ATE238279T1 - Zyklische aminoverbindungen - Google Patents
Zyklische aminoverbindungenInfo
- Publication number
- ATE238279T1 ATE238279T1 AT99906508T AT99906508T ATE238279T1 AT E238279 T1 ATE238279 T1 AT E238279T1 AT 99906508 T AT99906508 T AT 99906508T AT 99906508 T AT99906508 T AT 99906508T AT E238279 T1 ATE238279 T1 AT E238279T1
- Authority
- AT
- Austria
- Prior art keywords
- cyclic amino
- optionally substituted
- amino compounds
- preventives
- remedies
- Prior art date
Links
- -1 AMINO COMPOUNDS Chemical class 0.000 title 1
- 208000005189 Embolism Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 238000004220 aggregation Methods 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 230000000702 anti-platelet effect Effects 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Saccharide Compounds (AREA)
- Lubricants (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4692198 | 1998-02-27 | ||
| PCT/JP1999/000924 WO1999043648A1 (fr) | 1998-02-27 | 1999-02-26 | Composes amino cycliques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE238279T1 true ATE238279T1 (de) | 2003-05-15 |
Family
ID=12760807
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99906508T ATE238279T1 (de) | 1998-02-27 | 1999-02-26 | Zyklische aminoverbindungen |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6610708B1 (de) |
| EP (1) | EP1063230B1 (de) |
| KR (1) | KR100567950B1 (de) |
| CN (1) | CN100369896C (de) |
| AT (1) | ATE238279T1 (de) |
| AU (1) | AU737303B2 (de) |
| BR (1) | BRPI9908319B8 (de) |
| CA (1) | CA2322171C (de) |
| CZ (1) | CZ300821B6 (de) |
| DE (1) | DE69907166T2 (de) |
| DK (1) | DK1063230T3 (de) |
| ES (1) | ES2196772T3 (de) |
| HU (1) | HU225741B1 (de) |
| ID (1) | ID25589A (de) |
| IL (1) | IL138068A (de) |
| MX (1) | MXPA00008439A (de) |
| NO (1) | NO317882B1 (de) |
| NZ (1) | NZ506574A (de) |
| PL (1) | PL200666B1 (de) |
| PT (1) | PT1063230E (de) |
| RU (1) | RU2203887C2 (de) |
| TR (1) | TR200002505T2 (de) |
| WO (1) | WO1999043648A1 (de) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1695962A4 (de) * | 2003-11-28 | 2007-03-28 | Sankyo Co | Cyclisches aminderivat mit heteroarylring |
| WO2006002350A1 (en) * | 2004-06-24 | 2006-01-05 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| EA200700117A1 (ru) | 2004-06-24 | 2007-06-29 | Инсайт Корпорейшн | N-замещенные пиперидины и их применение в качестве фармацевтических препаратов |
| RU2382771C2 (ru) * | 2005-05-27 | 2010-02-27 | Дайити Санкио Компани, Лимитед | Циклическое производное амина, содержащее замещенную алкильную группу |
| RU2312660C2 (ru) * | 2005-07-25 | 2007-12-20 | Государственное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия" Федерального агентства по здравоохранению и социальному развитию (ГОУ ВПО ПГФА Росздрава) | 4-ацетил-3-гидрокси-1-(2-гидроксиэтиламиноэтил)-5-фенил-3-пирролин-2-он, проявляющий антикоагулянтную активность |
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| KR101841332B1 (ko) | 2013-01-09 | 2018-03-22 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | 티에노피리딘 화합물의 혼합된 이황화물 접합체 및 이들의 용도 |
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| SG11201509782TA (en) | 2013-06-04 | 2015-12-30 | Cellix Bio Private Ltd | Compositions and methods for the treatment of diabetes and pre-diabetes |
