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ATE485299T1 - Tricyclische benzopyranverbindungen als antiarrhythmika - Google Patents

Tricyclische benzopyranverbindungen als antiarrhythmika

Info

Publication number
ATE485299T1
ATE485299T1 AT05727581T AT05727581T ATE485299T1 AT E485299 T1 ATE485299 T1 AT E485299T1 AT 05727581 T AT05727581 T AT 05727581T AT 05727581 T AT05727581 T AT 05727581T AT E485299 T1 ATE485299 T1 AT E485299T1
Authority
AT
Austria
Prior art keywords
group
hydrogen atom
ring
atom
bond
Prior art date
Application number
AT05727581T
Other languages
English (en)
Inventor
Kazuhiko Ohrai
Yukihiro Shigeta
Osamu Uesugi
Takumi Okada
Tomoyuki Matsuda
Original Assignee
Nissan Chemical Ind Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Ind Ltd filed Critical Nissan Chemical Ind Ltd
Application granted granted Critical
Publication of ATE485299T1 publication Critical patent/ATE485299T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D515/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Dental Preparations (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT05727581T 2004-03-23 2005-03-23 Tricyclische benzopyranverbindungen als antiarrhythmika ATE485299T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004084605 2004-03-23
PCT/JP2005/006004 WO2005090357A1 (en) 2004-03-23 2005-03-23 Tricyclic benzopyran compound as anti-arrhythmic agents

Publications (1)

Publication Number Publication Date
ATE485299T1 true ATE485299T1 (de) 2010-11-15

Family

ID=34962589

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05727581T ATE485299T1 (de) 2004-03-23 2005-03-23 Tricyclische benzopyranverbindungen als antiarrhythmika

Country Status (31)

Country Link
US (2) US7652008B2 (de)
EP (1) EP1732929B1 (de)
JP (1) JP4840594B2 (de)
KR (2) KR101085979B1 (de)
CN (3) CN102190661B (de)
AT (1) ATE485299T1 (de)
AU (2) AU2005223612B2 (de)
BR (1) BRPI0508768A (de)
CA (1) CA2558139C (de)
CY (1) CY1111250T1 (de)
CZ (1) CZ2006598A3 (de)
DE (1) DE602005024245D1 (de)
DK (1) DK1732929T3 (de)
EG (1) EG27163A (de)
ES (1) ES2353021T3 (de)
HK (1) HK1099299A1 (de)
HR (1) HRP20110005T1 (de)
IL (1) IL177950A (de)
MX (1) MXPA06010880A (de)
NO (1) NO339495B1 (de)
NZ (2) NZ549570A (de)
PL (1) PL1732929T3 (de)
PT (1) PT1732929E (de)
RS (1) RS51742B (de)
RU (1) RU2380370C2 (de)
SI (1) SI1732929T1 (de)
SK (1) SK287994B6 (de)
TW (1) TWI352704B (de)
UA (1) UA91189C2 (de)
WO (1) WO2005090357A1 (de)
ZA (1) ZA200607388B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2380370C2 (ru) * 2004-03-23 2010-01-27 Ниссан Кемикал Индастриз, Лтд. Трициклические соединения бензопирана в качестве противоаритмических агентов
KR20080112290A (ko) 2006-03-10 2008-12-24 닛산 가가쿠 고교 가부시키 가이샤 광학 활성 크로멘 옥사이드화합물의 제조 방법
TW201022223A (en) * 2008-08-14 2010-06-16 Nissan Chemical Ind Ltd Di-substituted benzopyrane compound
AR076524A1 (es) * 2009-04-30 2011-06-15 Nissan Chemical Ind Ltd Forma cristalina de un compuesto de benzopirano triciclico y metodo de produccion de la misma
PT2445502T (pt) 2009-06-25 2017-09-22 Alkermes Pharma Ireland Ltd Compostos heterocíclicos para o tratamento de distúrbios neurológicos e psicológicos
WO2014050613A1 (ja) * 2012-09-27 2014-04-03 日産化学工業株式会社 含窒素複素環ｎ－オキシド化合物の製造方法
IN2015DN03012A (de) 2012-09-27 2015-10-02 Nissan Chemical Ind Ltd
JPWO2015012271A1 (ja) * 2013-07-25 2017-03-02 日産化学工業株式会社 複素環化合物の製造方法
CN110177796B (zh) * 2017-01-06 2022-04-08 阿斯克里斯有限公司 喹啉酮衍生物及其用于预防或治疗变应性疾病的药物组合物
CN112423754A (zh) 2018-03-05 2021-02-26 奥克梅斯制药爱尔兰有限公司 阿立哌唑的给药策略
CN108727261B (zh) * 2018-06-21 2021-09-24 济南大学 一种硝基取代喹那啶的制备方法
EP3903882A4 (de) 2018-12-28 2022-09-21 Osaka University Therapeutisches mittel für vererbte bradyarrhythmie
RU2754610C1 (ru) * 2020-04-14 2021-09-03 Георгий Викторович ТЕЦ Препарат для лечения заболеваний, вызванных бактериями
WO2021261598A1 (ja) 2020-06-26 2021-12-30 国立大学法人大阪大学 薬剤誘発性徐脈および徐脈性不整脈治療薬

