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ATE446372T1 - Vesikuläre komplexe und verfahren zu deren herstellung und verwendung - Google Patents

Vesikuläre komplexe und verfahren zu deren herstellung und verwendung

Info

Publication number
ATE446372T1
ATE446372T1 AT98920077T AT98920077T ATE446372T1 AT E446372 T1 ATE446372 T1 AT E446372T1 AT 98920077 T AT98920077 T AT 98920077T AT 98920077 T AT98920077 T AT 98920077T AT E446372 T1 ATE446372 T1 AT E446372T1
Authority
AT
Austria
Prior art keywords
disclosed
individuals
methods
production
cells
Prior art date
Application number
AT98920077T
Other languages
English (en)
Inventor
Richard Ciccarelli
C Satishchandran
Catherine Pachuk
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of ATE446372T1 publication Critical patent/ATE446372T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55555Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/70Nanostructure
    • Y10S977/773Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/905Specially adapted for travel through blood circulatory system
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906Drug delivery
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906Drug delivery
    • Y10S977/907Liposome
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915Therapeutic or pharmaceutical composition
    • Y10S977/916Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT98920077T 1997-04-30 1998-04-30 Vesikuläre komplexe und verfahren zu deren herstellung und verwendung ATE446372T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4512297P 1997-04-30 1997-04-30
PCT/US1998/008799 WO1998048780A1 (en) 1997-04-30 1998-04-30 Vesicular complexes and methods of making and using the same

Publications (1)

Publication Number Publication Date
ATE446372T1 true ATE446372T1 (de) 2009-11-15

Family

ID=21936112

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98920077T ATE446372T1 (de) 1997-04-30 1998-04-30 Vesikuläre komplexe und verfahren zu deren herstellung und verwendung

Country Status (12)

Country Link
US (2) US6217900B1 (de)
EP (1) EP0986372B1 (de)
JP (1) JP2002508747A (de)
KR (1) KR100554344B1 (de)
CN (1) CN1092045C (de)
AT (1) ATE446372T1 (de)
AU (1) AU728115C (de)
BR (1) BR9809006B1 (de)
CA (1) CA2285298C (de)
DE (1) DE69841251D1 (de)
ES (1) ES2333282T3 (de)
WO (1) WO1998048780A1 (de)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2222334C2 (ru) * 1998-05-25 2004-01-27 Ниппон Синяку Ко., Лтд. Способ получения композитного препарата, содержащего нуклеиновую кислоту
EP1147204A1 (de) * 1999-01-28 2001-10-24 Medical College Of Georgia Research Institute, Inc. Zusammensetzung und verfahren zur in vivo und in vitro abschwächung der genexpression mittels dobbelsträngigem rna
EP1097993A3 (de) * 1999-11-05 2004-01-07 National Institute of Advanced Industrial Science and Technology Funktionelle Ribozymchimermolekulen die schlittfähig sind
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
WO2003067399A2 (en) * 2002-02-07 2003-08-14 Byington Carrie L Method for creating and using a treatment protocol
US20040180438A1 (en) * 2002-04-26 2004-09-16 Pachuk Catherine J. Methods and compositions for silencing genes without inducing toxicity
JP4868739B2 (ja) 2002-05-06 2012-02-01 アルナイラム ファーマシューティカルズ, インコーポレイテッド 核酸の送達法
JP2005529959A (ja) * 2002-06-14 2005-10-06 マイラス コーポレイション 細胞へのポリヌクレオチドの伝達をするための新規な方法
JP2006500012A (ja) * 2002-07-31 2006-01-05 ヌクレオニクス インコーポレーティッド 二本鎖rnaの構造および構築物、並びにその作製法および使用法
WO2004073631A2 (en) * 2003-02-14 2004-09-02 Combinatorx, Incorporated Combination therapy for the treatment of neoplasms
EP2284268A3 (de) 2003-06-12 2012-05-30 Alnylam Pharmaceuticals Inc. Konservierte HBV- und HCV-Sequenzen zur Genausschaltung
TW200613554A (en) 2004-06-17 2006-05-01 Wyeth Corp Plasmid having three complete transcriptional units and immunogenic compositions for inducing an immune response to HIV
ATE505541T1 (de) 2004-09-24 2011-04-15 Alnylam Pharmaceuticals Inc Targeting von zwischenprodukten zur gegenstrangreplikation von einzelstrangigen viren durch rnai
EP1833967B1 (de) 2004-12-22 2011-04-27 Alnylam Pharmaceuticals, Inc. Zum gen-silencing geeignete konservierte hbv- und hcv-sequenzen
NZ594275A (en) 2005-07-25 2013-04-26 Emergent Product Dev Seattle B-Cell Reduction Using CD37-Specific and CD20-Specific Binding Molecules
EP2418223A3 (de) 2006-06-12 2013-01-16 Emergent Product Development Seattle, LLC Einkettige, multivalente Bindungsproteine mit Effektorfunktion
RU2463345C2 (ru) 2006-07-13 2012-10-10 Вайет Получение гликопротеинов
DK2548438T3 (en) 2006-11-08 2015-10-19 Veritas Bio LLC IN VIVO SUBMITTING DOUBLE-STRENGTH RNA TO A CELL
AU2008287195A1 (en) * 2007-07-06 2009-02-19 Emergent Product Development Seattle, Llc Binding peptides having a C-terminally disposed specific binding domain
WO2009126944A1 (en) 2008-04-11 2009-10-15 Trubion Pharmaceuticals, Inc. Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof
CA2761106C (en) 2009-05-05 2019-01-15 Miragen Therapeutics Lipophilic polynucleotide conjugates
BRPI1010885A2 (pt) 2009-06-08 2015-09-22 Miragen Therapeutics motivos de modificação química para inibidores mirna e miméticos.
HUE031107T2 (en) * 2010-04-01 2017-06-28 Pharmanest Ab Heat-gelling anesthetic preparations
CN103492569B (zh) 2010-11-05 2020-04-07 米拉根医疗公司 碱基经修饰的寡核苷酸
EA201370139A1 (ru) 2010-12-15 2013-10-30 Мираген Терапеутикс Ингибиторы микро-рнк, содержащие закрытые нуклеотиды
US10131905B2 (en) 2011-04-12 2018-11-20 Beth Israel Deaconess Medical Center Micro-RNA inhibitors and their uses in disease
CA2844577A1 (en) 2011-09-13 2013-03-21 Ottawa Hospital Research Institute Microrna inhibitors
DK3354734T3 (da) 2012-06-21 2020-06-29 Miragen Therapeutics Inc Oligonukleotid-baserede hæmmere omfattende låst nukleinsyremønster
MX364814B (es) 2013-03-15 2019-05-08 Miragen Therapeutics Inc Nucleosidos biciclicos unidos en puente.
US10172916B2 (en) 2013-11-15 2019-01-08 The Board Of Trustees Of The Leland Stanford Junior University Methods of treating heart failure with agonists of hypocretin receptor 2
US10772974B2 (en) 2013-11-18 2020-09-15 Beth Israel Deaconess Medical Center, Inc. Compositions and methods for cardiac regeneration
WO2016022536A2 (en) 2014-08-04 2016-02-11 MiRagen Therapeutics, Inc. Inhibitors of myh7b and uses thereof
