[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ATE365745T1 - Verfahren zur herstellung von perindopril unter verwendung von tetramethyluroniumsalzen als kopplungsreagenzien - Google Patents

Verfahren zur herstellung von perindopril unter verwendung von tetramethyluroniumsalzen als kopplungsreagenzien

Info

Publication number
ATE365745T1
ATE365745T1 AT04731809T AT04731809T ATE365745T1 AT E365745 T1 ATE365745 T1 AT E365745T1 AT 04731809 T AT04731809 T AT 04731809T AT 04731809 T AT04731809 T AT 04731809T AT E365745 T1 ATE365745 T1 AT E365745T1
Authority
AT
Austria
Prior art keywords
coupling reagents
tetramethyluronium salts
perindopril
hydrogenation
tetramethyluronium
Prior art date
Application number
AT04731809T
Other languages
English (en)
Inventor
Rudolf Rucman
Original Assignee
Lek Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Pharmaceuticals filed Critical Lek Pharmaceuticals
Application granted granted Critical
Publication of ATE365745T1 publication Critical patent/ATE365745T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
AT04731809T 2003-05-08 2004-05-07 Verfahren zur herstellung von perindopril unter verwendung von tetramethyluroniumsalzen als kopplungsreagenzien ATE365745T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI200300118A SI21506A (sl) 2003-05-08 2003-05-08 Postopek za pripravo perindoprila

Publications (1)

Publication Number Publication Date
ATE365745T1 true ATE365745T1 (de) 2007-07-15

Family

ID=33434252

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04731809T ATE365745T1 (de) 2003-05-08 2004-05-07 Verfahren zur herstellung von perindopril unter verwendung von tetramethyluroniumsalzen als kopplungsreagenzien

Country Status (9)

Country Link
US (1) US20070173637A1 (de)
EP (1) EP1628995B1 (de)
AT (1) ATE365745T1 (de)
DE (1) DE602004007265T2 (de)
ES (1) ES2287725T3 (de)
PL (1) PL1628995T3 (de)
RU (1) RU2363695C2 (de)
SI (2) SI21506A (de)
WO (1) WO2004099236A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI21703A (en) * 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd Inclusion complexes of perindopril, procedure of their preparation, pharmaceutical compositions containing these complexes and their application in treatment of hypertensia
CN111116709B (zh) * 2019-12-31 2022-06-24 北京鑫开元医药科技有限公司 一种培哚普利制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002094857A1 (en) * 2001-05-23 2002-11-28 The Curators Of The University Of Missouri Inverse solid phase synthesis of peptides
AR036187A1 (es) * 2001-07-24 2004-08-18 Adir Un proceso para la preparacion de perindopril, compuestos analogos y sus sales, compuesto intermediario 2,5-dioxo-oxazolidina y proceso para preparar un intermediario

Also Published As

Publication number Publication date
US20070173637A1 (en) 2007-07-26
DE602004007265T2 (de) 2008-02-28
PL1628995T3 (pl) 2007-11-30
EP1628995A1 (de) 2006-03-01
SI1628995T1 (sl) 2007-12-31
DE602004007265D1 (de) 2007-08-09
RU2005138050A (ru) 2006-08-10
EP1628995B1 (de) 2007-06-27
RU2363695C2 (ru) 2009-08-10
WO2004099236A1 (en) 2004-11-18
SI21506A (sl) 2004-12-31
ES2287725T3 (es) 2007-12-16

Similar Documents

Publication Publication Date Title
ATE312192T1 (de) Verfahren zur fermentativen herstellung von aminosäuren und aminosäure-derivaten der phosphoglycerat-familie
ATE423756T1 (de) Verfahren zur herstellung von hochreinem methyl- tert.-butylether
DE60309019D1 (de) Verfahren zur herstellung von peptidamiden durch seitenkettenanknüpfung an einer festphase
DE602005022387D1 (de) Verfahren zur Herstellung von Dipeptiden
ATE480509T1 (de) Verfahren zur herstellung von isopulegol
DE502006003143D1 (de) Verbessertes verfahren zur herstellung von ramipril
ATE462690T1 (de) Verfahren zur herstellung von lactamen
ATE365745T1 (de) Verfahren zur herstellung von perindopril unter verwendung von tetramethyluroniumsalzen als kopplungsreagenzien
ATE407111T1 (de) Isolierte atomoxetinverunreinigung, verfahren zur herstellung von atomoxetinverunreinigungen und deren verwendung als referenzstandards
ATE423096T1 (de) Verfahren zur herstellung von 2- azabicycloä3.3.0üoctan-3-carbonsäurederivaten
ATE515496T1 (de) Verfahren zur herstellung von enantiomerenangereicherter indolin-2-carbonsäure
ATE451452T1 (de) Verfahren zur enzymatischen reduktion von alkinderivaten
ATE488597T1 (de) Verfahren zur herstellung optisch aktiver aminosäuren unter verwendung eines ganzzellenkatalysators
ATE321039T1 (de) Verfahren zur herstellung von losartan und losartan-kaliumsalz
ATE539071T1 (de) Verfahren zur herstellung von s-(-)-6-hydroxy-2,5,7,8-tetramethylchroman-2-ca bonsäure
DE602005024809D1 (de) Verfahren zur herstellung von gabapentin
ATE488498T1 (de) Verfahren zur herstellung von ace hemmern
ATE370950T1 (de) Verfahren zur herstellung von (1s,4r)-cis-4-(2- amino-6-chlor-9h-purin-9-yl)-2-cyclopenten-1- methanol
ATE502045T1 (de) Verfahren zur herstellung von perindoprilerbumin
ATE473990T1 (de) Verfahren zur synthese von ibandronat-natrium
ATE305939T1 (de) Verfahren zur synthese von (2s,3as,7as)-1-((s)-
DE602006003873D1 (de) Verfahren zur herstellung von l-aminosäuren unter verwendung eines bakteriums der familie enterobacteriaceae
DE602004021814D1 (de) Verfahren zur peptidsynthese
DK2198037T3 (da) Kemo-enzymatisk peptidsyntese ved hjælp af C-terminal ester-interkonvertering
DE60327813D1 (de) Verfahren zu herstellung von lovastatin.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1628995

Country of ref document: EP