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ATE340857T1 - Verfahren zur herstellung von l-aminosäuren durch erhöhung des zellulären nadph - Google Patents

Verfahren zur herstellung von l-aminosäuren durch erhöhung des zellulären nadph

Info

Publication number
ATE340857T1
ATE340857T1 AT00950529T AT00950529T ATE340857T1 AT E340857 T1 ATE340857 T1 AT E340857T1 AT 00950529 T AT00950529 T AT 00950529T AT 00950529 T AT00950529 T AT 00950529T AT E340857 T1 ATE340857 T1 AT E340857T1
Authority
AT
Austria
Prior art keywords
amino acids
producing
bacterial cells
increasing cellular
nadph
Prior art date
Application number
AT00950529T
Other languages
English (en)
Inventor
Michael R O'donohue
Paul D Hanke
Original Assignee
Archer Daniels Midland Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Archer Daniels Midland Co filed Critical Archer Daniels Midland Co
Application granted granted Critical
Publication of ATE340857T1 publication Critical patent/ATE340857T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C12N9/92—Glucose isomerase (5.3.1.5; 5.3.1.9; 5.3.1.18)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT00950529T 1999-07-23 2000-07-21 Verfahren zur herstellung von l-aminosäuren durch erhöhung des zellulären nadph ATE340857T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14521799P 1999-07-23 1999-07-23
US15001799P 1999-08-20 1999-08-20

Publications (1)

Publication Number Publication Date
ATE340857T1 true ATE340857T1 (de) 2006-10-15

Family

ID=26842765

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00950529T ATE340857T1 (de) 1999-07-23 2000-07-21 Verfahren zur herstellung von l-aminosäuren durch erhöhung des zellulären nadph

Country Status (16)

Country Link
US (2) US6465238B1 (de)
EP (1) EP1208205B1 (de)
JP (2) JP4841093B2 (de)
KR (1) KR100575403B1 (de)
CN (1) CN1372597A (de)
AT (1) ATE340857T1 (de)
AU (1) AU6362200A (de)
BR (1) BR0012712B1 (de)
CA (1) CA2377693C (de)
DE (1) DE60030988T2 (de)
DK (1) DK1208205T3 (de)
ES (1) ES2272303T3 (de)
MX (1) MXPA02000729A (de)
NZ (1) NZ517295A (de)
PT (1) PT1208205E (de)
WO (1) WO2001007626A2 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6465238B1 (en) * 1999-07-23 2002-10-15 Archer-Daniels-Midland Company Gene encoding phosphoglucoisomerase
US6830903B1 (en) 1999-07-23 2004-12-14 Archer-Daniels-Midland Company Methods for producing L-amino acids using a corynebacterium glutamicum with a disrupted pgi gene
US6586214B1 (en) * 1999-09-15 2003-07-01 Degussa Ag Method for increasing the metabolic flux through the pentose phosphate cycle in coryneform bacteria by regulation of the phosphoglucose isomerase (pgi gene)
CA2374265A1 (en) * 2000-03-20 2001-09-27 Degussa Ag Process for the fermentative preparation of l-amino acids with amplification of the gnd gene
DE10112992A1 (de) * 2001-03-17 2002-09-26 Degussa Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien
US7160711B2 (en) * 2001-08-06 2007-01-09 Degussa Ag Coryneform bacteria which produce chemical compounds I
DE10220574A1 (de) * 2002-05-08 2003-11-20 Degussa Verfahren zur Herstellung von Aminosäuren mit coryneformen Bakterien unter Verwendung von Phosphoglucose-Isomerasen aus coryneformen Bakterien
AU2004299728A1 (en) * 2003-12-18 2005-06-30 Basf Aktiengesellschaft Methods for the preparation of a fine chemical by fermentation
IN2006CH02603A (de) 2003-12-18 2007-06-08 Basf Ag
WO2005121349A2 (en) * 2003-12-18 2005-12-22 Basf Aktiengesellschaft Methods for the preparation of a fine chemical by fermentation
RU2288264C2 (ru) * 2004-02-12 2006-11-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Бактерия, принадлежащая к роду escherichia - продуцент l-треонина и способ получения l-треонина
KR101201687B1 (ko) * 2004-02-25 2012-11-15 아지노모토 가부시키가이샤 Ｌ-아미노산을 생산하는 방법
RU2004105179A (ru) * 2004-02-25 2005-08-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) 6-фосфоглюконолактоназа из escherichia coli, фрагмент днк, бактерия, принадлежащая к роду escherichia, -продуцент l-аминокислоты, и способ получения l-аминокислоты
US20050191684A1 (en) * 2004-02-25 2005-09-01 Zimenkov Danila V. Method for producing L-amino acids
US20080020433A1 (en) * 2004-02-27 2008-01-24 Kyowa Hakko Kogyo Co,M Ltd. Process for Producing Amino Acids
KR100563226B1 (ko) * 2004-08-10 2006-03-21 한국생산기술연구원 연료전지용 분리판
RU2004124226A (ru) * 2004-08-10 2006-01-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) Использование фосфокетолазы для продукции полезных метаболитов
MX2007007834A (es) 2004-12-22 2007-09-04 Michigan Biotech Inst Microorganismos recombinantes para la produccion incrementada de acidos organicos.
DE102005013676A1 (de) 2005-03-24 2006-09-28 Degussa Ag Allele des zwf-Gens aus coryneformen Bakterien
DE102005023829A1 (de) 2005-05-24 2006-11-30 Degussa Ag Allele des opcA-Gens aus coryneformen Bakterien
DE102005048818A1 (de) 2005-10-10 2007-04-12 Degussa Ag Mikrobiologische Herstellung von 3-Hydroxypropionsäure
KR100873168B1 (ko) * 2007-03-07 2008-12-10 전북대학교산학협력단 ｌｏｎ 유전자 및／또는 ｃｐｘＲ 유전자가 결실된살모넬라 변이균주 및 이를 함유하는 살모넬라 생백신
JP2011516029A (ja) 2007-11-10 2011-05-26 ジュール アンリミテッド インコーポレイテッド 高光合成生物
EP2553107A2 (de) * 2010-03-31 2013-02-06 E.I. Du Pont De Nemours And Company Pentose-phosphat-pfad-aufwärtsregulierung für erhöhte produktion nicht-nativer produkte von interesse in transgenen mikroorganismen
US9181568B2 (en) 2012-04-23 2015-11-10 Exxonmobil Research And Engineering Company Cell systems and methods for improving fatty acid synthesis by expression of dehydrogenases
KR101429814B1 (ko) * 2012-10-05 2014-08-12 상지대학교산학협력단 Ｇｄｈ 활성 조절을 통해 ｌ-쓰레오닌 생산능이 향상된 코리네박테리움 속 미생물 및 이를 이용한 ｌ-쓰레오닌 생산 방법
CN106559997B (zh) * 2014-05-12 2021-04-09 代谢探索者公司 基于nadph依赖型丙酮醇还原酶和改进的nadph供给用于生产1,2-丙二醇的新微生物和方法
KR102384227B1 (ko) 2015-05-18 2022-04-07 삼성전자주식회사 Nadph 생성이 증가된 유전적으로 조작된 효모 세포, 효모 세포 중 nadph 수준을 증가시키는 방법, 상기 효모 세포를 제조하는 방법 및 상기 효모 세포를 이용하여 락테이트를 생산하는 방법
CN112725253B (zh) * 2020-12-30 2023-01-06 宁夏伊品生物科技股份有限公司 一种改造基因bbd29_14900的重组菌株及其构建方法与应用
CN113930465A (zh) * 2021-10-21 2022-01-14 呼伦贝尔东北阜丰生物科技有限公司 一种苏氨酸发酵代谢调控工艺
CN113774096A (zh) * 2021-10-21 2021-12-10 呼伦贝尔东北阜丰生物科技有限公司 一种苏氨酸生产提取工艺的优化方法
CN114181288B (zh) * 2022-02-17 2022-05-03 北京中科伊品生物科技有限公司 制备l-缬氨酸的方法及其所用的基因与该基因编码的蛋白质

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS594988B2 (ja) * 1976-02-03 1984-02-02 日石三菱株式会社 グリコ−スイソメラ−ゼの製法
EP0672161B1 (de) 1992-11-05 1999-09-22 Xyrofin Oy Rekombinante methode und wirt zur herstellung von xylitol
WO1994010325A1 (en) 1992-11-05 1994-05-11 Xyrofin Oy Recombinant method and host for manufacture of xylitol
DK0733712T3 (da) * 1993-10-28 2002-03-18 Ajinomoto Kk Fremgangsmåde til fremstilling af et stof
EP1293560B1 (de) * 1994-08-19 2007-11-14 Ajinomoto Co., Inc. Verfahren zur fermentativen Herstellung von L-Lysin und L-glutaminsäure
JPH09224662A (ja) * 1996-02-23 1997-09-02 Mitsubishi Chem Corp ６−ホスホグルコン酸デヒドロゲナーゼおよびそれをコードするｄｎａ
JPH09224661A (ja) * 1996-02-23 1997-09-02 Mitsubishi Chem Corp グルコース−６−リン酸デヒドロゲナーゼおよびそれをコードするｄｎａ
CN1187446C (zh) * 1997-07-18 2005-02-02 味之素株式会社 通过发酵生产嘌呤核苷的方法及所用的微生物
FR2772788B1 (fr) * 1997-12-19 2000-11-17 Roquette Freres Procede pour accroitre la production de certains polyols par une souche osmotolerante
US6465238B1 (en) * 1999-07-23 2002-10-15 Archer-Daniels-Midland Company Gene encoding phosphoglucoisomerase
US6586214B1 (en) * 1999-09-15 2003-07-01 Degussa Ag Method for increasing the metabolic flux through the pentose phosphate cycle in coryneform bacteria by regulation of the phosphoglucose isomerase (pgi gene)

Also Published As

Publication number Publication date
US6680190B2 (en) 2004-01-20
US20030017557A1 (en) 2003-01-23
DK1208205T3 (da) 2007-02-05
BR0012712B1 (pt) 2011-12-13
NZ517295A (en) 2004-04-30
JP2011041582A (ja) 2011-03-03
PT1208205E (pt) 2006-12-29
KR20020048928A (ko) 2002-06-24
CA2377693A1 (en) 2001-02-01
ES2272303T3 (es) 2007-05-01
CA2377693C (en) 2016-11-08
DE60030988T2 (de) 2007-01-04
US6465238B1 (en) 2002-10-15
WO2001007626A3 (en) 2001-05-31
JP2003521888A (ja) 2003-07-22
WO2001007626A2 (en) 2001-02-01
CN1372597A (zh) 2002-10-02
AU6362200A (en) 2001-02-13
DE60030988D1 (de) 2006-11-09
EP1208205B1 (de) 2006-09-27
JP4841093B2 (ja) 2011-12-21
KR100575403B1 (ko) 2006-05-03
BR0012712A (pt) 2002-04-09
EP1208205A2 (de) 2002-05-29
MXPA02000729A (es) 2002-08-20

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties