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ATE491022T1 - CONDITIONALLY IMMORTALIZED ADULT LONG-TERM STEM CELLS AND METHOD FOR THE PRODUCTION AND USE OF SUCH CELLS - Google Patents

CONDITIONALLY IMMORTALIZED ADULT LONG-TERM STEM CELLS AND METHOD FOR THE PRODUCTION AND USE OF SUCH CELLS

Info

Publication number
ATE491022T1
ATE491022T1 AT06826025T AT06826025T ATE491022T1 AT E491022 T1 ATE491022 T1 AT E491022T1 AT 06826025 T AT06826025 T AT 06826025T AT 06826025 T AT06826025 T AT 06826025T AT E491022 T1 ATE491022 T1 AT E491022T1
Authority
AT
Austria
Prior art keywords
cells
methods
stem cells
production
conditionally immortalized
Prior art date
Application number
AT06826025T
Other languages
German (de)
Inventor
John Cambier
Yosef Refaeli
Sara Johnson
Brian Curtis Turner
Original Assignee
Nat Jewish Health
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Publication date
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Publication of ATE491022T1 publication Critical patent/ATE491022T1/en

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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0647Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/00Drugs for immunological or allergic disorders
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Abstract

Disclosed are methods for conditionally immortalizing stem cells, including adult and embryonic stem cells, the cells produced by such methods, therapeutic and laboratory or research methods of using such cells, and methods to identify compounds related to cell differentiation and development or to treat diseases, using such cells. A mouse model of acute myeloid leukemia (AML) and cells and methods related to such mouse model are also described.
AT06826025T 2005-10-18 2006-10-18 CONDITIONALLY IMMORTALIZED ADULT LONG-TERM STEM CELLS AND METHOD FOR THE PRODUCTION AND USE OF SUCH CELLS ATE491022T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72813105P 2005-10-18 2005-10-18
US76599306P 2006-02-06 2006-02-06
PCT/US2006/040379 WO2007047583A2 (en) 2005-10-18 2006-10-18 Conditionally immortalized long-term stem cells and methods of making and using such cells

Publications (1)

Publication Number Publication Date
ATE491022T1 true ATE491022T1 (en) 2010-12-15

Family

ID=37963171

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06826025T ATE491022T1 (en) 2005-10-18 2006-10-18 CONDITIONALLY IMMORTALIZED ADULT LONG-TERM STEM CELLS AND METHOD FOR THE PRODUCTION AND USE OF SUCH CELLS

Country Status (13)

Country Link
US (7) US8883507B2 (en)
EP (1) EP1942739B1 (en)
JP (8) JP2009511081A (en)
KR (2) KR101441693B1 (en)
CN (2) CN105483088B (en)
AT (1) ATE491022T1 (en)
AU (1) AU2006304392B2 (en)
CA (2) CA2626525C (en)
DE (1) DE602006018768D1 (en)
HK (2) HK1126623A1 (en)
IL (7) IL296832A (en)
IN (1) IN2014DN06624A (en)
WO (1) WO2007047583A2 (en)

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