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ATE310018T1 - Modifikationen des vegf-rezeptor-2 proteins und verfahren zu seiner verwendung - Google Patents

Modifikationen des vegf-rezeptor-2 proteins und verfahren zu seiner verwendung

Info

Publication number
ATE310018T1
ATE310018T1 AT99945505T AT99945505T ATE310018T1 AT E310018 T1 ATE310018 T1 AT E310018T1 AT 99945505 T AT99945505 T AT 99945505T AT 99945505 T AT99945505 T AT 99945505T AT E310018 T1 ATE310018 T1 AT E310018T1
Authority
AT
Austria
Prior art keywords
protein
comparable
kinase activity
kid
vitro kinase
Prior art date
Application number
AT99945505T
Other languages
English (en)
Inventor
Michele A Mctigue
Chris Pinko
Camran V Parast
Michael R Gehring
Chen-Chen Kan
Drive Watson
Krzysztof Appelt
John A Wickersham
Richard Edward Showalter
Anna-Maria Tempcyzk-Russell
Barbara Mroczkowski
Jesus Ernesto Villafranca
Original Assignee
Agouron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharma filed Critical Agouron Pharma
Application granted granted Critical
Publication of ATE310018T1 publication Critical patent/ATE310018T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • CCHEMISTRY; METALLURGY
    • C30CRYSTAL GROWTH
    • C30BSINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT99945505T 1998-09-08 1999-09-07 Modifikationen des vegf-rezeptor-2 proteins und verfahren zu seiner verwendung ATE310018T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9950398P 1998-09-08 1998-09-08
PCT/US1999/020319 WO2000014105A1 (en) 1998-09-08 1999-09-07 Modifications of the vegf receptor-2 protein and methods of use

Publications (1)

Publication Number Publication Date
ATE310018T1 true ATE310018T1 (de) 2005-12-15

Family

ID=22275320

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99945505T ATE310018T1 (de) 1998-09-08 1999-09-07 Modifikationen des vegf-rezeptor-2 proteins und verfahren zu seiner verwendung

Country Status (10)

Country Link
US (5) US6316603B1 (de)
EP (1) EP1109823B1 (de)
JP (1) JP2002534058A (de)
KR (1) KR100442221B1 (de)
AT (1) ATE310018T1 (de)
AU (1) AU760008B2 (de)
CA (1) CA2340598A1 (de)
DE (1) DE69928411D1 (de)
ES (1) ES2252972T3 (de)
WO (1) WO2000014105A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69928411D1 (de) * 1998-09-08 2005-12-22 Agouron Pharma Modifikationen des vegf-rezeptor-2 proteins und verfahren zu seiner verwendung
ATE287951T1 (de) * 2000-03-29 2005-02-15 Max Planck Gesellschaft Raumform von tpr-strukturmotiv enthaltenden polypeptiden mit chaperon-bindungsfunktion, deren kristalle und verbindungen zur inhibierung derartiger polypeptide
DE60114196T2 (de) * 2000-06-07 2006-07-20 Ortho-Mcneil Pharmaceutical, Inc. Verfahren zur erkennung von modulatoren der vegf-kinase-domäne
AU2001279090A1 (en) * 2000-08-18 2002-03-04 Agouron Pharmaceuticals, Inc. Heterocyclic-hydroxyimino-fluorenes and their use for inhibiting protein kinases
US7105530B2 (en) 2000-12-21 2006-09-12 Smithkline Beecham Corporation Pyrimidineamines as angiogenesis modulators
AU2003202914A1 (en) * 2002-01-07 2003-07-24 Sequoia Pharmaceuticals Broad spectrum inhibitors
US20040229293A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui Surface receptor complexes as biomarkers
AU2004230700A1 (en) * 2003-04-01 2004-10-28 Monogram Biosciences, Inc. Surface receptor complexes as biomarkers
EP1618133A1 (de) * 2003-04-17 2006-01-25 Pfizer Inc. Kristallstukturen von vegfrkd:ligandkomplexen und verfahren zur deren verwendung
EP1697508A2 (de) * 2003-12-05 2006-09-06 Vertex Pharmaceuticals, Inc. Kristallstruktur der interleukin-2 tyrosin kinase (itk) und bindungsstellen davon
WO2006047505A2 (en) * 2004-10-22 2006-05-04 Janssen Pharmaceutica, N.V. Crystal structure of the c-fms kinase domain
JO3067B1 (ar) 2008-10-27 2017-03-15 Glaxosmithkline Llc بيرميدينات بيرازولو امينو كمثبطات ل fak
AU2023224888A1 (en) * 2022-02-28 2024-09-05 The Board Of Trustees Of The Leland Stanford Junior University Functionalized nanoclusters and their use in treating bacterial infections

