ATE453639T1 - Phenylsubstituierte pyrimidinverbindungen zur verwendung als kinasehemmer - Google Patents
Phenylsubstituierte pyrimidinverbindungen zur verwendung als kinasehemmerInfo
- Publication number
- ATE453639T1 ATE453639T1 AT06734200T AT06734200T ATE453639T1 AT E453639 T1 ATE453639 T1 AT E453639T1 AT 06734200 T AT06734200 T AT 06734200T AT 06734200 T AT06734200 T AT 06734200T AT E453639 T1 ATE453639 T1 AT E453639T1
- Authority
- AT
- Austria
- Prior art keywords
- kinase inhibitors
- phenyl substituted
- pyrimidine compounds
- substituted pyrimidine
- kinase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65007705P | 2005-02-04 | 2005-02-04 | |
| US11/344,881 US20060178388A1 (en) | 2005-02-04 | 2006-02-01 | Phenyl-substituted pyrimidine compounds useful as kinase inhibitors |
| PCT/US2006/003659 WO2006084017A2 (en) | 2005-02-04 | 2006-02-02 | Phenyl-substituted pyrimidine compounds useful as kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE453639T1 true ATE453639T1 (de) | 2010-01-15 |
Family
ID=36481437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06734200T ATE453639T1 (de) | 2005-02-04 | 2006-02-02 | Phenylsubstituierte pyrimidinverbindungen zur verwendung als kinasehemmer |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20060178388A1 (de) |
| EP (1) | EP1848714B1 (de) |
| JP (1) | JP4906738B2 (de) |
| AT (1) | ATE453639T1 (de) |
| DE (1) | DE602006011434D1 (de) |
| ES (1) | ES2336025T3 (de) |
| WO (1) | WO2006084017A2 (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200533357A (en) * | 2004-01-08 | 2005-10-16 | Millennium Pharm Inc | 2-(amino-substituted)-4-aryl pyrimidines and related compounds useful for treating inflammatory diseases |
| DE102005048072A1 (de) * | 2005-09-24 | 2007-04-05 | Bayer Cropscience Ag | Thiazole als Fungizide |
| MY149143A (en) * | 2006-01-18 | 2013-07-15 | Amgen Inc | Thiazole compounds as protien kinase b (pkb) inhibitors |
| US20080242694A1 (en) * | 2006-09-18 | 2008-10-02 | D Sidocky Neil R | Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith |
| EP1992344A1 (de) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 Alpha als therapeutisches Target für Erkrankungen, die mit einer FGFR3- Mutation assoziiert sind |
| US7919504B2 (en) * | 2007-07-17 | 2011-04-05 | Amgen Inc. | Thiadiazole modulators of PKB |
| US7897619B2 (en) | 2007-07-17 | 2011-03-01 | Amgen Inc. | Heterocyclic modulators of PKB |
| EP2597098A1 (de) | 2007-08-08 | 2013-05-29 | Lexicon Pharmaceuticals, Inc. | (7H-Pyrrolo-[2, 3-D]-pyrimidin-4-yl)-Piperazine als Kinasehemmer zur Behandlung von Krebs und Entzündungen |
| AU2008333929A1 (en) * | 2007-12-03 | 2009-06-11 | Signum Biosciences, Inc. | Acid mimic compounds for the inhibition of isoprenyl-S-cysteinyl methyltransferase |
| WO2009093981A1 (en) * | 2008-01-23 | 2009-07-30 | S Bio Pte Ltd | Triazine compounds as kinase inhibitors |
| WO2009096198A1 (ja) * | 2008-02-01 | 2009-08-06 | Pharma Ip Limited Liability Intermediary Corporations | 新規ビアリール誘導体 |
| WO2009125870A1 (en) | 2008-04-09 | 2009-10-15 | Mitsubishi Tanabe Pharma Corporation | Pyrimidine, pyridine and triazine derivatives as maxi-k channel openers. |
| KR20160129909A (ko) | 2008-04-21 | 2016-11-09 | 렉시컨 파마슈티컬스 인코퍼레이티드 | Ｌｉｍｋ2 억제제, 그를 포함하는 조성물 및 그의 사용 방법 |
| KR20120131161A (ko) * | 2010-01-25 | 2012-12-04 | 씨에이치디아이 파운데이션, 인코포레이티드 | 특정 키뉴레닌-3-모노옥시게나제 억제제, 그의 제약 조성물 및 사용 방법 |
| JP2013107824A (ja) * | 2010-03-17 | 2013-06-06 | Dainippon Sumitomo Pharma Co Ltd | 新規単環ピリミジン誘導体 |
| WO2012078687A1 (en) * | 2010-12-06 | 2012-06-14 | Confluence Life Sciences, Inc. | Substituted pyrimidine urea compounds |
| KR20140072037A (ko) | 2011-08-30 | 2014-06-12 | 씨에이치디아이 파운데이션, 인코포레이티드 | 키뉴레닌-3-모노옥시게나제 억제제, 약학적 조성물 및 이의 사용 방법 |
| EA032526B1 (ru) | 2011-08-30 | 2019-06-28 | Схди Фаундейшн, Инк. | Применение ингибитора кинуренин-3-монооксигеназы для лечения заболеваний и состояний, опосредованных активностью кинуренин-3-монооксигеназы |
| US9532972B2 (en) * | 2012-02-07 | 2017-01-03 | University Of Central Florida Research Foundation, Inc. | Increasing taxane sensitivity in cancer cells |
| US10105351B2 (en) | 2012-03-14 | 2018-10-23 | University Of Central Florida Research Foundation, Inc. | Neurofibromatoses therapeutic agents and screening for same |
| WO2015025172A1 (en) * | 2013-08-22 | 2015-02-26 | Mark David Charles | 5-aryl-thiazol-2-yl-amine compounds and their therapeutic use |
| PT3080103T (pt) * | 2013-12-11 | 2018-07-23 | Sunesis Pharmaceuticals Inc | Compostos de biaril úteis no tratamento de doenças humanas em oncologia, neurologia e imunologia |
| KR20170026633A (ko) | 2014-07-17 | 2017-03-08 | 씨에이치디아이 파운데이션, 인코포레이티드 | Hiv-관련 장애의 치료 방법 및 치료용 조성물 |
| US10292122B2 (en) * | 2014-10-11 | 2019-05-14 | Telefonaktiebolaget Lm Ericsson (Publ) | Method and access point for maintaining synchronization among access points in radio access network |
| JP6616244B2 (ja) * | 2015-05-29 | 2019-12-04 | 北興化学工業株式会社 | 新規なヒドロキシフェニルボロン酸エステルとその製造方法、およびヒドロキシビフェニル化合物の製造法 |
| PL3319959T3 (pl) | 2015-07-06 | 2022-02-14 | Alkermes, Inc. | Hetero-haloinhibitory deacetylazy histonowej |
| WO2017007755A1 (en) | 2015-07-06 | 2017-01-12 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
| CA3030581C (en) * | 2016-07-18 | 2021-05-25 | National Institute Of Biological Sciences, Beijing | Apoptosis inhibitors |
| JP2019532944A (ja) | 2016-09-23 | 2019-11-14 | セルイプセ | Ｌｉｍｋ介在性疾患における、ｌｉｍキナーゼ阻害剤、医薬組成物および使用方法 |
| CN106727536B (zh) * | 2016-11-30 | 2019-05-31 | 东南大学 | LIM激酶抑制剂LIMKi3在制备治疗疼痛药物中的应用 |
| AU2018207402B2 (en) | 2017-01-11 | 2023-09-28 | Alkermes, Inc. | Bicyclic inhibitors of histone deacetylase |
| US11040947B2 (en) | 2017-03-22 | 2021-06-22 | The Research Foundation For The State University Of New York | Substituted quinazolines as matrix metalloproteinase-9 hemopexin domain inhibitors |
| ES2914355T3 (es) | 2017-08-07 | 2022-06-09 | Alkermes Inc | Inhibidores bicíclicos de la histona desacetilasa |
| CN111601593B (zh) | 2017-10-05 | 2022-04-15 | 弗尔康医疗公司 | P38激酶抑制剂降低dux4和下游基因表达以用于治疗fshd |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| CA3082855A1 (en) | 2017-11-21 | 2019-05-31 | Bayer Aktiengesellschaft | 2-hetarylpyrimidine-4-carboxamides as aryl hydrocarbon receptor anatgonists |
| EP3740484B1 (de) | 2018-01-15 | 2024-09-11 | Aucentra Therapeutics Pty Ltd | 5-(pyrimidin-4-yl)thiazol-2-yl-harnstoffderivate als therapeutika |
| CN117003730A (zh) * | 2022-04-29 | 2023-11-07 | 德明药泰生物技术（深圳）有限公司 | 取代嘧啶酰肼类化合物及其制备方法和应用 |
| CN117624135A (zh) * | 2022-08-19 | 2024-03-01 | 德明药泰生物技术（深圳）有限公司 | 2-氮取代嘧啶类化合物及其制备方法和应用 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2201083A1 (en) * | 1972-09-28 | 1974-04-26 | Ferlux | 6-Phenyl pyrimidine-4-carboxylic acids - analgesics, vasodilators, cardiac stimulants and respiratory analeptics |
| US4200750A (en) | 1977-01-07 | 1980-04-29 | Westwood Pharmaceuticals Inc. | 4-Substituted imidazo [1,2-a]quinoxalines |
| CA1288433C (en) * | 1986-12-03 | 1991-09-03 | Tsuguhiro Katoh | Pyridinylpyrimidine derivatives, method for production thereof and a fungicide containing them as the active ingredient |
| DE3922735A1 (de) * | 1989-07-11 | 1991-01-24 | Hoechst Ag | Aminopyrimidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als fungizide |
| DE3940476A1 (de) * | 1989-12-07 | 1991-06-13 | Bayer Ag | Pyridinylpyrimidin-derivate |
| US5022915A (en) * | 1990-03-01 | 1991-06-11 | Ici Americas Inc. | Substituted 2,4-diarylpyrimidines and their use as herbicides |
| US5739135A (en) | 1993-09-03 | 1998-04-14 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
| DE69624437T2 (de) * | 1995-04-13 | 2003-08-07 | Taiho Pharmaceutical Co. Ltd., Tokio/Tokyo | 4,6-diarylpyrimidin-derivate und deren salze |
| US5658903A (en) | 1995-06-07 | 1997-08-19 | Smithkline Beecham Corporation | Imidazole compounds, compositions and use |
| ES2205167T3 (es) | 1996-01-11 | 2004-05-01 | Smithkline Beecham Corporation | Nuevos compuestos de imidazol sustituidos. |
| US5760246A (en) | 1996-12-17 | 1998-06-02 | Biller; Scott A. | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method |
| US6147080A (en) | 1996-12-18 | 2000-11-14 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
| US5945418A (en) | 1996-12-18 | 1999-08-31 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
| KR20010012808A (ko) | 1997-05-22 | 2001-02-26 | 윌리암스 로저 에이 | ｐ38 키나아제로서 4-아릴-3(5)-헤테로아릴 치환 피라졸 |
| US6087496A (en) | 1998-05-22 | 2000-07-11 | G. D. Searle & Co. | Substituted pyrazoles suitable as p38 kinase inhibitors |
| AU8381098A (en) | 1997-07-02 | 1999-01-25 | Smithkline Beecham Corporation | Novel cycloalkyl substituted imidazoles |
| US6130235A (en) | 1998-05-22 | 2000-10-10 | Scios Inc. | Compounds and methods to treat cardiac failure and other disorders |
| CA2342251A1 (en) | 1998-08-28 | 2000-03-09 | Scios Inc. | Use of piperidines and/or piperazines as inhibitors of p38-alpha kinase |
| US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| AR023659A1 (es) * | 1998-09-18 | 2002-09-04 | Vertex Pharma | Un compuesto inhibidor de p38, una composicion farmaceutica que lo comprende y el uso de dicha composicion en el tratamiento y prevencion de estados patologicos |
| WO2000034244A1 (en) | 1998-12-04 | 2000-06-15 | Bristol-Myers Squibb Company | 3-substituted-4-arylquinolin-2-one derivatives as potassium channel modulators |
| GB9906566D0 (en) | 1999-03-23 | 1999-05-19 | Zeneca Ltd | Chemical compounds |
| US6548529B1 (en) | 1999-04-05 | 2003-04-15 | Bristol-Myers Squibb Company | Heterocyclic containing biphenyl aP2 inhibitors and method |
| JP2001089452A (ja) | 1999-09-22 | 2001-04-03 | Sankyo Co Ltd | ピリミジン誘導体 |
| GB9924092D0 (en) | 1999-10-13 | 1999-12-15 | Zeneca Ltd | Pyrimidine derivatives |
| JP2003513977A (ja) | 1999-11-10 | 2003-04-15 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | 置換２−アリール−３−（ヘテロアリール）−イミダゾ［１，２−α］ピリミジン類および関連薬剤組成物および方法 |
| MY125533A (en) | 1999-12-06 | 2006-08-30 | Bristol Myers Squibb Co | Heterocyclic dihydropyrimidine compounds |
| JP2001199982A (ja) * | 2000-01-14 | 2001-07-24 | Dainippon Pharmaceut Co Ltd | ６−ヘテロアリールピリミジン誘導体及びそれを含有する医薬組成物 |
| AR029489A1 (es) * | 2000-03-10 | 2003-07-02 | Euro Celtique Sa | Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento |
| NZ521068A (en) * | 2000-03-29 | 2005-04-29 | Cyclacel Ltd | 2-substituted 4-heteroaryl-pyrimidines and their use in the treatment of proliferative disorders |
| PE20020451A1 (es) | 2000-09-15 | 2002-06-06 | Vertex Pharma | Compuestos de pirazol utiles como inhibidores de cinasa proteina |
| US6670357B2 (en) | 2000-11-17 | 2003-12-30 | Bristol-Myers Squibb Company | Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors |
| ES2254611T3 (es) | 2001-05-11 | 2006-06-16 | Pfizer Products Inc. | Derivados de tiazol. |
| EP1760082A1 (de) * | 2001-09-28 | 2007-03-07 | Cyclacel Limited | N-(4-(4-methylthiazol-5-yl)pyrimidin-2-yl)-N-Phenylamine als antiproliferative Verbindungen |
| US6916813B2 (en) * | 2001-12-10 | 2005-07-12 | Bristol-Myers Squibb Co. | (1-phenyl-2-heteoaryl)ethyl-guanidine compounds as inhibitors of mitochondrial F1F0 ATP hydrolase |
| JP2003206230A (ja) | 2002-01-10 | 2003-07-22 | Yamanouchi Pharmaceut Co Ltd | シアノヘテロ環誘導体又はその塩 |
| TW200400034A (en) | 2002-05-20 | 2004-01-01 | Bristol Myers Squibb Co | Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors |
| GB0217431D0 (en) | 2002-07-27 | 2002-09-04 | Astrazeneca Ab | Novel compounds |
| GB0226582D0 (en) | 2002-11-14 | 2002-12-18 | Cyclacel Ltd | Anti-viral compounds |
| DE602004028907D1 (de) * | 2003-02-06 | 2010-10-14 | Bristol Myers Squibb Co | Als kinaseinhibitoren geeignete verbindungen auf thiazolylbasis |
| WO2004080979A1 (en) * | 2003-03-14 | 2004-09-23 | Lg Life Sciences Ltd. | Novel 3-(2-amino-4-pyrimidinyl)-4-hydroxyphenyl ketone derivatives |
| US20060293339A1 (en) | 2003-03-24 | 2006-12-28 | Chakravarty Prasun K | Biaryl substituted 6-membered heterocycles as sodium channel blockers |
| EP1644338A1 (de) * | 2003-04-01 | 2006-04-12 | Aponetics AG | 2,4,6-trisubstituierte pyrimidinderivate, die sich für die behandlung von neoplastischen krankheiten und autoimmunkrankheiten eignen |
| TW200519106A (en) * | 2003-05-02 | 2005-06-16 | Novartis Ag | Organic compounds |
| WO2005007648A2 (en) * | 2003-07-16 | 2005-01-27 | Neurogen Corporation | Biaryl piperazinyl-pyridine analogues |
| GB0403155D0 (en) * | 2004-02-12 | 2004-03-17 | Vernalis Res Ltd | Chemical compounds |
| US20050282824A1 (en) * | 2004-05-07 | 2005-12-22 | Xiaobing Li | Substituted pyrimidines as inhibitors of bacterial type III protein secretion systems |
| WO2006071538A2 (en) * | 2004-12-13 | 2006-07-06 | Neurogen Corporation | Substituted biaryl analogues |
-
2006
- 2006-02-01 US US11/344,881 patent/US20060178388A1/en not_active Abandoned
- 2006-02-02 AT AT06734200T patent/ATE453639T1/de not_active IP Right Cessation
- 2006-02-02 ES ES06734200T patent/ES2336025T3/es active Active
- 2006-02-02 EP EP06734200A patent/EP1848714B1/de not_active Not-in-force
- 2006-02-02 DE DE602006011434T patent/DE602006011434D1/de active Active
- 2006-02-02 JP JP2007554206A patent/JP4906738B2/ja not_active Expired - Fee Related
- 2006-02-02 WO PCT/US2006/003659 patent/WO2006084017A2/en active Application Filing
-
2009
- 2009-09-30 US US12/570,010 patent/US7923556B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| DE602006011434D1 (de) | 2010-02-11 |
| EP1848714A2 (de) | 2007-10-31 |
| ES2336025T3 (es) | 2010-04-07 |
| JP2008530012A (ja) | 2008-08-07 |
| US20100029649A1 (en) | 2010-02-04 |
| EP1848714B1 (de) | 2009-12-30 |
| US7923556B2 (en) | 2011-04-12 |
| WO2006084017A2 (en) | 2006-08-10 |
| US20060178388A1 (en) | 2006-08-10 |
| JP4906738B2 (ja) | 2012-03-28 |
| WO2006084017A3 (en) | 2006-12-14 |
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