| US9096537B1 (en) | 2014-12-31 | 2015-08-04 | Mahesh Kandula | Compositions and methods for the treatment of mucositis |
| CA2976314C (en) | 2014-09-26 | 2021-02-23 | Cellix Bio Private Limited | Compositions and methods for the treatment of epilepsy and neurological disorders |
| EP3201168B1 (de) | 2014-09-29 | 2020-03-18 | Cellix Bio Private Limited | Verbindungen und zusammensetzungen zur behandlung multipler sklerose |
| SG11201703369WA (en) | 2014-10-27 | 2017-05-30 | Cellix Bio Private Ltd | Three component salts of fumaric acid monomethyl ester with piperazine or ethylene diamine for the treatment of multiple sclerosis |
| US9175008B1 (en) | 2014-11-05 | 2015-11-03 | Cellix Bio Private Limited | Prodrugs of anti-platelet agents |
| US9284287B1 (en) | 2014-11-05 | 2016-03-15 | Cellix Bio Private Limited | Compositions and methods for the suppression of carbonic anhydrase activity |
| US9150557B1 (en) | 2014-11-05 | 2015-10-06 | Cellix Bio Private Limited | Compositions and methods for the treatment of hyperglycemia |
| US9290486B1 (en) | 2014-11-05 | 2016-03-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of epilepsy |
| US9321716B1 (en) | 2014-11-05 | 2016-04-26 | Cellix Bio Private Limited | Compositions and methods for the treatment of metabolic syndrome |
| US10208014B2 (en) | 2014-11-05 | 2019-02-19 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological disorders |
| US9173877B1 (en) | 2014-11-05 | 2015-11-03 | Cellix Bio Private Limited | Compositions and methods for the treatment of local pain |
| US9932294B2 (en) | 2014-12-01 | 2018-04-03 | Cellix Bio Private Limited | Compositions and methods for the treatment of multiple sclerosis |
| US9206111B1 (en) | 2014-12-17 | 2015-12-08 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological diseases |
| DK3242869T3 (da) | 2015-01-06 | 2022-01-31 | Cellix Bio Private Ltd | Sammensætninger og fremgangsmåder til behanding af inflammation og smerte |
| CN116478086A (zh) | 2015-04-30 | 2023-07-25 | 密歇根大学董事会 | 噻吩并吡啶化合物的混合二硫共轭物及其用法 |
| CN106554368A (zh) * | 2015-09-25 | 2017-04-05 | 陕西合成药业股份有限公司 | 噻吩并吡啶类衍生物及其制备方法和用途 |
| CN106554369A (zh) * | 2015-09-25 | 2017-04-05 | 陕西合成药业股份有限公司 | 噻吩并吡啶类衍生物及其制备方法和用途 |
| CN106554302A (zh) * | 2015-09-25 | 2017-04-05 | 陕西合成药业股份有限公司 | 噻吩并吡啶类衍生物及其制备方法和用途 |
| EA202091702A1 (ru) | 2018-01-31 | 2021-02-24 | Зе Реджентс Оф Зе Юниверсити Оф Мичиган | Биокатализатор и способы синтеза смешанных дисульфидных конъюгатов тиенопиридиновых соединений |
| US11642335B2 (en) * | 2019-09-26 | 2023-05-09 | Board Of Regents, The University Of Texas System | Chemical synthesis of clopidogrel active metabolites and disulfide conjugate prodrugs |
| CN111484446A (zh) * | 2020-04-02 | 2020-08-04 | 北京翼方生物科技有限责任公司 | 氯吡格雷代谢活性体二硫衍生物、其制备方法及医药用途 |
| CN111848497A (zh) * | 2020-07-28 | 2020-10-30 | 内蒙古医科大学 | 氯吡格雷活性代谢物衍生物、其前药及其制备方法与应用 |
| CN112851570A (zh) * | 2021-01-13 | 2021-05-28 | 北京沃邦医药科技有限公司 | 不饱和环胺半胱氨酸二硫衍生物制备方法及其医药用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US555854A (en) * | 1896-03-03 | Brush-handle attachment | ||
| US3647796A (en) * | 1968-12-23 | 1972-03-07 | Parke Davis & Co | Cyclicamino alkylaminothioacridine |
| FR2215948B1 (de) | 1973-02-01 | 1976-05-14 | Centre Etd Ind Pharma | |
| FR2495156A1 (fr) * | 1980-11-28 | 1982-06-04 | Sanofi Sa | Derives de la thieno-pyridinone, leur procede de preparation et leur application therapeutique |
| FR2530247B1 (fr) * | 1982-07-13 | 1986-05-16 | Sanofi Sa | Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique |
| FR2576901B1 (fr) | 1985-01-31 | 1987-03-20 | Sanofi Sa | Nouveaux derives de l'acide a-(oxo-2 hexahydro-2,4,5,6,7,7a thieno (3,2-c) pyridyl-5) phenyl acetique, leur procede de preparation et leur application therapeutique |
| US4845121A (en) * | 1986-06-13 | 1989-07-04 | The Ohio State University Research Foundation | Aci-reductone compounds belonging to the 6,7-disubstituted-3,4-dihydro benzopyan-2H-one class having antiaggregatory properties |
| JPH04334358A (ja) * | 1991-05-02 | 1992-11-20 | Ono Pharmaceut Co Ltd | 縮合ベンゼンオキシ酢酸誘導体 |
| FI101150B (fi) | 1991-09-09 | 1998-04-30 | Sankyo Co | Menetelmä lääkeaineina käyttökelpoisten tetrahydrotienopyridiinin johd annaisten valmistamiseksi |
| WO1993014077A1 (en) * | 1992-01-21 | 1993-07-22 | Glaxo Group Limited | Piperidineacetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation |
| WO1994022440A1 (en) * | 1993-03-29 | 1994-10-13 | Smithkline Beecham Corporation | Bicyclic compounds which inhibit platelet aggregation |
| ES2134284T3 (es) | 1993-04-23 | 1999-10-01 | Hoechst Ag | Pirido-pirimidindionas, procedimiento para su preparacion y su empleo como medicamentos. |
| EP1393723A3 (de) * | 1993-09-17 | 2004-10-20 | The Brigham And Women's Hospital, Inc. | Verwendung von Stickstoffoxid-addukten zur Vorbeugung von Thrombosen auf künstlichen und vaskularen Oberflächen |
| NZ334389A (en) | 1996-08-28 | 2001-05-25 | Ube Industries | Cyclic amine derivatives |
-
1999
- 1999-02-26 CA CA002322171A patent/CA2322171C/en not_active Expired - Lifetime
- 1999-02-26 MX MXPA00008439A patent/MXPA00008439A/es active IP Right Grant
- 1999-02-26 CZ CZ20003119A patent/CZ300821B6/cs not_active IP Right Cessation
- 1999-02-26 RU RU2000122434/04A patent/RU2203887C2/ru active
- 1999-02-26 KR KR1020007009485A patent/KR100567950B1/ko not_active Expired - Lifetime
- 1999-02-26 DE DE69907166T patent/DE69907166T2/de not_active Expired - Lifetime
- 1999-02-26 WO PCT/JP1999/000924 patent/WO1999043648A1/ja active IP Right Grant
- 1999-02-26 NZ NZ506574A patent/NZ506574A/xx not_active IP Right Cessation
- 1999-02-26 TR TR2000/02505T patent/TR200002505T2/xx unknown
- 1999-02-26 ES ES99906508T patent/ES2196772T3/es not_active Expired - Lifetime
- 1999-02-26 IL IL13806899A patent/IL138068A/xx not_active IP Right Cessation
- 1999-02-26 CN CNB998055786A patent/CN100369896C/zh not_active Expired - Lifetime
- 1999-02-26 AU AU26413/99A patent/AU737303B2/en not_active Expired
- 1999-02-26 HU HU0100950A patent/HU225741B1/hu unknown
- 1999-02-26 EP EP99906508A patent/EP1063230B1/de not_active Expired - Lifetime
- 1999-02-26 PT PT99906508T patent/PT1063230E/pt unknown
- 1999-02-26 PL PL342573A patent/PL200666B1/pl unknown
- 1999-02-26 BR BRPI9908319-1 patent/BRPI9908319B8/pt not_active IP Right Cessation
- 1999-02-26 DK DK99906508T patent/DK1063230T3/da active
- 1999-02-26 ID IDW20001635A patent/ID25589A/id unknown
- 1999-02-26 AT AT99906508T patent/ATE238279T1/de active
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2000
- 2000-08-24 US US09/622,849 patent/US6610708B1/en not_active Expired - Lifetime
- 2000-08-25 NO NO20004279A patent/NO317882B1/no not_active IP Right Cessation
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