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ATE482966T1 - Verfahren zur herstellung von 7-alpha-alkylierte 19-norsteroide - Google Patents

Verfahren zur herstellung von 7-alpha-alkylierte 19-norsteroide

Info

Publication number
ATE482966T1
ATE482966T1 AT05776411T AT05776411T ATE482966T1 AT E482966 T1 ATE482966 T1 AT E482966T1 AT 05776411 T AT05776411 T AT 05776411T AT 05776411 T AT05776411 T AT 05776411T AT E482966 T1 ATE482966 T1 AT E482966T1
Authority
AT
Austria
Prior art keywords
norsteroids
alkylated
alpha
producing
fulvestrant
Prior art date
Application number
AT05776411T
Other languages
English (en)
Inventor
Peter Macdonald
Ettore Bigatti
Pierluigi Rossetto
Original Assignee
Sicor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sicor Inc filed Critical Sicor Inc
Application granted granted Critical
Publication of ATE482966T1 publication Critical patent/ATE482966T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0074—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT05776411T 2004-07-27 2005-07-27 Verfahren zur herstellung von 7-alpha-alkylierte 19-norsteroide ATE482966T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US59168904P 2004-07-27 2004-07-27
US60029204P 2004-08-09 2004-08-09
US63392704P 2004-12-06 2004-12-06
PCT/US2005/026715 WO2006015081A2 (en) 2004-07-27 2005-07-27 A PROCESS FOR THE PREPARATION OF 7α-ALKYLATED 19-NORSTEROIDS

Publications (1)

Publication Number Publication Date
ATE482966T1 true ATE482966T1 (de) 2010-10-15

Family

ID=35385883

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05776411T ATE482966T1 (de) 2004-07-27 2005-07-27 Verfahren zur herstellung von 7-alpha-alkylierte 19-norsteroide

Country Status (9)

Country Link
US (3) US7790910B2 (de)
EP (1) EP1771462B1 (de)
JP (1) JP2007506805A (de)
KR (1) KR20070061526A (de)
AT (1) ATE482966T1 (de)
CA (1) CA2574967A1 (de)
DE (1) DE602005023877D1 (de)
TW (1) TW200617019A (de)
WO (1) WO2006015081A2 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20071479A1 (it) * 2007-07-23 2009-01-24 Ind Chimica Srl Processo per la preparazione di 7alfa-[9-(4,4,5,5,5-pentafluortiopentil)nonil]estra-1,3,5(10)-trien-3,17beta-diolo
US20100174101A1 (en) * 2007-09-24 2010-07-08 Xi'an Liband Pharmaceutical Co., Ltd. Process for the manufacture of 7-alpha-[9-(4,4,5,5,5-penta fluoropentylsulphinyl) nonyl]estra-1,3,5-(10)- triene-3,17-beta-diol
CN101525364B (zh) * 2008-03-07 2012-12-12 杭州九源基因工程有限公司 一种氟维司群的晶型及其制备方法
PT2616078T (pt) 2010-09-16 2020-03-31 Shimoda Biotech Pty Ltd Composições de fulvestrant e métodos de uso
CN102600064A (zh) * 2012-03-31 2012-07-25 西安力邦制药有限公司 氟维司群或其衍生物缓释制剂及其制备方法
TW201408641A (zh) 2012-05-21 2014-03-01 Novartis Ag 可作爲激酶抑制劑之新穎環取代ｎ－吡啶基醯胺
CA2884806A1 (en) 2012-10-22 2014-05-01 Intas Pharmaceuticals Limited An improved process for the preparation of fulvestrant
JP6356218B2 (ja) * 2013-04-18 2018-07-11 シーアン リーバン ファーマシューティカル テクノロジー シーオー．， エルティーディー．Ｘｉ’Ａｎ Ｌｉｂａｎｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏ．， Ｌｔｄ． 抗腫瘍活性を有する７−α−［９−（４，４，５，５，５−ペンタフルオロペンチルスルフィニル）ノニル］−エストラ−１，３，５（１０）−トリエン−３，１７β−ジオールのエステル誘導体及びその調製方法
CN103980336B (zh) * 2014-05-21 2016-10-05 天津孚音生物科技发展有限公司 一种新的氟维司群的合成方法
CN103965280B (zh) * 2014-05-21 2016-04-20 天津孚音生物科技发展有限公司 一种氟维司群中间体的制备方法
WO2015181116A1 (en) 2014-05-26 2015-12-03 Crystal Pharma, S.A.U. Process and intermediades for the preparation of 7-alkylated steroids
CN104387435B (zh) * 2014-12-10 2017-05-10 天津孚音生物科技发展有限公司 一种化合物及其制备方法与应用
CN107033210B (zh) * 2016-02-03 2019-08-16 正大天晴药业集团股份有限公司 一种氟维司群及其中间体的制备方法
CN107286213A (zh) * 2016-03-31 2017-10-24 杭州共泽医药科技有限公司 一种氟维司群中间体的制备方法
CN107325143B (zh) * 2017-08-07 2019-09-10 连云港恒运药业有限公司 氟维司群中间体合成方法
CN110128497A (zh) * 2018-02-09 2019-08-16 鲁南制药集团股份有限公司 一种氟维司群制备方法
CN110818764A (zh) * 2018-08-07 2020-02-21 重庆圣华曦药业股份有限公司 一种应用加料监测系统制备氟维斯群中间体的方法
CN111662356A (zh) * 2019-03-06 2020-09-15 正大天晴药业集团股份有限公司 一种氟维司群的杂质控制方法
CN112094308B (zh) * 2020-09-28 2022-05-17 湖南新合新生物医药有限公司 氟维司群中间体的制备方法
CN114671922A (zh) * 2020-12-24 2022-06-28 鲁南制药集团股份有限公司 一种氟维司群有关物质
CN114685593B (zh) * 2020-12-31 2024-01-23 鲁南制药集团股份有限公司 一种氟维司群制备方法及其中间体
CN115448971A (zh) * 2021-06-09 2022-12-09 上海弼领生物技术有限公司 一种用于制备氟维司群的中间体及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2235949B1 (de) 1973-06-18 1978-03-17 Roussel Uclaf
GB8327256D0 (en) 1983-10-12 1983-11-16 Ici Plc Steroid derivatives
US5395842A (en) * 1988-10-31 1995-03-07 Endorecherche Inc. Anti-estrogenic compounds and compositions
US6500669B1 (en) 1994-05-04 2002-12-31 Massachusetts Institute Of Technology Programmable genotoxic agents and uses therefor
DE19622457A1 (de) 1996-05-24 1997-11-27 Schering Ag 7alpha-(5-Methylaminopentyl)-estratriene, Verfahren zu deren Herstellung, pharmazeutische Präparate, die diese 7alpha-(5-Methylaminopentyl)-estratriene enthalten sowie deren Verwendung zur Herstellung von Arzneimitteln
DE19635525A1 (de) 1996-08-20 1998-02-26 Schering Ag 7alpha-(xi-Aminoalkyl)-estratriene, Verfahren zu deren Herstellung, pharmazeutische Präparate, die diese 7alpha(xi-Aminoalkyl-estratriene enthalten sowie deren Verwendung zur Herstellung von Arzneimitteln
US5866560A (en) 1996-08-20 1999-02-02 Schering Ag 7α-(ξ-aminoalkyl)-estratrienes, process for their production, pharmaceutical preparations which contain these 7α-(ξ-aminoalkyl)-estratrienes as well as their use for the production of pharmaceutical agents
AR015500A1 (es) * 1997-12-23 2001-05-02 Schering Ag 11 BETA-HALoGENO-ESTRATRIENOS SUSTITUIDOS EN 7 ALFA, PROCEDIMIENTO PARA ELABORAR PREPARADOS FARMACEUTICOS QUE CONTIENEN TALES 11 BETA-HALOGENO-ESTRATRIENOSSUSTITUIDOS EN 7 ALFA, ASI COMO SU UTILIZACION EN LA ELABORACION DE MEDICAMENTOS.
DE19807791A1 (de) * 1998-02-19 1999-08-26 Schering Ag Kombinationspräparat aus Östrogen und Antiöstrogen
GB0025221D0 (en) 2000-10-14 2000-11-29 Astrazeneca Ab New process
GB0123961D0 (en) 2001-10-05 2001-11-28 Astrazeneca Ab Process and intermediates
DE10159217A1 (de) 2001-11-27 2003-06-05 Schering Ag 17alpha-Alkyl-17ß-oxy-estratriene und Zwischenprodukte zu deren Herstellung, Verwendung der 17alpha-Alkyl-17ß-oxy-estratriene zur Herstellung von Arzneimitteln sowie pharmazeutische Präparate

Also Published As

Publication number Publication date
EP1771462A2 (de) 2007-04-11
CA2574967A1 (en) 2006-02-09
US20060030552A1 (en) 2006-02-09
US20090306417A1 (en) 2009-12-10
JP2007506805A (ja) 2007-03-22
WO2006015081A3 (en) 2006-05-04
EP1771462B1 (de) 2010-09-29
KR20070061526A (ko) 2007-06-13
US20090318721A1 (en) 2009-12-24
WO2006015081A2 (en) 2006-02-09
TW200617019A (en) 2006-06-01
US7790910B2 (en) 2010-09-07
DE602005023877D1 (de) 2010-11-11

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Legal Events

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