[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ATE304349T1 - Herstellungsverfahren von submikrometerwirkstoffpartikeln - Google Patents

Herstellungsverfahren von submikrometerwirkstoffpartikeln

Info

Publication number
ATE304349T1
ATE304349T1 AT00984565T AT00984565T ATE304349T1 AT E304349 T1 ATE304349 T1 AT E304349T1 AT 00984565 T AT00984565 T AT 00984565T AT 00984565 T AT00984565 T AT 00984565T AT E304349 T1 ATE304349 T1 AT E304349T1
Authority
AT
Austria
Prior art keywords
droplets
active agent
biologically active
submicron particles
submicrometer
Prior art date
Application number
AT00984565T
Other languages
English (en)
Inventor
Henry R Costantino
Warren E Jaworowicz
Mark A Tracy
Christopher P Beganski
Original Assignee
Alkermes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkermes Inc filed Critical Alkermes Inc
Application granted granted Critical
Publication of ATE304349T1 publication Critical patent/ATE304349T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
AT00984565T 1999-10-21 2000-10-18 Herstellungsverfahren von submikrometerwirkstoffpartikeln ATE304349T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/422,751 US6284283B1 (en) 1999-10-21 1999-10-21 Method of producing sub-micron particles of biologically active agents and uses thereof
PCT/US2000/041308 WO2001028525A2 (en) 1999-10-21 2000-10-18 Method of producing sub-micron particles of biologically active agents

Publications (1)

Publication Number Publication Date
ATE304349T1 true ATE304349T1 (de) 2005-09-15

Family

ID=23676209

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00984565T ATE304349T1 (de) 1999-10-21 2000-10-18 Herstellungsverfahren von submikrometerwirkstoffpartikeln

Country Status (8)

Country Link
US (2) US6284283B1 (de)
EP (1) EP1221943B1 (de)
JP (1) JP2003512316A (de)
AT (1) ATE304349T1 (de)
AU (1) AU761472B2 (de)
CA (1) CA2388653A1 (de)
DE (1) DE60022664D1 (de)
WO (1) WO2001028525A2 (de)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030035845A1 (en) * 1992-06-11 2003-02-20 Zale Stephen E. Composition for sustained release of non-aggregated erythropoietin
US6284283B1 (en) * 1999-10-21 2001-09-04 Alkermes Controlled Therapeutics, Inc. Method of producing sub-micron particles of biologically active agents and uses thereof
IN192188B (de) * 2000-06-16 2004-03-13 Ranbaxy Lab Ltd
US6824822B2 (en) * 2001-08-31 2004-11-30 Alkermes Controlled Therapeutics Inc. Ii Residual solvent extraction method and microparticles produced thereby
EP1399131A2 (de) * 2001-06-08 2004-03-24 Powderject Vaccines, Inc. Sprüh- gefriergetrockneten zubereitungen
WO2003043585A2 (en) * 2001-11-20 2003-05-30 Advanced Inhalation Research, Inc. Improved particulate compositions for pulmonary delivery
WO2003066585A2 (en) * 2002-02-08 2003-08-14 Alkermes Controlled Therapeutics, Inc. Polymer-based compositions for sustained release
US6592852B1 (en) * 2002-04-25 2003-07-15 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Zinc citrate beads in oral compositions
US20040247624A1 (en) * 2003-06-05 2004-12-09 Unger Evan Charles Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility
WO2005058474A1 (en) * 2003-12-19 2005-06-30 Alk-Abelló A/S Cryogranulation and storage method for active pharmaceutical agents
US20050220887A1 (en) * 2004-01-20 2005-10-06 Alkermes Controlled Therapeutics, Inc. Method for milling frozen microparticles
EP2409707B8 (de) 2004-04-15 2015-05-06 Alkermes Pharma Ireland Limited Vorrichtung auf Polymerbasis mit verzögerter Freisetzung
US20060110423A1 (en) * 2004-04-15 2006-05-25 Wright Steven G Polymer-based sustained release device
US7456254B2 (en) * 2004-04-15 2008-11-25 Alkermes, Inc. Polymer-based sustained release device
US20060165667A1 (en) * 2004-12-03 2006-07-27 Case Western Reserve University Novel methods, compositions and devices for inducing neovascularization
US20080213593A1 (en) * 2005-01-21 2008-09-04 President And Fellows Of Harvard College Systems And Methods For Forming Fluidic Droplets Encapsulated In Particles Such As Colloidal Particles
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
US20080075777A1 (en) * 2006-07-31 2008-03-27 Kennedy Michael T Apparatus and methods for preparing solid particles
US7682356B2 (en) 2006-08-09 2010-03-23 Intarcia Therapeutics, Inc. Osmotic delivery systems and piston assemblies for use therein
WO2008118712A1 (en) * 2007-03-22 2008-10-02 Alkermes, Inc. Coacervation process
PL2157967T3 (pl) 2007-04-23 2013-06-28 Intarcia Therapeutics Inc Formulacje zawiesinowe peptydów insulinotropowych i ich zastosowania
US10092524B2 (en) 2008-06-11 2018-10-09 Edge Therapeutics, Inc. Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage
CN101873858B (zh) * 2007-06-11 2016-05-25 R·骆克·麦克唐纳 用于预防脑血管痉挛的药物递送系统
US20080317865A1 (en) * 2007-06-20 2008-12-25 Alkermes, Inc. Quench liquids and washing systems for production of microparticles
US8083162B2 (en) * 2007-08-23 2011-12-27 Liquajet L.L.C. Method for micro-sizing organic, inorganic and engineered compounds
CA2726861C (en) 2008-02-13 2014-05-27 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
KR101695800B1 (ko) 2008-03-05 2017-02-22 사노피 파스퇴르 항원보강제 함유 백신 조성물의 안정화 방법
US8409376B2 (en) * 2008-10-31 2013-04-02 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8793075B2 (en) 2008-10-31 2014-07-29 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8563012B2 (en) 2008-10-31 2013-10-22 The Invention Science Fund I, Llc Compositions and methods for administering compartmentalized frozen particles
US8414356B2 (en) 2008-10-31 2013-04-09 The Invention Science Fund I, Llc Systems, devices, and methods for making or administering frozen particles
US8731841B2 (en) 2008-10-31 2014-05-20 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8721583B2 (en) 2008-10-31 2014-05-13 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US9072688B2 (en) 2008-10-31 2015-07-07 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8762067B2 (en) 2008-10-31 2014-06-24 The Invention Science Fund I, Llc Methods and systems for ablation or abrasion with frozen particles and comparing tissue surface ablation or abrasion data to clinical outcome data
US8784385B2 (en) 2008-10-31 2014-07-22 The Invention Science Fund I, Llc Frozen piercing implements and methods for piercing a substrate
US8551505B2 (en) 2008-10-31 2013-10-08 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8603496B2 (en) 2008-10-31 2013-12-10 The Invention Science Fund I, Llc Compositions and methods for biological remodeling with frozen particle compositions
US9060926B2 (en) 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8545855B2 (en) 2008-10-31 2013-10-01 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US9050070B2 (en) 2008-10-31 2015-06-09 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8551506B2 (en) 2008-10-31 2013-10-08 The Invention Science Fund I, Llc Compositions and methods for administering compartmentalized frozen particles
US8725420B2 (en) 2008-10-31 2014-05-13 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8788211B2 (en) 2008-10-31 2014-07-22 The Invention Science Fund I, Llc Method and system for comparing tissue ablation or abrasion data to data related to administration of a frozen particle composition
US20100111857A1 (en) 2008-10-31 2010-05-06 Boyden Edward S Compositions and methods for surface abrasion with frozen particles
US9060934B2 (en) 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8731840B2 (en) 2008-10-31 2014-05-20 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US9050317B2 (en) 2008-10-31 2015-06-09 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US9060931B2 (en) 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for delivery of frozen particle adhesives
US9056047B2 (en) 2008-10-31 2015-06-16 The Invention Science Fund I, Llc Compositions and methods for delivery of frozen particle adhesives
US9072799B2 (en) 2008-10-31 2015-07-07 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8603495B2 (en) 2008-10-31 2013-12-10 The Invention Science Fund I, Llc Compositions and methods for biological remodeling with frozen particle compositions
CA2749993C (en) * 2009-01-23 2016-12-20 Surmodics Pharmaceuticals, Inc. Continuous double emulsion process for making microparticles
NZ747990A (en) 2009-09-28 2020-06-26 Intarcia Therapeutics Inc Rapid establishment and/or termination of substantial steady-state drug delivery
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
CN105764491A (zh) 2013-12-09 2016-07-13 度瑞公司 药物活性剂复合物、聚合物复合物，以及包括其的组合物和方法
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
CA2987766A1 (en) 2015-06-03 2016-12-08 Intarcia Therapeutics, Inc. Implant placement and removal systems
TWI754643B (zh) 2016-05-16 2022-02-11 美商因塔希亞治療公司 升糖素受體選擇性多肽和彼之使用方法
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
EP3565580B1 (de) 2017-01-03 2024-03-06 i2o Therapeutics, Inc. Kontinuierlicher verabreichung von exenatid und co-verabreichung von acetaminophen, ethinylestradiol oder levonorgestrel
FR3098091B1 (fr) * 2019-07-05 2021-06-04 Genialis Procede de deshydratation de produits liquides, semi-liquides ou pateux comprenant une etape de cryogenie sous pression et une etape de lyophilisation

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3313032A (en) 1966-07-28 1967-04-11 George J Malecki Freeze-drying process and apparatus
US3620776A (en) 1968-06-28 1971-11-16 Nestle Sa Spray drying process
US3928566A (en) 1970-08-14 1975-12-23 Du Pont Lyophilized biological products
SE7512179L (sv) 1974-11-07 1976-05-10 Jacques Guiller Forfaringssett for omvandling av en massa i flytande form till kulor granuler eller andra mindre kroppar i djupfryst form, samt anordning for utovande av forfaringssettet
US4323478A (en) 1977-01-18 1982-04-06 Baxter Travenol Laboratories, Inc. Novel particulate compositions
US4329787A (en) 1980-01-04 1982-05-18 Newton William A Droplet exploding and freezing apparatus and method
US4479363A (en) 1983-02-10 1984-10-30 The Boc Group Plc Freezing a liquid
US4704873A (en) 1985-11-14 1987-11-10 Taiyo Sanso Co., Ltd. Method and apparatus for producing microfine frozen particles
CA1273498A (en) 1986-02-25 1990-09-04 Peter Harrold Gibson Freezing apparatus
EP0266859A1 (de) 1986-10-06 1988-05-11 Taiyo Sanso Co Ltd. Verfahren und Vorrichtung zur Erzeugung von sehr feinkörnigen, gefrorenen Partikeln
US4848094A (en) 1988-04-29 1989-07-18 Union Carbide Corporation Droplet freezing method and apparatus
US5019400A (en) * 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
ATE99546T1 (de) 1989-05-01 1994-01-15 Alkermes Inc Verfahren zur herstellung von kleinen partikeln von biologisch aktiven molekuelen.
JPH089582Y2 (ja) 1990-08-31 1996-03-21 大陽酸素株式会社 凍結粒製造装置
US5656297A (en) 1992-03-12 1997-08-12 Alkermes Controlled Therapeutics, Incorporated Modulated release from biocompatible polymers
US5912015A (en) 1992-03-12 1999-06-15 Alkermes Controlled Therapeutics, Inc. Modulated release from biocompatible polymers
EP0630234B1 (de) 1992-03-12 1997-06-11 Alkermes Controlled Therapeutics, Inc. Acth enthaltende mikrokugeln mit gesteuerter abgabe
US5711968A (en) 1994-07-25 1998-01-27 Alkermes Controlled Therapeutics, Inc. Composition and method for the controlled release of metal cation-stabilized interferon
US5674534A (en) 1992-06-11 1997-10-07 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
JPH07507806A (ja) 1992-06-11 1995-08-31 アルカーメス　コントロールド　セラピューティクス，インコーポレイテッド エリスロポエチン薬物送達システム
IL107120A (en) 1992-09-29 1997-09-30 Boehringer Ingelheim Int Atomising nozzle and filter and spray generating device
EP0674506B1 (de) 1992-12-02 2000-08-23 Alkermes Controlled Therapeutics, Inc. Wachstumhormon enthaltende mikrosphaeren mit kontrollierter freisetzung
US5307640A (en) 1993-01-25 1994-05-03 E. I. Du Pont De Nemours And Company Apparatus and method for producing frozen particles of a liquid
JPH06323712A (ja) 1993-04-20 1994-11-25 E I Du Pont De Nemours & Co 霧化した極低温液滴の閉じ込め帯域を用いて凍結粒子を製造する方法および装置
WO1995022036A1 (en) 1994-02-09 1995-08-17 Kinerton Limited Process for drying a material from solution
US5922253A (en) * 1995-05-18 1999-07-13 Alkermes Controlled Therapeutics, Inc. Production scale method of forming microparticles
AU705968B2 (en) 1995-06-07 1999-06-03 Alkermes Controlled Therapeutics, Inc. Device for releasing aggregation-stabilized, biologically active agent
US5817343A (en) 1996-05-14 1998-10-06 Alkermes, Inc. Method for fabricating polymer-based controlled-release devices
WO2000059476A1 (en) * 1999-04-05 2000-10-12 Pharmaceutical Discovery Corporation Methods for fine powder formation
SE9903236D0 (sv) * 1999-09-10 1999-09-10 Astra Ab Method to obtain microparticles
US6284283B1 (en) * 1999-10-21 2001-09-04 Alkermes Controlled Therapeutics, Inc. Method of producing sub-micron particles of biologically active agents and uses thereof

Also Published As

Publication number Publication date
EP1221943A2 (de) 2002-07-17
CA2388653A1 (en) 2001-04-26
JP2003512316A (ja) 2003-04-02
WO2001028525A2 (en) 2001-04-26
US20020028252A1 (en) 2002-03-07
DE60022664D1 (de) 2005-10-20
US6428815B1 (en) 2002-08-06
AU2116501A (en) 2001-04-30
US6284283B1 (en) 2001-09-04
WO2001028525A3 (en) 2002-05-02
EP1221943B1 (de) 2005-09-14
AU761472B2 (en) 2003-06-05

Similar Documents

Publication Publication Date Title
ATE304349T1 (de) Herstellungsverfahren von submikrometerwirkstoffpartikeln
SE9903236D0 (sv) Method to obtain microparticles
BR0214279A (pt) Composições farmacêuticas em forma particulada
FR2862536B1 (fr) Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques
ES2422757T3 (es) Uso terapéutico de microesferas de ácido nucleico
DK1429731T3 (da) Nanopartikelformuleringer indeholdende insulin
FR2809309B1 (fr) Microspheres a liberation prolongee pour administration injectable
MXPA05003591A (es) Materiales basados en ciclodextrina, composiciones y usos relacionados a los mismos.
BR9808888A (pt) Formas de dosagem e método de melhorar disfunção erétil masculina
AU4859601A (en) Particulate composition
ATE221773T1 (de) Formulierungen mit gesteuerter freisetzung
ES2079389T3 (es) Dispersiones de polimeros liofilizados y su uso para preparar composiciones farmaceuticas de liberacion retardada.
CY1110106T1 (el) Φαρμακοτεχνικες μορφες για την παρατεταμενη απελευθερωση ιντερφερονων και θεραπευτικες εφαρμογες αυτων
DE60103865D1 (de) Arzneizubereitungen und deren herstellungsverfahren
BR0215303A (pt) Formulações farmacêuticas de base aquosa de pró-drogas solúveis em água de propofol
ATE289801T1 (de) Verabreichungssystem für wasserunlösliche arzneistoffe
SE9704400D0 (sv) Porous inorganic particles as carriers for drug substances
CN101653714A (zh) 用静电喷射技术制备的丝蛋白纳米微球及其制备方法和制备装置
SE0000730D0 (sv) Lipid carrier
ATE536882T1 (de) Pharmazeutische formulierungen für die verzögerte freisetzung von interleukonen und ihre therapeutischen anwendungen
ATE444739T1 (de) Polymerzusammensetzung sowie diese enthaltende darreichungsformen
ES2174734B1 (es) Nueva formulacion galenica de paracetamol dispersable y soluble, procedimiento para su preparacion y aplicaciones.
ATE334658T1 (de) Arzneimittel zur verabreichung an schleimhäute
EP1634585A4 (de) Arzneimittel enthaltendes mikroteilchen mit verzögerter freisetzung, verfahren zu seiner herstellung und das mikroteilchen enthaltende zubereitung
KR20000022894A (ko) 생분해성 고분자 미립자형 제제 및 그 제조방법

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties