[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ATE399558T1 - Anti-tumorale formulierungen mit defibrotid allein oder in kombination mit anderen antitumoralen mitteln - Google Patents

Anti-tumorale formulierungen mit defibrotid allein oder in kombination mit anderen antitumoralen mitteln

Info

Publication number
ATE399558T1
ATE399558T1 AT04764686T AT04764686T ATE399558T1 AT E399558 T1 ATE399558 T1 AT E399558T1 AT 04764686 T AT04764686 T AT 04764686T AT 04764686 T AT04764686 T AT 04764686T AT E399558 T1 ATE399558 T1 AT E399558T1
Authority
AT
Austria
Prior art keywords
tumoral
combination
formulations containing
antitumoral agents
alone
Prior art date
Application number
AT04764686T
Other languages
English (en)
Inventor
Laura Ferro
Massimo Iacobelli
Paul Richardson
Original Assignee
Gentium Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gentium Spa filed Critical Gentium Spa
Application granted granted Critical
Publication of ATE399558T1 publication Critical patent/ATE399558T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT04764686T 2003-09-05 2004-08-27 Anti-tumorale formulierungen mit defibrotid allein oder in kombination mit anderen antitumoralen mitteln ATE399558T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001714A ITMI20031714A1 (it) 2003-09-05 2003-09-05 Formazioni ad azione antitumorale.
US53934404P 2004-01-28 2004-01-28

Publications (1)

Publication Number Publication Date
ATE399558T1 true ATE399558T1 (de) 2008-07-15

Family

ID=37064585

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04764686T ATE399558T1 (de) 2003-09-05 2004-08-27 Anti-tumorale formulierungen mit defibrotid allein oder in kombination mit anderen antitumoralen mitteln

Country Status (23)

Country Link
US (2) US8551967B2 (de)
EP (1) EP1660100B1 (de)
JP (1) JP4671962B2 (de)
KR (1) KR20060061367A (de)
CN (1) CN100490820C (de)
AT (1) ATE399558T1 (de)
AU (1) AU2004269896B2 (de)
BR (1) BRPI0414114A (de)
CA (1) CA2537226C (de)
DE (1) DE602004014787D1 (de)
DK (1) DK1660100T3 (de)
ES (1) ES2308223T3 (de)
IL (1) IL173785A0 (de)
IS (1) IS8334A (de)
IT (1) ITMI20031714A1 (de)
MX (1) MXPA06002489A (de)
NO (1) NO20061402L (de)
PT (1) PT1660100E (de)
RS (1) RS20060154A (de)
RU (1) RU2348413C2 (de)
UA (1) UA83500C2 (de)
WO (1) WO2005023273A1 (de)
ZA (1) ZA200601852B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2598613A1 (en) * 2005-03-03 2006-09-14 Gentium S.P.A. Defibrotide and/or oligodeoxyribonucleotides for treating angiogenesis-dependent tumors
EP1872787A1 (de) * 2006-06-27 2008-01-02 Gentium S.p.A. Verwendung von Defibrotide als Heparanasehemmer
EP2103689A1 (de) * 2008-03-19 2009-09-23 Gentium S.p.A. Synthetische Phosphodiester-Oligonukleotide und deren therapeutische Verwendungen
CA2813413C (en) 2010-11-12 2018-03-06 Gentium S.P.A. Defibrotide for use in prophylaxis and/or treatment of graft versus host disease (gvhd)
WO2013190582A1 (en) 2012-06-22 2013-12-27 Gentium S.P.A. Euglobulin-based method for determining the biological activity of defibrotide
EP3026122A1 (de) 2014-11-27 2016-06-01 Gentium S.p.A. Zellenbasiertes Verfahren zur Bestimmung der Wirksamkeit von Defibrotid
US10380734B2 (en) * 2017-02-27 2019-08-13 Aniket Bharat Parikh System, method and computer program product for security analysis of jewelry items
JP2020530004A (ja) * 2017-08-03 2020-10-15 ジャズ ファーマシューティカルズ アイルランド リミテッド 核酸を高濃度で含む製剤
MX2020010689A (es) 2018-04-12 2021-01-20 Jazz Pharmaceuticals Inc Defibrotida para la prevencion y tratamiento del sindrome de liberacion de citocinas y la neurotoxicidad asociada con la inmunodeplecion.
US20220023533A1 (en) 2018-12-07 2022-01-27 Jazz Phrmaceticals Ireland Limited Subcutaneous delivery of high concentration formulations
US20230190783A1 (en) 2020-02-28 2023-06-22 Jazz Pharmaceuticals Ireland Limited Delivery of low viscosity formulations
WO2022234101A1 (en) 2021-05-06 2022-11-10 Jazz Pharmaceuticals Ireland Limited Defibrotide for the treatment and prevention of acute respiratory distress syndrome

