung von fsh
DE50206295D1 (de) Verfahren zur Aufbereitung von Industrieabwässern
DE50303241D1 (de) Verfahren zur bereitstellung von abwesenheitsinformation
DE502004001216D1 (de) Verfahren zur aufreinigung von blausäure
ATE286041T1 (de) Verfahren zur industriellen herstellung von 5- amino-3-carboxymethyl-4-cyano-2- thiphencarboxydimethylester
ATE297909T1 (de) Verfahren zur epoxidierung von olefinen
DE60214629D1 (de) Verfahren zur Zersetzung von Michael-Addukten
DE60113157D1 (de) Verbessertes verfahren zur herstellung von simvastatin
DE60104535D1 (de) Verfahren zur hydroxylation von aliphatischen verbindungen
ATE387367T1 (de) Verfahren und system zur unterstützung des betriebs von arbeitszügen
ATE394369T1 (de) Verfahren zur aufreinigung von mesotrion
DE60331527D1 (de) Gereinigtes lasofoxifen und verfahren zur aufreinigung von racemischem lasofoxifen durch umkristallisieren
ATE412409T1 (de) Verfahren zur reinigung von pravastatin
DE50302124D1 (de) Verfahren zur verbesserung des regelverhaltens von kraftfahrzeugregelungssystemen
DE50201799D1 (de) Verfahren zur gewinnung von n-phosphonomethylglycin
DE60109565D1 (de) Verfahren zur Reinigung von Schwefel
DE60317652D1 (de) Verfahren zur Reinigung von Polyetherpolyolen
DE10290206D2 (de) Verfahren zur Regelung der Fahrstabilität

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1641447

Country of ref document: EP