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ATE456665T1 - Verfahren zur herstellung erhöhter mengen an richtig gefalteten heterologen proteinen in einschlussteilchen - Google Patents

Verfahren zur herstellung erhöhter mengen an richtig gefalteten heterologen proteinen in einschlussteilchen

Info

Publication number
ATE456665T1
ATE456665T1 AT03783975T AT03783975T ATE456665T1 AT E456665 T1 ATE456665 T1 AT E456665T1 AT 03783975 T AT03783975 T AT 03783975T AT 03783975 T AT03783975 T AT 03783975T AT E456665 T1 ATE456665 T1 AT E456665T1
Authority
AT
Austria
Prior art keywords
heterologue
proteins
correctly folded
increased quantities
inclusion particles
Prior art date
Application number
AT03783975T
Other languages
English (en)
Inventor
Viktor Menart
Vladka Gaberc-Porekar
Simona Jevsevar
Original Assignee
Lek Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Pharmaceuticals filed Critical Lek Pharmaceuticals
Application granted granted Critical
Publication of ATE456665T1 publication Critical patent/ATE456665T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT03783975T 2002-07-31 2003-06-11 Verfahren zur herstellung erhöhter mengen an richtig gefalteten heterologen proteinen in einschlussteilchen ATE456665T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI200200187A SI21273A (sl) 2002-07-31 2002-07-31 Priprava inkluzijskih teles z visokim deležem pravilno zvitega prekurzorja heterolognega proteina
PCT/EP2003/006134 WO2004015124A1 (en) 2002-07-31 2003-06-11 Process for the production of a heterologous protein

Publications (1)

Publication Number Publication Date
ATE456665T1 true ATE456665T1 (de) 2010-02-15

Family

ID=31713326

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03783975T ATE456665T1 (de) 2002-07-31 2003-06-11 Verfahren zur herstellung erhöhter mengen an richtig gefalteten heterologen proteinen in einschlussteilchen

Country Status (9)

Country Link
US (1) US20050283000A1 (de)
EP (1) EP1527188B1 (de)
JP (2) JP4703186B2 (de)
AR (1) AR040719A1 (de)
AT (1) ATE456665T1 (de)
AU (1) AU2003250347A1 (de)
DE (1) DE60331149D1 (de)
SI (2) SI21273A (de)
WO (1) WO2004015124A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI21639A (sl) * 2003-12-23 2005-06-30 LEK farmacevtska dru�ba d.d. Farmacevtski pripravek, ki vsebuje nemicelarne sulfobetaine
EP1939212A1 (de) * 2006-12-20 2008-07-02 LEK Pharmaceuticals D.D. Organische Verbindungen
WO2008096370A2 (en) * 2007-02-05 2008-08-14 Natco Pharma Limited An efficient and novel purification method of recombinant hg-csf
WO2008133141A1 (ja) * 2007-04-24 2008-11-06 Toyo Boseki Kabushiki Kaisha オスモチン組換えタンパク質およびその製造方法、並びにその利用
NZ583276A (en) 2007-08-27 2012-06-29 Biogenerix Ag Liquid formulations of granulocyte colony stimulating factor and polymer conjugates
US20090294362A1 (en) * 2008-05-30 2009-12-03 Persson Jonas Par Stationary phase for hydrophilic interaction chromatography
PE20130557A1 (es) * 2010-03-04 2013-05-19 Pfenex Inc Metodo para producir proteinas de interferon recombinantes solubles sin desnaturalizacion
EP2552949B1 (de) 2010-04-01 2016-08-17 Pfenex Inc. Verfahren zur g-csf-herstellung in einer pseudomonas-wirtszelle
JP5836621B2 (ja) 2011-03-31 2015-12-24 株式会社マキタ 動力工具
HUP1200171A1 (hu) 2012-03-19 2013-09-30 Richter Gedeon Nyrt Módszerek polipeptidek elõállítására
HUP1200172A2 (en) * 2012-03-19 2013-10-28 Richter Gedeon Nyrt Methods for refolding g-csf from inclusion bodies
ES2870802T3 (es) 2013-02-12 2021-10-27 Bristol Myers Squibb Co Métodos de replegado de proteínas a elevado pH
WO2014126871A1 (en) 2013-02-12 2014-08-21 Bristol-Myers Squibb Company Tangential flow filtration based protein refolding methods
CA2928526A1 (en) * 2013-11-01 2015-05-07 Spherium Biomed S.L. Inclusion bodies for transdermal delivery of therapeutic and cosmetic agents
CN104152515B (zh) * 2014-08-14 2019-12-31 江苏奥赛康药业有限公司 一种制备重组人粒细胞集落刺激因子的培养基及发酵方法
JP2020080727A (ja) * 2018-11-26 2020-06-04 Ｓｐｉｂｅｒ株式会社 目的タンパク質の製造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4810643A (en) * 1985-08-23 1989-03-07 Kirin- Amgen Inc. Production of pluripotent granulocyte colony-stimulating factor
JPH0618778B2 (ja) * 1985-10-04 1994-03-16 中外製薬株式会社 白血球減少症治療剤
IE912365A1 (en) * 1990-07-23 1992-01-29 Zeneca Ltd Continuous release pharmaceutical compositions
DE4037196A1 (de) * 1990-11-22 1992-05-27 Boehringer Mannheim Gmbh Verfahren zur reaktivierung von denaturiertem protein
WO1996040912A1 (en) * 1995-06-07 1996-12-19 Amgen Inc. Ob protein compositions and method
US5912327A (en) * 1996-09-30 1999-06-15 Human Genome Sciences, Inc. Method of purifying chemokines from inclusion bodies
ATE399858T1 (de) * 1996-12-27 2008-07-15 Japan Tobacco Inc Blütenorgan-spezifische promotersequenzen
US20020052026A1 (en) * 1997-10-08 2002-05-02 Steven M. Vicik Methods of refolding proteins
US6677139B1 (en) * 1999-12-23 2004-01-13 Genecor International, Inc. Methods for production of proteins in host cells
WO2003102013A2 (en) * 2001-02-23 2003-12-11 Gonzalez-Villasenor Lucia Iren Methods and compositions for production of recombinant peptides
SI21102A (sl) * 2001-12-19 2003-06-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za izolacijo biološko aktivnega granulocitne kolonije stimulirajočega dejavnika

Also Published As

Publication number Publication date
JP2006502708A (ja) 2006-01-26
WO2004015124A1 (en) 2004-02-19
EP1527188A1 (de) 2005-05-04
DE60331149D1 (de) 2010-03-18
SI1527188T1 (sl) 2010-05-31
JP2011078421A (ja) 2011-04-21
EP1527188B1 (de) 2010-01-27
JP4703186B2 (ja) 2011-06-15
US20050283000A1 (en) 2005-12-22
SI21273A (sl) 2004-02-29
AR040719A1 (es) 2005-04-20
AU2003250347A1 (en) 2004-02-25

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