[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ATE301709T1 - Lipidabkömmlinge von pentaerythritol - Google Patents

Lipidabkömmlinge von pentaerythritol

Info

Publication number
ATE301709T1
ATE301709T1 AT99914333T AT99914333T ATE301709T1 AT E301709 T1 ATE301709 T1 AT E301709T1 AT 99914333 T AT99914333 T AT 99914333T AT 99914333 T AT99914333 T AT 99914333T AT E301709 T1 ATE301709 T1 AT E301709T1
Authority
AT
Austria
Prior art keywords
pentaerythritol
lipid derivatives
useful
lipid
delivery
Prior art date
Application number
AT99914333T
Other languages
English (en)
Inventor
Michael H Nantz
Alfred M Aberle
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of ATE301709T1 publication Critical patent/ATE301709T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
AT99914333T 1998-04-03 1999-04-02 Lipidabkömmlinge von pentaerythritol ATE301709T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/055,021 US6043390A (en) 1998-04-03 1998-04-03 Pentaerythritol lipid derivatives and nucleic-acid complexes
PCT/US1999/007305 WO1999051729A1 (en) 1998-04-03 1999-04-02 Pentaerythritol lipid derivatives

Publications (1)

Publication Number Publication Date
ATE301709T1 true ATE301709T1 (de) 2005-08-15

Family

ID=21995049

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99914333T ATE301709T1 (de) 1998-04-03 1999-04-02 Lipidabkömmlinge von pentaerythritol

Country Status (8)

Country Link
US (2) US6043390A (de)
EP (1) EP1068306B1 (de)
JP (1) JP2002510713A (de)
AT (1) ATE301709T1 (de)
AU (1) AU762354B2 (de)
CA (1) CA2325849A1 (de)
DE (1) DE69926615T2 (de)
WO (1) WO1999051729A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6008202A (en) * 1995-01-23 1999-12-28 University Of Pittsburgh Stable lipid-comprising drug delivery complexes and methods for their production
US5795587A (en) * 1995-01-23 1998-08-18 University Of Pittsburgh Stable lipid-comprising drug delivery complexes and methods for their production
US6043390A (en) 1998-04-03 2000-03-28 The Regents Of The University Of California Pentaerythritol lipid derivatives and nucleic-acid complexes
US20030009013A1 (en) * 1998-12-30 2003-01-09 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2002088318A2 (en) * 2001-04-30 2002-11-07 Targeted Genetics Corporation Lipid-comprising drug delivery complexes and methods for their production
AU2003268041A1 (en) * 2002-05-07 2003-11-11 Emu Unterwasserpumpen Gmbh Driving motor, especially for a pump
WO2003094850A2 (en) 2002-05-09 2003-11-20 Biomira, Inc. Lipid a and other carbohydrate ligand analogs
WO2003101952A2 (en) * 2002-05-31 2003-12-11 The Regents Of The University Of California Polyamine-mediated transfection
WO2003102150A2 (en) * 2002-05-31 2003-12-11 Genteric, Inc. Multi-functional polyamines for delivery of biologically-active polynucleotides
US20040016013A1 (en) * 2002-07-18 2004-01-22 Gonzalo Hortelano Transgenic animals produced using oral administration of a genetic agent coupled to a transporting agent
US20040014698A1 (en) * 2002-07-18 2004-01-22 Gonzalo Hortelano Oral administration of therapeutic agent coupled to transporting agent
US20040014704A1 (en) * 2002-07-18 2004-01-22 Gonzalo Hortelano Oral administration of therapeutic agent coupled to transporting agent induces tolerance
US20050208032A1 (en) * 2004-01-16 2005-09-22 Gonzalo Hortelano Oral administration of therapeutic agent coupled to transporting agent
EP1868571A4 (de) * 2005-03-02 2011-10-26 Univ Northeastern Mitochondriotropische phospholipid-vesikel
WO2007070705A2 (en) * 2005-12-15 2007-06-21 The Trustees Of The University Of Pennsylvania Cationic lipid-mediated vectors
GB0720486D0 (en) * 2007-10-19 2007-11-28 Univ Edinburgh Cationic lipids
BRPI0914474A2 (pt) * 2008-10-30 2015-10-27 St Francis Xavier University composto, uso de um composto, fluido para a produção ou recuperação de petroléo, composição detergente, composição de emulsão
US8853446B2 (en) 2010-11-30 2014-10-07 Green Products & Technologies, L.L.C. Synthetic acid and associated methods
JP2014518841A (ja) 2011-02-24 2014-08-07 オンコシレオン インク. アジュバントを備えたmuc1ベースのグリコリポペプチドワクチン
ES2799409T3 (es) * 2014-08-07 2020-12-17 Takeda Pharmaceuticals Co Lípido catiónico
AR127615A1 (es) * 2021-11-10 2024-02-14 Takeda Pharmaceuticals Co Lípido catiónico