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899481A (en) * 1970-11-03 1975-08-12 Crinos Industria Farmaco Process for the controlled partial degradation of deoxyribonucleic acid extracted from animal organs
IT1043823B (it) * 1970-11-03 1980-02-29 Prephar Procedimento per l estrazione di acidi nucleici da organi animali
DE2154279A1 (de) * 1970-11-03 1972-05-25 Crinos Industria Farmaco Medikamente für das fibrinolytische System
US4853221A (en) * 1980-11-13 1989-08-01 Warner-Lambert Company Method for treating non-small cell lung cancer, head and neck cancers and breast cancer
IT1170214B (it) * 1983-09-12 1987-06-03 Crinos Industria Farmaco Composizione farmaceutica per la cura delle arteriopatie periferiche
IT1206341B (it) * 1984-02-16 1989-04-14 Crinos Industria Farmaco Composizione farmaceutica per il trattamento dell'ischemia acuta del miocardio.
US4694134A (en) * 1985-05-28 1987-09-15 Ajax Magnethermic Corporation Apparatus for overheating edges of skelp for the production of compression welded pipe
IT1190313B (it) * 1986-04-17 1988-02-16 Crinos Industria Farmaco Procedimento per l'ottenimento di polidesossiribonucleotidi chimicamente definiti e riproducibili e prodotto farmacologicamente attivo risultante
US5223609A (en) * 1986-04-17 1993-06-29 Crinos Industria Farmacobiologica S.P.A. Process for obtaining chemically defined and reproducible polydeoxyribonucleotides
US5977083A (en) * 1991-08-21 1999-11-02 Burcoglu; Arsinur Method for using polynucleotides, oligonucleotides and derivatives thereof to treat various disease states
US6699985B2 (en) * 1991-08-21 2004-03-02 Arsinur Burcoglu Method of treating HIV infection and related secondary infections thereof
IT1252174B (it) * 1991-12-09 1995-06-05 Crinos Industria Farmaco Oligodesossimibonucleotidi ad attivita' antiischemica e procedimenti per il loro ottenimento
DE9202745U1 (de) 1992-03-02 1992-04-30 Howmedica Gmbh, 2314 Schoenkirchen Vorrichtung zum Verspannen von Wirbeln der menschlichen Wirbelsäule
US5578716A (en) * 1993-12-01 1996-11-26 Mcgill University DNA methyltransferase antisense oligonucleotides
WO1998048843A1 (en) * 1997-04-28 1998-11-05 Arsinur Burcoglu Method of treating hiv infection and related secondary infections thereof
CA2291595A1 (en) 1997-05-30 1998-12-03 Mcgill University Dna methyltransferase genomic sequences and antisense oligonucleotides
US6177545B1 (en) 1997-09-02 2001-01-23 Insight Strategy & Marketing Ltd. Heparanase specific molecular probes and their use in research and medical applications
DE19740384A1 (de) 1997-09-08 1999-03-11 Max Delbrueck Centrum Antisense Oligodesoxynukleotide (ODN) gegen Proteinkinase C (PKC)-Isoformen, ihre Verwendung und pharmazeutische Zubereitungen dieser ODN
AU780454B2 (en) * 1999-06-03 2005-03-24 Jessie L.S. Au Methods and compositions for modulating cell proliferation and cell death
BR0116764A (pt) * 2000-12-29 2007-01-09 Savient Pharmaceuticals Inc moléculas isoladas compreendendo epitopos contendo porções sulfatadas, anticorpos para os referidos epitopos e seus usos
US6770753B2 (en) 2001-07-05 2004-08-03 The Trustees Of Columbia University In The City Of New York Phosphorothioate antisense heparanase oligonucleotides
AU2002353783A1 (en) 2001-09-24 2003-04-07 The Government Of The United States Of America As Represented By The Secretary Of The Department Of SUPPRESSORS OF CpG OLIGONUCLEOTIDES AND METHODS OF USE
US20050032882A1 (en) * 2002-03-06 2005-02-10 Sophie Chen Botanical extract compositions and methods of use
PL374402A1 (en) * 2002-05-31 2005-10-17 Klinikum Universitaet Regensburg Method for the protection of endothelial and epithelial cells during chemotherapy
JP2005536199A (ja) * 2002-07-01 2005-12-02 サビエント ファーマシューティカルズ，インコーポレイティド 抗体及びそれらの使用
US20060293256A1 (en) 2002-08-06 2006-12-28 Masateru Yamada Remedy or preventive for kidney disease and method of diagnosing kidney disease
DE10244453A1 (de) 2002-09-24 2004-04-01 Phenomiques Gmbh Hemmung der Proteinkinase C-alpha zur Behandlung von Krankheiten
US7803781B2 (en) 2003-02-28 2010-09-28 Isis Pharmaceuticals, Inc. Modulation of growth hormone receptor expression and insulin-like growth factor expression
CA2598613A1 (en) 2005-03-03 2006-09-14 Gentium S.P.A. Defibrotide and/or oligodeoxyribonucleotides for treating angiogenesis-dependent tumors
EP1872787A1 (de) 2006-06-27 2008-01-02 Gentium S.p.A. Verwendung von Defibrotide als Heparanasehemmer
EP1982722A1 (de) 2007-04-16 2008-10-22 Gentium S.p.A. Verwendung von Oligotid zur Behandlung von Nierenerkrankungen

Also Published As

Publication number Publication date
US20140005256A1 (en) 2014-01-02
EP1660100A1 (de) 2006-05-31
BRPI0414114A (pt) 2006-10-31
US20060211646A1 (en) 2006-09-21
RS20060154A (en) 2008-08-07
CA2537226C (en) 2016-05-03
NO20061402L (no) 2006-03-28
AU2004269896B2 (en) 2009-11-19
CA2537226A1 (en) 2005-03-17
CN1845746A (zh) 2006-10-11
CN100490820C (zh) 2009-05-27
RU2348413C2 (ru) 2009-03-10
EP1660100B1 (de) 2008-07-02
IL173785A0 (en) 2006-07-05
ZA200601852B (en) 2007-06-27
ES2308223T3 (es) 2008-12-01
JP4671962B2 (ja) 2011-04-20
DK1660100T3 (da) 2008-11-10
JP2007504194A (ja) 2007-03-01
AU2004269896A1 (en) 2005-03-17
IS8334A (is) 2006-02-28
WO2005023273A1 (en) 2005-03-17
RU2006109210A (ru) 2007-10-10
PT1660100E (pt) 2008-10-14
KR20060061367A (ko) 2006-06-07
ITMI20031714A1 (it) 2005-03-06
UA83500C2 (uk) 2008-07-25
DE602004014787D1 (de) 2008-08-14
US8551967B2 (en) 2013-10-08
MXPA06002489A (es) 2006-06-20

Similar Documents

Publication Publication Date Title
IL173785A0 (en) Anti-tumor formulations comprising defibrotide alone or in combination with other anti-tumor agents
RS51569B (en) COMPOSITIONS CONTAINING CRYSTAL TRANS - (+/-) - DELTA-9-TETRAHYDROCANABINOL
ITMI20041550A1 (it) Uso di batteri probiotici per la preparazione di composizioni topiche per la protezione dell&#39;epidermide
AR028296A1 (es) Metodos sinergisticos y composiciones para el tratamiento del cancer
FR2869231B1 (fr) Composition therapeutique contenant au moins un derive de la pyrrolobenzodiazepine et la fludarabine
AR048878A1 (es) Composiciones topicas de metadona y metodos para usarlas
RS50660B (sr) Dihidrotetrabenazini i farmaceutske kompozicije koje ih sadrže
DE60045394D1 (de) Zusammensetzungen gegen infektionen zur behandlung erkrankten gewebes wie z.b. fieberbläschen
SG155189A1 (en) Novel fenofibrate formulations and related methods of treatment
CR11167A (es) Uso de homo y copolimeros para la estabilizacion de formulaciones de principios activos
RS50510B (sr) Formulacije koje sadrže ekteinascidin i disaharid
MY144318A (en) Methods of treating hiv infection.
ATE286664T1 (de) Pharmazeutische oder diätetische zusammensetzungen aus pilzen und deren verwendung
PT1121127E (pt) Composicoes farmaceuticas orais contendo buprenorfina
PT1893237E (pt) Composição farmacêutica compreendendo um elastómero organopolissiloxano e um princípio activo solubilizado
ECSP034790A (es) Combinaciones antineoplásticas tales como rapamicin junto con gemcitabina o fluorouracil
ITRM20030363A0 (it) Composizioni comprendenti la 3, 5diiodotironina e uso farmaceutico diesse.
TW200505437A (en) Composition possessing autonomic nerve function regulating action and use thereof
CA105215S (en) Packaging with cosmetic composition
AR038560A1 (es) Una composicion antitranspirante/ desodorante
UY29236A1 (es) 2-alcoxi-3,4,5-trihidroxi-alquilamidas. su preparación, composiciones que las contienen y su utilización.
BRPI0417265A (pt) composição farmacêutica compreendendo um princìpio ativo e sulfobetaìna
WO2006033713A3 (en) Methods for ciprofloxacin inhalation
ATE410154T1 (de) Pharmazeutische zusammensetzung enthaltend 2,4- dichlorbenzylalkohol und amylmetakresol
SE0203817D0 (sv) New composition

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1660100

Country of ref document: EP