ATE332127T1 - Verwendung von kreatin oder kreatinanologen zur behandlung von huntington chorea, morbus parkinson und amyotrophen lateralsklerose - Google Patents
Verwendung von kreatin oder kreatinanologen zur behandlung von huntington chorea, morbus parkinson und amyotrophen lateralskleroseInfo
- Publication number
- ATE332127T1 ATE332127T1 AT95939858T AT95939858T ATE332127T1 AT E332127 T1 ATE332127 T1 AT E332127T1 AT 95939858 T AT95939858 T AT 95939858T AT 95939858 T AT95939858 T AT 95939858T AT E332127 T1 ATE332127 T1 AT E332127T1
- Authority
- AT
- Austria
- Prior art keywords
- creatine
- analogs
- disease
- compounds
- diseases
- Prior art date
Links
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 title abstract 14
- 229960003624 creatine Drugs 0.000 title abstract 5
- 239000006046 creatine Substances 0.000 title abstract 5
- 208000023105 Huntington disease Diseases 0.000 title abstract 2
- 208000018737 Parkinson disease Diseases 0.000 title abstract 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 title 1
- DRBBFCLWYRJSJZ-UHFFFAOYSA-N N-phosphocreatine Chemical compound OC(=O)CN(C)C(=N)NP(O)(O)=O DRBBFCLWYRJSJZ-UHFFFAOYSA-N 0.000 abstract 5
- 102000004420 Creatine Kinase Human genes 0.000 abstract 3
- 108010042126 Creatine kinase Proteins 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- AMHZIUVRYRVYBA-UHFFFAOYSA-N 2-(2-amino-4,5-dihydroimidazol-1-yl)acetic acid Chemical compound NC1=NCCN1CC(O)=O AMHZIUVRYRVYBA-UHFFFAOYSA-N 0.000 abstract 2
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 abstract 2
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 210000000653 nervous system Anatomy 0.000 abstract 2
- 239000000758 substrate Substances 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000016192 Demyelinating disease Diseases 0.000 abstract 1
- 206010012305 Demyelination Diseases 0.000 abstract 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 abstract 1
- 206010067601 Dysmyelination Diseases 0.000 abstract 1
- 208000026072 Motor neurone disease Diseases 0.000 abstract 1
- 208000028389 Nerve injury Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 206010067722 Toxic neuropathy Diseases 0.000 abstract 1
- 231100000126 Toxic neuropathy Toxicity 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 cyclocreatine Chemical compound 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000002427 irreversible effect Effects 0.000 abstract 1
- 230000003278 mimic effect Effects 0.000 abstract 1
- 208000012268 mitochondrial disease Diseases 0.000 abstract 1
- 208000005264 motor neuron disease Diseases 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 230000008764 nerve damage Effects 0.000 abstract 1
- 208000027232 peripheral nervous system disease Diseases 0.000 abstract 1
- 230000002441 reversible effect Effects 0.000 abstract 1
- 230000000472 traumatic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/664—Amides of phosphorus acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33638894A | 1994-11-08 | 1994-11-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE332127T1 true ATE332127T1 (de) | 2006-07-15 |
Family
ID=23315864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95939858T ATE332127T1 (de) | 1994-11-08 | 1995-11-07 | Verwendung von kreatin oder kreatinanologen zur behandlung von huntington chorea, morbus parkinson und amyotrophen lateralsklerose |
Country Status (8)
Country | Link |
---|---|
US (5) | US6706764B2 (de) |
EP (3) | EP0804183B1 (de) |
AT (1) | ATE332127T1 (de) |
AU (1) | AU4151996A (de) |
CA (1) | CA2235350C (de) |
DE (1) | DE69535104T2 (de) |
ES (1) | ES2268696T3 (de) |
