ATE399776T1 - Pyrrol-2,5-dithionderivate als modulatoren des liver-x-rezeptors - Google Patents

Pyrrol-2,5-dithionderivate als modulatoren des liver-x-rezeptors

Info

Publication number: ATE399776T1
Authority: AT; Austria
Prior art keywords: pyrrole; modulators; liver; receptor; dithione
Prior art date: 2003-07-11

Application number

AT04749151T

Other languages

English (en)

Inventor

Patrik Holm

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-11

Filing date

2004-07-08

Publication date

2008-07-15

2004-07-08 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2008-07-15 Application granted granted Critical

2008-07-15 Publication of ATE399776T1 publication Critical patent/ATE399776T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)

AT04749151T 2003-07-11 2004-07-08 Pyrrol-2,5-dithionderivate als modulatoren des liver-x-rezeptors ATE399776T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0316237.7A GB0316237D0 (en)	2003-07-11	2003-07-11	Therapeutic agents

Publications (1)

Publication Number	Publication Date
ATE399776T1 true ATE399776T1 (de)	2008-07-15

Family

ID=27741986

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04749151T ATE399776T1 (de)	2003-07-11	2004-07-08	Pyrrol-2,5-dithionderivate als modulatoren des liver-x-rezeptors

Country Status (26)

Country	Link
US (1)	US20060189663A1 (de)
EP (1)	EP1646625B1 (de)
JP (1)	JP2007521313A (de)
KR (1)	KR20060034284A (de)
CN (1)	CN100478340C (de)
AR (1)	AR045720A1 (de)
AT (1)	ATE399776T1 (de)
AU (1)	AU2004256000B2 (de)
BR (1)	BRPI0412479A (de)
CA (1)	CA2532068A1 (de)
CO (1)	CO5640134A2 (de)
DE (1)	DE602004014772D1 (de)
ES (1)	ES2308205T3 (de)
GB (1)	GB0316237D0 (de)
HK (1)	HK1088318A1 (de)
IL (1)	IL172759A0 (de)
IS (1)	IS8291A (de)
MX (1)	MXPA06000447A (de)
NO (1)	NO20060080L (de)
RU (1)	RU2006102129A (de)
SA (1)	SA04250203B1 (de)
TW (1)	TW200507836A (de)
UA (1)	UA82108C2 (de)
UY (1)	UY28407A1 (de)
WO (1)	WO2005005416A1 (de)
ZA (1)	ZA200600229B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE0500055D0 (sv)	2005-01-10	2005-01-10	Astrazeneca Ab	Therapeutic agents 3
JP2008526841A (ja)	2005-01-10	2008-07-24	アストラゼネカアクチボラグ	肝臓ｘ受容体調節因子としてのイソチアゾール−３（２ｈ）−オン１，１−ジオキシドのアニリン系誘導体
SE0500058D0 (sv) *	2005-01-10	2005-01-10	Astrazeneca Ab	Therapeutic agents 5
JP4936476B2 (ja) *	2005-06-28	2012-05-23	第一三共株式会社	Ｌｘｒリガンドの試験方法
ES2528797T3 (es)	2006-08-21	2015-02-12	Genentech, Inc.	Compuestos de aza-benzotiofenilo y métodos de uso
US10004703B2 (en)	2006-10-12	2018-06-26	Biogen Chesapeake Llc	Treatment of alzheimer's disease using compounds that reduce the activity of non-selective CA++ activated ATP-sensitive cation channels regulated by SUR1 channels
US20100056444A1 (en) *	2006-10-12	2010-03-04	Sven Martin Jacobson	Treatment of Alzheimer's Disease Using Compounds that Reduce the Activity of Non Selective Ca Activated ATP- Sensitive Cation Channels Regulated by SUR1 Receptors
US20100143270A1 (en) *	2007-02-21	2010-06-10	University Of Louisville Research Foubdation	Therapeutic cotinine compositions
DK2868315T3 (en)	2007-12-04	2017-09-04	Biogen Chesapeake Llc	IMPROVED FORMULATIONS AND PROCEDURES FOR FREEZING DRYING AND THEREOF, LYOFILATES PREPARED
US20110034560A1 (en) *	2008-01-29	2011-02-10	Sven Jacobson	Liquid formulations of compounds active at sulfonylurea receptors
KR20110029161A (ko)	2008-07-01	2011-03-22	제넨테크, 인크.	Ｍｅｋ 키나제 억제제로서의 비시클릭 헤테로사이클
RU2495028C2 (ru)	2008-07-01	2013-10-10	Дженентек, Инк.	Изоиндолоны и способы их применения
RU2013115395A (ru)	2010-09-07	2014-10-20	СНУ Ар энд ДиБи ФАУНДЕЙШН	Сестертерпеновое соединение и его применение
WO2015106164A1 (en)	2014-01-10	2015-07-16	Rgenix, Inc.	Lxr agonists and uses thereof
US11648220B2 (en)	2016-01-11	2023-05-16	The Rockefeller University	Methods for the treatment of myeloid derived suppressor cells related disorders
US11214536B2 (en)	2017-11-21	2022-01-04	Inspirna, Inc.	Polymorphs and uses thereof
KR200492570Y1 (ko)	2018-12-04	2020-11-05	박규환	조립식 계단장치를 위한 발판
EP4073025B1 (de)	2019-12-13	2024-03-27	Inspirna, Inc.	Metallsalze und verwendungen davon

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2234300T3 (es) *	1998-10-08	2005-06-16	Smithkline Beecham Plc	3-(3-cloro-4-hidroxifenilamino)-4-(2-nitrofenil)-1h-pirrol-2,5-diona como inhibidor de glucogeno cinasa-3 (gsk-3)sintetasa.
EP1212065A4 (de) *	1999-07-08	2004-02-11	Tularik Inc	Zusammenstellungen und methoden zur erhöhung des hdl cholesterolspiegels

2003
- 2003-07-11 GB GBGB0316237.7A patent/GB0316237D0/en not_active Ceased
2004
- 2004-06-29 TW TW093119119A patent/TW200507836A/zh unknown
- 2004-07-05 SA SA4250203A patent/SA04250203B1/ar unknown
- 2004-07-08 CN CNB2004800197194A patent/CN100478340C/zh not_active Expired - Fee Related
- 2004-07-08 EP EP04749151A patent/EP1646625B1/de not_active Expired - Lifetime
- 2004-07-08 KR KR1020067000616A patent/KR20060034284A/ko not_active Application Discontinuation
- 2004-07-08 DE DE602004014772T patent/DE602004014772D1/de not_active Expired - Fee Related
- 2004-07-08 US US10/563,676 patent/US20060189663A1/en not_active Abandoned
- 2004-07-08 AR ARP040102418A patent/AR045720A1/es not_active Application Discontinuation
- 2004-07-08 WO PCT/SE2004/001115 patent/WO2005005416A1/en active IP Right Grant
- 2004-07-08 AT AT04749151T patent/ATE399776T1/de not_active IP Right Cessation
- 2004-07-08 RU RU2006102129/04A patent/RU2006102129A/ru not_active Application Discontinuation
- 2004-07-08 BR BRPI0412479-0A patent/BRPI0412479A/pt not_active IP Right Cessation
- 2004-07-08 MX MXPA06000447A patent/MXPA06000447A/es not_active Application Discontinuation
- 2004-07-08 CA CA002532068A patent/CA2532068A1/en not_active Abandoned
- 2004-07-08 JP JP2006520139A patent/JP2007521313A/ja not_active Withdrawn
- 2004-07-08 AU AU2004256000A patent/AU2004256000B2/en not_active Ceased
- 2004-07-08 ES ES04749151T patent/ES2308205T3/es not_active Expired - Lifetime
- 2004-07-09 UY UY28407A patent/UY28407A1/es unknown
- 2004-08-07 UA UAA200600270A patent/UA82108C2/uk unknown
2005
- 2005-12-22 IL IL172759A patent/IL172759A0/en unknown
2006
- 2006-01-05 NO NO20060080A patent/NO20060080L/no not_active Application Discontinuation
- 2006-01-10 ZA ZA200600229A patent/ZA200600229B/xx unknown
- 2006-01-20 CO CO06005238A patent/CO5640134A2/es not_active Application Discontinuation
- 2006-02-09 IS IS8291A patent/IS8291A/is unknown
- 2006-08-07 HK HK06108722.2A patent/HK1088318A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
RU2006102129A (ru)	2006-08-27
BRPI0412479A (pt)	2006-09-19
US20060189663A1 (en)	2006-08-24
JP2007521313A (ja)	2007-08-02
WO2005005416A1 (en)	2005-01-20
CA2532068A1 (en)	2005-01-20
KR20060034284A (ko)	2006-04-21
AU2004256000B2 (en)	2007-07-26
EP1646625B1 (de)	2008-07-02
ES2308205T3 (es)	2008-12-01
EP1646625A1 (de)	2006-04-19
AR045720A1 (es)	2005-11-09
NO20060080L (no)	2006-02-08
HK1088318A1 (en)	2006-11-03
DE602004014772D1 (de)	2008-08-14
IL172759A0 (en)	2006-04-10
CO5640134A2 (es)	2006-05-31
UA82108C2 (uk)	2008-03-11
IS8291A (is)	2006-02-09
AU2004256000A1 (en)	2005-01-20
ZA200600229B (en)	2007-04-25
MXPA06000447A (es)	2006-04-07
UY28407A1 (es)	2005-02-28
SA04250203B1 (ar)	2008-02-25
GB0316237D0 (en)	2003-08-13
CN1820003A (zh)	2006-08-16
CN100478340C (zh)	2009-04-15
TW200507836A (en)	2005-03-01

Publication	Publication Date	Title
HK1088318A1 (en)	2006-11-03	Pyrrole-2, 5-dithione derivatives as liver x receptor modulators
HK1088320A1 (en)	2006-11-03	Pyrrole-2, 5-dione derivatives as liver x receptor modulators
ATE440085T1 (de)	2009-09-15	3-substituierte 1,5-diphenylpyrazolderivate, die sich als cb1-modulatoren eignen
ATE439357T1 (de)	2009-08-15	Indolylderivate als liver-x-rezeptormodulatoren
ATE451364T1 (de)	2009-12-15	Als modulatoren des dopamin-d3-rezeptors geeignete azabicycloä3.1.0ühexanderivate
MA28391B1 (fr)	2007-01-02	Dérivés de 3-cycloalkylaminopyrrolidine utiles comme modulateurs de récepteurs de chimiokines
ATE497953T1 (de)	2011-02-15	Thiazolderivate als modulatoren des cannabinoidrezeptors
PT1444215E (pt)	2006-10-31	Derivados de 1,2,4-triadiazolio como moduladores do receptor de melanocortina
DE602005027307D1 (de)	2011-05-19	Arylanilinderivate als agonisten des beta2-adrenergen rezeptors
DE602004015724D1 (de)	2008-09-25	Diazepinoindolderivate als kinaseinhibitoren
ATE420881T1 (de)	2009-01-15	Kondensierte heterocyclische verbindungen als modulatoren des serotoninrezeptors
DE602004024420D1 (de)	2010-01-14	Chinazolinderivate als antitumormittel
DE60305903D1 (de)	2006-07-20	Tropanderivative als ccr5-modulatoren
ZA200609234B (en)	2008-08-27	Substituted azeplne derivatives as serotonin receptor modulators
ATE387202T1 (de)	2008-03-15	Pyrrolidinderivate als histaminrezeptor-liganden
AU2003256922A8 (en)	2004-02-16	Substituted heterocyclic compounds as modulators of the ccr5 receptor
ZA200804349B (en)	2009-04-29	1,1-dioxo-thiomorpholinyl indolyl methanone derivatives for use as H3 modulators
ATE394372T1 (de)	2008-05-15	G-lactamderivate als prostaglandinagonisten
DE602005023600D1 (de)	2010-10-28	Substituierte 1-phenyl-1,5-dihydro-pyridoä3,2-büindol-2-on-derivate verwendbar als pharmazeutische antiinfektiva
BRPI0509256A (pt)	2007-09-11	derivados de pirrolidina-3,4-dicarboxamida
ATE398620T1 (de)	2008-07-15	Spirokondensierte indolinderivate als pestizide
DE602004009583D1 (de)	2007-11-29	Piperidin- oder 8-azabicycloä3.2.1üoct-3-ylderivate, die sich als modulatoren der chemokinrezeptoraktivität eignen
DE602004006424D1 (de)	2007-06-21	Piperidinderivate als ccr5-rezeptormodulatoren
ZA200606563B (en)	2008-10-29	3-Substituted 1,5-diphenylpyrazole derivatives useful as CB1 Modulators
IL165408A0 (en)	2006-01-15	Novel substituted indoles

Legal Events

Date	Code	Title	Description
2009-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties