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ATE323677T1 - Verfahren zur herstellung von 4-amino-2,5- bisheterocyclylchinazolinen - Google Patents

Verfahren zur herstellung von 4-amino-2,5- bisheterocyclylchinazolinen

Info

Publication number
ATE323677T1
ATE323677T1 AT02745749T AT02745749T ATE323677T1 AT E323677 T1 ATE323677 T1 AT E323677T1 AT 02745749 T AT02745749 T AT 02745749T AT 02745749 T AT02745749 T AT 02745749T AT E323677 T1 ATE323677 T1 AT E323677T1
Authority
AT
Austria
Prior art keywords
bisheterocyclylchinazolines
amino
producing
Prior art date
Application number
AT02745749T
Other languages
English (en)
Inventor
Lee Terence Boulton
Robert James Crook
Alan John Pettman
Robert Walton
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE323677T1 publication Critical patent/ATE323677T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57Nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT02745749T 2001-08-01 2002-07-19 Verfahren zur herstellung von 4-amino-2,5- bisheterocyclylchinazolinen ATE323677T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0118752.5A GB0118752D0 (en) 2001-08-01 2001-08-01 Process for the production of quinazolines

Publications (1)

Publication Number Publication Date
ATE323677T1 true ATE323677T1 (de) 2006-05-15

Family

ID=9919612

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02745749T ATE323677T1 (de) 2001-08-01 2002-07-19 Verfahren zur herstellung von 4-amino-2,5- bisheterocyclylchinazolinen

Country Status (27)

Country Link
US (1) US7026479B2 (de)
EP (1) EP1412331B1 (de)
JP (1) JP2005501054A (de)
KR (1) KR20040019097A (de)
CN (1) CN1533378A (de)
AP (1) AP1299A (de)
AR (1) AR036204A1 (de)
AT (1) ATE323677T1 (de)
BR (1) BR0211670A (de)
CA (1) CA2451075A1 (de)
CZ (1) CZ2004151A3 (de)
DE (1) DE60210778T2 (de)
DO (1) DOP2002000443A (de)
EG (1) EG23204A (de)
ES (1) ES2260457T3 (de)
GB (1) GB0118752D0 (de)
HN (1) HN2002000197A (de)
HU (1) HUP0401573A3 (de)
IL (1) IL158998A0 (de)
MX (1) MXPA04000978A (de)
PA (1) PA8550301A1 (de)
PE (1) PE20030346A1 (de)
PL (1) PL368520A1 (de)
RU (1) RU2261861C1 (de)
UY (1) UY27399A1 (de)
WO (1) WO2003011829A1 (de)
ZA (1) ZA200309043B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4703183B2 (ja) 2002-07-15 2011-06-15 シンフォニー エボルーション, インク. 受容体型キナーゼモジュレーターおよびその使用方法
ES2651730T3 (es) * 2003-09-26 2018-01-29 Exelixis, Inc. Moduladores c-Met y métodos de uso
DK1746999T3 (da) * 2004-05-06 2012-01-23 Warner Lambert Co 4-phenylamino-quinazolin-6-yl-amider
RU2009107688A (ru) * 2006-08-04 2010-09-10 Мерц Фарма Гмбх Унд Ко. Кгаа (De) Пиразолопиримидины, способ их получения и их применение в качестве лекарственного средства
CN102388024A (zh) 2009-01-16 2012-03-21 埃克塞里艾克西斯公司 N-(4-{[6,7-双(甲基氧基)喹啉-4-基]氧基}苯基)-n’-(4-氟苯基)环丙烷-1,1-二甲酰胺的苹果酸盐及其用于癌症治疗的结晶型
MX337352B (es) 2009-03-18 2016-02-29 Resverlogix Corp Nuevos agentes anti-inflamatorios.
IN2012DN00352A (de) * 2009-06-16 2015-08-21 Bikam Pharmaceuticals Inc
UA108618C2 (uk) 2009-08-07 2015-05-25 Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
EP2944628B1 (de) * 2011-11-30 2017-01-04 Bikam Pharmaceuticals, Inc. Opsinbindende liganden, zusammensetzungen und verfahren zur verwendung
NZ707276A (en) * 2012-10-15 2016-02-26 Resverlogix Corp Compounds useful in the synthesis of benzamide compounds
WO2016147053A1 (en) 2015-03-13 2016-09-22 Resverlogix Corp. Compositions and therapeutic methods for the treatment of complement-associated diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8719378D0 (en) * 1987-08-15 1987-09-23 Pfizer Ltd Antiarrythmic agents
EP0894797A4 (de) * 1997-01-09 2001-08-16 Terumo Corp Neue amidderivate und intermediate zu ihrer synthese

Also Published As

Publication number Publication date
PA8550301A1 (es) 2003-09-05
CZ2004151A3 (cs) 2005-01-12
RU2004102692A (ru) 2005-07-10
HUP0401573A2 (hu) 2005-01-28
IL158998A0 (en) 2004-05-12
PL368520A1 (en) 2005-04-04
RU2261861C1 (ru) 2005-10-10
EP1412331B1 (de) 2006-04-19
AR036204A1 (es) 2004-08-18
GB0118752D0 (en) 2001-09-26
UY27399A1 (es) 2003-02-28
US20030100753A1 (en) 2003-05-29
JP2005501054A (ja) 2005-01-13
EP1412331A1 (de) 2004-04-28
MXPA04000978A (es) 2004-04-20
KR20040019097A (ko) 2004-03-04
AP2002002602A0 (en) 2002-09-30
WO2003011829A1 (en) 2003-02-13
DOP2002000443A (es) 2003-02-15
HN2002000197A (es) 2003-02-27
CA2451075A1 (en) 2003-02-13
HUP0401573A3 (en) 2005-06-28
ES2260457T3 (es) 2006-11-01
CN1533378A (zh) 2004-09-29
PE20030346A1 (es) 2003-04-05
DE60210778T2 (de) 2007-01-04
EG23204A (en) 2004-07-31
AP1299A (en) 2004-09-06
ZA200309043B (en) 2004-11-22
BR0211670A (pt) 2004-07-13
DE60210778D1 (de) 2006-05-24
US7026479B2 (en) 2006-04-11

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties