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ATE440094T1 - Fumagillolderivate und verfahren zu deren herstellung - Google Patents

Fumagillolderivate und verfahren zu deren herstellung

Info

Publication number
ATE440094T1
ATE440094T1 AT02738910T AT02738910T ATE440094T1 AT E440094 T1 ATE440094 T1 AT E440094T1 AT 02738910 T AT02738910 T AT 02738910T AT 02738910 T AT02738910 T AT 02738910T AT E440094 T1 ATE440094 T1 AT E440094T1
Authority
AT
Austria
Prior art keywords
angiogenesis
production
fumagillol derivatives
fumagillol
psoriasis
Prior art date
Application number
AT02738910T
Other languages
English (en)
Inventor
Cheol-Kyu Han
Jeong-Hyeok Yoon
Seung-Moak Kim
Nam-Doo Kim
Byung-Ha Chang
Jee-Young Lee
Tae-Bo Sim
Original Assignee
Equispharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR10-2001-0060017A external-priority patent/KR100455900B1/ko
Priority claimed from KR10-2002-0029915A external-priority patent/KR100483836B1/ko
Application filed by Equispharm Co Ltd filed Critical Equispharm Co Ltd
Application granted granted Critical
Publication of ATE440094T1 publication Critical patent/ATE440094T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
AT02738910T 2001-09-27 2002-06-11 Fumagillolderivate und verfahren zu deren herstellung ATE440094T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2001-0060017A KR100455900B1 (ko) 2001-09-27 2001-09-27 새로운 푸마질롤 유도체 및 그의 제조방법
KR10-2002-0029915A KR100483836B1 (ko) 2002-05-29 2002-05-29 푸마질롤 유도체 및 그의 제조방법
PCT/KR2002/001102 WO2003027104A1 (en) 2001-09-27 2002-06-11 Fumagillol derivatives and preparing method thereof

Publications (1)

Publication Number Publication Date
ATE440094T1 true ATE440094T1 (de) 2009-09-15

Family

ID=26639368

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02738910T ATE440094T1 (de) 2001-09-27 2002-06-11 Fumagillolderivate und verfahren zu deren herstellung

Country Status (5)

Country Link
US (3) US7087768B2 (de)
EP (1) EP1436286B1 (de)
AT (1) ATE440094T1 (de)
DE (1) DE60233420D1 (de)
WO (1) WO2003027104A1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE440094T1 (de) * 2001-09-27 2009-09-15 Equispharm Co Ltd Fumagillolderivate und verfahren zu deren herstellung
KR100552043B1 (ko) * 2004-02-28 2006-02-20 주식회사종근당 푸마질롤 유도체를 포함하는 비만치료용 조성물
US20100056623A1 (en) * 2005-01-26 2010-03-04 Chong Kun Dang Pharmaceutical Corp. Fumagillol derivatives or method for preparation of fumagillol derivatives, and pharmaceutical compositions comprising the same
AU2008268262C1 (en) 2007-06-26 2015-02-19 Children's Medical Center Corporation MetAP-2 inhibitor polymersomes for therapeutic administration
NZ585547A (en) * 2007-11-28 2012-12-21 Mersana Therapeutics Inc Biocompatible biodegradable fumagillin analog conjugates
EP2317845A4 (de) 2008-07-18 2011-11-09 Zafgen Inc Verfahren zur behandlung einer übergewichtigen oder fettleibigen person
WO2010065883A2 (en) 2008-12-04 2010-06-10 Zafgen Corporation Method of treating an overweight or obese subject
US20120004162A1 (en) 2008-12-04 2012-01-05 Vath James E Methods of Treating an Overweight or Obese Subject
MX337575B (es) 2009-10-09 2016-03-10 Zafgen Corp Compuestos de sulfona y métodos para lafabricación y uso de éstos.
WO2011085201A1 (en) 2010-01-08 2011-07-14 Zafgen Corporation Fumagillol type compounds and methods of making and using same
US8815309B2 (en) 2010-01-08 2014-08-26 Zafgen, Inc. Methods of treating a subject with benign prostate hyperplasia
US20130266578A1 (en) 2010-04-07 2013-10-10 Thomas E. Hughes Methods of treating an overweight subject
US9895449B2 (en) 2010-05-25 2018-02-20 Syndevrx, Inc. Polymer-conjugated MetAP2 inhibitors, and therapeutic methods of use thereof
DK2576638T3 (da) 2010-05-25 2021-03-15 Syndevrx Inc Polymerkonjugerede metap2-inhibitorer og terapeutiske fremgangsmåder til anvendelse deraf
EP2595988B1 (de) 2010-07-22 2014-12-17 Zafgen, Inc. Tricyclische verbindungen und verfahren zu ihrer herstellung
UA111479C2 (uk) 2010-11-09 2016-05-10 Зафджен, Інк. Кристалічні форми інгібітору metap-2 та способи їх отримання і застосування
US9173865B2 (en) 2010-11-29 2015-11-03 Zafgen, Inc. Treatment of obesity using non-daily administration of 6-O-(4-dimethylaminoethoxy) cinnamoyl fumagillol
CA2825408A1 (en) 2011-01-26 2012-08-02 Zafgen, Inc. Tetrazole compounds and methods of making and using same
JP5876513B2 (ja) 2011-03-08 2016-03-02 ザフゲン，インコーポレイテッド オキサスピロ［２．５］オクタン誘導体および類似体
FR2973376B1 (fr) * 2011-03-28 2013-05-10 Atlanthera Derives utiles dans le traitement ou la prevention de tumeurs osseuses
BR112013028666A2 (pt) 2011-05-06 2017-08-08 Zafgen Inc compostos de pirazolo sulfonamida tricícilos e métodos para fazer e usar o mesmo
WO2012154678A1 (en) 2011-05-06 2012-11-15 Zafgen Corporation Tricyclic sulfonamide compounds and methods of making and using same
JP6062423B2 (ja) 2011-05-06 2017-01-18 ザフゲン，インコーポレイテッド 部分飽和三環式化合物ならびにその製造および使用方法
EP2763671A2 (de) * 2011-10-03 2014-08-13 Zafgen, Inc. Verfahren zur behandlung von altersbedingten erkrankungen
JP2015509102A (ja) 2012-01-18 2015-03-26 ザフゲン，インコーポレイテッド 三環式スルホン化合物並びにその作製および使用方法
CA2861390A1 (en) 2012-01-18 2013-07-25 Zafgen, Inc. Tricyclic sulfonamide compounds and methods of making and using same
KR20150016303A (ko) 2012-05-07 2015-02-11 자프겐 인크. 6-o-(4-디메틸아미노에톡시) 신나모일 푸마지롤의 옥살레이트 염의 다형체 염 및 이의 제조 및 사용 방법
KR20150013222A (ko) 2012-05-08 2015-02-04 자프겐 인크. Metap2 저해제를 이용한 시상하부 비만의 치료
CN104364251B (zh) 2012-05-09 2017-02-22 扎夫根股份有限公司 烟曲霉醇型化合物及其制备和使用方法
JP2015536981A (ja) 2012-11-05 2015-12-24 ザフゲン，インコーポレイテッド 三環式化合物ならびにその製造および使用方法
NZ707773A (en) 2012-11-05 2019-05-31 Zafgen Inc Methods of treating liver diseases
AU2013337288A1 (en) 2012-11-05 2015-05-21 Zafgen, Inc. Tricyclic compounds for use in the treatment and/or control of obesity
KR20150126924A (ko) 2013-03-14 2015-11-13 자프겐 인크. 신장 질환 및 기타 장애의 치료 방법
CN112494476A (zh) 2013-04-10 2021-03-16 新德发制药有限公司 用于治疗肥胖症的化合物的用途
TW201636342A (zh) 2014-12-19 2016-10-16 武田藥品工業有限公司 煙黴醇衍生物
AR105671A1 (es) 2015-08-11 2017-10-25 Zafgen Inc Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso
CN106432255A (zh) 2015-08-11 2017-02-22 扎夫根公司 烟曲霉素醇螺环化合物和制备和使用其的方法
CA3005450A1 (en) 2015-12-10 2017-06-15 Syndevrx, Inc. Fumagillol derivatives and polymorphs thereof
EP3402529A1 (de) 2016-01-11 2018-11-21 Syndevrx, Inc. Behandlung von durch stoffwechselstörungen hervorgerufen tumoren
WO2020087077A1 (en) 2018-10-26 2020-04-30 Syndevrx,Inc. Biomarkers of metap2 inhibitors and applications thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5164410A (en) * 1988-01-09 1992-11-17 Takeda Chemical Industries, Ltd. Fumagillol derivatives and pharmaceutical compositions thereof
EP0357061B1 (de) * 1988-09-01 1994-06-08 Takeda Chemical Industries, Ltd. Angiogenese hemmendes Mittel
US5166172A (en) * 1988-09-01 1992-11-24 Takeda Chemical Industries, Ltd. Fumagillol derivatives and pharmaceutical compositions thereof
US5180738A (en) * 1988-09-01 1993-01-19 Takeda Chemical Industries Fumagillol derivatives and pharmaceutical compositions thereof
EP0682020A1 (de) * 1988-09-01 1995-11-15 Takeda Chemical Industries, Ltd. Fumagillolderivate verwendbar als Angiogeneseinhibitoren
EP0387650B1 (de) * 1989-03-06 1993-03-31 Takeda Chemical Industries, Ltd. 6-Epifumagillole, ihre Herstellung und ihre Verwendung
US5290807A (en) * 1989-08-10 1994-03-01 Children's Medical Center Corporation Method for regressing angiogenesis using o-substituted fumagillol derivatives
EP0415294A3 (en) * 1989-08-31 1991-06-12 Takeda Chemical Industries, Ltd. Cyclohexanol derivatives, production and use thereof
TW282399B (de) 1990-05-25 1996-08-01 Takeda Pharm Industry Co Ltd
EP0799616A1 (de) * 1996-04-01 1997-10-08 Takeda Chemical Industries, Ltd. Orale Zubereitung enthaltend ein Fumagillolderivat
DE19653036A1 (de) 1996-12-19 1998-06-25 Merck Patent Gmbh Cyclopeptidderivate
WO1998056372A1 (en) * 1997-06-09 1998-12-17 Massachusetts Institute Of Technology TYPE 2 METHIONINE AMINOPEPTIDASE (MetAP2) INHIBITORS AND USES THEROF
KR100357541B1 (ko) * 1998-05-15 2002-10-18 주식회사종근당 5-데메톡시 푸마질롤 유도체 및 그 제조방법
OA12046A (en) 1999-08-12 2006-05-02 Pharmacia Italia Spa 3(5)-Amino-pyrazole derivatives, process for theirpreparation and their use as antitumor agents.
US6114365A (en) 1999-08-12 2000-09-05 Pharmacia & Upjohn S.P.A. Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents
US6458810B1 (en) 2000-11-14 2002-10-01 George Muller Pharmaceutically active isoindoline derivatives
ATE440094T1 (de) * 2001-09-27 2009-09-15 Equispharm Co Ltd Fumagillolderivate und verfahren zu deren herstellung
WO2003037330A1 (en) 2001-11-02 2003-05-08 Pfizer Products Inc. Sulfonyl-and sulfonylheteroaryl-pyrazoles with a hydrazinyl or nitrogen oxide substituent at the 5-position for use as cyclooxygenase inhibitors

Also Published As

Publication number Publication date
EP1436286A1 (de) 2004-07-14
US20070149613A1 (en) 2007-06-28
US20060276512A1 (en) 2006-12-07
EP1436286B1 (de) 2009-08-19
WO2003027104A1 (en) 2003-04-03
US20040242681A1 (en) 2004-12-02
EP1436286A4 (de) 2004-12-15
DE60233420D1 (de) 2009-10-01
US7087768B2 (en) 2006-08-08

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties