ATE395904T1 - Liposome - Google Patents
LiposomeInfo
- Publication number
- ATE395904T1 ATE395904T1 AT02016936T AT02016936T ATE395904T1 AT E395904 T1 ATE395904 T1 AT E395904T1 AT 02016936 T AT02016936 T AT 02016936T AT 02016936 T AT02016936 T AT 02016936T AT E395904 T1 ATE395904 T1 AT E395904T1
- Authority
- AT
- Austria
- Prior art keywords
- liposomes
- polynucleotide
- cationic
- dotap
- eliciting
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/788—Of specified organic or carbon-based composition
- Y10S977/802—Virus-based particle
- Y10S977/803—Containing biological material in its interior
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
- Y10S977/907—Liposome
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/915—Therapeutic or pharmaceutical composition
- Y10S977/917—Vaccine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/918—Immunological
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Dispersion Chemistry (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9619172.1A GB9619172D0 (en) | 1996-09-13 | 1996-09-13 | Liposomes |
GBGB9625917.1A GB9625917D0 (en) | 1996-12-13 | 1996-12-13 | Liposomes |
GBGB9713994.3A GB9713994D0 (en) | 1997-07-01 | 1997-07-01 | Liposomes |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE395904T1 true ATE395904T1 (de) | 2008-06-15 |
Family
ID=27268476
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02016936T ATE395904T1 (de) | 1996-09-13 | 1997-09-15 | Liposome |
AT97940250T ATE228824T1 (de) | 1996-09-13 | 1997-09-15 | Liposomenzusammensetzung |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97940250T ATE228824T1 (de) | 1996-09-13 | 1997-09-15 | Liposomenzusammensetzung |
Country Status (11)
Country | Link |
---|---|
US (1) | US7790696B2 (de) |
EP (2) | EP0938298B1 (de) |
JP (1) | JP2001502299A (de) |
KR (1) | KR100507660B1 (de) |
CN (1) | CN1138533C (de) |
AT (2) | ATE395904T1 (de) |
AU (1) | AU728581B2 (de) |
CA (1) | CA2271388C (de) |
DE (2) | DE69738719D1 (de) |
ES (2) | ES2187812T3 (de) |
WO (1) | WO1998010748A1 (de) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1146907A2 (de) * | 1999-02-05 | 2001-10-24 | Genzyme Corporation | Anwendung von kationische lipiden zu induzieren von anti-tumorimmunität |
CN1196474C (zh) * | 1999-10-01 | 2005-04-13 | 利普森技术有限公司 | 脂质体包封的dna口服疫苗 |
AU1871501A (en) | 1999-12-13 | 2001-06-18 | Lipoxen Limited | Liposomes |
US6372250B1 (en) * | 2000-04-25 | 2002-04-16 | The Regents Of The University Of California | Non-invasive gene targeting to the brain |
DE10109897A1 (de) * | 2001-02-21 | 2002-11-07 | Novosom Ag | Fakultativ kationische Liposomen und Verwendung dieser |
DE60310562T2 (de) | 2002-07-05 | 2007-10-11 | Lipoxen Technologies Ltd. | Verfahren zur verstärkung einer immunantwort von nukleinsäureimpfungen |
DE10347710B4 (de) | 2003-10-14 | 2006-03-30 | Johannes-Gutenberg-Universität Mainz | Rekombinante Impfstoffe und deren Verwendung |
JP4546115B2 (ja) * | 2004-03-05 | 2010-09-15 | 三菱化学メディエンス株式会社 | 細胞中atpの定量法 |
DE102004057303A1 (de) * | 2004-11-26 | 2006-06-01 | Merck Patent Gmbh | Stabile Kristallmodifikationen von DOTAP Chlorid |
DE102005046490A1 (de) | 2005-09-28 | 2007-03-29 | Johannes-Gutenberg-Universität Mainz | Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen |
CN100400667C (zh) * | 2006-06-27 | 2008-07-09 | 浙江大学 | 脂质体包裹弓形虫pGRA4真核表达质粒的方法及用途 |
CA2687208C (en) | 2006-12-22 | 2017-02-14 | Soluciones Biotecnologicas Innovacion Ltda | Process and formulation for immunizing fish in aquaculture systems |
EP2184054A1 (de) | 2008-11-08 | 2010-05-12 | Lipoxen Technologies Limited | SiRNA-Abgabe |
WO2011005772A1 (en) | 2009-07-06 | 2011-01-13 | Variation Biotechnologies, Inc. | Methods for preparing vesicles and formulations produced therefrom |
ES2573427T3 (es) * | 2009-07-06 | 2016-06-07 | Variation Biotechnologies Inc. | Procedimientos para preparar vesículas y formulaciones producidas a partir de las mismas |
US10894098B2 (en) | 2012-04-09 | 2021-01-19 | Signablok, Inc. | Methods and compositions for targeted imaging |
WO2011044545A2 (en) | 2009-10-09 | 2011-04-14 | Sigalov Alexander B | Methods and compositions for targeted imaging |
HUE038039T2 (hu) | 2009-12-01 | 2018-09-28 | Translate Bio Inc | mRNS bejuttatása fehérjék és enzimek kiegészítésére humán genetikai betegségekben |
CN102884041B (zh) * | 2010-04-28 | 2015-04-15 | 协和发酵麒麟株式会社 | 阳离子性脂质 |
PL2591114T3 (pl) | 2010-07-06 | 2017-08-31 | Glaxosmithkline Biologicals Sa | Immunizacja dużych ssaków małymi dawkami rna |
MX343410B (es) | 2010-07-06 | 2016-11-04 | Novartis Ag * | Emulsiones cationicas de agua en aceite. |
HUE047796T2 (hu) | 2010-07-06 | 2020-05-28 | Glaxosmithkline Biologicals Sa | RNS bevitele több immunútvonal bekapcsolására |
PL2590626T3 (pl) | 2010-07-06 | 2016-04-29 | Glaxosmithkline Biologicals Sa | Liposomy z lipidami o korzystnej wartości pka do dostarczania rna |
MX342138B (es) | 2010-07-06 | 2016-09-14 | Variation Biotechnologies Inc | Composiciones y metodos para el tratamiento de influenza. |
DK2590676T3 (en) | 2010-07-06 | 2016-10-24 | Glaxosmithkline Biologicals Sa | Virionlignende feed particles to self-replicating RNA molecules |
EP3981427B9 (de) | 2010-08-31 | 2022-07-27 | GlaxoSmithKline Biologicals S.A. | Pegylierte liposomen zur auslieferung von immunogen-kodierender rns |
MX363307B (es) | 2010-10-11 | 2019-03-20 | Novartis Ag Star | Plataformas para suministro de antigenos. |
BR112013017939B1 (pt) | 2011-01-13 | 2022-11-16 | Variation Biotechnologies Inc | Composição imunogênica liofilizada termoestável, uso e método para preparação da mesma |
RU2491062C2 (ru) * | 2011-03-16 | 2013-08-27 | Общество С Ограниченной Ответственностью "Биотехнологии Пущино" | Композиции протекторов острых и хронических печеночных энцелопатий и способ лечения острых и хронических печеночных энцелопатий |
US10738355B2 (en) | 2011-05-24 | 2020-08-11 | Tron-Translationale Onkologie An Der Universitätsmedizin Der Johannes Gutenberg-Universität Mainz Ggmbh | Individualized vaccines for cancer |
KR20240135871A (ko) | 2011-06-08 | 2024-09-12 | 샤이어 휴먼 지네틱 테라피즈 인크. | Mrna 전달을 위한 지질 나노입자 조성물 및 방법 |
EP3332802A1 (de) | 2011-07-06 | 2018-06-13 | GlaxoSmithKline Biologicals SA | Immunogene kombinationszusammensetzungen und ihre verwendung |
MX350258B (es) | 2011-07-06 | 2017-08-31 | Novartis Ag | Emulsiones cationicas de aceite en agua. |
CA2840913C (en) | 2011-07-06 | 2020-01-21 | Novartis Ag | Oil-in-water emulsions that contain nucleic acids |
WO2013104995A2 (en) | 2012-01-12 | 2013-07-18 | Variation Biotechnologies, Inc. | Compositions and methods for treating viral infections |
EP4008354A1 (de) | 2012-01-27 | 2022-06-08 | Variation Biotechnologies Inc. | Verfahren und zusammensetzungen für therapeutika |
WO2013143555A1 (en) | 2012-03-26 | 2013-10-03 | Biontech Ag | Rna formulation for immunotherapy |
WO2013185067A1 (en) | 2012-06-08 | 2013-12-12 | Shire Human Genetic Therapies, Inc. | Nuclease resistant polynucleotides and uses thereof |
EP3884949A1 (de) * | 2012-06-08 | 2021-09-29 | Translate Bio, Inc. | Pulmonale verabreichung von mrns an nicht pulmonale zielzellen |
WO2014082729A1 (en) | 2012-11-28 | 2014-06-05 | Biontech Ag | Individualized vaccines for cancer |
IL305374A (en) | 2013-03-14 | 2023-10-01 | Ethris Gmbh | CFTR mRNA Assemblies and Related Methods and Uses |
AU2014236396A1 (en) | 2013-03-14 | 2015-08-13 | Shire Human Genetic Therapies, Inc. | Methods for purification of messenger RNA |
WO2014180490A1 (en) | 2013-05-10 | 2014-11-13 | Biontech Ag | Predicting immunogenicity of t cell epitopes |
ES2707966T3 (es) | 2013-10-22 | 2019-04-08 | Translate Bio Inc | Terapia de ARNm para la deficiencia en síntesis de argininosuccinato |
CN105658242A (zh) | 2013-10-22 | 2016-06-08 | 夏尔人类遗传性治疗公司 | 用于苯丙酮尿症的mrna疗法 |
RU2016130595A (ru) * | 2013-12-27 | 2018-02-01 | Телореджен, Инк. | Композиции и способы, обеспечивающие активную теломеразу в клетках in vivo |
US12048765B2 (en) * | 2014-01-17 | 2024-07-30 | Fundacio Institut D'investigació En Ciències De La Slut Germans Triast Pujol | Liposome-based immunotherapy |
KR102470198B1 (ko) | 2014-04-25 | 2022-11-22 | 샤이어 휴먼 지네틱 테라피즈 인크. | 메신저 rna 의 정제 방법 |
WO2016045732A1 (en) | 2014-09-25 | 2016-03-31 | Biontech Rna Pharmaceuticals Gmbh | Stable formulations of lipids and liposomes |
WO2016128060A1 (en) | 2015-02-12 | 2016-08-18 | Biontech Ag | Predicting t cell epitopes useful for vaccination |
WO2017059902A1 (en) | 2015-10-07 | 2017-04-13 | Biontech Rna Pharmaceuticals Gmbh | 3' utr sequences for stabilization of rna |
AU2018224326B2 (en) | 2017-02-27 | 2024-01-04 | Translate Bio, Inc. | Novel codon-optimized CFTR mRNA |
EP3624824B1 (de) | 2017-05-16 | 2024-07-10 | Translate Bio, Inc. | Codonoptimierter mrna, die cftr codiert, zur verwendung in der behandlung von zystischer fibrose |
WO2020041793A1 (en) | 2018-08-24 | 2020-02-27 | Translate Bio, Inc. | Methods for purification of messenger rna |
EP3892260A1 (de) * | 2020-04-10 | 2021-10-13 | Bayer Animal Health GmbH | Immunstimulierende zusammensetzungen auf der basis von liposomen mit zwitterinischen und kationischen lipiden |
AU2022245985A1 (en) | 2021-03-22 | 2023-09-21 | Illumina Cambridge Limited | Methods for improving nucleic acid cluster clonality |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4515736A (en) | 1983-05-12 | 1985-05-07 | The Regents Of The University Of California | Method for encapsulating materials into liposomes |
DE3582905D1 (de) | 1984-08-10 | 1991-06-27 | Syntex Inc | Stabile liposome mit wasserloeslichen arzneimitteln. |
JPH0662517B2 (ja) | 1985-01-07 | 1994-08-17 | シンテツクス(ユー・エス・エイ)インコーポレイテツド | 置換アルキルートリ置換アンモニウム界面活性剤 |
US4946787A (en) | 1985-01-07 | 1990-08-07 | Syntex (U.S.A.) Inc. | N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
US5545412A (en) | 1985-01-07 | 1996-08-13 | Syntex (U.S.A.) Inc. | N-[1, (1-1)-dialkyloxy]-and N-[1, (1-1)-dialkenyloxy]-alk-1-yl-n,n,n-tetrasubstituted ammonium lipids and uses therefor |
US5049386A (en) | 1985-01-07 | 1991-09-17 | Syntex (U.S.A.) Inc. | N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
US5208036A (en) | 1985-01-07 | 1993-05-04 | Syntex (U.S.A.) Inc. | N-(ω, (ω-1)-dialkyloxy)- and N-(ω, (ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
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JP2627899B2 (ja) * | 1987-08-19 | 1997-07-09 | 株式会社 ビタミン研究所 | 遺伝子封入リポソームの製法 |
US4882172A (en) * | 1988-04-08 | 1989-11-21 | Nabisco Brands, Inc. | System for processing chewing gum |
JP2923296B2 (ja) * | 1988-11-14 | 1999-07-26 | 株式会社ビタミン研究所 | 細胞への遺伝子導入法 |
ATE165516T1 (de) | 1989-03-21 | 1998-05-15 | Vical Inc | Expression von exogenen polynukleotidsequenzen in wirbeltieren |
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CA2128616A1 (en) | 1992-01-23 | 1993-08-05 | Gary H. Rhodes | Ex vivo gene transfer |
US6113946A (en) | 1992-04-03 | 2000-09-05 | The Regents Of The University Of California | Self-assembling polynucleotide delivery system comprising dendrimer polycations |
US5334761A (en) | 1992-08-28 | 1994-08-02 | Life Technologies, Inc. | Cationic lipids |
US5593972A (en) * | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
DE69418334T2 (de) * | 1993-08-06 | 2000-01-27 | Opperbas Holding B.V., Amsterdam | Verfahren zur hohen beladung von vesikeln mit biopolymeren substanzen |
AU683957B2 (en) * | 1993-11-05 | 1997-11-27 | Amgen, Inc. | Liposome preparation and material encapsulation method |
JP3002702B2 (ja) * | 1993-11-16 | 2000-01-24 | スカイファーム インコーポレーテッド | 活性物質の制御放出を有する小胞 |
IL112820A0 (en) * | 1994-03-07 | 1995-05-26 | Merck & Co Inc | Coordinate in vivo gene expression |
US5830430A (en) * | 1995-02-21 | 1998-11-03 | Imarx Pharmaceutical Corp. | Cationic lipids and the use thereof |
ES2231819T3 (es) * | 1995-06-07 | 2005-05-16 | Inex Pharmaceuticals Corp | Particulas de lipido-acido nucleico preparadas a traves de un intermedio complejo de lipido-acido nucleico hidrofobo y uso para transferir genes. |
US5830878A (en) | 1995-06-07 | 1998-11-03 | Megabios Corporation | Cationic lipid: DNA complexes for gene targeting |
US5753235A (en) | 1996-02-15 | 1998-05-19 | Heska Corporation | Recombinant canine herpesviruses |
US7384923B2 (en) * | 1999-05-14 | 2008-06-10 | Lipoxen Technologies Limited | Liposomes |
-
1997
- 1997-09-15 AT AT02016936T patent/ATE395904T1/de not_active IP Right Cessation
- 1997-09-15 ES ES97940250T patent/ES2187812T3/es not_active Expired - Lifetime
- 1997-09-15 CN CNB971996741A patent/CN1138533C/zh not_active Expired - Fee Related
- 1997-09-15 DE DE69738719T patent/DE69738719D1/de not_active Expired - Lifetime
- 1997-09-15 JP JP10513398A patent/JP2001502299A/ja not_active Ceased
- 1997-09-15 EP EP97940250A patent/EP0938298B1/de not_active Expired - Lifetime
- 1997-09-15 EP EP02016936A patent/EP1254657B1/de not_active Expired - Lifetime
- 1997-09-15 DE DE69717661T patent/DE69717661T2/de not_active Expired - Lifetime
- 1997-09-15 AT AT97940250T patent/ATE228824T1/de not_active IP Right Cessation
- 1997-09-15 AU AU42154/97A patent/AU728581B2/en not_active Ceased
- 1997-09-15 CA CA002271388A patent/CA2271388C/en not_active Expired - Fee Related
- 1997-09-15 KR KR10-1999-7002103A patent/KR100507660B1/ko not_active IP Right Cessation
- 1997-09-15 ES ES02016936T patent/ES2305157T3/es not_active Expired - Lifetime
- 1997-09-15 WO PCT/GB1997/002490 patent/WO1998010748A1/en active IP Right Grant
-
2008
- 2008-04-10 US US12/101,107 patent/US7790696B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1254657A3 (de) | 2003-03-05 |
ES2305157T3 (es) | 2008-11-01 |
CN1237102A (zh) | 1999-12-01 |
US7790696B2 (en) | 2010-09-07 |
CA2271388A1 (en) | 1998-03-19 |
WO1998010748A1 (en) | 1998-03-19 |
DE69717661D1 (de) | 2003-01-16 |
KR20000036088A (ko) | 2000-06-26 |
KR100507660B1 (ko) | 2005-08-10 |
US20080286353A1 (en) | 2008-11-20 |
ES2187812T3 (es) | 2003-06-16 |
EP1254657B1 (de) | 2008-05-21 |
DE69717661T2 (de) | 2003-09-25 |
CA2271388C (en) | 2007-11-06 |
JP2001502299A (ja) | 2001-02-20 |
EP0938298B1 (de) | 2002-12-04 |
EP0938298A1 (de) | 1999-09-01 |
CN1138533C (zh) | 2004-02-18 |
AU4215497A (en) | 1998-04-02 |
AU728581B2 (en) | 2001-01-11 |
EP1254657A2 (de) | 2002-11-06 |
DE69738719D1 (de) | 2008-07-03 |
ATE228824T1 (de) | 2002-12-15 |
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