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4529561A (en) * 1978-03-24 1985-07-16 The Regents Of The University Of California Method for producing liposomes in selected size range
US4737323A (en) * 1986-02-13 1988-04-12 Liposome Technology, Inc. Liposome extrusion method
US5264618A (en) * 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5334761A (en) * 1992-08-28 1994-08-02 Life Technologies, Inc. Cationic lipids
RU2143903C1 (ru) * 1993-02-19 2000-01-10 Ниппон Синяку Ко., Лтд. Фармацевтическая композиция, содержащая сополимер нуклеиновой кислоты
US5527928A (en) * 1994-09-30 1996-06-18 Nantz; Michael H. Cationic transport reagents
US5948767A (en) * 1994-12-09 1999-09-07 Genzyme Corporation Cationic amphiphile/DNA complexes
US5910487A (en) * 1994-12-09 1999-06-08 Genzyme Corporation Cationic amphiphiles and plasmids for intracellular delivery of therapeutic molecules
US5939401A (en) * 1994-12-09 1999-08-17 Genzyme Corporation Cationic amphiphile compositions for intracellular delivery of therapeutic molecules
JPH09111660A (ja) * 1995-10-12 1997-04-28 Lion Corp 柔軟仕上げ剤
JP4430135B2 (ja) * 1995-11-30 2010-03-10 バイカル インコーポレイテッド カチオン脂質複合体
US5925628A (en) * 1997-03-31 1999-07-20 Genzyme Corporation Cationic amphiphiles for intracellular delivery of therapeutic molecules
US6043390A (en) 1998-04-03 2000-03-28 The Regents Of The University Of California Pentaerythritol lipid derivatives and nucleic-acid complexes

Also Published As

Publication number Publication date
AU762354B2 (en) 2003-06-26
EP1068306A1 (de) 2001-01-17
DE69926615D1 (de) 2005-09-15
AU3220599A (en) 1999-10-25
EP1068306A4 (de) 2001-05-16
EP1068306B1 (de) 2005-08-10
JP2002510713A (ja) 2002-04-09
US6316421B1 (en) 2001-11-13
DE69926615T2 (de) 2006-05-18
US6043390A (en) 2000-03-28
CA2325849A1 (en) 1999-10-14
WO1999051729A1 (en) 1999-10-14

Similar Documents

Publication Publication Date Title
ATE301709T1 (de) Lipidabkömmlinge von pentaerythritol
WO1998019709A3 (en) Cationic reagents for transfection
ATE178584T1 (de) Kationische lipide
CA2259179A1 (en) Emulsion formulations for hydrophilic active agents
DE69841002D1 (de) Hochwirksame verkapselung von nukleinsäuren in lipidvesikeln
AU3559895A (en) Polyethylene glycol modified ceramide lipids and liposome uses thereof
DE69730218D1 (de) Fusogene liposomen
DK0752997T3 (da) Hidtil ukendte kationiske fosfolipider til transfektion
PT852490E (pt) Formulacoes em emulsao para a entrega de substancias biologicamente activas a celulas
PT975329E (pt) Complexos de lipidos e lipossomas de complexos de platina altamente insoluveis
EP0759694A4 (de) Verfahren zur in-vivo abgabe therapeutischer agenzien mittels liposomen
NO993257D0 (no) N-acylfosfatidyletanolaminformidlet liposomal legemiddelavlevering
ATE322255T1 (de) Polyamid-oligomere
ATE453380T1 (de) Verabreichung von in lipidvesikeln verpackten kleinen hydrophilen molekülen
WO2003102150A3 (en) Multi-functional polyamines for delivery of biologically-active polynucleotides
ES2185418T3 (es) Agentes previstos para tratar tumores, basados en liposomas y que contienen tamoxifeno.
WO1996040627A3 (en) Thiocationic lipids, pharmaceutical compositions and methods of use thereof
DK0740547T3 (da) Liposomer indeholdende deri indkapslede proteiner, fremgangsmåde til deres fremstilling, samt farmaceutiske og kosmetiske p
DE69520231D1 (de) Liposomzubereitungen enthaltend hybrid-interferon
Tiller BINDING OF ACETYLCHOLINESTERASE TO LIPID VESICLES: EFFECT OF MEMBRANE FLUIDITY.
MX9708111A (es) Lipidos cationicos para terapia genica.
TR199701225A2 (xx) Gen terapisi için katyonik lipidler.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1068306

Country of ref document: EP

REN Ceased due to non-payment of the annual fee