WO (1) | WO1996014063A1 (de) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE332127T1 (de) * | 1994-11-08 | 2006-07-15 | Avicena Group Inc | Verwendung von kreatin oder kreatinanologen zur behandlung von huntington chorea, morbus parkinson und amyotrophen lateralsklerose |
CH688760A5 (de) * | 1995-04-28 | 1998-03-13 | Synergen Ag | Topisches Praeparat zur Foerderung des Muskelaufbaus. |
DE19537494C2 (de) * | 1995-09-25 | 1997-10-02 | Desitin Arzneimittel Gmbh | Kreatin zum Schutz von neuralem Gewebe |
GB9611356D0 (en) * | 1996-05-31 | 1996-08-07 | Howard Alan N | Improvements in or relating to compositions containing Creatine, and other ergogenic compounds |
US7150880B2 (en) | 1996-05-31 | 2006-12-19 | The Original Creatine Patent Co. Ltd. | Compositions containing creatine and creatinine and a methyl xanthine |
US6168802B1 (en) | 1996-05-31 | 2001-01-02 | The Howard Foundation | Compositions containing creatine and aloe vera extract |
US8128955B2 (en) | 1996-05-31 | 2012-03-06 | The Original Creatine Patent Company | Food compositions containing creatine |
US6274161B1 (en) | 1996-05-31 | 2001-08-14 | The Howard Foundation | Compositions containing creatine in suspension |
US6524611B2 (en) | 1996-05-31 | 2003-02-25 | The Howard Foundation | Compositions containing creatine and creatinine |
US20060128671A1 (en) * | 1998-04-02 | 2006-06-15 | The General Hospital Corporation | Compositions containing a combination of a creatine compound and a second agent |
JP2002510604A (ja) * | 1998-04-02 | 2002-04-09 | アビセナ グループ, インク. | クレアチン化合物及び第二物質の組み合わせを含む組成 |
ES2198067T3 (es) * | 1998-07-28 | 2004-01-16 | Synthes Ag Chur | Utilizacion de compuestos a base de creatina para tratar las celulas y los tejidos oseos y cartilaginosos. |
US7915233B1 (en) | 1998-08-31 | 2011-03-29 | Wellstat Therapeutics Corporation | Compositions and methods for treatment of mitochondrial diseases |
US6472378B2 (en) | 1998-08-31 | 2002-10-29 | Pro-Neuron, Inc. | Compositions and methods for treatment of mitochondrial diseases |
US7807654B2 (en) | 1998-08-31 | 2010-10-05 | Wellstat Therapeutics Corporation | Compositions and methods for treatment of mitochondrial diseases |
US6242491B1 (en) | 1999-06-25 | 2001-06-05 | Rima Kaddurah-Daouk | Use of creatine or creatine compounds for skin preservation |
WO2001003325A2 (de) * | 1999-06-30 | 2001-01-11 | Skw Trostberg Aktiengesellschaft | Verwendung von kreatin und/oder kreatin-derivaten zur behandlung von befindlichkeitsstörungen bei frauen |
DE19929995B4 (de) | 1999-06-30 | 2004-06-03 | Skw Trostberg Ag | Verwendung von Kreatin und/oder Kreatin-Derivaten zur Behandlung von Befindlichkeitsstörungen bei Frauen |
ES2425114T3 (es) * | 2000-03-16 | 2013-10-11 | The Mclean Hospital Corporation | CDP-colina y uridina para el tratamiento del abuso del acohol |
DK1292294T3 (da) | 2000-05-01 | 2009-06-22 | Accera Inc | Anvendelse af mediumkæde-triglycerider til behandling og forebyggelse af Alzheimers sygdom |
US6835750B1 (en) | 2000-05-01 | 2004-12-28 | Accera, Inc. | Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II |
EP1567180A4 (de) * | 2002-06-04 | 2010-03-10 | Avicena Group Inc | Verfahren zur behandlung von kognitiver dysfunktion durch modulierung des energiestoffwechsels im gehirn |
WO2005077040A2 (en) * | 2004-02-11 | 2005-08-25 | Rensselaer Polytechnic Institute | Compositions and methods for treating amyotrophic lateral sclerosis (als) |
EP1781094B1 (de) * | 2004-07-07 | 2016-04-27 | Kampavata AB | Transgenes nichtmenschliches tier für den einsatz als forschungsmodelle für die morbus-parkinson-forschung |
WO2006020703A1 (en) * | 2004-08-11 | 2006-02-23 | The Mclean Hospital Corporation | Compounds for the treatment of marihuana dependence, withdrawal, and usage |
US20060052448A1 (en) * | 2004-09-04 | 2006-03-09 | Mr. Stanley Antosh | Use of methyl pyruvate or methyl pyruvic acid for the treatment of diseases of the nervous system and for protecting a human central nervous system against neuronal degeneration caused by defective intracellular energy production. |
US7858599B2 (en) * | 2005-12-30 | 2010-12-28 | Hander Robert W | Enhancement of urogenital function |
DK2500017T3 (da) | 2006-04-03 | 2017-11-06 | Accera Inc | Anvendelse af ketogene forbindelser til behandling af aldersrelateret hukommelsessvækkelse |
EP2023718A4 (de) * | 2006-05-11 | 2010-04-21 | Avicena Group Inc | Kreatinligandverbindungen und anwendungsverfahren dafür |
AU2007249847A1 (en) * | 2006-05-11 | 2007-11-22 | Avicena Group, Inc. | Methods of treating a neurological disorder with creatine monohydrate |
US20070281995A1 (en) * | 2006-06-06 | 2007-12-06 | Xenoport, Inc. | Creatine analog prodrugs, compositions and uses thereof |
US20070281909A1 (en) * | 2006-06-06 | 2007-12-06 | Xenoport, Inc. | Creatine phosphate prodrugs, compositions and uses thereof |
US20070281983A1 (en) * | 2006-06-06 | 2007-12-06 | Xenoport, Inc. | Creatine analog prodrugs, compositions and uses thereof |
US7683043B2 (en) * | 2006-06-06 | 2010-03-23 | Xenoport, Inc. | Creatine phosphate analog prodrugs, compositions and uses thereof |
WO2007146088A1 (en) * | 2006-06-06 | 2007-12-21 | Xenoport, Inc. | Salicyl alcohol creatine phosphate prodrugs, compositions and uses thereof |
DE102007004781A1 (de) * | 2007-01-31 | 2008-08-07 | Alzchem Trostberg Gmbh | Verwendung von Guanidinoessigsäure(-Salzen) zur Herstellung eines gesundheitsfördernden Mittels |
US20090005450A1 (en) * | 2007-04-09 | 2009-01-01 | Belinda Tsao Nivaggioli | Use of creatine compounds for the treatment of eye disorders |
WO2008137137A1 (en) * | 2007-05-03 | 2008-11-13 | Avicena Group, Inc. | Creatine ascorbyl derivatives and methods of use thereof |
DE102007030495A1 (de) | 2007-06-30 | 2009-01-15 | Alzchem Trostberg Gmbh | Verwendung einer eine Kreatin-Komponente enthaltende Zusammensetzung zur Verbesserung der Gedächtnisleistung, der Merkfähigkeit, des Langzeitgedächtnisses und zur Vorbeugung geistiger Ermüdungszustände |
AU2008282130B2 (en) | 2007-07-31 | 2014-08-21 | Cerecin Inc. | Use of genomic testing and ketogenic compounds for treatment of reduced cognitive function |
EP2197890A1 (de) * | 2007-09-07 | 2010-06-23 | Gencia Corporation | Mitochondriale zusammensetzungen und anwendungen davon |
DE102007053369A1 (de) | 2007-11-09 | 2009-07-02 | Alzchem Trostberg Gmbh | Verwendung einer eine Kreatin-Komponente enthaltende Zusammensetzung zur Verbesserung der männlichen Fruchtbarkeit |
DE102007062288A1 (de) | 2007-12-21 | 2009-06-25 | Alzchem Trostberg Gmbh | Kreatin-Zubereitung und Verfahren zu deren Herstellung |
US8105809B2 (en) | 2008-07-03 | 2012-01-31 | Accera, Inc. | Enzymatic synthesis of acetoacetate esters and derivatives |
JP5674652B2 (ja) | 2008-07-03 | 2015-02-25 | アクセラ・インコーポレーテッド | 神経障害の処置のためのアセトアセテートのモノグリセリドおよび誘導体 |
US20100041621A1 (en) * | 2008-08-15 | 2010-02-18 | Perry Renshaw | Methods and compositions for improving cognitive performance |
EP2269980A4 (de) | 2008-12-24 | 2011-05-18 | Vertex Closed Joint Stock Company | Creatinamide, verfahren zu ihrer herstellung und wirkstoff zur ausführung einer neuroprotektiven aktion |
US20100215707A1 (en) * | 2009-02-25 | 2010-08-26 | Mcdonald Thomas | Activated creatinine and precursors thereof as antibacterial agents, compositions and products containing such agents and uses thereof |
WO2010115291A1 (en) | 2009-04-06 | 2010-10-14 | Moeddel Michael | Hemodialysis and peritoneal dialysis solutions comprising one or more creatine compounds |
RU2428414C2 (ru) | 2009-11-03 | 2011-09-10 | Закрытое Акционерное Общество "Вертекс" | Способ получения амидов креатина |
US20130243847A1 (en) * | 2010-02-24 | 2013-09-19 | Board Of Regents Of The University Of Nebraska | Activated creatinine and precursors thereof as antibacterial agents, compositions and products containing such agents and use thereof |
US20130281410A1 (en) * | 2010-05-13 | 2013-10-24 | University Of Utah Research Foundation | Methods for the treatment of psychiatric disorders |
DE102011008016A1 (de) * | 2011-01-06 | 2012-07-12 | Johannes F. Coy | Schokoladenmasse |
WO2013043580A2 (en) | 2011-09-19 | 2013-03-28 | Gencia Corporation | Modified creatine compounds |
US9233099B2 (en) | 2012-01-11 | 2016-01-12 | University Of Cincinnati | Methods of treating cognitive dysfunction by modulating brain energy metabolism |
JP2015193582A (ja) * | 2014-03-28 | 2015-11-05 | 国立大学法人 東京大学 | イミダゾールジペプチドを含む剤 |
CN107001280A (zh) * | 2014-09-03 | 2017-08-01 | 卢莫斯制药公司 | 环肌酸及其类似物的合成 |
US9617230B2 (en) | 2014-12-22 | 2017-04-11 | Farmington Pharma Development | Creatine prodrugs, compositions and methods of use thereof |
CA2979224A1 (en) | 2015-03-11 | 2016-09-15 | Lumos Pharma, Inc. | Synthesis of cyclocreatine and analogs thereof |
WO2016172148A1 (en) * | 2015-04-20 | 2016-10-27 | Vireo Systems, Inc. | Compositions and methods for neuroprotection and treatment of neurodegeneration |
WO2016176636A1 (en) * | 2015-04-30 | 2016-11-03 | Rgenix, Inc. | Inhibitors of creatine transport and uses thereof |
US20190008812A1 (en) * | 2017-07-07 | 2019-01-10 | Washington University | Methods for treating microglial dysfunction |
BR112020010805B1 (pt) | 2017-12-01 | 2024-01-30 | Ultragenyx Pharmaceutical Inc | Compostos ou sais farmaceuticamente aceitáveis dos mesmos, respectivos usos e composição farmacêutica |
CN108771668B (zh) * | 2018-07-24 | 2019-10-08 | 四川九章生物科技有限公司 | 一种用于治疗肌萎缩性脊髓侧索硬化症的联合用药组合物及其制备方法和用途 |
KR102141737B1 (ko) * | 2018-10-23 | 2020-08-05 | 이화여자대학교 산학협력단 | 크레아틴 및 타우린의 혼합물을 함유하는 우울장애 및 불안장애의 치료용 약학적 조성물 |
Family Cites Families (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE58849B1 (en) * | 1984-12-18 | 1993-11-17 | Gruenenthal Chemie | Use of dipeptide derivatives for the manufacture of medicaments for the treatment of patients with amyotrophic lateral sclerosis |
US4871718A (en) * | 1987-12-29 | 1989-10-03 | Raymond A. Roncari | Composition of matter for increasing intracellular ATP levels and physical performance levels and for increasing the rate of wound repair |
US5324731A (en) * | 1989-02-14 | 1994-06-28 | Amira, Inc. | Method of inhibiting transformation of cells in which purine metabolic enzyme activity is elevated |
CA2046607C (en) * | 1989-02-14 | 2002-04-16 | Rima Kaddurah-Daouk | Inhibiting transformation of cells having elevated purine metabolic enzyme activity |
US5321030A (en) | 1989-02-14 | 1994-06-14 | Amira, Inc. | Creatine analogs having antiviral activity |
US5676978A (en) * | 1989-02-14 | 1997-10-14 | Amira, Inc. | Methods of inhibiting undesirable cell growth using a combination of a cyclocreatine compound and a hyperplastic inhibitory agent |
US5091404A (en) | 1990-10-05 | 1992-02-25 | Elgebaly Salwa A | Method for restoring functionality in muscle tissue |
US5741661A (en) * | 1991-02-08 | 1998-04-21 | Cambridge Neuroscience, Inc. | Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for identifying neurotransmitter release blockers |
PT100115B (pt) * | 1991-02-08 | 1999-06-30 | Cambridge Neuroscience Inc | Guanidinas substituidas e seus derivados uteis como moduladores de libertacao de neurotransmissores e ensaios de rastreio para de bloqueadores de libertacao de neurotransmissores |
WO1994016687A1 (en) | 1993-01-28 | 1994-08-04 | The Trustees Of The University Of Pennsylvania | Use of creatine or analogs for the manufacture of a medicament for inhibiting tumor growth |
WO1994017794A1 (en) * | 1993-02-03 | 1994-08-18 | Steven Andrew Jennings | Blends of glycine derivatives and sugars |
US5492930A (en) * | 1994-04-25 | 1996-02-20 | Schering Corporation | Method and formulation for treating CNS disorders |
ATE332127T1 (de) * | 1994-11-08 | 2006-07-15 | Avicena Group Inc | Verwendung von kreatin oder kreatinanologen zur behandlung von huntington chorea, morbus parkinson und amyotrophen lateralsklerose |
IT1275434B (it) * | 1995-05-19 | 1997-08-07 | Farmila Farma Milano | Composizioni farmaceutiche e/o dietetiche ad attivita' antiossidante |
US5676976A (en) * | 1995-05-19 | 1997-10-14 | Etex Corporation | Synthesis of reactive amorphous calcium phosphates |
ATE239462T1 (de) * | 1995-10-11 | 2003-05-15 | Avicena Group Inc | Verwendung von kreatinanalogen zur behandlung von störungen des glukosemetabolismus |
US5998457A (en) * | 1995-10-26 | 1999-12-07 | Avicena Group, Inc. | Creatine analogues for treatment of obesity |
DE19653225A1 (de) * | 1996-12-20 | 1998-06-25 | Sueddeutsche Kalkstickstoff | Kreatin-pyruvate und Verfahren zu deren Herstellung |
DE19707694A1 (de) * | 1997-02-26 | 1998-08-27 | Sueddeutsche Kalkstickstoff | Kreatin-ascorbate und Verfahren zu deren Herstellung |
US5886040A (en) * | 1997-06-17 | 1999-03-23 | Amt Labs, Inc. | Creatine pyruvate salt with enhanced palatability |
US6465018B1 (en) * | 1997-08-22 | 2002-10-15 | B. David Tuttle | Dietary supplement for increasing energy, strength, and immune function |
US6193973B1 (en) * | 1997-08-22 | 2001-02-27 | B. David Tuttle | Dietary supplement for boosting energy and increasing muscular strength |
EP1032403B1 (de) * | 1997-10-24 | 2012-05-02 | John P. Blass | Nahrungsergänzungsmittel für metabolische hirnleistungsstörungen |
US20060128671A1 (en) * | 1998-04-02 | 2006-06-15 | The General Hospital Corporation | Compositions containing a combination of a creatine compound and a second agent |
JP2002510604A (ja) * | 1998-04-02 | 2002-04-09 | アビセナ グループ, インク. | クレアチン化合物及び第二物質の組み合わせを含む組成 |
US6169115B1 (en) * | 1998-05-22 | 2001-01-02 | Rima Kaddurah-Daouk | Use of aminoguanidine analogs for the treatment of diseases of the nervous system |
US6288124B1 (en) * | 1998-05-22 | 2001-09-11 | Rima Kaddurah-Daouk | Methods of inhibiting undesirable cell growth using an aminoguanidine compound |
US20030013633A1 (en) * | 1999-06-07 | 2003-01-16 | Rima Kaddurah-Daouk | Use of molecules that modulate an energy related associated state |
AU5636300A (en) * | 1999-06-25 | 2001-01-31 | Avicena Group, Inc. | Use of creatine or creatine analogs for the prevention and treatment of transmissible spongiform encephalopathies |
US6242491B1 (en) * | 1999-06-25 | 2001-06-05 | Rima Kaddurah-Daouk | Use of creatine or creatine compounds for skin preservation |
DE19929995B4 (de) * | 1999-06-30 | 2004-06-03 | Skw Trostberg Ag | Verwendung von Kreatin und/oder Kreatin-Derivaten zur Behandlung von Befindlichkeitsstörungen bei Frauen |
DE10032964B4 (de) * | 2000-07-06 | 2017-10-12 | Beiersdorf Ag | Verwendung von Kreatin in kosmetischen oder dermatologischen Zubereitungen |
DE10065478C1 (de) * | 2000-12-28 | 2002-08-29 | Sueddeutsche Kalkstickstoff | Kreatin/Citronensäure-Verbindung, Verfahren zu ihrer Herstellung und Verwendung |
DE10106288A1 (de) * | 2001-02-02 | 2002-09-05 | Coty Bv | Revitalisierender Wirkkomplex für die Haut |
DE10133198A1 (de) * | 2001-07-07 | 2003-01-23 | Beiersdorf Ag | Kreatin enthaltende kosmetische und dermatologische Zubereitungen zur Behandlung und aktiven Prävention trockener Haut und anderer negativer Veränderungen der physiologischen Homöostase der gesunden Haut |
DE10136077A1 (de) * | 2001-07-25 | 2003-02-13 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitungen mit einer Kombination von Kreatinin und/oder Kreatininderivaten mit Kreatin und/oder seinen Derivaten |
US6588124B2 (en) * | 2001-08-13 | 2003-07-08 | Ballet Makers, Inc. | Ballet shoe sole with gusset |
US7608258B2 (en) * | 2002-04-13 | 2009-10-27 | Allan Mishra | Method for treatment of tendinosis using platelet rich plasma |
EP1567180A4 (de) * | 2002-06-04 | 2010-03-10 | Avicena Group Inc | Verfahren zur behandlung von kognitiver dysfunktion durch modulierung des energiestoffwechsels im gehirn |
DE10301632A1 (de) * | 2003-01-17 | 2004-07-29 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitungen mit einem Gehalt an Kreatin, Kreatinin und/oder seinen Derivaten in Kombination mit Sojabohnenkeimextrakten |
US7179477B2 (en) * | 2003-08-15 | 2007-02-20 | Shyam K Gupta | Cosmetic dermabrasion treatment system |
DE10355716A1 (de) * | 2003-11-26 | 2005-06-23 | Beiersdorf Ag | Kosmetische Zubereitungen mit einem Gehalt Kreatin und/oder Kreatinderivaten und/oder Kreatinin und/oderKreatininderivaten und organischen Verdickern |
US20060039887A1 (en) * | 2004-08-20 | 2006-02-23 | Infinity2 Health Sciences, Inc. | Cosmetic or pharmaceutical composition for skin care |
-
1995
- 1995-11-07 AT AT95939858T patent/ATE332127T1/de not_active IP Right Cessation
- 1995-11-07 ES ES95939858T patent/ES2268696T3/es not_active Expired - Lifetime
- 1995-11-07 CA CA002235350A patent/CA2235350C/en not_active Expired - Lifetime
- 1995-11-07 EP EP95939858A patent/EP0804183B1/de not_active Revoked
- 1995-11-07 EP EP06011215A patent/EP1719510A1/de not_active Withdrawn
- 1995-11-07 WO PCT/US1995/014567 patent/WO1996014063A1/en active IP Right Grant
- 1995-11-07 DE DE69535104T patent/DE69535104T2/de not_active Expired - Lifetime
- 1995-11-07 AU AU41519/96A patent/AU4151996A/en not_active Abandoned
- 1995-11-07 EP EP10012009A patent/EP2327404A1/de not_active Withdrawn
-
1997
- 1997-05-07 US US08/853,174 patent/US6706764B2/en not_active Expired - Lifetime
-
2003
- 2003-11-21 US US10/718,846 patent/US7285573B2/en not_active Expired - Fee Related
- 2003-11-21 US US10/718,765 patent/US20040102419A1/en not_active Abandoned
-
2007
- 2007-09-04 US US11/899,135 patent/US20080119450A1/en not_active Abandoned
-
2009
- 2009-12-18 US US12/642,484 patent/US20100303840A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US6706764B2 (en) | 2004-03-16 |
EP1719510A1 (de) | 2006-11-08 |
US20040106680A1 (en) | 2004-06-03 |
CA2235350C (en) | 2009-01-06 |
DE69535104T2 (de) | 2007-02-08 |
DE69535104D1 (de) | 2006-08-17 |
US20100303840A1 (en) | 2010-12-02 |
EP0804183A1 (de) | 1997-11-05 |
CA2235350A1 (en) | 1996-05-17 |
WO1996014063A1 (en) | 1996-05-17 |
US20040102419A1 (en) | 2004-05-27 |
EP0804183B1 (de) | 2006-07-05 |
US20080119450A1 (en) | 2008-05-22 |
US7285573B2 (en) | 2007-10-23 |
AU4151996A (en) | 1996-05-31 |
ES2268696T3 (es) | 2007-03-16 |
EP2327404A1 (de) | 2011-06-01 |
US20020161049A1 (en) | 2002-10-31 |
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