[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ATE369877T1 - Synergismus von photodynamischen und elektropermeationseffekten auf die zellvitalität als ein neues cytotoxisches mittel - Google Patents

Synergismus von photodynamischen und elektropermeationseffekten auf die zellvitalität als ein neues cytotoxisches mittel

Info

Publication number
ATE369877T1
ATE369877T1 AT99935345T AT99935345T ATE369877T1 AT E369877 T1 ATE369877 T1 AT E369877T1 AT 99935345 T AT99935345 T AT 99935345T AT 99935345 T AT99935345 T AT 99935345T AT E369877 T1 ATE369877 T1 AT E369877T1
Authority
AT
Austria
Prior art keywords
cell
electropermeation
photodynamic
synergism
effects
Prior art date
Application number
AT99935345T
Other languages
English (en)
Inventor
Maya Lambreva
Hermann Berg
Original Assignee
Genetronics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetronics Inc filed Critical Genetronics Inc
Application granted granted Critical
Publication of ATE369877T1 publication Critical patent/ATE369877T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0047—Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT99935345T 1998-06-26 1999-06-25 Synergismus von photodynamischen und elektropermeationseffekten auf die zellvitalität als ein neues cytotoxisches mittel ATE369877T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9075198P 1998-06-26 1998-06-26

Publications (1)

Publication Number Publication Date
ATE369877T1 true ATE369877T1 (de) 2007-09-15

Family

ID=22224133

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99935345T ATE369877T1 (de) 1998-06-26 1999-06-25 Synergismus von photodynamischen und elektropermeationseffekten auf die zellvitalität als ein neues cytotoxisches mittel

Country Status (9)

Country Link
US (2) US7181271B2 (de)
EP (1) EP1100576B1 (de)
AT (1) ATE369877T1 (de)
AU (1) AU760619B2 (de)
CA (1) CA2335888A1 (de)
DE (1) DE69936866T2 (de)
DK (1) DK1100576T3 (de)
ES (1) ES2291035T3 (de)
WO (1) WO2000000250A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6708066B2 (en) * 1999-12-10 2004-03-16 Ewa Herbst Electrochemical treatment of tissues, especially tumors
US20110040295A1 (en) * 2003-02-28 2011-02-17 Photometics, Inc. Cancer treatment using selective photo-apoptosis
US7354433B2 (en) * 2003-02-28 2008-04-08 Advanced Light Technologies, Llc Disinfection, destruction of neoplastic growth, and sterilization by differential absorption of electromagnetic energy
ES2629960T3 (es) 2004-03-25 2017-08-16 University College Cork-National University Of Ireland, Cork Aparato para profilaxis o tratamiento de tejido
US20080268542A1 (en) * 2007-04-30 2008-10-30 Bio-Rad Laboratories, Inc. High Efficiency Electroporation Buffer
US20090035725A1 (en) * 2007-08-02 2009-02-05 Ondine International, Ltd. Photodisinfection of oral cavity
FR2943550A1 (fr) 2009-03-31 2010-10-01 Kader Simone Nadia Leonardi Procede et appareil de soin cosmetique de la peau
US8348929B2 (en) 2009-08-05 2013-01-08 Rocin Laboratories, Inc. Endoscopically-guided tissue aspiration system for safely removing fat tissue from a patient
US20110213336A1 (en) 2009-08-05 2011-09-01 Cucin Robert L Method of and apparatus for sampling, processing and collecting tissue and reinjecting the same into human patients
US8465471B2 (en) 2009-08-05 2013-06-18 Rocin Laboratories, Inc. Endoscopically-guided electro-cauterizing power-assisted fat aspiration system for aspirating visceral fat tissue within the abdomen of a patient
US9457183B2 (en) 2011-06-15 2016-10-04 Tripep Ab Injection needle and device
US10233419B2 (en) 2016-06-30 2019-03-19 Zymergen Inc. Apparatuses and methods for electroporation

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2800039C2 (de) * 1978-01-02 1984-06-20 Horst Dr.Med. 6700 Ludwigshafen Kief Akupunkturgerät
US5421819A (en) * 1992-08-12 1995-06-06 Vidamed, Inc. Medical probe device
US5389069A (en) * 1988-01-21 1995-02-14 Massachusetts Institute Of Technology Method and apparatus for in vivo electroporation of remote cells and tissue
JP2798459B2 (ja) * 1988-01-21 1998-09-17 マサチユセツツ・インスチチユート・オブ・テクノロジー エレクトロポレーションを利用した診断装置及び分子の組織内移動装置
US5749847A (en) * 1988-01-21 1998-05-12 Massachusetts Institute Of Technology Delivery of nucleotides into organisms by electroporation
US5547467A (en) * 1988-01-21 1996-08-20 Massachusettes Institute Of Technology Method for rapid temporal control of molecular transport across tissue
EP0346513A1 (de) * 1988-06-15 1989-12-20 Etama Ag Anordnung zur Elektrotherapie
CS275292B2 (en) * 1989-02-22 1992-02-19 Cvut Fakulta Elektrotechnick Private rehabilitation apparatus with ion transcutaneous acceleration
US6001617A (en) * 1989-06-07 1999-12-14 Queen's University At Kingston Electroporation device and method of use
US5079262A (en) * 1989-07-28 1992-01-07 Queen's University At Kingston Method of detection and treatment of malignant and non-malignant lesions utilizing 5-aminolevulinic acid
US5503721A (en) * 1991-07-18 1996-04-02 Hri Research, Inc. Method for photoactivation
US5215088A (en) * 1989-11-07 1993-06-01 The University Of Utah Three-dimensional electrode device
US5498238A (en) * 1990-06-15 1996-03-12 Cortrak Medical, Inc. Simultaneous angioplasty and phoretic drug delivery
US5328451A (en) * 1991-08-15 1994-07-12 Board Of Regents, The University Of Texas System Iontophoretic device and method for killing bacteria and other microbes
US5277913A (en) * 1991-09-09 1994-01-11 Thompson David H Liposomal delivery system with photoactivatable triggered release
NZ245015A (en) * 1991-11-05 1995-12-21 Transkaryotic Therapies Inc Delivery of human growth hormone through the administration of transfected cell lines encoding human growth hormone, which are physically protected from host immune response; the transfected cells and their production
US5425752A (en) * 1991-11-25 1995-06-20 Vu'nguyen; Dung D. Method of direct electrical myostimulation using acupuncture needles
US5507724A (en) * 1992-07-01 1996-04-16 Genetronics, Inc. Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells
US5304120A (en) * 1992-07-01 1994-04-19 Btx Inc. Electroporation method and apparatus for insertion of drugs and genes into endothelial cells
US5514131A (en) * 1992-08-12 1996-05-07 Stuart D. Edwards Method for the ablation treatment of the uvula
US5273525A (en) * 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
US5468223A (en) * 1992-11-30 1995-11-21 C.N.R.S. Paris Electrochemotherapy
WO1994017856A1 (en) * 1993-02-02 1994-08-18 Vidamed, Inc. Transurethral needle ablation device and method
FR2703253B1 (fr) * 1993-03-30 1995-06-23 Centre Nat Rech Scient Applicateur d'impulsions electriques pour traitement de tissus biologiques.
US5439440A (en) * 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US5702359A (en) * 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
US5993434A (en) * 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
US5777078A (en) * 1993-04-28 1998-07-07 Worcester Foundation For Experimental Biology Triggered pore-forming agents
WO1994027670A1 (en) * 1993-06-02 1994-12-08 Cardiac Pathways Corporation Catheter having tip with fixation means
US5536267A (en) * 1993-11-08 1996-07-16 Zomed International Multiple electrode ablation apparatus
US5814599A (en) * 1995-08-04 1998-09-29 Massachusetts Insitiute Of Technology Transdermal delivery of encapsulated drugs
IL108775A (en) * 1994-02-25 2003-09-17 Univ Ramot Method for efficient incorporation of molecules into cells
US5474528A (en) * 1994-03-21 1995-12-12 Dusa Pharmaceuticals, Inc. Combination controller and patch for the photodynamic therapy of dermal lesion
US5807308A (en) * 1996-02-23 1998-09-15 Somnus Medical Technologies, Inc. Method and apparatus for treatment of air way obstructions
US5786454A (en) * 1994-09-16 1998-07-28 Washington University School Of Medicine Modified SH2 domains
US5720921A (en) * 1995-03-10 1998-02-24 Entremed, Inc. Flow electroporation chamber and method
US5868740A (en) * 1995-03-24 1999-02-09 Board Of Regents-Univ Of Nebraska Method for volumetric tissue ablation
US5810762A (en) * 1995-04-10 1998-09-22 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US5780052A (en) * 1995-04-24 1998-07-14 Northeastern University Compositions and methods useful for inhibiting cell death and for delivering an agent into a cell
US5789213A (en) * 1995-05-11 1998-08-04 Health Research Inc. Method and compositions for high efficiency loading, transfection and fusion of cells by electric pulses
US6041252A (en) * 1995-06-07 2000-03-21 Ichor Medical Systems Inc. Drug delivery system and method
US6002961A (en) * 1995-07-25 1999-12-14 Massachusetts Institute Of Technology Transdermal protein delivery using low-frequency sonophoresis
US5983131A (en) * 1995-08-11 1999-11-09 Massachusetts Institute Of Technology Apparatus and method for electroporation of tissue
US5980517A (en) * 1995-08-15 1999-11-09 Rita Medical Systems, Inc. Cell necrosis apparatus
AU3309097A (en) * 1996-06-12 1998-01-07 Alza Corporation Reduction of skin sensitization in electrotransport drug delivery
GB2314274A (en) * 1996-06-20 1997-12-24 Gyrus Medical Ltd Electrode construction for an electrosurgical instrument
US5944710A (en) * 1996-06-24 1999-08-31 Genetronics, Inc. Electroporation-mediated intravascular delivery
US5911223A (en) * 1996-08-09 1999-06-15 Massachusetts Institute Of Technology Introduction of modifying agents into skin by electroporation
US5869326A (en) * 1996-09-09 1999-02-09 Genetronics, Inc. Electroporation employing user-configured pulsing scheme
US5874268A (en) * 1996-09-23 1999-02-23 Duke University Method of introducing exogenous compounds into cells by electroporation and apparatus for same
US5908753A (en) * 1996-10-04 1999-06-01 Merck & Co., Inc. Transformation of Candida albicans by electroporation
US5845646A (en) * 1996-11-05 1998-12-08 Lemelson; Jerome System and method for treating select tissue in a living being
US6017758A (en) * 1997-02-20 2000-01-25 Vanderbilt University DMNPE caged nucleic acid and vector
US5873849A (en) * 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields
US6241701B1 (en) * 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
US6055453A (en) * 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US5879891A (en) * 1997-09-17 1999-03-09 Merck & Co., Inc. Transformation of saccharomyces cerevisiae by electroporation
TW368420B (en) * 1997-11-04 1999-09-01 Genetronics Inc Apparatus and method for transdermal molecular delivery by applying sufficient amplitude of electric field to induce migration of molecules through pores in the stratum corneum

Also Published As

Publication number Publication date
AU760619B2 (en) 2003-05-22
US20050177207A1 (en) 2005-08-11
DK1100576T3 (da) 2007-12-03
US7181271B2 (en) 2007-02-20
DE69936866D1 (de) 2007-09-27
EP1100576B1 (de) 2007-08-15
EP1100576A1 (de) 2001-05-23
EP1100576A4 (de) 2003-05-28
ES2291035T3 (es) 2008-02-16
WO2000000250A1 (en) 2000-01-06
DE69936866T2 (de) 2008-04-30
CA2335888A1 (en) 2000-01-06
US20060270967A1 (en) 2006-11-30
AU5084199A (en) 2000-01-17

Similar Documents

Publication Publication Date Title
ATE369877T1 (de) Synergismus von photodynamischen und elektropermeationseffekten auf die zellvitalität als ein neues cytotoxisches mittel
ATE332725T1 (de) Verfahren zur elektropermeabilisation einzelner zellulärer und organeller strukturen
CA2555561C (en) Electrical stimulation of the acoustic nerve based on selected groups
ATE287277T1 (de) Vorrichtung zur selektiven äusseren netzhautstimulation
WO2004030706A3 (en) Bioactive implants
ATE205101T1 (de) Gerät zur photodynamischen behandlung von lebewesen bzw. organen derselben
ATE311927T1 (de) Perkutanes intramuskuläres stimulationssystem
DE3854476D1 (de) Inhibierung von eukaryotischen pathogenen und neoplasmen mit lytischen peptiden.
ATE286679T1 (de) Elektromagnetische energie gebrauchender zellnekroseapparat
IL119683A (en) Method and device for light irradiation into tissue
WO2001010496A3 (en) Method and apparatus for waveform output
KR850006144A (ko) 비(鼻) 분비물 억제장치 및 그 방법
HU9601572D0 (en) Method and device for depilation
AR022583A1 (es) Secuencias antitumorales anti-sentido dirigidas contra los componentes r1 y r2 de la reductasa de los ribonucleotidos
DE69829281D1 (de) Implantierbarer dreiphasenwellenformdefibrillator
PT768886E (pt) Efeitos de revestimento endotelial e tratamento de desordens vasospasticas
WO2003076006A3 (en) Electrode assembly for constant-current electroporation and use
MD1979G2 (ro) Metodă de tratament al cataractei secundare
WO2012070850A2 (ko) 광조사 기능을 갖는 휴대폰
CN205814884U (zh) 生物光刺激促进骨再生装置
Continenza et al. Effects of low power 904 nm radiation on rat fibroblasts explanted and in vitro cultured
DE69928407D1 (de) Ex vivo behandlung von allogenen und xenogenen t-zellen mit gp39-antagonisten
WO2002033053A3 (en) Method for enhancing primordial germ cell number
DE69831336D1 (de) Tazaroten und uvb-phototherapie zur behandlung von psoriasis
RU97111358A (ru) Способ лечения кандидозного вульвовагинита

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1100576

Country of ref document: EP

REN Ceased due to non-payment of the annual fee