KR20170068452A (ko) 2014-09-08 2017-06-19 미라젠 세러퓨틱스 인코포레이티드 Mir-29 모방체 및 이의 용도
CN107636003A (zh) 2015-01-20 2018-01-26 米拉根医疗股份有限公司 miR‑92抑制剂及其用途
KR102034619B1 (ko) 2015-06-05 2019-11-11 미라젠 세러퓨틱스 인코포레이티드 피부 t 세포 림프종(ctcl) 치료용 mir-155 억제제
MX2018003292A (es) 2015-09-21 2018-08-01 Aptevo Res & Development Llc Polipéptidos de unión a cd3.
US10357543B2 (en) 2015-11-16 2019-07-23 Ohio State Innovation Foundation Methods and compositions for treating disorders and diseases using Survival Motor Neuron (SMN) protein
UY37376A (es) 2016-08-26 2018-03-23 Amgen Inc Construcciones de arni para inhibir expresión de asgr1 y métodos para su uso
ES2659845B1 (es) 2016-09-19 2019-01-04 Univ Valencia Modulación de microRNAs contra la distrofia miotónica tipo 1 y antagonistas de microRNAs para ello
AR113490A1 (es) 2017-12-12 2020-05-06 Amgen Inc CONSTRUCCIONES DE ARNi PARA INHIBIR LA EXPRESIÓN DE PNPLA3 Y MÉTODOS DE USO DE LAS MISMAS
SG11202008921YA (en) 2018-03-14 2020-10-29 Beth Israel Deaconess Medical Ct Inc Micro-rna and obesity
MX2021006745A (es) 2018-12-10 2021-07-15 Amgen Inc Constructos de iarn modificados quimicamente y usos de estos.
JP2022511550A (ja) 2018-12-10 2022-01-31 アムジエン・インコーポレーテツド PNPLA3発現を阻害するためのRNAiコンストラクト
BR112021024080A2 (pt) 2019-05-30 2022-02-08 Amgen Inc Construtos de rnai para inibir a expressão de scap e métodos de uso dos mesmos
AU2020329286A1 (en) 2019-08-13 2022-03-17 Amgen Inc. RNAi constructs for inhibiting SLC30A8 expression and methods of use thereof
MX2022007005A (es) 2019-12-09 2022-08-25 Amgen Inc Construcciones de iarn y metodos para inhibir la expresion de lpa.
US20230088509A1 (en) 2020-05-20 2023-03-23 St. Jude Children's Research Hospital Detection of alzheimer's disease using specific biomarkers
KR20240004092A (ko) 2020-06-01 2024-01-11 암젠 인크 Hsd17b13 발현을 억제하기 위한 rnai 작제물 및 이의 사용 방법
EP3929295A1 (de) 2020-06-26 2021-12-29 Universitat Pompeu Fabra Künstliche rnas zur modulation von rna-fragmenten
MX2023001786A (es) 2020-08-13 2023-03-10 Amgen Inc Construcciones de iarn y metodos para inhibir la expresion de marc1.
WO2022098841A1 (en) 2020-11-05 2022-05-12 Amgen Inc. METHODS FOR TREATING ATHEROSCLEROTIC CARDIOVASCULAR DISEASE WITH LPA-TARGETED RNAi CONSTRUCTS
WO2023278295A1 (en) 2021-06-29 2023-01-05 The Broad Institute, Inc. Compositions and methods for ameliorating anterodorsal thalamus hyperexcitability
CN118556125A (zh) 2021-10-05 2024-08-27 美国安进公司 用于增强寡核苷酸化合物的基因沉默活性的组合物和方法
JP2024539097A (ja) 2021-10-22 2024-10-28 アムジェン インコーポレイテッド Gpam発現を阻害するためのrnaiコンストラクト及びその使用方法
US20240084301A1 (en) 2022-07-25 2024-03-14 Amgen Inc. Rnai constructs and methods for inhibiting fam13a expression
EP4353823A1 (de) 2022-10-12 2024-04-17 Resalis Therapeutics S.r.l. Inhibitoren von mikro-rna 22
WO2024130142A2 (en) 2022-12-16 2024-06-20 Amgen Inc. Rnai constructs for inhibiting ttr expression and methods of use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US5948441A (en) * 1988-03-07 1999-09-07 The Liposome Company, Inc. Method for size separation of particles
US5514788A (en) 1993-05-17 1996-05-07 Isis Pharmaceuticals, Inc. Oligonucleotide modulation of cell adhesion
US5593972A (en) 1993-01-26 1997-01-14 The Wistar Institute Genetic immunization
AU675702B2 (en) * 1993-01-26 1997-02-13 Leslie R. Coney Compositions and methods for delivery of genetic material
EP0800579B1 (de) * 1994-12-30 2002-07-24 Chiron Corporation Kombinationsvektoren zum austragen von genmaterial
KR20140137679A (ko) 2013-05-23 2014-12-03 삼성전자주식회사 카드 소켓 장치

Also Published As

Publication number Publication date
US6217900B1 (en) 2001-04-17
EP0986372A4 (de) 2002-06-19
AU728115C (en) 2004-01-22
KR100554344B1 (ko) 2006-02-22
WO1998048780A1 (en) 1998-11-05
AU7272498A (en) 1998-11-24
US6383512B1 (en) 2002-05-07
JP2002508747A (ja) 2002-03-19
EP0986372B1 (de) 2009-10-21
DE69841251D1 (de) 2009-12-03
KR20010020161A (ko) 2001-03-15
BR9809006A (pt) 2000-08-08
ES2333282T3 (es) 2010-02-18
CN1092045C (zh) 2002-10-09
AU728115B2 (en) 2001-01-04
BR9809006B1 (pt) 2010-02-09
EP0986372A1 (de) 2000-03-22
CA2285298A1 (en) 1998-11-05
CA2285298C (en) 2008-12-23
CN1277549A (zh) 2000-12-20

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