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4966849A (en) 1985-09-20 1990-10-30 President And Fellows Of Harvard College CDNA and genes for human angiogenin (angiogenesis factor) and methods of expression
US5217999A (en) 1987-12-24 1993-06-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Styryl compounds which inhibit EGF receptor protein tyrosine kinase
US6043211A (en) * 1988-02-02 2000-03-28 The Regents Of The University Of California Method for inhibiting the activity of a platelet-derived growth factor receptor binding protein
US5326905A (en) 1990-04-02 1994-07-05 Pfizer Inc. Benzylphosphonic acid tyrosine kinase inhibitors
US5302606A (en) 1990-04-16 1994-04-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Styryl-substituted pyridyl compounds which inhibit EGF receptor tyrosine kinase
AU658646B2 (en) 1991-05-10 1995-04-27 Rhone-Poulenc Rorer International (Holdings) Inc. Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
WO1992021660A1 (en) 1991-05-29 1992-12-10 Pfizer, Inc. Tricyclic polyhydroxylic tyrosine kinase inhibitors
CZ283965B6 (cs) 1992-08-06 1998-07-15 Warner-Lambert Company 2-thioindolové, 2-indolinthionové a polysulfidové sloučeniny, 2-selenoindolové, 2-indolinselenonové a selenidové sloučeniny a farmaceutické prostředky na jejich bázi
US5330992A (en) 1992-10-23 1994-07-19 Sterling Winthrop Inc. 1-cyclopropyl-4-pyridyl-quinolinones
DK1975181T3 (da) 1992-10-28 2011-06-06 Genentech Inc Anvendelse af vaskulære endothelcelle-vækstfaktor-antagonister
US6037329A (en) * 1994-03-15 2000-03-14 Selective Genetics, Inc. Compositions containing nucleic acids and ligands for therapeutic treatment
JP2001524828A (ja) 1997-04-25 2001-12-04 コラテラル・セラピューティクス 切断型vegf関連蛋白質
DE69928411D1 (de) * 1998-09-08 2005-12-22 Agouron Pharma Modifikationen des vegf-rezeptor-2 proteins und verfahren zu seiner verwendung
WO2002036785A1 (fr) * 2000-10-30 2002-05-10 Protein Crystal Co., Ltd. Complexes de proteines et leur procede de production

Also Published As

Publication number Publication date
US6849721B2 (en) 2005-02-01
US6794146B2 (en) 2004-09-21
CA2340598A1 (en) 2000-03-16
EP1109823A4 (de) 2003-06-18
ES2252972T3 (es) 2006-05-16
KR20010086386A (ko) 2001-09-10
US20020164641A1 (en) 2002-11-07
US6753416B2 (en) 2004-06-22
US6784285B1 (en) 2004-08-31
AU760008B2 (en) 2003-05-08
AU5809399A (en) 2000-03-27
EP1109823B1 (de) 2005-11-16
KR100442221B1 (ko) 2004-07-30
US20020051965A1 (en) 2002-05-02
WO2000014105A1 (en) 2000-03-16
EP1109823A1 (de) 2001-06-27
US6316603B1 (en) 2001-11-13
DE69928411D1 (de) 2005-12-22
US20020127538A1 (en) 2002-09-12
JP2002534058A (ja) 2002-10-15

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