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZM7682A1 (en) 1981-09-25 1983-05-23 Beecham Group Plc Active compounds
JPS5867683U (ja) 1981-10-28 1983-05-09 株式会社ナムコ 歩行ロボツト
JPH0699439B2 (ja) 1988-02-03 1994-12-07 日産化学工業株式会社 ピラノベンゾオキサジアゾール誘導体
JP2658198B2 (ja) 1988-06-23 1997-09-30 日産化学工業株式会社 ピラノベンゾトリアゾール誘導体
US5097037A (en) 1989-07-17 1992-03-17 Nissan Chemical Industries, Ltd. Process for the optical resolution of pyranobenzoxadiazole compounds
JP2876712B2 (ja) * 1989-07-17 1999-03-31 日産化学工業株式会社 光学活性ピラノベンゾオキサジアゾール誘導体
US5164509A (en) * 1990-11-26 1992-11-17 E. R. Squibb & Sons, Inc. Benzodiazolo analogs
JPH07300414A (ja) * 1993-04-02 1995-11-14 Nissan Chem Ind Ltd 心不全治療薬
RU2128043C1 (ru) 1993-04-02 1999-03-27 Ниссан Кемикал Индастриз, Лтд. Лекарственные средства для сердечной недостаточности
JP2734457B2 (ja) 1994-02-23 1998-03-30 日産化学工業株式会社 不斉エポキシ化反応
US5843989A (en) 1994-06-10 1998-12-01 Smithkline Beecham P.L.C. C4 -amide substituted compounds and their use as therapeutic agents
TR199700369A2 (xx) * 1996-05-15 1997-12-21 Hoechst Ag S�lfonamid ile s�bstit�e edilmi� kroman'lar, bunlar�n �retilmesine mahsus usul, ila� veya diyagnostik olarak kullan�lmalar� ve bunlar� i�eren ila�.
DE69921815T2 (de) 1998-06-03 2005-11-10 Nissan Chemical Industries, Ltd. Indanderivate
AU5444499A (en) 1998-09-01 2000-03-21 Nissan Chemical Industries Ltd. Benzoxazine derivatives
AU2830800A (en) 1999-03-25 2000-10-16 Nissan Chemical Industries Ltd. Chroman derivatives
IL147968A0 (en) 1999-09-17 2002-09-12 Nissan Chemical Ind Ltd Benzopyran derivative
WO2001021609A1 (en) 1999-09-24 2001-03-29 Nissan Chemical Industries, Ltd. 4-oxybenzopyran derivative
AU7453900A (en) 1999-10-05 2001-05-10 Nissan Chemical Industries Ltd. 4-oxybenzopyran derivative
TW589305B (en) 2001-02-14 2004-06-01 Nissan Chemical Ind Ltd 4-aminobenzopyran derivatives
CA2450541A1 (en) 2001-06-25 2003-01-03 Nissan Chemical Industries, Ltd. Substituted benzopyran derivatives against arrhythmia
WO2003014113A1 (en) 2001-08-06 2003-02-20 Glenmark Pharmaceuticals Limited Novel benzopyran compounds and process for their preparation and use
RU2380370C2 (ru) * 2004-03-23 2010-01-27 Ниссан Кемикал Индастриз, Лтд. Трициклические соединения бензопирана в качестве противоаритмических агентов

Also Published As

Publication number Publication date
SK50792006A3 (sk) 2007-09-06
IL177950A (en) 2013-04-30
CN101429200B (zh) 2012-05-30
US7652008B2 (en) 2010-01-26
ES2353021T3 (es) 2011-02-24
PL1732929T3 (pl) 2011-04-29
RU2006137284A (ru) 2008-04-27
CN102190661A (zh) 2011-09-21
KR20070009638A (ko) 2007-01-18
AU2010202900B2 (en) 2011-10-27
DE602005024245D1 (de) 2010-12-02
KR101019402B1 (ko) 2011-03-07
KR20100130249A (ko) 2010-12-10
CN1934116B (zh) 2012-10-10
EG27163A (en) 2015-08-24
RU2380370C2 (ru) 2010-01-27
JP2007530436A (ja) 2007-11-01
DK1732929T3 (da) 2010-12-20
CA2558139C (en) 2012-01-17
MXPA06010880A (es) 2006-12-15
CN102190661B (zh) 2013-07-31
CN101429200A (zh) 2009-05-13
TW200600509A (en) 2006-01-01
PT1732929E (pt) 2010-12-21
TWI352704B (en) 2011-11-21
US20080004262A1 (en) 2008-01-03
WO2005090357A1 (en) 2005-09-29
NO339495B1 (no) 2016-12-19
CY1111250T1 (el) 2015-06-11
HRP20110005T1 (hr) 2011-02-28
CA2558139A1 (en) 2005-09-29
NZ585606A (en) 2011-11-25
RS51742B (en) 2011-10-31
NZ549570A (en) 2010-08-27
SK287994B6 (sk) 2012-09-03
UA91189C2 (en) 2010-07-12
KR101085979B1 (ko) 2011-11-22
US20100069374A1 (en) 2010-03-18
BRPI0508768A (pt) 2007-02-27
IL177950A0 (en) 2006-12-31
SI1732929T1 (sl) 2010-12-31
JP4840594B2 (ja) 2011-12-21
EP1732929B1 (de) 2010-10-20
AU2005223612A1 (en) 2005-09-29
HK1099299A1 (en) 2007-08-10
AU2005223612B2 (en) 2010-06-24
ZA200607388B (en) 2008-07-30
US7964623B2 (en) 2011-06-21
CZ2006598A3 (cs) 2006-11-15
CN1934116A (zh) 2007-03-21
NO20064819L (no) 2006-10-23
AU2010202900A1 (en) 2010-07-29
EP1732929A1 (de) 2006-12-20

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