ATE446372T1 - Vesikuläre komplexe und verfahren zu deren herstellung und verwendung - Google Patents
Vesikuläre komplexe und verfahren zu deren herstellung und verwendungInfo
- Publication number
- ATE446372T1 ATE446372T1 AT98920077T AT98920077T ATE446372T1 AT E446372 T1 ATE446372 T1 AT E446372T1 AT 98920077 T AT98920077 T AT 98920077T AT 98920077 T AT98920077 T AT 98920077T AT E446372 T1 ATE446372 T1 AT E446372T1
- Authority
- AT
- Austria
- Prior art keywords
- disclosed
- individuals
- methods
- production
- cells
- Prior art date
Links
- 239000000203 mixture Substances 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 230000028993 immune response Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 239000003589 local anesthetic agent Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/905—Specially adapted for travel through blood circulatory system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
- Y10S977/907—Liposome
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/915—Therapeutic or pharmaceutical composition
- Y10S977/916—Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4512297P | 1997-04-30 | 1997-04-30 | |
PCT/US1998/008799 WO1998048780A1 (en) | 1997-04-30 | 1998-04-30 | Vesicular complexes and methods of making and using the same |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE446372T1 true ATE446372T1 (de) | 2009-11-15 |
Family
ID=21936112
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98920077T ATE446372T1 (de) | 1997-04-30 | 1998-04-30 | Vesikuläre komplexe und verfahren zu deren herstellung und verwendung |
Country Status (12)
Country | Link |
---|---|
US (2) | US6217900B1 (de) |
EP (1) | EP0986372B1 (de) |
JP (1) | JP2002508747A (de) |
KR (1) | KR100554344B1 (de) |
CN (1) | CN1092045C (de) |
AT (1) | ATE446372T1 (de) |
AU (1) | AU728115C (de) |
BR (1) | BR9809006B1 (de) |
CA (1) | CA2285298C (de) |
DE (1) | DE69841251D1 (de) |
ES (1) | ES2333282T3 (de) |
WO (1) | WO1998048780A1 (de) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2222334C2 (ru) * | 1998-05-25 | 2004-01-27 | Ниппон Синяку Ко., Лтд. | Способ получения композитного препарата, содержащего нуклеиновую кислоту |
EP1147204A1 (de) * | 1999-01-28 | 2001-10-24 | Medical College Of Georgia Research Institute, Inc. | Zusammensetzung und verfahren zur in vivo und in vitro abschwächung der genexpression mittels dobbelsträngigem rna |
EP1097993A3 (de) * | 1999-11-05 | 2004-01-07 | National Institute of Advanced Industrial Science and Technology | Funktionelle Ribozymchimermolekulen die schlittfähig sind |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
WO2003067399A2 (en) * | 2002-02-07 | 2003-08-14 | Byington Carrie L | Method for creating and using a treatment protocol |
US20040180438A1 (en) * | 2002-04-26 | 2004-09-16 | Pachuk Catherine J. | Methods and compositions for silencing genes without inducing toxicity |
JP4868739B2 (ja) | 2002-05-06 | 2012-02-01 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | 核酸の送達法 |
JP2005529959A (ja) * | 2002-06-14 | 2005-10-06 | マイラス コーポレイション | 細胞へのポリヌクレオチドの伝達をするための新規な方法 |
JP2006500012A (ja) * | 2002-07-31 | 2006-01-05 | ヌクレオニクス インコーポレーティッド | 二本鎖rnaの構造および構築物、並びにその作製法および使用法 |
WO2004073631A2 (en) * | 2003-02-14 | 2004-09-02 | Combinatorx, Incorporated | Combination therapy for the treatment of neoplasms |
EP2284268A3 (de) | 2003-06-12 | 2012-05-30 | Alnylam Pharmaceuticals Inc. | Konservierte HBV- und HCV-Sequenzen zur Genausschaltung |
TW200613554A (en) | 2004-06-17 | 2006-05-01 | Wyeth Corp | Plasmid having three complete transcriptional units and immunogenic compositions for inducing an immune response to HIV |
ATE505541T1 (de) | 2004-09-24 | 2011-04-15 | Alnylam Pharmaceuticals Inc | Targeting von zwischenprodukten zur gegenstrangreplikation von einzelstrangigen viren durch rnai |
EP1833967B1 (de) | 2004-12-22 | 2011-04-27 | Alnylam Pharmaceuticals, Inc. | Zum gen-silencing geeignete konservierte hbv- und hcv-sequenzen |
NZ594275A (en) | 2005-07-25 | 2013-04-26 | Emergent Product Dev Seattle | B-Cell Reduction Using CD37-Specific and CD20-Specific Binding Molecules |
EP2418223A3 (de) | 2006-06-12 | 2013-01-16 | Emergent Product Development Seattle, LLC | Einkettige, multivalente Bindungsproteine mit Effektorfunktion |
RU2463345C2 (ru) | 2006-07-13 | 2012-10-10 | Вайет | Получение гликопротеинов |
DK2548438T3 (en) | 2006-11-08 | 2015-10-19 | Veritas Bio LLC | IN VIVO SUBMITTING DOUBLE-STRENGTH RNA TO A CELL |
AU2008287195A1 (en) * | 2007-07-06 | 2009-02-19 | Emergent Product Development Seattle, Llc | Binding peptides having a C-terminally disposed specific binding domain |
WO2009126944A1 (en) | 2008-04-11 | 2009-10-15 | Trubion Pharmaceuticals, Inc. | Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof |
CA2761106C (en) | 2009-05-05 | 2019-01-15 | Miragen Therapeutics | Lipophilic polynucleotide conjugates |
BRPI1010885A2 (pt) | 2009-06-08 | 2015-09-22 | Miragen Therapeutics | motivos de modificação química para inibidores mirna e miméticos. |
HUE031107T2 (en) * | 2010-04-01 | 2017-06-28 | Pharmanest Ab | Heat-gelling anesthetic preparations |
CN103492569B (zh) | 2010-11-05 | 2020-04-07 | 米拉根医疗公司 | 碱基经修饰的寡核苷酸 |
EA201370139A1 (ru) | 2010-12-15 | 2013-10-30 | Мираген Терапеутикс | Ингибиторы микро-рнк, содержащие закрытые нуклеотиды |
US10131905B2 (en) | 2011-04-12 | 2018-11-20 | Beth Israel Deaconess Medical Center | Micro-RNA inhibitors and their uses in disease |
CA2844577A1 (en) | 2011-09-13 | 2013-03-21 | Ottawa Hospital Research Institute | Microrna inhibitors |
DK3354734T3 (da) | 2012-06-21 | 2020-06-29 | Miragen Therapeutics Inc | Oligonukleotid-baserede hæmmere omfattende låst nukleinsyremønster |
MX364814B (es) | 2013-03-15 | 2019-05-08 | Miragen Therapeutics Inc | Nucleosidos biciclicos unidos en puente. |
US10172916B2 (en) | 2013-11-15 | 2019-01-08 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of treating heart failure with agonists of hypocretin receptor 2 |
US10772974B2 (en) | 2013-11-18 | 2020-09-15 | Beth Israel Deaconess Medical Center, Inc. | Compositions and methods for cardiac regeneration |
WO2016022536A2 (en) | 2014-08-04 | 2016-02-11 | MiRagen Therapeutics, Inc. | Inhibitors of myh7b and uses thereof |
KR20170068452A (ko) | 2014-09-08 | 2017-06-19 | 미라젠 세러퓨틱스 인코포레이티드 | Mir-29 모방체 및 이의 용도 |
CN107636003A (zh) | 2015-01-20 | 2018-01-26 | 米拉根医疗股份有限公司 | miR‑92抑制剂及其用途 |
KR102034619B1 (ko) | 2015-06-05 | 2019-11-11 | 미라젠 세러퓨틱스 인코포레이티드 | 피부 t 세포 림프종(ctcl) 치료용 mir-155 억제제 |
MX2018003292A (es) | 2015-09-21 | 2018-08-01 | Aptevo Res & Development Llc | Polipéptidos de unión a cd3. |
US10357543B2 (en) | 2015-11-16 | 2019-07-23 | Ohio State Innovation Foundation | Methods and compositions for treating disorders and diseases using Survival Motor Neuron (SMN) protein |
UY37376A (es) | 2016-08-26 | 2018-03-23 | Amgen Inc | Construcciones de arni para inhibir expresión de asgr1 y métodos para su uso |
ES2659845B1 (es) | 2016-09-19 | 2019-01-04 | Univ Valencia | Modulación de microRNAs contra la distrofia miotónica tipo 1 y antagonistas de microRNAs para ello |
AR113490A1 (es) | 2017-12-12 | 2020-05-06 | Amgen Inc | CONSTRUCCIONES DE ARNi PARA INHIBIR LA EXPRESIÓN DE PNPLA3 Y MÉTODOS DE USO DE LAS MISMAS |
SG11202008921YA (en) | 2018-03-14 | 2020-10-29 | Beth Israel Deaconess Medical Ct Inc | Micro-rna and obesity |
MX2021006745A (es) | 2018-12-10 | 2021-07-15 | Amgen Inc | Constructos de iarn modificados quimicamente y usos de estos. |
JP2022511550A (ja) | 2018-12-10 | 2022-01-31 | アムジエン・インコーポレーテツド | PNPLA3発現を阻害するためのRNAiコンストラクト |
BR112021024080A2 (pt) | 2019-05-30 | 2022-02-08 | Amgen Inc | Construtos de rnai para inibir a expressão de scap e métodos de uso dos mesmos |
AU2020329286A1 (en) | 2019-08-13 | 2022-03-17 | Amgen Inc. | RNAi constructs for inhibiting SLC30A8 expression and methods of use thereof |
MX2022007005A (es) | 2019-12-09 | 2022-08-25 | Amgen Inc | Construcciones de iarn y metodos para inhibir la expresion de lpa. |
US20230088509A1 (en) | 2020-05-20 | 2023-03-23 | St. Jude Children's Research Hospital | Detection of alzheimer's disease using specific biomarkers |
KR20240004092A (ko) | 2020-06-01 | 2024-01-11 | 암젠 인크 | Hsd17b13 발현을 억제하기 위한 rnai 작제물 및 이의 사용 방법 |
EP3929295A1 (de) | 2020-06-26 | 2021-12-29 | Universitat Pompeu Fabra | Künstliche rnas zur modulation von rna-fragmenten |
MX2023001786A (es) | 2020-08-13 | 2023-03-10 | Amgen Inc | Construcciones de iarn y metodos para inhibir la expresion de marc1. |
WO2022098841A1 (en) | 2020-11-05 | 2022-05-12 | Amgen Inc. | METHODS FOR TREATING ATHEROSCLEROTIC CARDIOVASCULAR DISEASE WITH LPA-TARGETED RNAi CONSTRUCTS |
WO2023278295A1 (en) | 2021-06-29 | 2023-01-05 | The Broad Institute, Inc. | Compositions and methods for ameliorating anterodorsal thalamus hyperexcitability |
CN118556125A (zh) | 2021-10-05 | 2024-08-27 | 美国安进公司 | 用于增强寡核苷酸化合物的基因沉默活性的组合物和方法 |
JP2024539097A (ja) | 2021-10-22 | 2024-10-28 | アムジェン インコーポレイテッド | Gpam発現を阻害するためのrnaiコンストラクト及びその使用方法 |
US20240084301A1 (en) | 2022-07-25 | 2024-03-14 | Amgen Inc. | Rnai constructs and methods for inhibiting fam13a expression |
EP4353823A1 (de) | 2022-10-12 | 2024-04-17 | Resalis Therapeutics S.r.l. | Inhibitoren von mikro-rna 22 |
WO2024130142A2 (en) | 2022-12-16 | 2024-06-20 | Amgen Inc. | Rnai constructs for inhibiting ttr expression and methods of use thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
US5948441A (en) * | 1988-03-07 | 1999-09-07 | The Liposome Company, Inc. | Method for size separation of particles |
US5514788A (en) | 1993-05-17 | 1996-05-07 | Isis Pharmaceuticals, Inc. | Oligonucleotide modulation of cell adhesion |
US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
AU675702B2 (en) * | 1993-01-26 | 1997-02-13 | Leslie R. Coney | Compositions and methods for delivery of genetic material |
EP0800579B1 (de) * | 1994-12-30 | 2002-07-24 | Chiron Corporation | Kombinationsvektoren zum austragen von genmaterial |
KR20140137679A (ko) | 2013-05-23 | 2014-12-03 | 삼성전자주식회사 | 카드 소켓 장치 |
-
1997
- 1997-04-30 US US09/402,507 patent/US6217900B1/en not_active Expired - Fee Related
-
1998
- 1998-04-30 AT AT98920077T patent/ATE446372T1/de not_active IP Right Cessation
- 1998-04-30 BR BRPI9809006-2A patent/BR9809006B1/pt not_active IP Right Cessation
- 1998-04-30 WO PCT/US1998/008799 patent/WO1998048780A1/en not_active Application Discontinuation
- 1998-04-30 AU AU72724/98A patent/AU728115C/en not_active Ceased
- 1998-04-30 CN CN98810484A patent/CN1092045C/zh not_active Expired - Fee Related
- 1998-04-30 JP JP54741798A patent/JP2002508747A/ja active Pending
- 1998-04-30 KR KR1019997009723A patent/KR100554344B1/ko not_active IP Right Cessation
- 1998-04-30 DE DE69841251T patent/DE69841251D1/de not_active Expired - Lifetime
- 1998-04-30 CA CA 2285298 patent/CA2285298C/en not_active Expired - Fee Related
- 1998-04-30 ES ES98920077T patent/ES2333282T3/es not_active Expired - Lifetime
- 1998-04-30 EP EP19980920077 patent/EP0986372B1/de not_active Expired - Lifetime
-
2000
- 2000-04-04 US US09/542,409 patent/US6383512B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6217900B1 (en) | 2001-04-17 |
EP0986372A4 (de) | 2002-06-19 |
AU728115C (en) | 2004-01-22 |
KR100554344B1 (ko) | 2006-02-22 |
WO1998048780A1 (en) | 1998-11-05 |
AU7272498A (en) | 1998-11-24 |
US6383512B1 (en) | 2002-05-07 |
JP2002508747A (ja) | 2002-03-19 |
EP0986372B1 (de) | 2009-10-21 |
DE69841251D1 (de) | 2009-12-03 |
KR20010020161A (ko) | 2001-03-15 |
BR9809006A (pt) | 2000-08-08 |
ES2333282T3 (es) | 2010-02-18 |
CN1092045C (zh) | 2002-10-09 |
AU728115B2 (en) | 2001-01-04 |
BR9809006B1 (pt) | 2010-02-09 |
EP0986372A1 (de) | 2000-03-22 |
CA2285298A1 (en) | 1998-11-05 |
CA2285298C (en) | 2008-12-23 |
CN1277549A (zh) | 2000-12-20 |
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